AR005896A1 - Compuestos n-metil-n-(4-(4-(1h-bencimidazol-2-il-amino)pipiridin-1-il)-2- (aril)butil) benzamidas sustituidos utiles para el tratamiento deenfermedades alergicas y composiciones con dichos compuestos. - Google Patents
Compuestos n-metil-n-(4-(4-(1h-bencimidazol-2-il-amino)pipiridin-1-il)-2- (aril)butil) benzamidas sustituidos utiles para el tratamiento deenfermedades alergicas y composiciones con dichos compuestos.Info
- Publication number
- AR005896A1 AR005896A1 ARP970100645A ARP970100645A AR005896A1 AR 005896 A1 AR005896 A1 AR 005896A1 AR P970100645 A ARP970100645 A AR P970100645A AR P970100645 A ARP970100645 A AR P970100645A AR 005896 A1 AR005896 A1 AR 005896A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- amino
- methyl
- treatment
- pipiridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen compuestos N-metil-N-(4-(4-(1H-bencimidazol-2-il-amino) pipiridin-1-il)-2-(aril)benzamidas de fórmula (I) y composiciones farmacéuticasque incluyen dichos compuestos. También se describe su utilización como antagonistasde los receptores de histamina y antagonistas de los receptores detaquiquininas, tales antagonistas son útiles en el tratamiento del asma; bronquitis; enfermedades inflamatorias del intestino, incluyendo la enfermedadde Crohn y la colitisulcera tiva; la rinitis alérgica, incluyendo la rinitis estacional y la sinusitis; las alergias; y la emesis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60421696A | 1996-02-21 | 1996-02-21 | |
US08/778,996 US5922737A (en) | 1996-02-21 | 1997-01-06 | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005896A1 true AR005896A1 (es) | 1999-07-21 |
Family
ID=27084615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100645A AR005896A1 (es) | 1996-02-21 | 1997-02-19 | Compuestos n-metil-n-(4-(4-(1h-bencimidazol-2-il-amino)pipiridin-1-il)-2- (aril)butil) benzamidas sustituidos utiles para el tratamiento deenfermedades alergicas y composiciones con dichos compuestos. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0888336B1 (es) |
JP (1) | JP2001504798A (es) |
KR (1) | KR19990087131A (es) |
CN (1) | CN1115341C (es) |
AR (1) | AR005896A1 (es) |
AT (1) | ATE221882T1 (es) |
AU (1) | AU710488B2 (es) |
BR (1) | BR9707652A (es) |
CA (1) | CA2247105C (es) |
DE (1) | DE69714579T2 (es) |
DK (1) | DK0888336T3 (es) |
ES (1) | ES2176687T3 (es) |
HK (1) | HK1019734A1 (es) |
HU (1) | HUP9901030A3 (es) |
IL (1) | IL125578A (es) |
NO (1) | NO983830L (es) |
NZ (1) | NZ330908A (es) |
PT (1) | PT888336E (es) |
TW (1) | TW562804B (es) |
WO (1) | WO1997030989A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
GB0315203D0 (en) * | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
CA2676357A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
FR2676054B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
JPH10504580A (ja) * | 1994-08-25 | 1998-05-06 | メレルファーマスーティカルズ インコーポレイテッド | アレルギー病の処置に有用な新規な置換ピペリジン類 |
-
1997
- 1997-01-29 DE DE69714579T patent/DE69714579T2/de not_active Expired - Fee Related
- 1997-01-29 NZ NZ330908A patent/NZ330908A/en unknown
- 1997-01-29 AU AU22519/97A patent/AU710488B2/en not_active Ceased
- 1997-01-29 DK DK97905689T patent/DK0888336T3/da active
- 1997-01-29 IL IL12557897A patent/IL125578A/en not_active IP Right Cessation
- 1997-01-29 JP JP53016697A patent/JP2001504798A/ja not_active Abandoned
- 1997-01-29 WO PCT/US1997/001571 patent/WO1997030989A1/en not_active Application Discontinuation
- 1997-01-29 EP EP97905689A patent/EP0888336B1/en not_active Expired - Lifetime
- 1997-01-29 HU HU9901030A patent/HUP9901030A3/hu unknown
- 1997-01-29 KR KR1019980706522A patent/KR19990087131A/ko active IP Right Grant
- 1997-01-29 CN CN97192390A patent/CN1115341C/zh not_active Expired - Fee Related
- 1997-01-29 CA CA002247105A patent/CA2247105C/en not_active Expired - Fee Related
- 1997-01-29 BR BR9707652A patent/BR9707652A/pt not_active IP Right Cessation
- 1997-01-29 ES ES97905689T patent/ES2176687T3/es not_active Expired - Lifetime
- 1997-01-29 PT PT97905689T patent/PT888336E/pt unknown
- 1997-01-29 AT AT97905689T patent/ATE221882T1/de not_active IP Right Cessation
