YU2098A - Derivati 8-supstituisanog-1,3,8-triaza-spiro/4,5/dekan-4- ona - Google Patents

Derivati 8-supstituisanog-1,3,8-triaza-spiro/4,5/dekan-4- ona

Info

Publication number
YU2098A
YU2098A YU2098A YU2098A YU2098A YU 2098 A YU2098 A YU 2098A YU 2098 A YU2098 A YU 2098A YU 2098 A YU2098 A YU 2098A YU 2098 A YU2098 A YU 2098A
Authority
YU
Yugoslavia
Prior art keywords
lower alkyl
phenyl
hydrogen
triaza
decan
Prior art date
Application number
YU2098A
Other languages
English (en)
Inventor
Geo Adam
Andrea Cesura
Guido Galley
Francois Jenck
Frederick Monsma
Stephan Rover
Jurgen Wichmann
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU2098A publication Critical patent/YU2098A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Ovaj pronalazak odnosi se na jedinjenja formule u kojoj R1 i R2 predstavljaju, nezavisno jedan od drugog, vodonik, niži alkil, niži alkoksi ili halogen; R3 je fenil, neobavezno supstituisan grupom niži alkil, CF3, niži alkoksi ili halogen; a R4 je vodonik, niži alkil, niži alkenil, -C-(O)-niži alkil, -C(O)-fenil, niži alkil-C(O)-fenil, niži alkilen-C-(O)O-niži alkil, niži alkantri-il-di-C-(O)O-niži alkil, hidroksi-niži alkil, niži alkil-O-niži alkil, niži alkil-CH(OH)CF3, fenil ili benzil, R5 i R6 su, nezavisno jedan od drugog, vodonik, fenil, niži alkil ili di-niži alkil ili zajedno mogu da formiraju prsten fenila, i R5 i jedan od R1 ili R2 mogu da zajedno formiraju zasićeni ili nezasićeni 6-lani prsten, A je 4-7-člani zasićeni prsten koji može da sadrži heteroatom kao što je O ili S, i na njihove farmaceutski prihvatljive soli koje nastaju dodavanjem kiseline, koja su agonisti i/ili antagonisti receptora OFQ.
YU2098A 1997-01-30 1998-01-15 Derivati 8-supstituisanog-1,3,8-triaza-spiro/4,5/dekan-4- ona YU2098A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101409 1997-01-30
EP97119311 1997-11-05

Publications (1)

Publication Number Publication Date
YU2098A true YU2098A (sh) 2001-03-07

Family

ID=26145196

Family Applications (1)

Application Number Title Priority Date Filing Date
YU2098A YU2098A (sh) 1997-01-30 1998-01-15 Derivati 8-supstituisanog-1,3,8-triaza-spiro/4,5/dekan-4- ona

Country Status (34)

Country Link
US (1) US6071925A (sh)
EP (1) EP0856514B1 (sh)
JP (1) JP3292457B2 (sh)
KR (1) KR100274107B1 (sh)
CN (1) CN1113881C (sh)
AR (1) AR011576A1 (sh)
AT (1) ATE202105T1 (sh)
AU (1) AU730147B2 (sh)
BR (1) BR9800524B1 (sh)
CA (1) CA2226058C (sh)
CO (1) CO4920223A1 (sh)
CZ (1) CZ27398A3 (sh)
DE (1) DE69800896T2 (sh)
DK (1) DK0856514T3 (sh)
EA (1) EA001357B1 (sh)
ES (1) ES2158622T3 (sh)
GR (1) GR3036523T3 (sh)
HR (1) HRP980043B1 (sh)
HU (1) HUP9800138A3 (sh)
ID (1) ID19773A (sh)
IL (1) IL123036A (sh)
MA (1) MA26470A1 (sh)
NO (1) NO310026B1 (sh)
NZ (1) NZ329627A (sh)
PE (1) PE59999A1 (sh)
PL (1) PL324571A1 (sh)
PT (1) PT856514E (sh)
SG (1) SG71077A1 (sh)
SI (1) SI0856514T1 (sh)
TR (1) TR199800085A2 (sh)
TW (1) TW457238B (sh)
UY (1) UY24865A1 (sh)
YU (1) YU2098A (sh)
ZA (1) ZA98570B (sh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2170446T3 (es) * 1997-12-05 2002-08-01 Hoffmann La Roche Derivados de 1,3,8-triaza-espiro(4,5)decan-4-ona.
SI0921125T1 (en) * 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
ES2194402T3 (es) 1998-06-12 2003-11-16 Hoffmann La Roche Derivados de di - o triaza-espiro(4,5)decano..
ES2181336T3 (es) * 1998-06-12 2003-02-16 Hoffmann La Roche Espiro(piperidin-4,1'-pirrolo(3,4-c)pirrol).
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
EP0997464B1 (en) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists
WO2000031061A1 (fr) * 1998-11-20 2000-06-02 Banyu Pharmaceutical Co., Ltd. Derives de 2-oxo-imidazole
GB9900078D0 (en) * 1999-01-05 1999-02-24 Zeneca Ltd Chemical compounds
GB9914024D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
AU1382901A (en) * 1999-11-17 2001-05-30 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
AU1948601A (en) 1999-12-06 2001-06-12 Euro-Celtique S.A. Triazospiro compounds having nociceptin receptor affinity
KR20020083533A (ko) 2000-03-31 2002-11-02 니뽄 신야쿠 가부시키가이샤 복소환 유도체 및 의약
NZ570181A (en) * 2001-04-10 2010-02-26 Ortho Mcneil Janssen Pharm 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
WO2003004034A1 (en) 2001-07-02 2003-01-16 Omeros Corporation Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
EP1491212B1 (en) 2002-03-29 2012-08-08 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
KR20050043935A (ko) * 2002-09-09 2005-05-11 얀센 파마슈티카 엔.브이. Ｏｒｌ-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체
EP1628978A2 (en) * 2003-05-23 2006-03-01 Zealand Pharma A/S Triaza-spiro compounds as nociceptin analogues and uses thereof
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
AU2007325355A1 (en) * 2006-11-28 2008-06-05 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza-spiro[4.5]decan-4-one
AU2008219980B2 (en) * 2007-03-01 2012-01-12 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
WO2008124209A1 (en) * 2007-04-09 2008-10-16 Janssen Pharmaceutica, N.V. 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
EP3383390A4 (en) * 2015-12-02 2019-11-20 Astraea Therapeutics, LLC PIPERIDINYL COMPOUNDS FOR NOCICEPTIN RECEPTOR
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
CN106467476A (zh) * 2016-09-04 2017-03-01 王际菊 一种左旋胺基化合物的合成方法
CN106397225A (zh) * 2016-09-04 2017-02-15 王际菊 一种手性化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US488082A (en) * 1892-12-13 Automatic gut-off for gas bxxenees
JPS5212171A (en) * 1975-07-17 1977-01-29 Yoshitomi Pharmaceut Ind Ltd Process for preparation of cyclohexane derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4126688A (en) * 1976-05-17 1978-11-21 Janssen Pharmaceutica N.V. Antiemetic 1-(benzotriazolyl-alkyl)-piperidine derivatives
US4329353A (en) * 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) * 1980-10-22 1984-05-30 Жансен Фармасетика Н.В. (Фирма) Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) * 1984-01-23 1985-04-01 吉富製薬株式会社 脂環式誘導体
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5153225A (en) * 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) * 1991-10-28 1993-04-29 Bayer Ag Triazaspirodecanon-methylchromane
DE4405178A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

