ES2177827T3 - 4-(1h-bencimidazol-2-il)(1,4)diazepanes utiles para el tratamiento de enfermedades alergicas. - Google Patents

4-(1h-bencimidazol-2-il)(1,4)diazepanes utiles para el tratamiento de enfermedades alergicas.

Info

Publication number
ES2177827T3
ES2177827T3 ES96944267T ES96944267T ES2177827T3 ES 2177827 T3 ES2177827 T3 ES 2177827T3 ES 96944267 T ES96944267 T ES 96944267T ES 96944267 T ES96944267 T ES 96944267T ES 2177827 T3 ES2177827 T3 ES 2177827T3
Authority
ES
Spain
Prior art keywords
bencimidazol
useful
treatment
diazepanes
allergic diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96944267T
Other languages
English (en)
Inventor
John Michael Kane
George Daniel Maynard
Timothy Paul Burkholder
Larry Don Bratton
Christopher Robin Dalton
Braulio Santiago
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2177827T3 publication Critical patent/ES2177827T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

LA PRESENTE INVENCION TRATA DE NUEVOS DERIVADOS DE 4 - (1H BENCIMIDAZOL - 2 - IL)[1,4]DIAZEPANOS DE FORMULA (1) Y SUS ESTEREOISOMEROS, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES QUE SON UTILES COMO ANTAGONISTAS DEL RECEPTOR DE LA HISTAMINA Y ANTAGONISTA DEL RECEPTOR DE LA TAQUIQUININA. TALES ANTAGONISTAS SE UTILIZAN EN EL TRATAMIENTO DE RINITIS ALERGICA, INCLUYENDO RINITIS ESTACIONAL Y SINUSITIS; ENFERMEDADES INFLAMATORIAS DEL INTESTINO, INCLUYENDO ENFERMEDAD DE CROHN Y COLITIS ULCEROSA; ASMA; BRONQUITIS Y EMESIS.
ES96944267T 1995-12-20 1996-12-04 4-(1h-bencimidazol-2-il)(1,4)diazepanes utiles para el tratamiento de enfermedades alergicas. Expired - Lifetime ES2177827T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58000495A 1995-12-20 1995-12-20
US73641196A 1996-10-24 1996-10-24

Publications (1)

Publication Number Publication Date
ES2177827T3 true ES2177827T3 (es) 2002-12-16

Family

ID=27077922

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96944267T Expired - Lifetime ES2177827T3 (es) 1995-12-20 1996-12-04 4-(1h-bencimidazol-2-il)(1,4)diazepanes utiles para el tratamiento de enfermedades alergicas.

Country Status (20)

Country Link
EP (1) EP0874843B1 (es)
JP (1) JP2000500772A (es)
KR (1) KR20000064487A (es)
CN (1) CN1080262C (es)
AR (1) AR005120A1 (es)
AT (1) ATE221883T1 (es)
AU (1) AU707914B2 (es)
BR (1) BR9612074A (es)
CA (1) CA2241827C (es)
DE (1) DE69622889T2 (es)
DK (1) DK0874843T3 (es)
ES (1) ES2177827T3 (es)
HK (1) HK1017684A1 (es)
IL (1) IL125002A0 (es)
MX (1) MX9804991A (es)
NO (1) NO316932B1 (es)
NZ (1) NZ325581A (es)
PT (1) PT874843E (es)
TW (1) TW335395B (es)
WO (1) WO1997022604A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194406B1 (en) * 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6552188B2 (en) * 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
NZ551076A (en) 2004-05-07 2009-05-31 Janssen Pharmaceutica Nv Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
CA2565630C (en) 2004-05-07 2013-05-28 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
ES2334246T3 (es) 2004-08-30 2010-03-08 Janssen Pharmaceutica Nv Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa.
EP1796657B1 (en) 2004-08-30 2009-12-23 Janssen Pharmaceutica N.V. N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
CN105646306B (zh) * 2015-12-11 2020-06-30 广东莱佛士制药技术有限公司 一种4-甲硫基苯乙酸的制备方法
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
DE69405862T2 (de) * 1993-05-06 1998-01-15 Merrell Pharma Inc Substituierte pyrrolidin-3-alkyl-piperidine verwendbar als tachykinin-antagonisten
US5624948A (en) * 1993-05-20 1997-04-29 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
MX9701305A (es) * 1994-08-25 1998-05-31 Merrell Pharma Inc Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas.

