TR199802685T2 - Ikameli/katkili indazol türevleri - Google Patents

Ikameli/katkili indazol türevleri

Info

Publication number
TR199802685T2
TR199802685T2 TR1998/02685T TR9802685T TR199802685T2 TR 199802685 T2 TR199802685 T2 TR 199802685T2 TR 1998/02685 T TR1998/02685 T TR 1998/02685T TR 9802685 T TR9802685 T TR 9802685T TR 199802685 T2 TR199802685 T2 TR 199802685T2
Authority
TR
Turkey
Prior art keywords
revleri
katk
kameli
indazol
compounds
Prior art date
Application number
TR1998/02685T
Other languages
English (en)
Inventor
Marfat Anthony
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of TR199802685T2 publication Critical patent/TR199802685T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bu bulus formül (I)'i havi bilesikler ve bunlarin farmasötik yönden kabul edilebilir tuzlari ile ilgili olup, burada R, R1 ve R2 bu tarifnamede tayin edildigi gibidir. Bu bulus, ayrica, bir memeli yaratikta fosfodiesteraz (PDE) tip IV'ün veya tümör nekroz faktörünün (TNF) üretiminin engellenmesi için formül (I)'i havi bilesikleri, veya bunlarin farmasötik yönden kabul edilebilir tuzlarini içeren farmasötik kompozisyonlar ve bu maddeleri kullanan metodlarla da ilgilidir.
TR1998/02685T 1996-06-25 1997-06-02 Ikameli/katkili indazol türevleri TR199802685T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2038596P 1996-06-25 1996-06-25

Publications (1)

Publication Number Publication Date
TR199802685T2 true TR199802685T2 (tr) 1999-03-22

Family

ID=21798354

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/02685T TR199802685T2 (tr) 1996-06-25 1997-06-02 Ikameli/katkili indazol türevleri

Country Status (43)

Country Link
US (1) US6040329A (tr)
EP (1) EP0912558B1 (tr)
JP (1) JP3152940B2 (tr)
KR (1) KR20000022516A (tr)
CN (1) CN1080260C (tr)
AP (1) AP1025A (tr)
AR (1) AR007456A1 (tr)
AT (1) ATE244713T1 (tr)
AU (1) AU716376B2 (tr)
BG (1) BG64052B1 (tr)
BR (1) BR9712782A (tr)
CA (1) CA2258285C (tr)
CO (1) CO4900056A1 (tr)
CZ (1) CZ423398A3 (tr)
DE (1) DE69723447T2 (tr)
DK (1) DK0912558T3 (tr)
DZ (1) DZ2254A1 (tr)
EA (1) EA002274B1 (tr)
ES (1) ES2201299T3 (tr)
GT (1) GT199700075A (tr)
HK (1) HK1018700A1 (tr)
HN (1) HN1997000079A (tr)
HR (1) HRP970350B1 (tr)
HU (1) HUP9903009A3 (tr)
ID (1) ID18579A (tr)
IL (1) IL127036A (tr)
IS (1) IS4910A (tr)
MA (1) MA24225A1 (tr)
MY (1) MY116915A (tr)
NO (1) NO986103L (tr)
NZ (1) NZ332752A (tr)
OA (1) OA10934A (tr)
PA (1) PA8432301A1 (tr)
PL (1) PL330974A1 (tr)
PT (1) PT912558E (tr)
SI (1) SI0912558T1 (tr)
SK (1) SK176598A3 (tr)
TN (1) TNSN97108A1 (tr)
TR (1) TR199802685T2 (tr)
TW (1) TW434237B (tr)
WO (1) WO1997049702A1 (tr)
YU (1) YU60198A (tr)
ZA (1) ZA975581B (tr)

