TR199902197T2 - Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar. - Google Patents

Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar.

Info

Publication number
TR199902197T2
TR199902197T2 TR1999/02197T TR9902197T TR199902197T2 TR 199902197 T2 TR199902197 T2 TR 199902197T2 TR 1999/02197 T TR1999/02197 T TR 1999/02197T TR 9902197 T TR9902197 T TR 9902197T TR 199902197 T2 TR199902197 T2 TR 199902197T2
Authority
TR
Turkey
Prior art keywords
thiazolidinediones
obtaining
formula
new
improved method
Prior art date
Application number
TR1999/02197T
Other languages
English (en)
Inventor
Wolff Hans-Peter
Witte Ernst-Christian
K�Hnle Hans-Frieder
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR199902197T2 publication Critical patent/TR199902197T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Formül (III)'e uygun bilesiklerin eldesi için olup FORMÜL (III).burada: A;CH=CH vya S;W,O;X,S,O veya NR2; buradaki R2 kismi hidrojen veya C1-C6 alkildir; Y, CH veya N; R, ihtiyari olarak C1-C3 alkil, CF3, C1-C3 alkoksi, F,CI veya brom ile mono veya di-sübstitüe olmus naftil, tiyenil veya fenil; R1, hidrojen veya C1-C6 alkil ve; n, 1-3 demektir, özelligi,A,W,X,Y,R,R1 ve n'nin yukaridaki gibi tanimlandigi Formül (IV) 'e uygun bir bilesigin, protik bir çözücü madde içinde metalik alüminyum ile indirgenmesidir. FORMÜL (IV).
TR1999/02197T 1997-03-20 1998-03-17 Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar. TR199902197T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19711616A DE19711616A1 (de) 1997-03-20 1997-03-20 Verbessertes Verfahren zur Herstellung von Thiazolidindionen

Publications (1)

Publication Number Publication Date
TR199902197T2 true TR199902197T2 (tr) 1999-12-21

Family

ID=7824011

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02197T TR199902197T2 (tr) 1997-03-20 1998-03-17 Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar.

Country Status (26)

