TR199902546T2 - Serotoninerjik maddeler olarak indazol amit bilesikleri. - Google Patents
Serotoninerjik maddeler olarak indazol amit bilesikleri.Info
- Publication number
- TR199902546T2 TR199902546T2 TR1999/02546T TR9902546T TR199902546T2 TR 199902546 T2 TR199902546 T2 TR 199902546T2 TR 1999/02546 T TR1999/02546 T TR 1999/02546T TR 9902546 T TR9902546 T TR 9902546T TR 199902546 T2 TR199902546 T2 TR 199902546T2
- Authority
- TR
- Turkey
- Prior art keywords
- amide compounds
- serotoninergic agents
- indazole amide
- indazole
- serotoninergic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paints Or Removers (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
R1, R2, R3, R'3, R4, R5 ve R6'nin açiklamada ifade edilen anlamlara sahip oldugu, genel formül(I)'i, farmasötik açidan kabul edilebilir organik ve inorganik asitler ile birlikte bunun asit katki tuzlarini ve bunun farmasötik açidan kabul edilebilir dörtlü tuzlarini ihtiva eden bir bilesiktir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI000867A IT1291569B1 (it) | 1997-04-15 | 1997-04-15 | Indazolammidi come agenti serotoninergici |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199902546T2 true TR199902546T2 (tr) | 2000-05-22 |
Family
ID=11376888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/02546T TR199902546T2 (tr) | 1997-04-15 | 1998-04-02 | Serotoninerjik maddeler olarak indazol amit bilesikleri. |
Country Status (27)
Country | Link |
---|---|
US (1) | US6197769B1 (tr) |
EP (1) | EP0975623B1 (tr) |
JP (2) | JP4578581B2 (tr) |
KR (1) | KR100563867B1 (tr) |
CN (1) | CN1318416C (tr) |
AR (1) | AR012426A1 (tr) |
AT (1) | ATE219490T1 (tr) |
AU (1) | AU740360B2 (tr) |
BG (1) | BG64006B1 (tr) |
CA (1) | CA2286870C (tr) |
CZ (1) | CZ295190B6 (tr) |
DE (1) | DE69806141T2 (tr) |
DK (1) | DK0975623T3 (tr) |
EA (1) | EA002352B1 (tr) |
ES (1) | ES2178205T3 (tr) |
GE (1) | GEP20022654B (tr) |
HK (1) | HK1027811A1 (tr) |
HU (1) | HU227973B1 (tr) |
IL (1) | IL132127A (tr) |
IT (1) | IT1291569B1 (tr) |
PL (1) | PL193308B1 (tr) |
PT (1) | PT975623E (tr) |
SK (1) | SK284731B6 (tr) |
TR (1) | TR199902546T2 (tr) |
UA (1) | UA58550C2 (tr) |
WO (1) | WO1998046589A2 (tr) |
ZA (1) | ZA982926B (tr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
CZ20032258A3 (cs) | 2001-02-23 | 2004-01-14 | Merck & Co., Inc. | N-substituované nearylové heterocyklické sloučeniny |
WO2002080928A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
ITMI20030287A1 (it) | 2003-02-18 | 2004-08-19 | Acraf | Indazolammidi dotate di attivita' analgesica metodo, per |
ITMI20030972A1 (it) * | 2003-05-15 | 2004-11-16 | Acraf | Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende. |
ITMI20031468A1 (it) * | 2003-07-18 | 2005-01-19 | Acraf | Farmaco ativo nel dolore neuropatico |
TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
EP1807423B1 (en) * | 2004-11-05 | 2009-05-20 | Theravance, Inc. | Quinolinone-carboxamide compounds |
ES2332808T3 (es) * | 2004-11-05 | 2010-02-12 | Theravance, Inc. | Compuestos agonistas del receptor 5-ht4. |
RU2404179C2 (ru) * | 2004-12-22 | 2010-11-20 | Тереванс, Инк. | Индазол-карбоксамидные соединения |
EP1848716A1 (en) * | 2005-02-17 | 2007-10-31 | Theravance, Inc. | Crystalline form of an indazole-carboxamide compound |
WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
ITMI20062230A1 (it) * | 2006-11-22 | 2008-05-23 | Acraf | Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende |
UA99927C2 (uk) * | 2007-11-12 | 2012-10-25 | Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. | Медикамент, який є активним при невропатичному болі |
