ATE555785T1 - Triazolderivate als smo-antagonisten - Google Patents
Triazolderivate als smo-antagonistenInfo
- Publication number
- ATE555785T1 ATE555785T1 AT08742913T AT08742913T ATE555785T1 AT E555785 T1 ATE555785 T1 AT E555785T1 AT 08742913 T AT08742913 T AT 08742913T AT 08742913 T AT08742913 T AT 08742913T AT E555785 T1 ATE555785 T1 AT E555785T1
- Authority
- AT
- Austria
- Prior art keywords
- triazole derivatives
- smo antagonists
- smo
- antagonists
- triazole
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92501807P | 2007-04-18 | 2007-04-18 | |
| PCT/US2008/004862 WO2008130552A1 (en) | 2007-04-18 | 2008-04-15 | Triazole derivatives which are smo antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555785T1 true ATE555785T1 (de) | 2012-05-15 |
Family
ID=39433852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08742913T ATE555785T1 (de) | 2007-04-18 | 2008-04-15 | Triazolderivate als smo-antagonisten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7691887B2 (enExample) |
| EP (1) | EP2136803B1 (enExample) |
| JP (1) | JP5498936B2 (enExample) |
| CN (1) | CN101663033B (enExample) |
| AR (1) | AR066063A1 (enExample) |
| AT (1) | ATE555785T1 (enExample) |
| AU (1) | AU2008241527B2 (enExample) |
| CA (1) | CA2683946C (enExample) |
| CL (1) | CL2008001074A1 (enExample) |
| PE (1) | PE20090806A1 (enExample) |
| TW (1) | TW200901987A (enExample) |
| WO (1) | WO2008130552A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| PE20091180A1 (es) * | 2007-12-27 | 2009-08-26 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer |
| ES2610130T3 (es) | 2007-12-27 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Métodos para reducción estereoselectiva |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| GB0813740D0 (en) * | 2008-07-28 | 2008-09-03 | Angeletti P Ist Richerche Biologica | Therapeutic compounds |
| WO2010023480A1 (en) * | 2008-08-29 | 2010-03-04 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Saturated bicyclic heterocyclic derivatives as smo antagonists |
| CN102574791A (zh) | 2009-08-05 | 2012-07-11 | 无限药品股份有限公司 | 环杷明类似物的酶促转氨基反应 |
| AU2010321773A1 (en) * | 2009-11-20 | 2012-06-14 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| AU2014251038A1 (en) | 2013-04-08 | 2015-11-26 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| CN104324039A (zh) * | 2014-10-20 | 2015-02-04 | 付茜 | 一种治疗人身体表面脂肪瘤的药剂及使用方法 |
| US10369147B2 (en) | 2015-06-04 | 2019-08-06 | PellePharm, Inc. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| CN108623446A (zh) * | 2017-03-24 | 2018-10-09 | 北京艾德旺科技发展有限公司 | 一种合成3，3-二氟环丁烷甲酸的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| EP1474139B1 (en) | 2002-02-01 | 2007-11-21 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
| JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| AU2004243301B2 (en) | 2003-05-29 | 2010-03-25 | Merck Sharp & Dohme Corp. | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 |
| US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
| AU2005325267B2 (en) | 2004-04-30 | 2010-11-04 | Curis Inc. | Quinoxaline inhibitors of the hedgehog signalling pathway |
| WO2006017542A1 (en) | 2004-08-06 | 2006-02-16 | Merck & Co., Inc. | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
| EP2316832B1 (en) | 2004-08-27 | 2017-03-08 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
| EP1789390B1 (en) | 2004-09-02 | 2011-11-09 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| RU2007119637A (ru) | 2004-10-28 | 2008-12-10 | Айрм Ллк (Bm) | Соединения и композиции в качестве модуляторов hedgehog-пути |