Country Link
US (2) US6258832B1 (tr)
EP (1) EP0970077B1 (tr)
JP (2) JP3484200B2 (tr)
KR (1) KR100340353B1 (tr)
CN (1) CN1105718C (tr)
AR (1) AR012124A1 (tr)
AT (1) ATE240324T1 (tr)
AU (1) AU726048B2 (tr)
BR (1) BR9808029A (tr)
CA (1) CA2285208C (tr)
DE (2) DE19711616A1 (tr)
DK (1) DK0970077T3 (tr)
ES (1) ES2198053T3 (tr)
HK (1) HK1025965A1 (tr)
HU (1) HUP0001551A3 (tr)
IL (1) IL131772A (tr)
NO (1) NO313292B1 (tr)
NZ (1) NZ337608A (tr)
PL (1) PL192201B1 (tr)
PT (1) PT970077E (tr)
RS (1) RS49771B (tr)
RU (1) RU2181724C2 (tr)
TR (1) TR199902197T2 (tr)
TW (1) TW487707B (tr)
WO (1) WO1998042704A1 (tr)
ZA (1) ZA982326B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1078923E (pt) 1999-08-02 2006-07-31 Hoffmann La Roche Processo para a preparacao de derivados de benzotiofeno
US6531609B2 (en) * 2000-04-14 2003-03-11 Hoffmann-La Roche Inc. Process for the preparation of thiazolidinedione derivatives
FR2820742B1 (fr) * 2001-02-14 2005-03-11 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
FR2820741A1 (fr) * 2001-02-14 2002-08-16 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
US7323481B2 (en) 2001-04-06 2008-01-29 Hoffmann-La Roche Inc. Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth
RU2278859C2 (ru) * 2001-05-15 2006-06-27 Ф.Хоффманн-Ля Рош Аг Замещенные карбоновыми кислотами оксазоловые производные в качестве ppar-альфа и гамма-активаторов при лечении диабета
ES2291688T3 (es) * 2002-07-03 2008-03-01 F. Hoffmann-La Roche Ag Derivados de oxazol y su empleo como sensibilizadores a la insulina.
RU2296754C2 (ru) * 2002-08-30 2007-04-10 Ф.Хоффманн-Ля Рош Аг НОВЫЕ СОЕДИНЕНИЯ 2-АРИЛТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ PPAR α И PPAR γ
BR0314261A (pt) * 2002-09-12 2005-07-26 Hoffmann La Roche Compostos, processo de preparação de um composto, composição farmacêutica que compreende o mesmo, utilização de um composto, método para tratamento e/ou profilaxia de enfermidades e utilização e/ou método de tratamento
JP4384052B2 (ja) * 2002-11-25 2009-12-16 エフ．ホフマン−ラ ロシュ アーゲー インドリル誘導体
CA2530309A1 (en) * 2003-06-26 2005-01-06 F. Hoffmann-La Roche Ag Process for the preparation of insulin sensitizer and intermediate compound thereof
US20210172624A1 (en) 2019-12-10 2021-06-10 Lg Electronics Inc. Air management apparatus or device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
US4703052A (en) 1985-05-21 1987-10-27 Pfizer Inc. Hypoglycemic thiazolidinediones
GB8713861D0 (en) 1987-06-13 1987-07-15 Beecham Group Plc Compounds
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
US5330998A (en) 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
MX15171A (es) 1988-03-08 1993-05-01 Pfizer Derivados de tiazolidinodiona hipoglicemicos
US5061717A (en) 1988-03-08 1991-10-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
HU217432B (hu) 1988-03-08 2000-01-28 Pfizer Inc. Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények
ATE205206T1 (de) * 1990-04-27 2001-09-15 Sankyo Co Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
JPH0678326B2 (ja) 1990-08-23 1994-10-05 フアイザー・インコーポレイテツド 血糖低下性ヒドロキシ尿素誘導体
WO1993013095A1 (en) 1991-12-20 1993-07-08 The Upjohn Company A reduction method for substituted 5-methylene-thiazolidinediones
FR2688220A1 (fr) 1992-03-06 1993-09-10 Adir Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
DK0684242T3 (da) 1993-12-27 1999-11-01 Japan Tobacco Inc Isoxazolidindionderivat og anvendelse deraf

Also Published As

Publication number Publication date
HUP0001551A3 (en) 2000-12-28
NO994505L (no) 1999-11-17
IL131772A (en) 2002-09-12
IL131772A0 (en) 2001-03-19
RS49771B (sr) 2008-06-05
CN1250448A (zh) 2000-04-12
CA2285208C (en) 2003-07-08
PL192201B1 (pl) 2006-09-29
CA2285208A1 (en) 1998-10-01
BR9808029A (pt) 2000-03-08
NO994505D0 (no) 1999-09-17
DE19711616A1 (de) 1998-09-24
HUP0001551A2 (hu) 2000-11-28
ATE240324T1 (de) 2003-05-15
ZA982326B (en) 1999-09-20
RU2181724C2 (ru) 2002-04-27
NZ337608A (en) 2001-05-25
YU46699A (sh) 2002-06-19
AR012124A1 (es) 2000-09-27
US20010008902A1 (en) 2001-07-19
CN1105718C (zh) 2003-04-16
JP2004067697A (ja) 2004-03-04
PL335903A1 (en) 2000-05-22
JP2000512312A (ja) 2000-09-19
TW487707B (en) 2002-05-21
US6258832B1 (en) 2001-07-10
JP3484200B2 (ja) 2004-01-06
AU7036198A (en) 1998-10-20
ES2198053T3 (es) 2004-01-16
EP0970077A1 (de) 2000-01-12
AU726048B2 (en) 2000-10-26
WO1998042704A1 (de) 1998-10-01
HK1025965A1 (en) 2000-12-01
US6441185B2 (en) 2002-08-27
KR100340353B1 (ko) 2002-06-12
DE59808365D1 (de) 2003-06-18
KR20000076344A (ko) 2000-12-26
PT970077E (pt) 2003-08-29
NO313292B1 (no) 2002-09-09
EP0970077B1 (de) 2003-05-14
DK0970077T3 (da) 2003-09-01

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