US8377968B2 (en) | 2008-06-02 | 2013-02-19 | Zalicus Pharmaceuticals, Ltd. | N-piperidinyl acetamide derivatives as calcium channel blockers |
RU2013157374A (ru) * | 2011-06-07 | 2015-07-20 | Сумитомо Дайниппон Фарма Ко., Лтд. | Производное индазола и пирролопиридина и его фармацевтическое применение |
CN104093712B (zh) * | 2012-02-21 | 2016-11-09 | 方济各安吉利克化学联合股份有限公司 | 作为糖原合酶激酶3β抑制剂的1H-吲唑-3-甲酰胺化合物 |
KR102101702B1 (ko) * | 2012-02-21 | 2020-04-20 | 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 | 글리코겐 합성효소 키나아제 3 베타 억제제로서 1h-인다졸-3-카복사미드 화합물의 용도 |
US10208023B2 (en) | 2013-03-01 | 2019-02-19 | Mark G. DeGiacomo | Heterocyclic inhibitors of the sodium channel |
WO2021007487A1 (en) | 2019-07-11 | 2021-01-14 | Praxis Precision Medicines, Inc. | Formulations of t-type calcium channel modulators and methods of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
CA2116024A1 (en) * | 1991-08-20 | 1993-03-04 | Francis David King | 5-ht4 receptor antagonists |
IL117438A (en) * | 1995-03-16 | 2001-12-23 | Lilly Co Eli | Indazolecarboxamides, their preparation and pharmaceutical compositions containing them |
CA2222532A1 (en) * | 1995-05-31 | 1996-12-05 | Nisshin Flour Milling Co., Ltd. | Indazole derivatives having monocyclic amine |
IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
-
1997
- 1997-04-15 IT IT97MI000867A patent/IT1291569B1/it active IP Right Grant
-
1998
- 1998-02-04 UA UA99116211A patent/UA58550C2/uk unknown
- 1998-04-02 US US09/403,007 patent/US6197769B1/en not_active Expired - Lifetime
- 1998-04-02 JP JP54347598A patent/JP4578581B2/ja not_active Expired - Fee Related
- 1998-04-02 AU AU72159/98A patent/AU740360B2/en not_active Ceased
- 1998-04-02 ES ES98919257T patent/ES2178205T3/es not_active Expired - Lifetime
- 1998-04-02 WO PCT/EP1998/002129 patent/WO1998046589A2/en active IP Right Grant
- 1998-04-02 DE DE69806141T patent/DE69806141T2/de not_active Expired - Lifetime
- 1998-04-02 KR KR1019997009198A patent/KR100563867B1/ko not_active IP Right Cessation
- 1998-04-02 IL IL13212798A patent/IL132127A/xx not_active IP Right Cessation
- 1998-04-02 CN CNB988041987A patent/CN1318416C/zh not_active Expired - Fee Related
- 1998-04-02 SK SK1423-99A patent/SK284731B6/sk not_active IP Right Cessation
- 1998-04-02 GE GEAP19985083A patent/GEP20022654B/en unknown
- 1998-04-02 CZ CZ19993625A patent/CZ295190B6/cs not_active IP Right Cessation
- 1998-04-02 HU HU0002057A patent/HU227973B1/hu not_active IP Right Cessation
- 1998-04-02 TR TR1999/02546T patent/TR199902546T2/tr unknown
- 1998-04-02 PT PT98919257T patent/PT975623E/pt unknown
- 1998-04-02 AT AT98919257T patent/ATE219490T1/de active
- 1998-04-02 PL PL336348A patent/PL193308B1/pl unknown
- 1998-04-02 DK DK98919257T patent/DK0975623T3/da active
- 1998-04-02 EA EA199900935A patent/EA002352B1/ru not_active IP Right Cessation
- 1998-04-02 EP EP98919257A patent/EP0975623B1/en not_active Expired - Lifetime
- 1998-04-02 CA CA002286870A patent/CA2286870C/en not_active Expired - Fee Related
- 1998-04-06 ZA ZA982926A patent/ZA982926B/xx unknown
- 1998-04-15 AR ARP980101721A patent/AR012426A1/es active IP Right Grant
-
1999
- 1999-11-05 BG BG103863A patent/BG64006B1/bg unknown
-
2000
- 2000-11-09 HK HK00107144A patent/HK1027811A1/xx not_active IP Right Cessation
-
2010
- 2010-04-26 JP JP2010100701A patent/JP5237324B2/ja not_active Expired - Fee Related
Also Published As
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