TR199902197T2 - Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar. - Google Patents

Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar.

Info

Publication number
TR199902197T2
TR199902197T2 TR1999/02197T TR9902197T TR199902197T2 TR 199902197 T2 TR199902197 T2 TR 199902197T2 TR 1999/02197 T TR1999/02197 T TR 1999/02197T TR 9902197 T TR9902197 T TR 9902197T TR 199902197 T2 TR199902197 T2 TR 199902197T2
Authority
TR
Turkey
Prior art keywords
thiazolidinediones
obtaining
formula
new
improved method
Prior art date
Application number
TR1999/02197T
Other languages
English (en)
Inventor
Wolff Hans-Peter
Witte Ernst-Christian
K�Hnle Hans-Frieder
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR199902197T2 publication Critical patent/TR199902197T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Formül (III)'e uygun bilesiklerin eldesi için olup FORMÜL (III).burada: A;CH=CH vya S;W,O;X,S,O veya NR2; buradaki R2 kismi hidrojen veya C1-C6 alkildir; Y, CH veya N; R, ihtiyari olarak C1-C3 alkil, CF3, C1-C3 alkoksi, F,CI veya brom ile mono veya di-sübstitüe olmus naftil, tiyenil veya fenil; R1, hidrojen veya C1-C6 alkil ve; n, 1-3 demektir, özelligi,A,W,X,Y,R,R1 ve n'nin yukaridaki gibi tanimlandigi Formül (IV) 'e uygun bir bilesigin, protik bir çözücü madde içinde metalik alüminyum ile indirgenmesidir. FORMÜL (IV).
TR1999/02197T 1997-03-20 1998-03-17 Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar. TR199902197T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19711616A DE19711616A1 (de) 1997-03-20 1997-03-20 Verbessertes Verfahren zur Herstellung von Thiazolidindionen

Publications (1)

Publication Number Publication Date
TR199902197T2 true TR199902197T2 (tr) 1999-12-21

Family

ID=7824011

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02197T TR199902197T2 (tr) 1997-03-20 1998-03-17 Tiyazolidindionlarin elde edilmesi için gelistirilmis yöntem ve yeni tiyazolidindionlar.

Country Status (26)

