ES2164235T3 - Derivados de piperazinona sustituidos por un heterociclo que actuan como antagonistas del receptor de taquiquinina. - Google Patents
Derivados de piperazinona sustituidos por un heterociclo que actuan como antagonistas del receptor de taquiquinina.Info
- Publication number
- ES2164235T3 ES2164235T3 ES96905333T ES96905333T ES2164235T3 ES 2164235 T3 ES2164235 T3 ES 2164235T3 ES 96905333 T ES96905333 T ES 96905333T ES 96905333 T ES96905333 T ES 96905333T ES 2164235 T3 ES2164235 T3 ES 2164235T3
- Authority
- ES
- Spain
- Prior art keywords
- piperazinona
- antagonist
- derivatives
- receiver
- taquiquinine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
LA PRESENTE INVENCION TRATA DE DERIVADOS DE PIPERAZINONA SUSTITUIDOS DE FORMULA (I), LOS ESTEREOISOMEROS O LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, Y SU UTILIZACION COMO ANTAGONISTAS DEL RECEPTOR DE TAQUICININA. ESTOS ANTAGONISTAS RESULTAN UTILES EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS MEDIADOS POR TAQUICININA DESCRITAS EN LA PRESENTE: ASMA, TOS Y BRONQUITIS. LA PRESENTE INVENCION TAMBIEN TRATA DE INTERMEDIOS UTILES EN LA PREPARACION DE COMPUESTOS DE FORMULA (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40478895A | 1995-03-15 | 1995-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2164235T3 true ES2164235T3 (es) | 2002-02-16 |
Family
ID=23601038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96905333T Expired - Lifetime ES2164235T3 (es) | 1995-03-15 | 1996-02-06 | Derivados de piperazinona sustituidos por un heterociclo que actuan como antagonistas del receptor de taquiquinina. |
Country Status (21)
Country | Link |
---|---|
US (2) | US5840726A (es) |
EP (1) | EP0815105B1 (es) |
JP (1) | JP3825472B2 (es) |
KR (1) | KR19980703032A (es) |
CN (1) | CN1067068C (es) |
AR (1) | AR002715A1 (es) |
AT (1) | ATE206421T1 (es) |
AU (1) | AU697599B2 (es) |
CA (1) | CA2215333C (es) |
DE (1) | DE69615670T2 (es) |
DK (1) | DK0815105T3 (es) |
ES (1) | ES2164235T3 (es) |
FI (1) | FI973671A0 (es) |
HU (1) | HUP9702149A3 (es) |
IL (1) | IL117453A (es) |
NO (1) | NO314693B1 (es) |
NZ (1) | NZ302948A (es) |
PT (1) | PT815105E (es) |
TW (1) | TW464647B (es) |
WO (1) | WO1996028441A1 (es) |
ZA (1) | ZA961954B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000502100A (ja) * | 1995-12-18 | 2000-02-22 | 藤沢薬品工業株式会社 | タキキニン拮抗薬としてのピペラジン誘導体 |
DE19939910A1 (de) * | 1999-08-23 | 2001-03-01 | Morphochem Ag | Neue Verbindungen, die Tryptase-Aktivität hemmen |
US20040033986A1 (en) * | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
US7652039B2 (en) * | 2002-05-17 | 2010-01-26 | Sequella, Inc. | Methods of use and compositions for the diagnosis and treatment of infectious disease |
US7456222B2 (en) * | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
EP1670314A4 (en) * | 2003-09-05 | 2009-02-25 | Sequella Inc | METHODS AND COMPOSITIONS INCLUDE DIAMINE AS A NEW THERAPEUTIC FOR TUBERCULOSIS |
WO2009136965A1 (en) * | 2008-05-06 | 2009-11-12 | Sequella, Inc. | Compositions and methods comprising capuramycin analogues |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3132882A1 (de) * | 1981-08-20 | 1983-03-03 | Cassella Ag, 6000 Frankfurt | Neue piperazinone, ihre herstellung und verwendung |
FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
WO1994003483A1 (en) * | 1992-07-30 | 1994-02-17 | Chiron Corporation | Endothelin receptor-binding compounds |
GB9222486D0 (en) * | 1992-10-26 | 1992-12-09 | Merck Sharp & Dohme | Therapeutic agents |
HU224496B1 (hu) * | 1993-05-06 | 2005-10-28 | Merrel Dow Pharmaceuticals Inc. | Pirrolidin-3-il-alkil-piperidin-származékok és e vegyületeket tartalmazó gyógyászati készítmények |
IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
-
1996
- 1996-02-06 AU AU49306/96A patent/AU697599B2/en not_active Ceased
- 1996-02-06 PT PT96905333T patent/PT815105E/pt unknown
- 1996-02-06 AT AT96905333T patent/ATE206421T1/de not_active IP Right Cessation
- 1996-02-06 HU HU9702149A patent/HUP9702149A3/hu unknown
- 1996-02-06 CA CA002215333A patent/CA2215333C/en not_active Expired - Fee Related
- 1996-02-06 DK DK96905333T patent/DK0815105T3/da active
- 1996-02-06 ES ES96905333T patent/ES2164235T3/es not_active Expired - Lifetime
- 1996-02-06 WO PCT/US1996/001437 patent/WO1996028441A1/en not_active Application Discontinuation
- 1996-02-06 NZ NZ302948A patent/NZ302948A/en unknown
- 1996-02-06 DE DE69615670T patent/DE69615670T2/de not_active Expired - Lifetime
- 1996-02-06 KR KR1019970706440A patent/KR19980703032A/ko not_active Application Discontinuation
- 1996-02-06 JP JP52757896A patent/JP3825472B2/ja not_active Expired - Fee Related
- 1996-02-06 EP EP96905333A patent/EP0815105B1/en not_active Expired - Lifetime
- 1996-02-06 CN CN96192564A patent/CN1067068C/zh not_active Expired - Fee Related
- 1996-03-11 ZA ZA961954A patent/ZA961954B/xx unknown
- 1996-03-12 AR ARP960101710A patent/AR002715A1/es active IP Right Grant
- 1996-03-12 IL IL11745396A patent/IL117453A/xx not_active IP Right Cessation
- 1996-03-12 TW TW085102987A patent/TW464647B/zh active
-
1997
- 1997-06-19 US US08/878,695 patent/US5840726A/en not_active Expired - Lifetime
- 1997-09-12 FI FI973671A patent/FI973671A0/fi not_active IP Right Cessation
- 1997-09-12 NO NO19974205A patent/NO314693B1/no unknown
-
1998
- 1998-04-27 US US09/067,386 patent/US5864045A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AR002715A1 (es) | 1998-04-29 |
KR19980703032A (ko) | 1998-09-05 |
AU697599B2 (en) | 1998-10-08 |
NZ302948A (en) | 2001-05-25 |
DE69615670T2 (de) | 2002-08-08 |
CA2215333C (en) | 2002-01-01 |
DK0815105T3 (da) | 2002-01-21 |
CN1067068C (zh) | 2001-06-13 |
US5864045A (en) | 1999-01-26 |
ATE206421T1 (de) | 2001-10-15 |
JP3825472B2 (ja) | 2006-09-27 |
DE69615670D1 (de) | 2001-11-08 |
HUP9702149A2 (hu) | 1999-06-28 |
HUP9702149A3 (en) | 1999-07-28 |
IL117453A0 (en) | 1996-07-23 |
EP0815105B1 (en) | 2001-10-04 |
TW464647B (en) | 2001-11-21 |
NO974205L (no) | 1997-11-13 |
ZA961954B (en) | 1996-09-17 |
WO1996028441A1 (en) | 1996-09-19 |
PT815105E (pt) | 2002-03-28 |
US5840726A (en) | 1998-11-24 |
FI973671A (fi) | 1997-09-12 |
FI973671A0 (fi) | 1997-09-12 |
JPH11501917A (ja) | 1999-02-16 |
CA2215333A1 (en) | 1996-09-19 |
AU4930696A (en) | 1996-10-02 |
IL117453A (en) | 2000-07-26 |
EP0815105A1 (en) | 1998-01-07 |
NO974205D0 (no) | 1997-09-12 |
CN1178529A (zh) | 1998-04-08 |
MX9706872A (es) | 1997-11-29 |
NO314693B1 (no) | 2003-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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