TR199800637T2 - Sitmaya karsi ilaçlarin hazirlanmasi için islem. - Google Patents

Sitmaya karsi ilaçlarin hazirlanmasi için islem.

Info

Publication number
TR199800637T2
TR199800637T2 TR1998/00637T TR9800637T TR199800637T2 TR 199800637 T2 TR199800637 T2 TR 199800637T2 TR 1998/00637 T TR1998/00637 T TR 1998/00637T TR 9800637 T TR9800637 T TR 9800637T TR 199800637 T2 TR199800637 T2 TR 199800637T2
Authority
TR
Turkey
Prior art keywords
formula
tmaya
rlanmas
kar
haz
Prior art date
Application number
TR1998/00637T
Other languages
English (en)
Inventor
Onwuzurike Ugwuegbulam Cletus
Original Assignee
Smithkline Beecham P.L.C
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C, Smithkline Beecham Corporation filed Critical Smithkline Beecham P.L.C
Publication of TR199800637T2 publication Critical patent/TR199800637T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bulus, yeni ara ürünlere ve malarya hastaligini önleyici ilaçlar olarak yararli kinolin bilesiklerinin hazirlanmasina yönelik proseslere ve proseste yararli yeni ara ürünlere iliskindir. Asagidaki (I) formülüne sahip bir bilesigin hazirlanmasina yönelik bir proses: (formül) yukaridaki R1, C1-6 alkil'dir; R2 ve R3, birbirlerinden bagimsiz olarak hidrojen, halojen, trifluorometil veya C1-6 alkoksildir; R4, C1-6 alkildir; R5, hidrojen veya C1-6 alkildir; ve R6, nitro veya amino'dur; söz konusu proses, R1, R4 ve R5 formül (I) için tanimladiklari gibi olmak ve X bir ornatilan grubu (veya nükleofüj grup) olmak üzere asagidaki (II) formülüne sahip bir bilesigi: (formül) asagidaki (III) formülüne sahip bir bilesik: (formül) ile tepkimeye sokmaya dayanir.
TR1998/00637T 1995-10-13 1996-10-11 Sitmaya karsi ilaçlarin hazirlanmasi için islem. TR199800637T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9521004.3A GB9521004D0 (en) 1995-10-13 1995-10-13 Process

Publications (1)

Publication Number Publication Date
TR199800637T2 true TR199800637T2 (tr) 1998-07-21

Family

ID=10782264

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00637T TR199800637T2 (tr) 1995-10-13 1996-10-11 Sitmaya karsi ilaçlarin hazirlanmasi için islem.

Country Status (28)

Country Link
US (1) US6479660B1 (tr)
EP (1) EP0871616B1 (tr)
JP (1) JP4083803B2 (tr)
KR (1) KR100453256B1 (tr)
CN (1) CN1147475C (tr)
AR (1) AR004015A1 (tr)
AT (1) ATE214372T1 (tr)
AU (1) AU709333B2 (tr)
BR (1) BR9611010A (tr)
CA (1) CA2231633C (tr)
CZ (1) CZ290380B6 (tr)
DE (1) DE69619863T2 (tr)
DK (1) DK0871616T3 (tr)
ES (1) ES2170874T3 (tr)
GB (1) GB9521004D0 (tr)
HK (1) HK1016180A1 (tr)
HU (1) HUP9900739A3 (tr)
IL (1) IL124060A (tr)
NO (1) NO313285B1 (tr)
NZ (1) NZ320209A (tr)
PL (1) PL186055B1 (tr)
PT (1) PT871616E (tr)
SA (1) SA97170574B1 (tr)
SI (1) SI0871616T1 (tr)
TR (1) TR199800637T2 (tr)
TW (1) TW450950B (tr)
WO (1) WO1997013753A1 (tr)
ZA (1) ZA968550B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08276712A (ja) * 1995-04-05 1996-10-22 Masao Tsuji チュ−ブレススパイクタイヤ
GB0210150D0 (en) 2002-05-03 2002-06-12 Smithkline Beecham Plc Process
JP2009507824A (ja) * 2005-09-12 2009-02-26 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 抗マラリアベイリス−ヒルマン付加物およびその調製方法
WO2007127930A2 (en) * 2006-04-28 2007-11-08 Kansas State University Research Foundation Compounds affecting gap junction activity
GB0620005D0 (en) 2006-10-10 2006-11-22 Glaxo Group Ltd Compounds
US20090076072A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched tafenoquine
ES2453206B1 (es) 2013-09-25 2015-01-12 Thyssenkrupp Elevator Innovation Center, S.A. Sistema de tracción para un sistema de transporte
CN113248431A (zh) * 2021-05-21 2021-08-13 重庆医药高等专科学校 一种磷酸伯氨喹的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431807A (en) * 1980-06-12 1984-02-14 The United States Of America As Represented By The Secretary Of The Army 4-Methyl-5-(unsubstituted and substituted phenoxy)-6-methoxy-8-(aminoalkylamino)quinolines
US4617394A (en) 1985-10-15 1986-10-14 The United States Of America As Represented By The Secretary Of The Army 4-methyl-5-(unsubstituted and substituted phenoxy)-2,6-dimethoxy-8-(aminoalkylamino) quinolines

Also Published As

Publication number Publication date
SI0871616T1 (en) 2002-12-31
PL326194A1 (en) 1998-08-31
GB9521004D0 (en) 1995-12-13
PL186055B1 (pl) 2003-09-30
NO313285B1 (no) 2002-09-09
ZA968550B (en) 1998-04-14
KR100453256B1 (ko) 2004-12-17
SA97170574B1 (ar) 2006-09-25
CN1199395A (zh) 1998-11-18
HUP9900739A2 (hu) 1999-09-28
AR004015A1 (es) 1998-09-30
DE69619863T2 (de) 2002-11-21
NO981537D0 (no) 1998-04-03
ATE214372T1 (de) 2002-03-15
WO1997013753A1 (en) 1997-04-17
TW450950B (en) 2001-08-21
PT871616E (pt) 2002-07-31
NZ320209A (en) 1999-08-30
CN1147475C (zh) 2004-04-28
US6479660B1 (en) 2002-11-12
AU709333B2 (en) 1999-08-26
DK0871616T3 (da) 2002-07-01
IL124060A (en) 2003-07-31
NO981537L (no) 1998-04-03
CZ110398A3 (cs) 1998-09-16
JPH11513399A (ja) 1999-11-16
EP0871616B1 (en) 2002-03-13
JP4083803B2 (ja) 2008-04-30
ES2170874T3 (es) 2002-08-16
HUP9900739A3 (en) 1999-11-29
CZ290380B6 (cs) 2002-07-17
HK1016180A1 (en) 1999-10-29
AU7291096A (en) 1997-04-30
CA2231633C (en) 2006-10-03
DE69619863D1 (de) 2002-04-18
BR9611010A (pt) 1999-07-13
CA2231633A1 (en) 1997-04-17
KR19990064210A (ko) 1999-07-26
EP0871616A1 (en) 1998-10-21

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