Country Link
US (2) US6258832B1 (tr)
EP (1) EP0970077B1 (tr)
JP (2) JP3484200B2 (tr)
KR (1) KR100340353B1 (tr)
CN (1) CN1105718C (tr)
AR (1) AR012124A1 (tr)
AT (1) ATE240324T1 (tr)
AU (1) AU726048B2 (tr)
BR (1) BR9808029A (tr)
CA (1) CA2285208C (tr)
DE (2) DE19711616A1 (tr)
DK (1) DK0970077T3 (tr)
ES (1) ES2198053T3 (tr)
HK (1) HK1025965A1 (tr)
HU (1) HUP0001551A3 (tr)
IL (1) IL131772A (tr)
NO (1) NO313292B1 (tr)
NZ (1) NZ337608A (tr)
PL (1) PL192201B1 (tr)
PT (1) PT970077E (tr)
RS (1) RS49771B (tr)
RU (1) RU2181724C2 (tr)
TR (1) TR199902197T2 (tr)
TW (1) TW487707B (tr)
WO (1) WO1998042704A1 (tr)
ZA (1) ZA982326B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2258431T3 (es) 1999-08-02 2006-09-01 F. Hoffmann-La Roche Ag Proceso para la preparacion de derivados de benzotiofeno.
US6531609B2 (en) 2000-04-14 2003-03-11 Hoffmann-La Roche Inc. Process for the preparation of thiazolidinedione derivatives
FR2820741A1 (fr) * 2001-02-14 2002-08-16 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
FR2820742B1 (fr) 2001-02-14 2005-03-11 Ppg Sipsy Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine
US7323481B2 (en) 2001-04-06 2008-01-29 Hoffmann-La Roche Inc. Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth
AU2002342244B2 (en) 2001-05-15 2005-06-16 F. Hoffmann-La Roche Ag Carboxylic acid substituted oxazole derivatives for use as PPAR-alpha and -gamma activators in the treatment of diabetes
CA2490152C (en) * 2002-07-03 2009-04-07 F. Hoffmann-La Roche Ag Oxazole derivatives and their use as insulin sensitizers
PL375779A1 (en) * 2002-08-30 2005-12-12 F.Hoffmann-La Roche Ag Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists
CN100577660C (zh) * 2002-09-12 2010-01-06 霍夫曼-拉罗奇有限公司 作为ppar激动剂用于治疗糖尿病的n-取代-1h-吲哚-5-丙酸化合物
PL377320A1 (pl) * 2002-11-25 2006-01-23 F. Hoffmann-La Roche Ag Pochodne indolilowe
CN1809562A (zh) * 2003-06-26 2006-07-26 霍夫曼-拉罗奇有限公司 制备胰岛素敏化剂及其中间体化合物的方法
US11566796B2 (en) 2019-12-10 2023-01-31 Lg Electronics Inc. Air management apparatus and method thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1003445B (zh) 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
HU210339B (en) 1985-05-21 1995-03-28 Pfizer Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
GB8713861D0 (en) 1987-06-13 1987-07-15 Beecham Group Plc Compounds
DE3856378T2 (de) * 1987-09-04 2000-05-11 Beecham Group Plc Substituierte Thiazolidindionderivate
WO1989008650A1 (en) 1988-03-08 1989-09-21 Pfizer Inc. Thiazolidinedione hypoglycemic agents
WO1989008651A1 (en) 1988-03-08 1989-09-21 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
HU217432B (hu) 1988-03-08 2000-01-28 Pfizer Inc. Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények
US5330998A (en) 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
EP0454501B1 (en) * 1990-04-27 2001-09-05 Sankyo Company Limited Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides
AU645112B2 (en) 1990-08-23 1994-01-06 Pfizer Inc. Hypoglycemic hydroxyurea derivatives
US5585495A (en) * 1991-12-20 1996-12-17 The Upjohn Company Reduction method for substituted 5-methylene-thiazolidinediones
FR2688220A1 (fr) 1992-03-06 1993-09-10 Adir Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
DK0684242T3 (da) 1993-12-27 1999-11-01 Japan Tobacco Inc Isoxazolidindionderivat og anvendelse deraf

Also Published As

Publication number Publication date
CN1250448A (zh) 2000-04-12
US6441185B2 (en) 2002-08-27
US20010008902A1 (en) 2001-07-19
PT970077E (pt) 2003-08-29
WO1998042704A1 (de) 1998-10-01
JP3484200B2 (ja) 2004-01-06
US6258832B1 (en) 2001-07-10
ES2198053T3 (es) 2004-01-16
DK0970077T3 (da) 2003-09-01
CN1105718C (zh) 2003-04-16
TW487707B (en) 2002-05-21
EP0970077B1 (de) 2003-05-14
RU2181724C2 (ru) 2002-04-27
AU726048B2 (en) 2000-10-26
DE19711616A1 (de) 1998-09-24
CA2285208C (en) 2003-07-08
NO994505D0 (no) 1999-09-17
CA2285208A1 (en) 1998-10-01
PL192201B1 (pl) 2006-09-29
RS49771B (sr) 2008-06-05
DE59808365D1 (de) 2003-06-18
JP2000512312A (ja) 2000-09-19
ZA982326B (en) 1999-09-20
AU7036198A (en) 1998-10-20
HUP0001551A3 (en) 2000-12-28
EP0970077A1 (de) 2000-01-12
IL131772A0 (en) 2001-03-19
YU46699A (sh) 2002-06-19
IL131772A (en) 2002-09-12
JP2004067697A (ja) 2004-03-04
KR20000076344A (ko) 2000-12-26
HUP0001551A2 (hu) 2000-11-28
ATE240324T1 (de) 2003-05-15
PL335903A1 (en) 2000-05-22
NO313292B1 (no) 2002-09-09
HK1025965A1 (en) 2000-12-01
AR012124A1 (es) 2000-09-27
NZ337608A (en) 2001-05-25
NO994505L (no) 1999-11-17
KR100340353B1 (ko) 2002-06-12
BR9808029A (pt) 2000-03-08

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