Also Published As

Publication number Publication date
EA001357B1 (ru) 2001-02-26
CA2226058A1 (en) 1998-07-30
SI0856514T1 (en) 2001-08-31
ID19773A (id) 1998-07-30
NO980332L (no) 1998-07-31
TR199800085A3 (tr) 1998-08-21
JP3292457B2 (ja) 2002-06-17
HU9800138D0 (en) 1998-03-30
KR19980070900A (ko) 1998-10-26
MA26470A1 (fr) 2004-12-20
IL123036A (en) 2000-12-06
CZ27398A3 (cs) 1998-08-12
DE69800896D1 (de) 2001-07-19
HUP9800138A2 (hu) 1998-09-28
HUP9800138A3 (en) 1999-03-01
SG71077A1 (en) 2000-03-21
EP0856514A1 (en) 1998-08-05
CA2226058C (en) 2008-01-29
ZA98570B (en) 1998-07-30
US6071925A (en) 2000-06-06
AU5280998A (en) 1998-08-06
NZ329627A (en) 1999-11-29
JPH10212290A (ja) 1998-08-11
EP0856514B1 (en) 2001-06-13
HRP980043B1 (en) 2001-12-31
PT856514E (pt) 2001-10-31
NO980332D0 (no) 1998-01-26
UY24865A1 (es) 2000-12-29
CN1113881C (zh) 2003-07-09
KR100274107B1 (ko) 2000-12-15
TR199800085A2 (xx) 1998-08-21
NO310026B1 (no) 2001-05-07
PE59999A1 (es) 1999-07-01
DK0856514T3 (da) 2001-09-17
AR011576A1 (es) 2000-08-30
TW457238B (en) 2001-10-01
CO4920223A1 (es) 2000-05-29
ES2158622T3 (es) 2001-09-01
HRP980043A2 (en) 1998-12-31
BR9800524B1 (pt) 2008-11-18
DE69800896T2 (de) 2002-03-28
AU730147B2 (en) 2001-03-01
ATE202105T1 (de) 2001-06-15
IL123036A0 (en) 1998-09-24
CN1191862A (zh) 1998-09-02
EA199800108A1 (ru) 1998-10-29
GR3036523T3 (en) 2001-12-31
BR9800524A (pt) 2000-03-14
PL324571A1 (en) 1998-08-03

Similar Documents

Publication Publication Date Title
YU2098A (sh) Derivati 8-supstituisanog-1,3,8-triaza-spiro/4,5/dekan-4- ona
CA2113229A1 (en) Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
DK0775129T3 (da) 3-Benzoylbenzofuranderivater som thyroidhormonantagonister
YU17591A (sh) Triazolni fungicidni agensi
ATE297910T1 (de) Retinoid x rezeptormodulatoren
AU560579B2 (en) N-aromatic-n:-cycloalkylalkanoyl-piperazines
ZA9610418B (en) Phenylimidazolidines containing in particular a nitrooxy or carbonyloxy radical, preparation process and intermediates, use as medicaments, new uses and pharmaceutical compositions.
IL57577A (en) 1,2-dihydroquinolin-2-one derivatives,processes for their preparation and pharmaceutical compositions containing the same
YU42397A (sh) Korišćenje raloksifena za pripremu leka
TR200003322T2 (tr) Geniş spektrumlu mantar ilacı olarak kullanılan suda çözülebilen azoller
LV10949A (lv) Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija
YU44301A (sh) 5ht1 antagonisti za antidepresantnu terapiju
EP1019047A4 (en) ANTITHROMBOTIC AGENTS
FI945582A0 (fi) Substituoidut (aryylialkyyliaminobentsyyli) aminopropioniamidijohdannaiset, niiden valmistus ja käyttö anti-epileptisinä, neuroprotektiivisina ja antidepressiivisina aineina
IL59128A0 (en) Pyrimido- and imidazo-pyridoindole derivatives,their preparation and pharmaceutical compositions containing them
FR2410641A1 (fr) Formes racemiques et optiquement actives de (biphenylyl-4)-2 n-(diethylamino alkyl) propionamides et de leurs sels utiles comme agents spasmolytiques et procedes de preparation
AR007052A1 (es) Un derivado de carbohidrato, su uso y una composicion farmaceutica que lo comprende
EP1027051A4 (en) ANTITHROMBOTIC AGENTS
NO950177D0 (no) Farmakologisk aktive erivater
ES8106128A1 (es) Un procedimiento para la preparacion de derivados de ciclo- hexadieno
IL58999A0 (en) Pharmaceutical compositions comprising certain imidazolinederivatives
ES2178080T3 (es) Procedimiento para la preparacion de derivados de alcoxi-o ariloxi-pirazina.
DK1351942T3 (da) Nye 2,3-benzodiazepinderivater og farmaceutiske sammensætninger indeholdende disse som den aktive bestanddel
ES8700653A1 (es) Procedimiento de preparar compuestos amidicos farmacologica-mente activos
IL67400A (en) Octahydro-3,7a-diazacyclohepta(j,k)fluorene derivatives,their preparation and pharmaceutical compositions containing them