ATE206421T1 - Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten - Google Patents
Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonistenInfo
- Publication number
- ATE206421T1 ATE206421T1 AT96905333T AT96905333T ATE206421T1 AT E206421 T1 ATE206421 T1 AT E206421T1 AT 96905333 T AT96905333 T AT 96905333T AT 96905333 T AT96905333 T AT 96905333T AT E206421 T1 ATE206421 T1 AT E206421T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazone
- derivatives
- receptor antagonists
- heterocyclic substituted
- tachykinin receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40478895A | 1995-03-15 | 1995-03-15 | |
| PCT/US1996/001437 WO1996028441A1 (en) | 1995-03-15 | 1996-02-06 | Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE206421T1 true ATE206421T1 (de) | 2001-10-15 |
Family
ID=23601038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96905333T ATE206421T1 (de) | 1995-03-15 | 1996-02-06 | Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US5840726A (de) |
| EP (1) | EP0815105B1 (de) |
| JP (1) | JP3825472B2 (de) |
| KR (1) | KR19980703032A (de) |
| CN (1) | CN1067068C (de) |
| AR (1) | AR002715A1 (de) |
| AT (1) | ATE206421T1 (de) |
| AU (1) | AU697599B2 (de) |
| CA (1) | CA2215333C (de) |
| DE (1) | DE69615670T2 (de) |
| DK (1) | DK0815105T3 (de) |
| ES (1) | ES2164235T3 (de) |
| FI (1) | FI973671A (de) |
| HU (1) | HUP9702149A3 (de) |
| IL (1) | IL117453A (de) |
| NO (1) | NO314693B1 (de) |
| NZ (1) | NZ302948A (de) |
| PT (1) | PT815105E (de) |
| TW (1) | TW464647B (de) |
| WO (1) | WO1996028441A1 (de) |
| ZA (1) | ZA961954B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997022597A1 (en) * | 1995-12-18 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine derivatives as tachykinin antagonists |
| DE19939910A1 (de) * | 1999-08-23 | 2001-03-01 | Morphochem Ag | Neue Verbindungen, die Tryptase-Aktivität hemmen |
| US7456222B2 (en) * | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
| US7652039B2 (en) * | 2002-05-17 | 2010-01-26 | Sequella, Inc. | Methods of use and compositions for the diagnosis and treatment of infectious disease |
| US20040033986A1 (en) * | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
| US7884097B2 (en) * | 2003-09-05 | 2011-02-08 | Sequella, Inc. | Methods and compositions comprising diamines as new anti-tubercular therapeutics |
| WO2009136965A1 (en) * | 2008-05-06 | 2009-11-12 | Sequella, Inc. | Compositions and methods comprising capuramycin analogues |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3132882A1 (de) * | 1981-08-20 | 1983-03-03 | Cassella Ag, 6000 Frankfurt | Neue piperazinone, ihre herstellung und verwendung |
| FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
| IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
| FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| WO1994003483A1 (en) * | 1992-07-30 | 1994-02-17 | Chiron Corporation | Endothelin receptor-binding compounds |
| GB9222486D0 (en) * | 1992-10-26 | 1992-12-09 | Merck Sharp & Dohme | Therapeutic agents |
| WO1994026735A1 (en) * | 1993-05-06 | 1994-11-24 | Merrell Dow Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists |
| IL111730A (en) * | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
-
1996
- 1996-02-06 DE DE69615670T patent/DE69615670T2/de not_active Expired - Lifetime
- 1996-02-06 CN CN96192564A patent/CN1067068C/zh not_active Expired - Fee Related
- 1996-02-06 ES ES96905333T patent/ES2164235T3/es not_active Expired - Lifetime
- 1996-02-06 AT AT96905333T patent/ATE206421T1/de not_active IP Right Cessation
- 1996-02-06 EP EP96905333A patent/EP0815105B1/de not_active Expired - Lifetime
- 1996-02-06 DK DK96905333T patent/DK0815105T3/da active
- 1996-02-06 NZ NZ302948A patent/NZ302948A/en unknown
- 1996-02-06 PT PT96905333T patent/PT815105E/pt unknown
- 1996-02-06 WO PCT/US1996/001437 patent/WO1996028441A1/en not_active Application Discontinuation
- 1996-02-06 HU HU9702149A patent/HUP9702149A3/hu unknown
- 1996-02-06 AU AU49306/96A patent/AU697599B2/en not_active Ceased
- 1996-02-06 JP JP52757896A patent/JP3825472B2/ja not_active Expired - Fee Related
- 1996-02-06 KR KR1019970706440A patent/KR19980703032A/ko not_active Application Discontinuation
- 1996-02-06 CA CA002215333A patent/CA2215333C/en not_active Expired - Fee Related
- 1996-03-11 ZA ZA961954A patent/ZA961954B/xx unknown
- 1996-03-12 IL IL11745396A patent/IL117453A/xx not_active IP Right Cessation
- 1996-03-12 TW TW085102987A patent/TW464647B/zh active
- 1996-03-12 AR ARP960101710A patent/AR002715A1/es active IP Right Grant
-
1997
- 1997-06-19 US US08/878,695 patent/US5840726A/en not_active Expired - Lifetime
- 1997-09-12 NO NO19974205A patent/NO314693B1/no unknown
- 1997-09-12 FI FI973671A patent/FI973671A/fi not_active IP Right Cessation
-
1998
- 1998-04-27 US US09/067,386 patent/US5864045A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU4930696A (en) | 1996-10-02 |
| HUP9702149A2 (hu) | 1999-06-28 |
| AU697599B2 (en) | 1998-10-08 |
| ES2164235T3 (es) | 2002-02-16 |
| EP0815105A1 (de) | 1998-01-07 |
| JPH11501917A (ja) | 1999-02-16 |
| CN1178529A (zh) | 1998-04-08 |
| CN1067068C (zh) | 2001-06-13 |
| HUP9702149A3 (en) | 1999-07-28 |
| TW464647B (en) | 2001-11-21 |
| PT815105E (pt) | 2002-03-28 |
| NZ302948A (en) | 2001-05-25 |
| IL117453A (en) | 2000-07-26 |
| NO974205D0 (no) | 1997-09-12 |
| WO1996028441A1 (en) | 1996-09-19 |
| EP0815105B1 (de) | 2001-10-04 |
| FI973671A0 (fi) | 1997-09-12 |
| DK0815105T3 (da) | 2002-01-21 |
| US5864045A (en) | 1999-01-26 |
| FI973671A (fi) | 1997-09-12 |
| IL117453A0 (en) | 1996-07-23 |
| ZA961954B (en) | 1996-09-17 |
| CA2215333C (en) | 2002-01-01 |
| NO314693B1 (no) | 2003-05-05 |
| DE69615670D1 (de) | 2001-11-08 |
| NO974205L (no) | 1997-11-13 |
| CA2215333A1 (en) | 1996-09-19 |
| DE69615670T2 (de) | 2002-08-08 |
| AR002715A1 (es) | 1998-04-29 |
| MX9706872A (es) | 1997-11-29 |
| JP3825472B2 (ja) | 2006-09-27 |
| KR19980703032A (ko) | 1998-09-05 |
| US5840726A (en) | 1998-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |