TR200000945T2 - İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod - Google Patents

İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod

Info

Publication number
TR200000945T2
TR200000945T2 TR2000/00945T TR200000945T TR200000945T2 TR 200000945 T2 TR200000945 T2 TR 200000945T2 TR 2000/00945 T TR2000/00945 T TR 2000/00945T TR 200000945 T TR200000945 T TR 200000945T TR 200000945 T2 TR200000945 T2 TR 200000945T2
Authority
TR
Turkey
Prior art keywords
phenyl
substituted
preparation
group
cyanocyclohexanoic
Prior art date
Application number
TR2000/00945T
Other languages
English (en)
Turkish (tr)
Inventor
Webb Kevin
Mendelson Wilford
Jianhoa Chen
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200000945T2 publication Critical patent/TR200000945T2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TR2000/00945T 1997-10-10 1998-10-07 İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod TR200000945T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
TR200000945T2 true TR200000945T2 (tr) 2000-10-23

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00945T TR200000945T2 (tr) 1997-10-10 1998-10-07 İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod

Country Status (30)

Country Link
EP (1) EP1043930A4 (ru)
JP (1) JP2001519363A (ru)
KR (1) KR100560038B1 (ru)
CN (1) CN1192025C (ru)
AP (1) AP1335A (ru)
AR (1) AR015952A1 (ru)
AU (1) AU741832B2 (ru)
BG (1) BG104302A (ru)
BR (1) BR9814064A (ru)
CA (1) CA2305614A1 (ru)
DZ (1) DZ2619A1 (ru)
EA (1) EA003609B1 (ru)
HU (1) HUP0003905A3 (ru)
ID (1) ID25536A (ru)
IL (1) IL135434A (ru)
MA (1) MA24670A1 (ru)
MY (1) MY122105A (ru)
NO (1) NO20001777L (ru)
NZ (1) NZ503759A (ru)
OA (1) OA11347A (ru)
PE (1) PE121599A1 (ru)
PL (1) PL191974B1 (ru)
SA (1) SA99191000A (ru)
SK (1) SK4902000A3 (ru)
TR (1) TR200000945T2 (ru)
TW (1) TW440557B (ru)
UA (1) UA67753C2 (ru)
UY (2) UY25201A1 (ru)
WO (1) WO1999018793A1 (ru)
ZA (1) ZA989228B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
JP2003534238A (ja) * 1999-12-15 2003-11-18 スミスクライン・ビーチャム・コーポレイション シス−4−シアノ−4−[3−(シクロペンチルオキシ)−4−メトキシフェニル]シクロヘキサン−1−カルボン酸の塩。
CZ20022590A3 (cs) * 2000-01-26 2003-01-15 Smithkline Beecham Corporation Monohydrát cis-lithium-kyan-4-[3-(cyklopentyloxy)-4-methoxyfenyl]cyklohexankarboxylátu
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
EA200300622A1 (ru) 2001-01-31 2003-12-25 Пфайзер Продактс Инк. Производные амидов тиазолил-, оксазолил, пирролил- и имидазолилкислот, полезные в качестве ингибиторов изоферментов pde4
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
OA12541A (en) 2001-01-31 2006-06-05 Pfizer Prod Inc Ether derivatives useful as inhibitors of PDE4 isozymes.
NZ526453A (en) 2001-01-31 2005-01-28 Pfizer Prod Inc Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
US5552438A (en) * 1992-04-02 1996-09-03 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) * 1997-02-12 2000-11-08 Smithkline Beecham Corp Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
PL339759A1 (en) 2001-01-02
BR9814064A (pt) 2000-09-26
JP2001519363A (ja) 2001-10-23
IL135434A (en) 2004-12-15
EA003609B1 (ru) 2003-06-26
NO20001777D0 (no) 2000-04-06
WO1999018793A1 (en) 1999-04-22
BG104302A (en) 2001-08-31
KR20010015709A (ko) 2001-02-26
KR100560038B1 (ko) 2006-03-13
OA11347A (en) 2003-12-17
SA99191000A (ar) 2005-12-03
MY122105A (en) 2006-03-31
IL135434A0 (en) 2001-05-20
UY25524A1 (es) 2000-02-23
UA67753C2 (ru) 2004-07-15
NZ503759A (en) 2002-03-01
AU741832B2 (en) 2001-12-13
CN1192025C (zh) 2005-03-09
TW440557B (en) 2001-06-16
HUP0003905A2 (en) 2001-03-28
AR015952A1 (es) 2001-05-30
PE121599A1 (es) 2000-02-19
AP1335A (en) 2004-11-29
PL191974B1 (pl) 2006-07-31
CN1275052A (zh) 2000-11-29
EP1043930A4 (en) 2004-09-15
DZ2619A1 (fr) 2003-03-08
ID25536A (id) 2000-10-12
AU9687498A (en) 1999-05-03
EA200000406A1 (ru) 2000-10-30
AP2000001782A0 (en) 2000-06-30
EP1043930A1 (en) 2000-10-18
CA2305614A1 (en) 1999-04-22
HUP0003905A3 (en) 2002-01-28
ZA989228B (en) 1999-04-12
SK4902000A3 (en) 2000-11-07
NO20001777L (no) 2000-05-03
MA24670A1 (fr) 1999-07-01
UY25201A1 (es) 2001-08-27

Similar Documents

Publication Publication Date Title
IE46264L (en) Substituted acyl derivatives of amino acids
IE780094L (en) Amino acid derivatives
FR2421874A1 (fr) Carboxyalkylacylamino-acides utiles comme agents hypotenseurs
ATE185558T1 (de) Prostaglandin-synthase hemmer
DE3580057D1 (de) Heterocylische mercaptocarbonsaeureamide, -imide und -nitrile als korrosionsinhibitoren.
DK0831100T3 (da) Nye peptidderivater
TR200001415T2 (tr) Taksoid sınıfı türevlerin hazırlanmasına yönelik metod
ES479410A1 (es) Un procedimiento para la preparacion de derivados del acido 4-tiazolidincarboxilico.
TR200000945T2 (tr) İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod
BG46451A3 (en) Herbicide means
FR2372817A1 (fr) Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
EP0296581A3 (en) Amino acid 1,2-diketo derivatives as renin inhibitors
ATE225774T1 (de) Imidazolidinonderivate als korrosionsinhibitoren
EA200000092A1 (ru) Противоаллергические средства
DE59403966D1 (de) Hydroxymethylfurazancarbonsäurederivate und ihre verwendung in der behandlung von kardiovaskulären erkrankungen
ATE241976T1 (de) N,n'-bis (sulfonyl) hydrazine die als antineoplastische mittel nützlich sind
NO173106C (no) Korrosjonsbeskyttelsesmiddel
ES2145510T3 (es) Disoluciones de hidroxilamina estabilizadas.
JPS51122188A (en) Method of aminating polyacrylamide
FI955556A0 (fi) Symmetristen tai epäsymmetristen disubstituoitujen N-syaaniditioiminokarbonaattien valmistus
DK1214315T5 (da) 1,4-Dihydropyridin-5-carboxylsyreesterderivater og fremgangsmåde til fremstilling af samme
KR960703346A (ko) 사용한 부동액 조성물로부터 증류에 의해 글리콜을 회수하는 방법(distillative method of recovering glycols from used antifreeze agents)
RU97108902A (ru) Способ защиты стали от кислотной коррозии
JPS5395938A (en) 4-chloro-3,5-dinitrobenzoic acid alkyl ester derivatives
BR9809611A (pt) Método para tratar hipertensão sistólica isolada