TR199800085A2 - 8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri. - Google Patents

8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.

Info

Publication number
TR199800085A2
TR199800085A2 TR1998/00085A TR9800085A TR199800085A2 TR 199800085 A2 TR199800085 A2 TR 199800085A2 TR 1998/00085 A TR1998/00085 A TR 1998/00085A TR 9800085 A TR9800085 A TR 9800085A TR 199800085 A2 TR199800085 A2 TR 199800085A2
Authority
TR
Turkey
Prior art keywords
revleri
edilmi
bstit
triaza
dean
Prior art date
Application number
TR1998/00085A
Other languages
English (en)
Other versions
TR199800085A3 (tr
Inventor
Adam Geo
Cesura Andrea
Galley Guido
Jenck Fran�Ois
Monsma Frederick
R�Ver Stephan
Wichmann Jurgen
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199800085A2 publication Critical patent/TR199800085A2/tr
Publication of TR199800085A3 publication Critical patent/TR199800085A3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Lubricants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Mevcut bulus, asagidaki formülün (I) bilesikleri ile; ve bunlarin, OFQ reseptörünün agonist ve/veya antagonistleri olan, farmasötik olarak kabul edilebilir tuzlari ile ilgilidir.
TR1998/00085A 1997-01-30 1998-01-20 8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri. TR199800085A3 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101409 1997-01-30
EP97119311 1997-11-05

Publications (2)

Publication Number Publication Date
TR199800085A2 true TR199800085A2 (tr) 1998-08-21
TR199800085A3 TR199800085A3 (tr) 1998-08-21

Family

ID=26145196

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00085A TR199800085A3 (tr) 1997-01-30 1998-01-20 8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.

Country Status (34)

Country Link
US (1) US6071925A (tr)
EP (1) EP0856514B1 (tr)
JP (1) JP3292457B2 (tr)
KR (1) KR100274107B1 (tr)
CN (1) CN1113881C (tr)
AR (1) AR011576A1 (tr)
AT (1) ATE202105T1 (tr)
AU (1) AU730147B2 (tr)
BR (1) BR9800524B1 (tr)
CA (1) CA2226058C (tr)
CO (1) CO4920223A1 (tr)
CZ (1) CZ27398A3 (tr)
DE (1) DE69800896T2 (tr)
DK (1) DK0856514T3 (tr)
EA (1) EA001357B1 (tr)
ES (1) ES2158622T3 (tr)
GR (1) GR3036523T3 (tr)
HR (1) HRP980043B1 (tr)
HU (1) HUP9800138A3 (tr)
ID (1) ID19773A (tr)
IL (1) IL123036A (tr)
MA (1) MA26470A1 (tr)
NO (1) NO310026B1 (tr)
NZ (1) NZ329627A (tr)
PE (1) PE59999A1 (tr)
PL (1) PL324571A1 (tr)
PT (1) PT856514E (tr)
SG (1) SG71077A1 (tr)
SI (1) SI0856514T1 (tr)
TR (1) TR199800085A3 (tr)
TW (1) TW457238B (tr)
UY (1) UY24865A1 (tr)
YU (1) YU2098A (tr)
ZA (1) ZA98570B (tr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE212635T1 (de) * 1997-12-05 2002-02-15 1,3,8-triazaspiro(4,5)decan-4-on-derivate
SI0921125T1 (en) * 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
PT963985E (pt) 1998-06-12 2003-06-30 Hoffmann La Roche Derivados de di- ou triaza-espiro(4,5)decano
ATE222908T1 (de) * 1998-06-12 2002-09-15 Hoffmann La Roche Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole)
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
ES2237047T3 (es) * 1998-10-23 2005-07-16 Pfizer Inc. Compuestos de 1,3,8-triazaespiro(4,5)decanona como agonistas del receptor orl1.
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
GB9900078D0 (en) * 1999-01-05 1999-02-24 Zeneca Ltd Chemical compounds
GB9914024D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
AU1382901A (en) * 1999-11-17 2001-05-30 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
JP3989247B2 (ja) 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
US6794389B2 (en) 2000-03-31 2004-09-21 Nippon Shinyaku Co., Ltd. Quinazoline derivatives and drugs
EP1392687B1 (en) * 2001-04-10 2017-02-01 Janssen Pharmaceuticals, Inc. 1,3,8-triazaspiro[4,5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
JP2005502619A (ja) 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
DK1491212T3 (da) 2002-03-29 2012-10-29 Mitsubishi Tanabe Pharma Corp Middel til behandling af søvnforstyrrelser
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
AU2003268512A1 (en) * 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
NZ544282A (en) * 2003-05-23 2009-07-31 Zealand Pharma As Triaza-spiro compounds as nociceptin analogues and uses thereof
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CN101622254B (zh) * 2006-11-28 2013-05-29 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101622241B (zh) * 2007-03-01 2013-05-22 田边三菱制药株式会社 苯并咪唑化合物及其医药用途
JP5490677B2 (ja) * 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
JP7011596B2 (ja) * 2015-12-02 2022-02-10 アストライア セラピューティクス， エルエルシー ピペリジニルノシセプチン受容体化合物
CN106467476A (zh) * 2016-09-04 2017-03-01 王际菊 一种左旋胺基化合物的合成方法
CN106397225A (zh) * 2016-09-04 2017-02-15 王际菊 一种手性化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US488082A (en) * 1892-12-13 Automatic gut-off for gas bxxenees
JPS5212171A (en) * 1975-07-17 1977-01-29 Yoshitomi Pharmaceut Ind Ltd Process for preparation of cyclohexane derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4126687A (en) * 1976-05-17 1978-11-21 Janssen Pharmaceutica N.V. Antiemetic, 1-(benzimidazolyl-alkyl)-piperidine derivatives
US4329353A (en) * 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) * 1980-10-22 1984-05-30 Жансен Фармасетика Н.В. (Фирма) Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) * 1984-01-23 1985-04-01 吉富製薬株式会社 脂環式誘導体
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5153225A (en) * 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) * 1991-10-28 1993-04-29 Bayer Ag Triazaspirodecanon-methylchromane
DE4405178A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

