TR200401779T2 - Astım, alerji ve enflamatuvar hastalıklara ilişkin bileşikler ve tedavi. - Google Patents

Astım, alerji ve enflamatuvar hastalıklara ilişkin bileşikler ve tedavi.

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Publication number
TR200401779T2
TR200401779T2 TR2004/01779T TR200401779T TR200401779T2 TR 200401779 T2 TR200401779 T2 TR 200401779T2 TR 2004/01779 T TR2004/01779 T TR 2004/01779T TR 200401779 T TR200401779 T TR 200401779T TR 200401779 T2 TR200401779 T2 TR 200401779T2
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TR
Turkey
Prior art keywords
compounds
asthma
disease
rhinitis
substituted
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TR2004/01779T
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English (en)
Inventor
Cai Xiong
Lewis Timothy
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Ucb, S.A.
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Application filed by Ucb, S.A. filed Critical Ucb, S.A.
Publication of TR200401779T2 publication Critical patent/TR200401779T2/tr

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    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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Abstract

Mevcut bulus 1,4 ikameli piperazinleri, 1,4 ikameli piperidinleri ve 1-ikameli, 4-alkilidenil piperidin bilesikleri sunmaktadir. Bulusa iliskin bilesikler hem lökotriyen inhibisyonu özellikleri, hem antihistaminik özelliklere sahip çifte etkili moleküllerdir. Bulusa iliskin bilesikler bir histamin ve/veya lökotriyen bilesenin mevcut olmasi ihtimali olan durumlarin tedavisi için faydalidirlar. Bu durumlar tercihen astim, mevsimsel ve devamli alarjik rinit, sinüzit, konjünktivit, gida alerjisi, uskumrugiller zehirlenmesi, sedef, ürtiker, siddetli kasinti, ekzema, romatizmal artrit, enflamatuvar bagirsak hastaligi, kronik tikayici akciger hastaligi, trombotik hastalik ve orta kulak iltihabidir. Ayni zamanda, bilesiklerin astimi ve riniti iyilestirmek için etkili bir miktarini buna ihtiyaci olan bir kisiye vermek suretiyle astim ve rinitin tedavi edilmesine iliskin yöntemler de sunulmaktadir.
TR2004/01779T 1999-03-26 2000-03-23 Astım, alerji ve enflamatuvar hastalıklara ilişkin bileşikler ve tedavi. TR200401779T2 (tr)

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US12652199P 1999-03-26 1999-03-26

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TR200401779T2 true TR200401779T2 (tr) 2005-01-24

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TR2001/02717T TR200102717T2 (tr) 1999-03-26 2000-03-23 Astım, alerji ve enflamatuvar hastalıklara ilişkin bileşikler ve tedavi .
TR2004/01779T TR200401779T2 (tr) 1999-03-26 2000-03-23 Astım, alerji ve enflamatuvar hastalıklara ilişkin bileşikler ve tedavi.

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TR2001/02717T TR200102717T2 (tr) 1999-03-26 2000-03-23 Astım, alerji ve enflamatuvar hastalıklara ilişkin bileşikler ve tedavi .

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US (3) US6451801B1 (tr)
EP (1) EP1165533B1 (tr)
JP (2) JP2002540198A (tr)
KR (1) KR20020005635A (tr)
CN (3) CN1528742A (tr)
AR (2) AR020026A1 (tr)
AT (1) ATE279401T1 (tr)
AU (1) AU761422B2 (tr)
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CA (1) CA2368090A1 (tr)
CO (1) CO5180543A1 (tr)
CZ (1) CZ20013471A3 (tr)
DE (1) DE60014876T2 (tr)
DZ (1) DZ3027A1 (tr)
EE (2) EE200100498A (tr)
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SK (1) SK13272001A3 (tr)
TR (2) TR200102717T2 (tr)
UA (1) UA69449C2 (tr)
WO (1) WO2000058295A2 (tr)
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