- 1997-02-18 TW TW086101887A patent/TW562804B/zh not_active IP Right Cessation
- 1997-02-19 AR ARP970100645A patent/AR005896A1/es not_active Application Discontinuation
-
1998
- 1998-08-20 NO NO983830A patent/NO983830L/no not_active Application Discontinuation
-
1999
- 1999-07-07 HK HK99102910A patent/HK1019734A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69714579D1 (de) | 2002-09-12 |
DE69714579T2 (de) | 2003-04-10 |
AU2251997A (en) | 1997-09-10 |
TW562804B (en) | 2003-11-21 |
HUP9901030A2 (hu) | 1999-07-28 |
NZ330908A (en) | 2001-04-27 |
WO1997030989A1 (en) | 1997-08-28 |
BR9707652A (pt) | 1999-07-27 |
ATE221882T1 (de) | 2002-08-15 |
CN1211246A (zh) | 1999-03-17 |
NO983830L (no) | 1998-10-20 |
HK1019734A1 (en) | 2000-02-25 |
JP2001504798A (ja) | 2001-04-10 |
IL125578A (en) | 2002-09-12 |
IL125578A0 (en) | 1999-03-12 |
HUP9901030A3 (en) | 2002-01-28 |
DK0888336T3 (da) | 2002-12-02 |
CN1115341C (zh) | 2003-07-23 |
CA2247105C (en) | 2002-05-14 |
EP0888336A1 (en) | 1999-01-07 |
KR19990087131A (ko) | 1999-12-15 |
CA2247105A1 (en) | 1997-08-28 |
PT888336E (pt) | 2002-12-31 |
EP0888336B1 (en) | 2002-08-07 |
ES2176687T3 (es) | 2002-12-01 |
NO983830D0 (no) | 1998-08-20 |
AU710488B2 (en) | 1999-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI970771A (fi) | Uusia allergisten sairauksien hoidossa käyttökelpoisia substituoituja piperidiinejä | |
ECSP045367A (es) | "derivados de bencimidazol utiles como antagonistas de histamina h3" | |
ES2184794T3 (es) | Profarmacos de morfolina como antagonistas de receptores de taquicininas. | |
ATE250577T1 (de) | Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten | |
CO5390086A1 (es) | Derivados benzimidazol y piridilimidazol como ligandos para gabaa | |
PT1513826E (pt) | Novos derivados de indolilpiperidina como agentes anti-histaminicos e antialergicos potentes | |
MX9300977A (es) | Compuetos heterobiciclicos. | |
PE20050036A1 (es) | COMPUESTOS DE FENIL-AZA-BENZIMIDAZOL PARA MODULAR LA IgE E INHIBIR LA PROLIFERACION CELULAR | |
ES2119174T3 (es) | Azaciclos espiro-sustituidos como antagonistas de los receptores de las taquiquininas. | |
AR047439A1 (es) | Antagonistas del receptor hidroisoindolina taquiquinina | |
ES2188801T3 (es) | 4-(1h-bencimidazol-2-yl-amino) piperidinas sustituidas utiles para el tratamiento de enfermedades alergicas. | |
AR041942A1 (es) | Derivados de 10-oxa -1-aza-dibenzo [a,d] ciclohepteno-7-carboxilico como antagonistas ccr1 para el tratamiento de la enfermedad desmielinizante inflamatoria | |
AR005896A1 (es) | Compuestos n-metil-n-(4-(4-(1h-bencimidazol-2-il-amino)pipiridin-1-il)-2- (aril)butil) benzamidas sustituidos utiles para el tratamiento deenfermedades alergicas y composiciones con dichos compuestos. | |
ES2177827T3 (es) | 4-(1h-bencimidazol-2-il)(1,4)diazepanes utiles para el tratamiento de enfermedades alergicas. | |
AR024840A1 (es) | Compuestos de 5ht1 para terapia antidepresiva; composiciones farmaceuticas y su uso en la preparacion de medicamentos. | |
PT882038E (pt) | N-metil-n-(4-(piperidin-1-il)-2-(aril)butil)benzamidas substituidas vantajosas para o tratamento de doencas alergicas | |
PT1497292E (pt) | Derivados de azaindolilpiperidina como agentes anti-histaminicos e antialergicos | |
AR005897A1 (es) | Derivados de n-metil-n-(4-(4-(1h-bencimidazol-2-il)[1,4]-diazepan-1-il)-2- (aril)butil)benzamidas utiles como antagonistas del receptor de histamina yantagonistas del receptor de taquiquininas y composicion farmaceutica conteniendolos. | |
ES2138366T3 (es) | Indol carbamatos como antagonistas de leucotrienos. | |
AR005895A1 (es) | Derivados de n-metil-n-(4-(piperidin-1-il)-2-(aril)butil)benzamida sustituida, utiles como antagonistas de los receptores de histamina yantagonista de los receptores de taquiquininas y composicion farmaceutica que los contiene. | |
UY26875A1 (es) | Compuestos de 1,4-dihidropiridina como antagonistas de bradicinina | |
ES2150848B1 (es) | Heterociclos metiloxinaftil sustituidos con accion antagonista de los leucotrienos. | |
ECSP972326A (es) | Derivados de espiro - piperidina y su uso como agentes terapeuticos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |