MX9804991A - 4-(1h-benzimidazol-2-il)(1,4) diazepanes sustituidos novedosos utiles para el tratamiento de enfermedades alergicas. - Google Patents
4-(1h-benzimidazol-2-il)(1,4) diazepanes sustituidos novedosos utiles para el tratamiento de enfermedades alergicas.Info
- Publication number
- MX9804991A MX9804991A MX9804991A MX9804991A MX9804991A MX 9804991 A MX9804991 A MX 9804991A MX 9804991 A MX9804991 A MX 9804991A MX 9804991 A MX9804991 A MX 9804991A MX 9804991 A MX9804991 A MX 9804991A
- Authority
- MX
- Mexico
- Prior art keywords
- benzimidazol
- treatment
- useful
- allergic diseases
- novel substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a derivados de 4-(1H-benzimidazol-2-il)[1,4]diazepan novedosos de la formula (1) y esteroisomeros del mismo, y sales farmacéuticamente aceptables de los mismos, los cuales son utiles como antagonistas de receptor de histamina y antagonistas de receptor de taquicinina. Dichos antagonistas son utiles en el tratamiento de rinitis alérgica, incluyendo rinitis de temporada y sinusitis; enfermedades inflamatorias del intestino, incluyendo enfermedad de Crohn y colitis ulcerativa, asma, bronquitis, y emesis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58000495A | 1995-12-20 | 1995-12-20 | |
US73641196A | 1996-10-24 | 1996-10-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9804991A true MX9804991A (es) | 1998-09-30 |
Family
ID=27077922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9804991A MX9804991A (es) | 1995-12-20 | 1998-06-19 | 4-(1h-benzimidazol-2-il)(1,4) diazepanes sustituidos novedosos utiles para el tratamiento de enfermedades alergicas. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0874843B1 (es) |
JP (1) | JP2000500772A (es) |
KR (1) | KR20000064487A (es) |
CN (1) | CN1080262C (es) |
AR (1) | AR005120A1 (es) |
AT (1) | ATE221883T1 (es) |
AU (1) | AU707914B2 (es) |
BR (1) | BR9612074A (es) |
CA (1) | CA2241827C (es) |
DE (1) | DE69622889T2 (es) |
DK (1) | DK0874843T3 (es) |
ES (1) | ES2177827T3 (es) |
HK (1) | HK1017684A1 (es) |
IL (1) | IL125002A0 (es) |
MX (1) | MX9804991A (es) |
NO (1) | NO316932B1 (es) |
NZ (1) | NZ325581A (es) |
PT (1) | PT874843E (es) |
TW (1) | TW335395B (es) |
WO (1) | WO1997022604A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
US6194406B1 (en) * | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
US6552188B2 (en) * | 2001-06-29 | 2003-04-22 | Kowa Co., Ltd. | Unsymmetrical cyclic diamine compound |
JP5014983B2 (ja) | 2004-05-07 | 2012-08-29 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 11−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのピロリジン−2−オン及びピペリジン−2−オン誘導体 |
CA2565632C (en) | 2004-05-07 | 2013-04-23 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
UA87328C2 (en) | 2004-08-30 | 2009-07-10 | Янссен Фармацевтика Н.В. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
ES2334246T3 (es) | 2004-08-30 | 2010-03-08 | Janssen Pharmaceutica Nv | Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa. |
DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
KR20090112722A (ko) | 2007-01-24 | 2009-10-28 | 글락소 그룹 리미티드 | 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 r(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 nk1을 포함하는 제약 조성물 |
CN105646306B (zh) * | 2015-12-11 | 2020-06-30 | 广东莱佛士制药技术有限公司 | 一种4-甲硫基苯乙酸的制备方法 |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
DK0696280T3 (da) * | 1993-05-06 | 1998-01-12 | Merrell Pharma Inc | Substituerede pyrrolidin-3-yl-alkyl-piperidiner anvendelige som tachykinin-antagonister |
CA2161876A1 (en) * | 1993-05-20 | 1994-12-08 | Den-Ichi Momose | 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds |
KR100362620B1 (ko) * | 1994-08-25 | 2003-02-14 | 메렐 파마슈티칼스 인크. | 알레르기성질환치료에유용한치환된피페리딘,이를포함하는약제학적조성물및이의제조방법 |
-
1996
- 1996-12-04 AT AT96944267T patent/ATE221883T1/de not_active IP Right Cessation
- 1996-12-04 PT PT96944267T patent/PT874843E/pt unknown
- 1996-12-04 NZ NZ325581A patent/NZ325581A/xx unknown
- 1996-12-04 DK DK96944267T patent/DK0874843T3/da active
- 1996-12-04 DE DE69622889T patent/DE69622889T2/de not_active Expired - Fee Related
- 1996-12-04 CA CA002241827A patent/CA2241827C/en not_active Expired - Fee Related
- 1996-12-04 JP JP9522863A patent/JP2000500772A/ja active Pending
- 1996-12-04 AU AU14119/97A patent/AU707914B2/en not_active Ceased
- 1996-12-04 BR BR9612074A patent/BR9612074A/pt unknown
- 1996-12-04 KR KR1019980704684A patent/KR20000064487A/ko active IP Right Grant
- 1996-12-04 WO PCT/US1996/019524 patent/WO1997022604A1/en not_active Application Discontinuation
- 1996-12-04 CN CN96199141A patent/CN1080262C/zh not_active Expired - Fee Related
- 1996-12-04 ES ES96944267T patent/ES2177827T3/es not_active Expired - Lifetime
- 1996-12-04 IL IL12500296A patent/IL125002A0/xx unknown
- 1996-12-04 EP EP96944267A patent/EP0874843B1/en not_active Expired - Lifetime
- 1996-12-18 AR ARP960105741A patent/AR005120A1/es active IP Right Grant
- 1996-12-21 TW TW085115838A patent/TW335395B/zh active
-
1998
- 1998-06-19 NO NO19982867A patent/NO316932B1/no not_active IP Right Cessation
- 1998-06-19 MX MX9804991A patent/MX9804991A/es not_active IP Right Cessation
-
1999
- 1999-07-05 HK HK99102816A patent/HK1017684A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20000064487A (ko) | 2000-11-06 |
DK0874843T3 (da) | 2002-11-25 |
CA2241827A1 (en) | 1997-06-26 |
NO316932B1 (no) | 2004-06-28 |
NO982867D0 (no) | 1998-06-19 |
JP2000500772A (ja) | 2000-01-25 |
NO982867L (no) | 1998-08-19 |
CN1080262C (zh) | 2002-03-06 |
ATE221883T1 (de) | 2002-08-15 |
IL125002A0 (en) | 1999-01-26 |
AR005120A1 (es) | 1999-04-14 |
AU1411997A (en) | 1997-07-14 |
HK1017684A1 (en) | 1999-11-26 |
EP0874843B1 (en) | 2002-08-07 |
DE69622889T2 (de) | 2003-04-10 |
WO1997022604A1 (en) | 1997-06-26 |
TW335395B (en) | 1998-07-01 |
CA2241827C (en) | 2002-04-30 |
NZ325581A (en) | 2000-03-27 |
CN1207097A (zh) | 1999-02-03 |
PT874843E (pt) | 2002-12-31 |
ES2177827T3 (es) | 2002-12-16 |
DE69622889D1 (de) | 2002-09-12 |
BR9612074A (pt) | 1999-03-30 |
EP0874843A1 (en) | 1998-11-04 |
AU707914B2 (en) | 1999-07-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |