CN1528742A - 治疗哮喘、过敏和炎症的化合物及其中间体 - Google Patents
治疗哮喘、过敏和炎症的化合物及其中间体 Download PDFInfo
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- CN1528742A CN1528742A CNA2004100282269A CN200410028226A CN1528742A CN 1528742 A CN1528742 A CN 1528742A CN A2004100282269 A CNA2004100282269 A CN A2004100282269A CN 200410028226 A CN200410028226 A CN 200410028226A CN 1528742 A CN1528742 A CN 1528742A
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US12652199P | 1999-03-26 | 1999-03-26 | |
US60/126,521 | 1999-03-26 |
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CNB008068216A Division CN1160344C (zh) | 1999-03-26 | 2000-03-23 | 治疗哮喘、过敏和炎症的化合物及其用途 |
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CN1528742A true CN1528742A (zh) | 2004-09-15 |
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CNA2004100495405A Pending CN1560041A (zh) | 1999-03-26 | 2000-03-23 | 治疗哮喘、过敏和炎症的化合物和方法 |
CNB008068216A Expired - Fee Related CN1160344C (zh) | 1999-03-26 | 2000-03-23 | 治疗哮喘、过敏和炎症的化合物及其用途 |
CNA2004100282269A Pending CN1528742A (zh) | 1999-03-26 | 2000-03-23 | 治疗哮喘、过敏和炎症的化合物及其中间体 |
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CNA2004100495405A Pending CN1560041A (zh) | 1999-03-26 | 2000-03-23 | 治疗哮喘、过敏和炎症的化合物和方法 |
CNB008068216A Expired - Fee Related CN1160344C (zh) | 1999-03-26 | 2000-03-23 | 治疗哮喘、过敏和炎症的化合物及其用途 |
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US (3) | US6451801B1 (tr) |
EP (1) | EP1165533B1 (tr) |
JP (2) | JP2002540198A (tr) |
KR (1) | KR20020005635A (tr) |
CN (3) | CN1560041A (tr) |
AR (2) | AR020026A1 (tr) |
AT (1) | ATE279401T1 (tr) |
AU (1) | AU761422B2 (tr) |
BG (1) | BG105909A (tr) |
BR (1) | BR0009341A (tr) |
CA (1) | CA2368090A1 (tr) |
CO (1) | CO5180543A1 (tr) |
CZ (1) | CZ20013471A3 (tr) |
DE (1) | DE60014876T2 (tr) |
DZ (1) | DZ3027A1 (tr) |
EE (2) | EE200100498A (tr) |
ES (1) | ES2231164T3 (tr) |
GT (1) | GT200000034A (tr) |
HK (1) | HK1041880B (tr) |
HU (1) | HUP0200613A2 (tr) |
ID (1) | ID30430A (tr) |
IL (1) | IL145481A0 (tr) |
IS (2) | IS6077A (tr) |
JO (1) | JO2250B1 (tr) |
MX (1) | MXPA01009664A (tr) |
NO (2) | NO20014648L (tr) |
NZ (1) | NZ514291A (tr) |
PA (1) | PA8493101A1 (tr) |
PE (1) | PE20001566A1 (tr) |
PL (1) | PL350845A1 (tr) |
RU (1) | RU2241707C2 (tr) |
SK (1) | SK13272001A3 (tr) |
TR (2) | TR200401779T2 (tr) |
UA (1) | UA69449C2 (tr) |
WO (1) | WO2000058295A2 (tr) |
YU (1) | YU68601A (tr) |
ZA (1) | ZA200107642B (tr) |
Families Citing this family (19)
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US6894059B1 (en) * | 1999-03-26 | 2005-05-17 | Ucb S.A. | Compounds and methods for treatment of asthma, allergy and inflammatory disorders |
PE20001566A1 (es) * | 1999-03-26 | 2001-02-05 | Ucb Sa | Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas |
US6686502B1 (en) * | 1999-03-26 | 2004-02-03 | Ucb S.A. | Compounds and methods for treatment of asthma, allergy and inflammatory disorders |
JP2004504266A (ja) * | 2000-01-17 | 2004-02-12 | バイエル アクチェンゲゼルシャフト | 置換アリールケトン類 |
US6440994B1 (en) * | 2000-03-29 | 2002-08-27 | Richard J. Sanders, Jr. | Method of treating acne |
GB0009479D0 (en) * | 2000-04-17 | 2000-06-07 | Cipla Limited | Antihistaminic compounds |
KR100995557B1 (ko) * | 2002-03-27 | 2010-11-22 | 썬 파마 어드밴스트 리서치 컴패니 리미티드 | 4-(디아릴메틸)-1-피페라지닐 유도체 |
PL378027A1 (pl) | 2003-01-23 | 2006-02-20 | Ucb Farchim Sa | Nowe pochodne piperazyny i ich zastosowanie jako związków pośrednich w syntezie |
EP1457485A1 (en) * | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonic acids, their derivatives and pharmaceutical compositions containing them |
