TR200000033T2 - Oksimorfon, oksikodon ve türevlerinin hazırlanması - Google Patents
Oksimorfon, oksikodon ve türevlerinin hazırlanmasıInfo
- Publication number
- TR200000033T2 TR200000033T2 TR2000/00033T TR200000033T TR200000033T2 TR 200000033 T2 TR200000033 T2 TR 200000033T2 TR 2000/00033 T TR2000/00033 T TR 2000/00033T TR 200000033 T TR200000033 T TR 200000033T TR 200000033 T2 TR200000033 T2 TR 200000033T2
- Authority
- TR
- Turkey
- Prior art keywords
- derivatives
- oxymorphone
- oxycodone
- preparation
- noroxymorphone
- Prior art date
Links
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 title abstract 2
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 title abstract 2
- 229960002085 oxycodone Drugs 0.000 title abstract 2
- 229960005118 oxymorphone Drugs 0.000 title abstract 2
- HLMSIZPQBSYUNL-IPOQPSJVSA-N Noroxymorphone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 HLMSIZPQBSYUNL-IPOQPSJVSA-N 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- WJZVCRUPHQAKSZ-IPOQPSJVSA-N (4r,4as,7ar,12bs)-4a,9-dihydroxy-1,2,3,4,7a,13-hexahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one Chemical compound O=C([C@@H]1O2)C=C[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4 WJZVCRUPHQAKSZ-IPOQPSJVSA-N 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 abstract 1
- 229960003086 naltrexone Drugs 0.000 abstract 1
- 230000003533 narcotic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/893,464 US5869669A (en) | 1996-07-26 | 1997-07-11 | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000033T2 true TR200000033T2 (tr) | 2000-12-21 |
Family
ID=25401603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00033T TR200000033T2 (tr) | 1997-07-11 | 1998-07-10 | Oksimorfon, oksikodon ve türevlerinin hazırlanması |
Country Status (19)
Country | Link |
---|---|
US (7) | US5869669A (forum.php) |
EP (1) | EP1000065B1 (forum.php) |
JP (1) | JP2001518444A (forum.php) |
KR (1) | KR100363486B1 (forum.php) |
CN (1) | CN1152880C (forum.php) |
AT (1) | ATE291023T1 (forum.php) |
AU (1) | AU740822B2 (forum.php) |
CA (1) | CA2296035C (forum.php) |
DE (1) | DE69829379D1 (forum.php) |
HU (1) | HUP0003918A3 (forum.php) |
IL (1) | IL133792A0 (forum.php) |
IN (1) | IN1998KO01500A (forum.php) |
NO (1) | NO20000111L (forum.php) |
RU (1) | RU2183636C2 (forum.php) |
SK (1) | SK102000A3 (forum.php) |
TR (1) | TR200000033T2 (forum.php) |
TW (1) | TW505648B (forum.php) |
WO (1) | WO1999002529A1 (forum.php) |
ZA (1) | ZA986144B (forum.php) |
Families Citing this family (92)
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US5912347A (en) * | 1996-09-30 | 1999-06-15 | Mallinckrodt Inc. | Process for preparing a morphinan derivative |
AU4823900A (en) * | 1999-05-05 | 2000-11-17 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Direct c-14 oxidation of opioids |
US6177567B1 (en) * | 1999-10-15 | 2001-01-23 | Boehringer Ingelheim Chemicals, Inc. | Method for preparing oxycodone |
EP1421085B1 (en) * | 2001-08-23 | 2010-04-28 | N.V. Organon | Process for the preparation of a 14-hydroxynormorphinone derivative |
JP3961796B2 (ja) * | 2001-08-27 | 2007-08-22 | ソニー株式会社 | 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム |
DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
US20040058946A1 (en) * | 2002-07-05 | 2004-03-25 | Buchwald Stephen L. | Abuse-resistant prodrugs of oxycodone and other pharmaceuticals |
RU2236412C2 (ru) * | 2002-07-18 | 2004-09-20 | Власов Михаил Иванович | Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона |
RU2215742C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов |
RU2215741C1 (ru) * | 2002-11-05 | 2003-11-10 | Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" | Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения |
JP2006509745A (ja) * | 2002-11-08 | 2006-03-23 | マリンクロッド・インコーポレイテッド | 第四級n−アルキルモルフィナンアルカロイド塩の製造方法 |
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US6864370B1 (en) * | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
US6790959B1 (en) | 2003-06-05 | 2004-09-14 | Halsey Drug Company, Inc. | Process for manufacturing thebaine |
EP1664061B1 (en) | 2003-09-22 | 2017-03-15 | GlaxoSmithKline Australia Pty Ltd | Process for the synthesis of morphinane compounds and intermediates thereof |
US7875718B2 (en) * | 2003-09-22 | 2011-01-25 | Johnson Matthey Public Limited Company | Process for the synthesis of morphinane compounds and intermediates thereof |
ES2313299T3 (es) * | 2004-02-06 | 2009-03-01 | Euro-Celtique S.A. | Procedimientos para producir morfinonas 3 o protegidas y carboxilatos de morfinona dienol 3 o protegidos. |
TW201509943A (zh) | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
SK286047B6 (sk) * | 2004-04-13 | 2008-01-07 | Zentiva, A. S. | Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu |
US6946556B1 (en) * | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
JP2008501797A (ja) * | 2004-06-08 | 2008-01-24 | マリンクロッド・インコーポレイテッド | アヘンからのアルカロイド類の抽出 |
CA2569958C (en) | 2004-06-12 | 2016-03-22 | Jane C. Hirsh | Abuse-deterrent drug formulations |
PL2415484T3 (pl) | 2004-09-17 | 2014-11-28 | Durect Corp | Kompozycja znieczulająca miejscowo o przedłużonym uwalnianiu zawierająca SAIB |
GB0421149D0 (en) * | 2004-09-23 | 2004-10-27 | Johnson Matthey Plc | Preparation of oxycodone |
GB0421687D0 (en) * | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
WO2006084389A1 (de) * | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
RS51131B (sr) * | 2005-03-04 | 2010-10-31 | Euro-Celtique S.A. | Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama |
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US8071768B2 (en) * | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
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US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
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AU2007224221B2 (en) | 2006-03-02 | 2013-02-14 | SpecGx LLC | Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
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PL2588481T3 (pl) | 2010-07-02 | 2018-05-30 | Johnson Matthey Public Limited Company | Sposób syntezy i oczyszczania oksykodonu |
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TW201521769A (zh) | 2013-03-15 | 2015-06-16 | Durect Corp | 具有流變改質劑以減少溶解變異性之組成物 |
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US9994571B2 (en) | 2013-12-26 | 2018-06-12 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
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1997
- 1997-07-11 US US08/893,464 patent/US5869669A/en not_active Expired - Fee Related
-
1998
- 1998-07-10 KR KR20007000252A patent/KR100363486B1/ko not_active Expired - Fee Related
- 1998-07-10 RU RU2000100062/04A patent/RU2183636C2/ru not_active IP Right Cessation
- 1998-07-10 ZA ZA986144A patent/ZA986144B/xx unknown
- 1998-07-10 HU HU0003918A patent/HUP0003918A3/hu unknown
- 1998-07-10 JP JP2000502051A patent/JP2001518444A/ja active Pending
- 1998-07-10 CN CNB988088169A patent/CN1152880C/zh not_active Expired - Fee Related
- 1998-07-10 CA CA002296035A patent/CA2296035C/en not_active Expired - Fee Related
- 1998-07-10 DE DE69829379T patent/DE69829379D1/de not_active Expired - Lifetime
- 1998-07-10 EP EP98934213A patent/EP1000065B1/en not_active Revoked
- 1998-07-10 IL IL13379298A patent/IL133792A0/xx unknown
- 1998-07-10 SK SK10-2000A patent/SK102000A3/sk unknown
- 1998-07-10 AU AU83791/98A patent/AU740822B2/en not_active Ceased
- 1998-07-10 TR TR2000/00033T patent/TR200000033T2/xx unknown
- 1998-07-10 WO PCT/US1998/013592 patent/WO1999002529A1/en not_active Application Discontinuation
- 1998-07-10 AT AT98934213T patent/ATE291023T1/de not_active IP Right Cessation
- 1998-07-16 US US09/116,284 patent/US5922876A/en not_active Expired - Fee Related
- 1998-07-16 US US09/116,285 patent/US6008354A/en not_active Expired - Fee Related
- 1998-07-16 US US09/116,286 patent/US5952495A/en not_active Expired - Fee Related
- 1998-07-16 US US09/116,283 patent/US6008355A/en not_active Expired - Fee Related
- 1998-07-16 US US09/116,282 patent/US6013796A/en not_active Expired - Fee Related
- 1998-07-17 US US09/118,577 patent/US5948788A/en not_active Expired - Fee Related
- 1998-08-21 IN IN1500KO1998 patent/IN1998KO01500A/en unknown
- 1998-09-29 TW TW087116132A patent/TW505648B/zh not_active IP Right Cessation
-
2000
- 2000-01-10 NO NO20000111A patent/NO20000111L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE291023T1 (de) | 2005-04-15 |
KR100363486B1 (ko) | 2002-12-16 |
AU740822B2 (en) | 2001-11-15 |
HK1028025A1 (en) | 2001-02-02 |
IL133792A0 (en) | 2001-04-30 |
IN1998KO01500A (forum.php) | 2005-03-11 |
JP2001518444A (ja) | 2001-10-16 |
EP1000065A1 (en) | 2000-05-17 |
US5952495A (en) | 1999-09-14 |
HUP0003918A3 (en) | 2003-04-28 |
AU8379198A (en) | 1999-02-08 |
CA2296035C (en) | 2004-04-13 |
NO20000111L (no) | 2000-02-25 |
CA2296035A1 (en) | 1999-01-21 |
US6008355A (en) | 1999-12-28 |
CN1152880C (zh) | 2004-06-09 |
TW505648B (en) | 2002-10-11 |
RU2183636C2 (ru) | 2002-06-20 |
US5869669A (en) | 1999-02-09 |
HUP0003918A2 (hu) | 2001-07-30 |
SK102000A3 (en) | 2000-07-11 |
NO20000111D0 (no) | 2000-01-10 |
US6013796A (en) | 2000-01-11 |
KR20010021693A (ko) | 2001-03-15 |
US5922876A (en) | 1999-07-13 |
US6008354A (en) | 1999-12-28 |
EP1000065B1 (en) | 2005-03-16 |
WO1999002529A1 (en) | 1999-01-21 |
CN1272845A (zh) | 2000-11-08 |
US5948788A (en) | 1999-09-07 |
DE69829379D1 (de) | 2005-04-21 |
ZA986144B (en) | 1999-05-19 |
EP1000065A4 (en) | 2001-09-12 |
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