| NZ555419A (en) | 2004-11-03 | 2009-07-31 | Curis Inc | Mediators of the hedgehog gene signaling pathways, compositions and uses related thereto |
| JP5036722B2 (ja) | 2005-10-20 | 2012-09-26 | メルク・シャープ・エンド・ドーム・コーポレイション | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ−１阻害剤としてのトリアゾール誘導体 |
-
2008
- 2008-04-15 US US12/082,933 patent/US7691887B2/en active Active
- 2008-04-15 JP JP2010504069A patent/JP5498936B2/ja active Active
- 2008-04-15 PE PE2008000654A patent/PE20090806A1/es not_active Application Discontinuation
- 2008-04-15 AU AU2008241527A patent/AU2008241527B2/en active Active
- 2008-04-15 CL CL2008001074A patent/CL2008001074A1/es unknown
- 2008-04-15 WO PCT/US2008/004862 patent/WO2008130552A1/en not_active Ceased
- 2008-04-15 TW TW097113665A patent/TW200901987A/zh unknown
- 2008-04-15 EP EP08742913A patent/EP2136803B1/en active Active
- 2008-04-15 AT AT08742913T patent/ATE555785T1/de active
- 2008-04-15 AR ARP080101540A patent/AR066063A1/es unknown
- 2008-04-15 CN CN2008800127274A patent/CN101663033B/zh active Active
- 2008-04-15 CA CA2683946A patent/CA2683946C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US7691887B2 (en) | 2010-04-06 |
| CL2008001074A1 (es) | 2009-06-05 |
| TW200901987A (en) | 2009-01-16 |
| US20080262051A1 (en) | 2008-10-23 |
| AU2008241527A1 (en) | 2008-10-30 |
| EP2136803B1 (en) | 2012-05-02 |
| CA2683946C (en) | 2013-01-22 |
| AR066063A1 (es) | 2009-07-22 |
| EP2136803A1 (en) | 2009-12-30 |
| PE20090806A1 (es) | 2009-06-27 |
| JP5498936B2 (ja) | 2014-05-21 |
| JP2010524937A (ja) | 2010-07-22 |
| CN101663033B (zh) | 2013-01-16 |
| CN101663033A (zh) | 2010-03-03 |
| CA2683946A1 (en) | 2008-10-30 |
| WO2008130552A1 (en) | 2008-10-30 |
| AU2008241527B2 (en) | 2014-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LTC2170860I2 (lt) | Benzimidazolo dariniai | |
| ATE555785T1 (de) | Triazolderivate als smo-antagonisten | |
| ATE526325T1 (de) | Substituierte benzimidazole als kinaseinhibitoren | |
| EP2194045A4 (en) | Substituted pyrazole derivative | |
| ATE540942T1 (de) | Imidazolderivate als ccr2-rezeptor-antagonisten | |
| ATE506358T1 (de) | 2-benzylpyridazinonderivate als met-kinasehemmer | |
| ATE549340T1 (de) | Spiroindolinon-derivate als mdm2-p53 inhibitoren | |
| DE602006015607D1 (de) | Thiazol-4-carboxamid-derivate als mglur5-antagonisten | |
| DK2351747T3 (da) | Fungicide N-cycloalkylbenzylamidderivater | |
| DK2164844T3 (da) | Pyrimidinyl-pyridazinonderivater | |
| DK2209786T3 (da) | Pyrimidinsubstituerede purinderivater | |
| BRPI0816461A2 (pt) | Derivados fungicidas de 2-alquiltio-2-quinolonolóxi-acetamida | |
| BRPI0813836A2 (pt) | Derivados pirazólicos | |
| ATE533761T1 (de) | Imidazolidinonderivate | |
| BRPI0906705A2 (pt) | Composto heterocíclicos | |
| ATE518837T1 (de) | Indazolamidderivate | |
| BRPI0915876A2 (pt) | composto azol | |
| ATE537149T1 (de) | Sulfonyl-pyrazolinyl-1-carboxamidinderivate als 5-ht6-antagonisten | |
| BRPI0817609A2 (pt) | Derivados de imidazol | |
| ATE545417T1 (de) | Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer | |
| DK2152370T3 (da) | Aryletherpyridazinonderivater | |
| BRPI0810926A2 (pt) | Antagonista de crig | |
| ATE522517T1 (de) | Neue imidazolderivate | |
| ATE545635T1 (de) | Substituierte n-oxidpyrazinderivate | |
| ATE449091T1 (de) | Substituierte triazolderivate als oxytocinantagonisten |