WO2006010283A1 (en) * | 2004-07-28 | 2006-02-02 | Universität Zürich | Prevention and treatment of thrombus formation |
KR100658436B1 (ko) * | 2005-12-09 | 2006-12-27 | 한국화학연구원 | 아데노실코발라민 함유 피부질환 치료용 외용제 조성물 |
JP2009540856A (ja) * | 2006-06-27 | 2009-11-26 | バイオリポックス エービー | エオキシン形成の修飾物質の同定方法 |
ES2357340T3 (es) | 2006-10-18 | 2011-04-25 | Pfizer Products Inc. | Compuestos de biaril éter urea. |
US8258306B2 (en) * | 2007-12-12 | 2012-09-04 | Amgen Inc. | Glycine transporter-1 inhibitors |
RU2469724C2 (ru) * | 2007-12-18 | 2012-12-20 | Мейдзи Сейка Фарма Ко., Лтд. | Профилактическое или терапевтическое вещество при воспалительных болезнях кишечника |
US20110172425A1 (en) * | 2008-09-17 | 2011-07-14 | Calyx Chemicals And Pharmaceuticals Pvt. Ltd. | Novel water based process for the preparation of substituted diphenylmethyl piperazines |
CN102924406B (zh) * | 2012-11-07 | 2014-11-05 | 南京医科大学 | 取代芳氧乙基哌嗪类衍生物及其制备方法和应用 |
CN107602534B (zh) * | 2017-09-05 | 2020-04-24 | 合肥医工医药股份有限公司 | 具有抗组胺和抗炎活性的化合物及其制备方法和应用 |
CN115215800B (zh) * | 2021-04-21 | 2023-07-18 | 赣江中药创新中心 | 一种二苯并环基-环胺基醚衍生物或盐及其制备方法和应用 |
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US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
GB1574822A (en) | 1976-03-23 | 1980-09-10 | Lafon Labor | Acetohydroxamic acid derivatives and pharmaceutical compositions thereof |
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
NO155805C (no) * | 1981-02-06 | 1987-06-10 | Ucb Sa | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter. |
US5438062A (en) * | 1986-10-31 | 1995-08-01 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and methods of use |
US4826853A (en) | 1986-10-31 | 1989-05-02 | Schering Corporation | 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use |
US5066658A (en) * | 1988-11-10 | 1991-11-19 | Ortho Pharmaceutical Corporation | Substituted hydroxyureas |
US5288751A (en) * | 1992-11-06 | 1994-02-22 | Abbott Laboratories | [(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis |
US5719148A (en) | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
TW308594B (tr) | 1993-10-15 | 1997-06-21 | Schering Corp | |
WO1995013264A1 (fr) | 1993-11-08 | 1995-05-18 | Terumo Kabushiki Kaisha | Derive d'acide hydroxamique et preparation medicamenteuse contenant ledit derive |
US5877177A (en) | 1997-06-17 | 1999-03-02 | Schering Corporation | Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
US6894059B1 (en) * | 1999-03-26 | 2005-05-17 | Ucb S.A. | Compounds and methods for treatment of asthma, allergy and inflammatory disorders |
US6686502B1 (en) * | 1999-03-26 | 2004-02-03 | Ucb S.A. | Compounds and methods for treatment of asthma, allergy and inflammatory disorders |
PE20001566A1 (es) * | 1999-03-26 | 2001-02-05 | Ucb Sa | Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas |
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- 2000-03-23 CN CNB008068216A patent/CN1160344C/zh not_active Expired - Fee Related
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- 2000-03-23 TR TR2004/01779T patent/TR200401779T2/tr unknown
- 2000-03-23 TR TR2001/02717T patent/TR200102717T2/tr unknown
- 2000-03-23 HU HU0200613A patent/HUP0200613A2/hu unknown
- 2000-03-23 AR ARP000101298A patent/AR020026A1/es not_active Application Discontinuation
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2002
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2003
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