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TR199900481T2 (tr) * 1996-09-04 1999-06-21 Pfizer Inc. Indazol türevleri; fosfodiesteraz tip IV inhibitörleri olarak kullanimlari.
US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
YU25400A (sh) * 1997-11-04 2003-07-07 Pfizer Products Inc. Terapeutski aktivna jedinjenja sa indazolom
WO2001047915A1 (en) * 1999-12-23 2001-07-05 Icos Corporation Cyclic amp-specific phosphodiesterase inhibitors
US6362213B1 (en) 1999-12-23 2002-03-26 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
US6953774B2 (en) 2000-08-11 2005-10-11 Applied Research Systems Ars Holding N.V. Methods of inducing ovulation
US7205320B2 (en) 2001-01-22 2007-04-17 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
US7153871B2 (en) 2001-01-22 2006-12-26 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs
CA2440842A1 (en) * 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
IL162506A0 (en) 2001-12-14 2005-11-20 Applied Research Systems Ovulation induction
JP2006504656A (ja) 2002-07-19 2006-02-09 メモリー・ファーマシューティカルズ・コーポレイション Ｎ−置換されたアニリン及びジフェニルアミンアナログを含むホスホジエステラーゼ４インヒビター
RU2354648C2 (ru) * 2002-07-19 2009-05-10 Мемори Фармасьютиклз Корпорейшн Соединения 6-амино-1н-индазола и 4-аминобензофурана в качестве ингибиторов фосфодиэстеразы 4
KR20050075430A (ko) 2002-11-19 2005-07-20 메모리 파마슈티칼스 코포레이션 포스포디에스테라제 4 억제제
US7226930B2 (en) 2003-04-18 2007-06-05 Memory Pharmaceutical Corporation Phosphodiesterase 4 inhibitors
US20090048255A1 (en) * 2003-07-21 2009-02-19 Schumacher Richard A Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
EP1799673A1 (en) 2004-10-15 2007-06-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
WO2006129158A2 (en) * 2005-05-30 2006-12-07 Ranbaxy Laboratories Limited 3 - indazolyl - isoxazoline derivatives as inhibitors of phosphodiesterase type - i
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1928866A1 (en) 2005-09-05 2008-06-11 Ranbaxy Laboratories Limited Substituted indazoles as inhibitors of phosphodiesterase type-iv
WO2007031838A1 (en) 2005-09-16 2007-03-22 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
MX2009009793A (es) 2007-03-14 2009-10-16 Ranbaxy Lab Ltd Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa.
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
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Also Published As

Publication number Publication date
AU716376B2 (en) 2000-02-24
ATE244713T1 (de) 2003-07-15
HUP9903009A3 (en) 2002-01-28
EA199801047A1 (ru) 1999-06-24
EP0912558B1 (en) 2003-07-09
YU60198A (sh) 1999-09-27
GT199700075A (es) 1998-12-04
ID18579A (id) 1998-04-23
IS4910A (is) 1998-11-27
HRP970350A2 (en) 1998-06-30
DK0912558T3 (da) 2003-08-18
OA10934A (en) 2002-02-18
CZ423398A3 (cs) 1999-12-15
BR9712782A (pt) 1999-12-07
BG103056A (en) 1999-10-29
CO4900056A1 (es) 2000-03-27
TW434237B (en) 2001-05-16
DZ2254A1 (fr) 2002-12-18
KR20000022516A (ko) 2000-04-25
PT912558E (pt) 2003-11-28
SI0912558T1 (en) 2003-10-31
NO986103D0 (no) 1998-12-23
AR007456A1 (es) 1999-10-27
JP3152940B2 (ja) 2001-04-03
CA2258285A1 (en) 1997-12-31
CA2258285C (en) 2002-11-26
IL127036A0 (en) 1999-09-22
MY116915A (en) 2004-04-30
WO1997049702A1 (en) 1997-12-31
JPH11514668A (ja) 1999-12-14
MA24225A1 (fr) 1997-12-31
CN1080260C (zh) 2002-03-06
CN1223651A (zh) 1999-07-21
TNSN97108A1 (fr) 2005-03-15
EA002274B1 (ru) 2002-02-28
HUP9903009A2 (hu) 2000-05-28
PL330974A1 (en) 1999-06-21
NO986103L (no) 1998-12-23
AU2785797A (en) 1998-01-14
US6040329A (en) 2000-03-21
HRP970350B1 (en) 2003-04-30
AP9701020A0 (en) 1997-07-31
HN1997000079A (es) 1997-12-26
HK1018700A1 (en) 1999-12-30
PA8432301A1 (es) 1999-12-27
DE69723447D1 (de) 2003-08-14
EP0912558A1 (en) 1999-05-06
AP1025A (en) 2001-11-19
ES2201299T3 (es) 2004-03-16
ZA975581B (en) 1998-12-24
BG64052B1 (bg) 2003-11-28
IL127036A (en) 2001-06-14
SK176598A3 (en) 2000-06-12
DE69723447T2 (de) 2003-12-24
NZ332752A (en) 2001-04-27

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