ES2176687T3 - Nuevas n-metil-n-(4-(4-(1h-benzimidazol-2-il-amino)piperidin-1-il)-2-(aril)butil)benzamidas sustituidas utiles para el tratamiento de enfermedades alergicas. - Google Patents
Nuevas n-metil-n-(4-(4-(1h-benzimidazol-2-il-amino)piperidin-1-il)-2-(aril)butil)benzamidas sustituidas utiles para el tratamiento de enfermedades alergicas.Info
- Publication number
- ES2176687T3 ES2176687T3 ES97905689T ES97905689T ES2176687T3 ES 2176687 T3 ES2176687 T3 ES 2176687T3 ES 97905689 T ES97905689 T ES 97905689T ES 97905689 T ES97905689 T ES 97905689T ES 2176687 T3 ES2176687 T3 ES 2176687T3
- Authority
- ES
- Spain
- Prior art keywords
- aril
- benzimidazol
- piperidin
- amino
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS DERIVADOS N - METIL N - (4 - (4 - (1H - BENZIMIDAZOL - 2 - IL - AMINO)PIPERIDIN -1 IL) - 2 - (ARIL)BUTILBENZAMIDA DE FORMULA (I), A LOS ESTEREOISOMEROS DE LOS MISMOS Y A LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS QUE SON UTILES COMO ANTAGONISTAS DEL RECEPTOR DE LA HISTAMINA Y ANTAGONISTAS DEL RECEPTOR DE LA TAQUIQUININA. DICHOS ANTAGONISTAS SON UTILES PARA EL TRATAMIENTO DE LA RINITIS ALERGICA, INCLUYENDO LA RINITIS ESTACIONAL Y LA SINUSITIS; LAS ENFERMEDADES INFLAMATORIAS DEL INTESTINO, INCLUYENDO LA ENFERMEDAD DE CROHN Y LA COLITIS ULCERATIVA; EL ASMA; LA BRONQUITIS Y LA EMESIS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60421696A | 1996-02-21 | 1996-02-21 | |
US08/778,996 US5922737A (en) | 1996-02-21 | 1997-01-06 | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176687T3 true ES2176687T3 (es) | 2002-12-01 |
Family
ID=27084615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97905689T Expired - Lifetime ES2176687T3 (es) | 1996-02-21 | 1997-01-29 | Nuevas n-metil-n-(4-(4-(1h-benzimidazol-2-il-amino)piperidin-1-il)-2-(aril)butil)benzamidas sustituidas utiles para el tratamiento de enfermedades alergicas. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0888336B1 (es) |
JP (1) | JP2001504798A (es) |
KR (1) | KR19990087131A (es) |
CN (1) | CN1115341C (es) |
AR (1) | AR005896A1 (es) |
AT (1) | ATE221882T1 (es) |
AU (1) | AU710488B2 (es) |
BR (1) | BR9707652A (es) |
CA (1) | CA2247105C (es) |
DE (1) | DE69714579T2 (es) |
DK (1) | DK0888336T3 (es) |
ES (1) | ES2176687T3 (es) |
HK (1) | HK1019734A1 (es) |
HU (1) | HUP9901030A3 (es) |
IL (1) | IL125578A (es) |
NO (1) | NO983830L (es) |
NZ (1) | NZ330908A (es) |
PT (1) | PT888336E (es) |
TW (1) | TW562804B (es) |
WO (1) | WO1997030989A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
GB0315203D0 (en) * | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
AU693936B2 (en) * | 1994-08-25 | 1998-07-09 | Merrell Pharmaceuticals Inc. | Novel substituted piperidines useful for the treatment of allergic diseases |
-
1997
- 1997-01-29 IL IL12557897A patent/IL125578A/en not_active IP Right Cessation
- 1997-01-29 WO PCT/US1997/001571 patent/WO1997030989A1/en not_active Application Discontinuation
- 1997-01-29 BR BR9707652A patent/BR9707652A/pt not_active IP Right Cessation
- 1997-01-29 DK DK97905689T patent/DK0888336T3/da active
- 1997-01-29 AU AU22519/97A patent/AU710488B2/en not_active Ceased
- 1997-01-29 EP EP97905689A patent/EP0888336B1/en not_active Expired - Lifetime
- 1997-01-29 NZ NZ330908A patent/NZ330908A/en unknown
- 1997-01-29 CN CN97192390A patent/CN1115341C/zh not_active Expired - Fee Related
- 1997-01-29 KR KR1019980706522A patent/KR19990087131A/ko active IP Right Grant
- 1997-01-29 ES ES97905689T patent/ES2176687T3/es not_active Expired - Lifetime
- 1997-01-29 CA CA002247105A patent/CA2247105C/en not_active Expired - Fee Related
- 1997-01-29 AT AT97905689T patent/ATE221882T1/de not_active IP Right Cessation
- 1997-01-29 JP JP53016697A patent/JP2001504798A/ja not_active Abandoned
- 1997-01-29 DE DE69714579T patent/DE69714579T2/de not_active Expired - Fee Related
- 1997-01-29 PT PT97905689T patent/PT888336E/pt unknown
- 1997-01-29 HU HU9901030A patent/HUP9901030A3/hu unknown
- 1997-02-18 TW TW086101887A patent/TW562804B/zh not_active IP Right Cessation
- 1997-02-19 AR ARP970100645A patent/AR005896A1/es not_active Application Discontinuation
-
1998
- 1998-08-20 NO NO983830A patent/NO983830L/no not_active Application Discontinuation
-
1999
- 1999-07-07 HK HK99102910A patent/HK1019734A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT888336E (pt) | 2002-12-31 |
IL125578A (en) | 2002-09-12 |
DE69714579D1 (de) | 2002-09-12 |
DE69714579T2 (de) | 2003-04-10 |
KR19990087131A (ko) | 1999-12-15 |
AR005896A1 (es) | 1999-07-21 |
IL125578A0 (en) | 1999-03-12 |
CN1211246A (zh) | 1999-03-17 |
HK1019734A1 (en) | 2000-02-25 |
NO983830D0 (no) | 1998-08-20 |
NO983830L (no) | 1998-10-20 |
TW562804B (en) | 2003-11-21 |
AU2251997A (en) | 1997-09-10 |
NZ330908A (en) | 2001-04-27 |
WO1997030989A1 (en) | 1997-08-28 |
JP2001504798A (ja) | 2001-04-10 |
CA2247105C (en) | 2002-05-14 |
ATE221882T1 (de) | 2002-08-15 |
HUP9901030A3 (en) | 2002-01-28 |
CN1115341C (zh) | 2003-07-23 |
AU710488B2 (en) | 1999-09-23 |
DK0888336T3 (da) | 2002-12-02 |
BR9707652A (pt) | 1999-07-27 |
EP0888336B1 (en) | 2002-08-07 |
CA2247105A1 (en) | 1997-08-28 |
HUP9901030A2 (hu) | 1999-07-28 |
EP0888336A1 (en) | 1999-01-07 |
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