EA199800108A1 - Производные 8-замещенного-1,3,8-триазаспиро [4.5]декан-4-она - Google Patents

Производные 8-замещенного-1,3,8-триазаспиро [4.5]декан-4-она

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Publication number
EA199800108A1
EA199800108A1 EA199800108A EA199800108A EA199800108A1 EA 199800108 A1 EA199800108 A1 EA 199800108A1 EA 199800108 A EA199800108 A EA 199800108A EA 199800108 A EA199800108 A EA 199800108A EA 199800108 A1 EA199800108 A1 EA 199800108A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
phenyl
hydrogen
ring
ness
Prior art date
Application number
EA199800108A
Other languages
English (en)
Other versions
EA001357B1 (ru
Inventor
Гео Адам
Андреа Чесура
Гуидо Галлей
Франсуа Женк
Фредерик Монсма
Стефан Рёвер
Йюрген Вихманн
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA199800108A1 publication Critical patent/EA199800108A1/ru
Publication of EA001357B1 publication Critical patent/EA001357B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

В заявке описаны соединения формулыгде Rи R, каждый независимо друг от друга обозначает водород, (низш.)алкил, (низш.)алкокси или галоген; Rобозначает фенил, необязательно замещенный (низш.)алкилом, CF, (низш.)алкоксигруппой или галогеном; и Rобозначает водород, (низш.)алкил, (низш.)алкенил, -C(O)-(низш.)алкил, -C(O)-фенил, (низш.)алкил-C(O)-фенил, (низш.)алкилен-C(O)O-(низш.)алкил, (низш.)алкантриил-ди-C(O)O-(низш.)алкил, гидрокси-(низш.)алкил, (низш.)алкил-O-(низш.)алкил, (низш.)алкил-CH(OH)CF, фенил или бензил; Rи R, каждый независимо друг от друга обозначает водород, фенил, (низш.)алкил или ди(низш.)алкил или могут вместе образовывать фенильное кольцо; и Rи один из Rили Rмогут вместе образовывать насыщенное или ненасыщенное 6-членное кольцо; A обозначает 4-7-членное насыщенное кольцо, которое может содержать гетероатом, такой как O или S; и их фармацевтически приемлемые кислотно-аддитивные соли, которые являются агонистами и/или антагонистами OFQ-рецептора.
EA199800108A 1997-01-30 1998-01-30 Производные 8-замещенного-1,3,8-триазаспиро [4.5]декан-4-она EA001357B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101409 1997-01-30
EP97119311 1997-11-05

Publications (2)

Publication Number Publication Date
EA199800108A1 true EA199800108A1 (ru) 1998-10-29
EA001357B1 EA001357B1 (ru) 2001-02-26

Family

ID=26145196

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800108A EA001357B1 (ru) 1997-01-30 1998-01-30 Производные 8-замещенного-1,3,8-триазаспиро [4.5]декан-4-она

Country Status (34)

Country Link
US (1) US6071925A (ru)
EP (1) EP0856514B1 (ru)
JP (1) JP3292457B2 (ru)
KR (1) KR100274107B1 (ru)
CN (1) CN1113881C (ru)
AR (1) AR011576A1 (ru)
AT (1) ATE202105T1 (ru)
AU (1) AU730147B2 (ru)
BR (1) BR9800524B1 (ru)
CA (1) CA2226058C (ru)
CO (1) CO4920223A1 (ru)
CZ (1) CZ27398A3 (ru)
DE (1) DE69800896T2 (ru)
DK (1) DK0856514T3 (ru)
EA (1) EA001357B1 (ru)
ES (1) ES2158622T3 (ru)
GR (1) GR3036523T3 (ru)
HR (1) HRP980043B1 (ru)
HU (1) HUP9800138A3 (ru)
ID (1) ID19773A (ru)
IL (1) IL123036A (ru)
MA (1) MA26470A1 (ru)
NO (1) NO310026B1 (ru)
NZ (1) NZ329627A (ru)
PE (1) PE59999A1 (ru)
PL (1) PL324571A1 (ru)
PT (1) PT856514E (ru)
SG (1) SG71077A1 (ru)
SI (1) SI0856514T1 (ru)
TR (1) TR199800085A3 (ru)
TW (1) TW457238B (ru)
UY (1) UY24865A1 (ru)
YU (1) YU2098A (ru)
ZA (1) ZA98570B (ru)

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AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
GB9900078D0 (en) * 1999-01-05 1999-02-24 Zeneca Ltd Chemical compounds
GB9914024D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
WO2001036418A1 (en) * 1999-11-17 2001-05-25 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
JP3989247B2 (ja) * 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
EP1306372B1 (en) * 2000-03-31 2009-11-18 Nippon Shinyaku Co., Ltd. Heterocycle derivatives and drugs
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US7566728B2 (en) * 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
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DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
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Also Published As

Publication number Publication date
DE69800896D1 (de) 2001-07-19
ID19773A (id) 1998-07-30
HU9800138D0 (en) 1998-03-30
IL123036A0 (en) 1998-09-24
DE69800896T2 (de) 2002-03-28
AU5280998A (en) 1998-08-06
IL123036A (en) 2000-12-06
ES2158622T3 (es) 2001-09-01
CA2226058C (en) 2008-01-29
ZA98570B (en) 1998-07-30
ATE202105T1 (de) 2001-06-15
CN1191862A (zh) 1998-09-02
HRP980043B1 (en) 2001-12-31
HRP980043A2 (en) 1998-12-31
JP3292457B2 (ja) 2002-06-17
CN1113881C (zh) 2003-07-09
EP0856514A1 (en) 1998-08-05
NO310026B1 (no) 2001-05-07
HUP9800138A3 (en) 1999-03-01
HUP9800138A2 (hu) 1998-09-28
TR199800085A2 (xx) 1998-08-21
CZ27398A3 (cs) 1998-08-12
DK0856514T3 (da) 2001-09-17
TW457238B (en) 2001-10-01
NZ329627A (en) 1999-11-29
PE59999A1 (es) 1999-07-01
CA2226058A1 (en) 1998-07-30
BR9800524B1 (pt) 2008-11-18
NO980332D0 (no) 1998-01-26
SI0856514T1 (en) 2001-08-31
US6071925A (en) 2000-06-06
MA26470A1 (fr) 2004-12-20
JPH10212290A (ja) 1998-08-11
KR19980070900A (ko) 1998-10-26
CO4920223A1 (es) 2000-05-29
PT856514E (pt) 2001-10-31
EP0856514B1 (en) 2001-06-13
EA001357B1 (ru) 2001-02-26
NO980332L (no) 1998-07-31
BR9800524A (pt) 2000-03-14
TR199800085A3 (tr) 1998-08-21
UY24865A1 (es) 2000-12-29
YU2098A (sh) 2001-03-07
AR011576A1 (es) 2000-08-30
KR100274107B1 (ko) 2000-12-15
SG71077A1 (en) 2000-03-21
GR3036523T3 (en) 2001-12-31
PL324571A1 (en) 1998-08-03
AU730147B2 (en) 2001-03-01

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