Also Published As

Publication number Publication date
ZA98570B (en) 1998-07-30
HUP9800138A2 (hu) 1998-09-28
HU9800138D0 (en) 1998-03-30
MA26470A1 (fr) 2004-12-20
HUP9800138A3 (en) 1999-03-01
IL123036A (en) 2000-12-06
KR19980070900A (ko) 1998-10-26
NO310026B1 (no) 2001-05-07
ATE202105T1 (de) 2001-06-15
AR011576A1 (es) 2000-08-30
CO4920223A1 (es) 2000-05-29
CN1191862A (zh) 1998-09-02
EP0856514B1 (en) 2001-06-13
BR9800524B1 (pt) 2008-11-18
JP3292457B2 (ja) 2002-06-17
CA2226058C (en) 2008-01-29
DK0856514T3 (da) 2001-09-17
PT856514E (pt) 2001-10-31
SI0856514T1 (en) 2001-08-31
PE59999A1 (es) 1999-07-01
KR100274107B1 (ko) 2000-12-15
BR9800524A (pt) 2000-03-14
ES2158622T3 (es) 2001-09-01
HRP980043A2 (en) 1998-12-31
CN1113881C (zh) 2003-07-09
AU5280998A (en) 1998-08-06
UY24865A1 (es) 2000-12-29
AU730147B2 (en) 2001-03-01
EA001357B1 (ru) 2001-02-26
HRP980043B1 (en) 2001-12-31
CZ27398A3 (cs) 1998-08-12
EA199800108A1 (ru) 1998-10-29
US6071925A (en) 2000-06-06
SG71077A1 (en) 2000-03-21
GR3036523T3 (en) 2001-12-31
TW457238B (en) 2001-10-01
EP0856514A1 (en) 1998-08-05
JPH10212290A (ja) 1998-08-11
DE69800896T2 (de) 2002-03-28
IL123036A0 (en) 1998-09-24
NO980332L (no) 1998-07-31
ID19773A (id) 1998-07-30
CA2226058A1 (en) 1998-07-30
DE69800896D1 (de) 2001-07-19
NZ329627A (en) 1999-11-29
NO980332D0 (no) 1998-01-26
TR199800085A3 (tr) 1998-08-21
PL324571A1 (en) 1998-08-03
YU2098A (sh) 2001-03-07

Similar Documents

Publication Publication Date Title
TR199800085A2 (tr) 8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.
EA200101177A1 (ru) Производные индола в качестве антагонистов прогестерона
NO20010603D0 (no) 2-substituert-1-piperidylbenzimidazol forbindelser som ORL 1- reseptor agonister
TR200002157T2 (tr) Kimyasal bileşikler
TR200002131T2 (tr) Kimyasal bileşikler
NO965036L (no) Kinolinderivater som techykinin NK3 reseptor-antagonister
WO1999024451A3 (en) Adenosine a1 receptor agonists
TR200000333T2 (tr) Y alıcı antagonistleri olarak 4-aminopirol (3,2-d) pirimidinler.
WO1999064401A3 (en) Imidazolyl derivatives and their use as somatostatin receptor ligands
CZ352196A3 (en) Heterocyclic compounds exhibiting antagonistic activity on tachykinin receptor, their preparation and use
TR199802269T2 (tr) Endotelin reseptör antagonistleri olarak faydali indol türevleri.
TR200101155T2 (tr) 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
SE9702773D0 (sv) Novel compounds
AU2002353844A1 (en) Beta 3 adrenergic agonists
ATE305781T1 (de) Non-peptidische vasopressin via antagonisten
EA200300593A1 (ru) Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора
NO20002036L (no) Cyklopentenderivater anvendbare som antagonister for motilinreseptoren
AU1667500A (en) N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthal necarboxamides and their use as neurokinin 1 (nk1) and/or neurokinin 2 (nk2) receptor antagonists
TR199901381A2 (tr) Diaza-spiro[3,5]nonan türevleri.
ATE198202T1 (de) Fibrinogen receptor antagonisten
TR200101493T2 (tr) Eletriptan hidrobromid monohidrat
DK0912556T3 (da) Indolinderivater, der er anvendelige som 5-HT-2C-receptorantagonister
TR200101654T2 (tr) Vitronektin resept”r antagonistleri
IT1270612B (it) Derivati eterociclo-condensatori di morfinoidi
ATE227276T1 (de) Neue pyrimidinderivate