Also Published As

Publication number Publication date
AU1411997A (en) 1997-07-14
AR005120A1 (es) 1999-04-14
DE69622889T2 (de) 2003-04-10
NO982867D0 (no) 1998-06-19
CN1080262C (zh) 2002-03-06
DK0874843T3 (da) 2002-11-25
MX9804991A (es) 1998-09-30
CA2241827A1 (en) 1997-06-26
CN1207097A (zh) 1999-02-03
NZ325581A (en) 2000-03-27
CA2241827C (en) 2002-04-30
NO982867L (no) 1998-08-19
NO316932B1 (no) 2004-06-28
AU707914B2 (en) 1999-07-22
HK1017684A1 (en) 1999-11-26
EP0874843A1 (en) 1998-11-04
DE69622889D1 (de) 2002-09-12
IL125002A0 (en) 1999-01-26
PT874843E (pt) 2002-12-31
JP2000500772A (ja) 2000-01-25
KR20000064487A (ko) 2000-11-06
EP0874843B1 (en) 2002-08-07
BR9612074A (pt) 1999-03-30
WO1997022604A1 (en) 1997-06-26
ATE221883T1 (de) 2002-08-15
TW335395B (en) 1998-07-01

Similar Documents

Publication Publication Date Title
ES2188801T3 (es) 4-(1h-bencimidazol-2-yl-amino) piperidinas sustituidas utiles para el tratamiento de enfermedades alergicas.
ES2177827T3 (es) 4-(1h-bencimidazol-2-il)(1,4)diazepanes utiles para el tratamiento de enfermedades alergicas.
ES2194265T3 (es) Derivados de piperidino 4-carboxamida y su utilizacion como antagonistas de la neuroquinina.
RS20100338A (en) FLUOROSUPSTITUTIONED CYCLOALCANOINDOLES AND THEIR USE AS AN ANTAGONISTS OF PROSTAGLAND D2 RECEPTORS
MX9307940A (es) Nuevos derivados de la imidazopiridina, proceso para su preparacion y formulaciones farmaceuticas que los incluyen
MX9300977A (es) Compuetos heterobiciclicos.
ATE177095T1 (de) Substituierte piperidine für die behandlung von allergischen krankheiten
ES2161290T3 (es) Derivados de quinazolina.
AR033659A1 (es) El compuesto 2-(3,5-bis -trifluormetil-fenil)-n-metil-n-(6-morfolin-4-il-4-o-tolil-piridin-3-il)-isobutiramida), su uso, un procedimiento para prepararlo y un medicamento que lo contiene
AR005102A1 (es) Compuestos derivados de octahidro-pirrolo [1,2-a]-pirazina 2,7-sustituidos, composiciones farmaceuticas y uso de dichos compuestos para la fabricacion deun medicamento.
ES2184992T3 (es) N-metil-n-(4-piperinin-1-il)-2-(aril)butil)benzamidas sustituidas utiles para el tratamiento de enfermedades alergicas.
ES2176687T3 (es) Nuevas n-metil-n-(4-(4-(1h-benzimidazol-2-il-amino)piperidin-1-il)-2-(aril)butil)benzamidas sustituidas utiles para el tratamiento de enfermedades alergicas.
AR005897A1 (es) Derivados de n-metil-n-(4-(4-(1h-bencimidazol-2-il)[1,4]-diazepan-1-il)-2- (aril)butil)benzamidas utiles como antagonistas del receptor de histamina yantagonistas del receptor de taquiquininas y composicion farmaceutica conteniendolos.
ES2164235T3 (es) Derivados de piperazinona sustituidos por un heterociclo que actuan como antagonistas del receptor de taquiquinina.
AR005472A1 (es) Inhibidores de la formacion cd23 humana soluble, un procedimiento para su preparacion, el uso de los mismos para la manufactura de un medicamento,composicion farmaceutica y compuestos intermediarios
HUP0203118A2 (hu) Béta-diszubsztituált metalloproteáz inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
MX9306563A (es) Derivados de imidazopiridinas, proceso para su preparacion y formulaciones farmaceuticas que los contienen.
MY106363A (en) Carbamoyl indole derivatives having leukotriene antagonists properties
ES2150149T3 (es) Derivados de 17-beta-(2-oxo-tetrahidrofuran-4-il)-tio-androstano (tioderivados de 17-beta-(lactona del acido gamma-butirico)) para el tratamiento de la inflamacion, composiciones farmaceuticas y un procedimiento para la produccion de los mismos.
AR005895A1 (es) Derivados de n-metil-n-(4-(piperidin-1-il)-2-(aril)butil)benzamida sustituida, utiles como antagonistas de los receptores de histamina yantagonista de los receptores de taquiquininas y composicion farmaceutica que los contiene.
AR027032A1 (es) Derivados de analogos de benzimidazol sustituidos de homopiperidinilo
AR015307A1 (es) Formas cristalinas de monoclorhidrato de pirazinas, composiciones, metodo de tratamiento que las utiliza y metodo de preparacion de dichas formas.