PL324571A1 - 8-substituted derivatives of 1,3,8-triazaspiro[4,5]dekan-4-one, method of obtaining them and therapeutic agents containing such compounds - Google Patents

8-substituted derivatives of 1,3,8-triazaspiro[4,5]dekan-4-one, method of obtaining them and therapeutic agents containing such compounds

Info

Publication number
PL324571A1
PL324571A1 PL98324571A PL32457198A PL324571A1 PL 324571 A1 PL324571 A1 PL 324571A1 PL 98324571 A PL98324571 A PL 98324571A PL 32457198 A PL32457198 A PL 32457198A PL 324571 A1 PL324571 A1 PL 324571A1
Authority
PL
Poland
Prior art keywords
dekan
triazaspiro
compounds
obtaining
therapeutic agents
Prior art date
Application number
PL98324571A
Other languages
English (en)
Inventor
Adam Geo
Andrea Cesura
Guido Galley
Francois Jenck
Frederick Monsma
Stephan Roever
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL324571A1 publication Critical patent/PL324571A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL98324571A 1997-01-30 1998-01-29 8-substituted derivatives of 1,3,8-triazaspiro[4,5]dekan-4-one, method of obtaining them and therapeutic agents containing such compounds PL324571A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97101409 1997-01-30
EP97119311 1997-11-05

Publications (1)

Publication Number Publication Date
PL324571A1 true PL324571A1 (en) 1998-08-03

Family

ID=26145196

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98324571A PL324571A1 (en) 1997-01-30 1998-01-29 8-substituted derivatives of 1,3,8-triazaspiro[4,5]dekan-4-one, method of obtaining them and therapeutic agents containing such compounds

Country Status (34)

Country Link
US (1) US6071925A (sh)
EP (1) EP0856514B1 (sh)
JP (1) JP3292457B2 (sh)
KR (1) KR100274107B1 (sh)
CN (1) CN1113881C (sh)
AR (1) AR011576A1 (sh)
AT (1) ATE202105T1 (sh)
AU (1) AU730147B2 (sh)
BR (1) BR9800524B1 (sh)
CA (1) CA2226058C (sh)
CO (1) CO4920223A1 (sh)
CZ (1) CZ27398A3 (sh)
DE (1) DE69800896T2 (sh)
DK (1) DK0856514T3 (sh)
EA (1) EA001357B1 (sh)
ES (1) ES2158622T3 (sh)
GR (1) GR3036523T3 (sh)
HR (1) HRP980043B1 (sh)
HU (1) HUP9800138A3 (sh)
ID (1) ID19773A (sh)
IL (1) IL123036A (sh)
MA (1) MA26470A1 (sh)
NO (1) NO310026B1 (sh)
NZ (1) NZ329627A (sh)
PE (1) PE59999A1 (sh)
PL (1) PL324571A1 (sh)
PT (1) PT856514E (sh)
SG (1) SG71077A1 (sh)
SI (1) SI0856514T1 (sh)
TR (1) TR199800085A3 (sh)
TW (1) TW457238B (sh)
UY (1) UY24865A1 (sh)
YU (1) YU2098A (sh)
ZA (1) ZA98570B (sh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0921125B1 (en) * 1997-12-05 2002-01-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro[4,5]decan-4-on derivatives
PT921125E (pt) * 1997-12-05 2002-06-28 Hoffmann La Roche Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
DE69902606T2 (de) * 1998-06-12 2003-04-24 Hoffmann La Roche Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole)
DE69905798T2 (de) * 1998-06-12 2004-02-12 F. Hoffmann-La Roche Ag Di- oder Triazaspiro[4,5]decanderivate
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
CO5150201A1 (es) * 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
EP0997464B1 (en) * 1998-10-23 2005-02-16 Pfizer Inc. 1,3,8-Triazaspiro[4,5] decanone compounds as orl1-receptor agonists
AU1185300A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivatives
GB9900078D0 (en) * 1999-01-05 1999-02-24 Zeneca Ltd Chemical compounds
GB9914024D0 (en) * 1999-06-17 1999-08-18 Zeneca Ltd Chemical compounds
AU1382901A (en) * 1999-11-17 2001-05-30 Novo Nordisk A/S Novel triazaspirodecanones with high affinity for opioid receptor subtypes
JP3989247B2 (ja) * 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
ATE449084T1 (de) * 2000-03-31 2009-12-15 Nippon Shinyaku Co Ltd Derivate von heterocyclen und arzneistoffe
WO2002083673A1 (en) * 2001-04-10 2002-10-24 Ortho-Mcneil Pharmaceutical, Inc. 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
CA2490386A1 (en) 2001-07-02 2003-01-16 Omeros Corporation Method for producing analgesia comprising administration of an opioid receptor agonist in rotation with an opioid receptor like-1 receptor agonist
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
ES2392340T3 (es) 2002-03-29 2012-12-07 Mitsubishi Tanabe Pharma Corporation Remedio para los trastornos del sueño
US6995168B2 (en) 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
AU2003268512A1 (en) * 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
EP1628978A2 (en) * 2003-05-23 2006-03-01 Zealand Pharma A/S Triaza-spiro compounds as nociceptin analogues and uses thereof
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
CA2670858C (en) * 2006-11-28 2015-01-13 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
AU2008219980B2 (en) 2007-03-01 2012-01-12 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
EP2150552B1 (en) * 2007-04-09 2013-01-02 Janssen Pharmaceutica NV 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
TW201016675A (en) * 2008-09-16 2010-05-01 Mitsubishi Tanabe Pharma Corp Crystalline benzoimidazole compound and salt thereof
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
AU2016365400C1 (en) * 2015-12-02 2022-11-10 Astraea Therapeutics, Llc Piperidinyl nociceptin receptor compounds
CN106467476A (zh) * 2016-09-04 2017-03-01 王际菊 一种左旋胺基化合物的合成方法
CN106397225A (zh) * 2016-09-04 2017-02-15 王际菊 一种手性化合物的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US488082A (en) * 1892-12-13 Automatic gut-off for gas bxxenees
JPS5212171A (en) * 1975-07-17 1977-01-29 Yoshitomi Pharmaceut Ind Ltd Process for preparation of cyclohexane derivatives
US4076821A (en) * 1976-02-27 1978-02-28 Yoshitomi Pharmaceutical Industries, Ltd. 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4126688A (en) * 1976-05-17 1978-11-21 Janssen Pharmaceutica N.V. Antiemetic 1-(benzotriazolyl-alkyl)-piperidine derivatives
US4329353A (en) * 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) * 1980-10-22 1984-05-30 Жансен Фармасетика Н.В. (Фирма) Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) * 1982-04-09 1983-02-15 Hoechst-Roussel Pharmaceuticals Inc. 8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) * 1984-01-23 1985-04-01 吉富製薬株式会社 脂環式誘導体
US4707484A (en) * 1986-11-25 1987-11-17 Hoffmann-La Roche Inc. Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
US5153225A (en) * 1986-12-10 1992-10-06 Bayer Aktiengesellschaft Substituted basic 2-aminotetralin in pharmaceuticals
US5039804A (en) * 1989-12-13 1991-08-13 Glaxo Inc. Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) * 1991-10-28 1993-04-29 Bayer Ag Triazaspirodecanon-methylchromane
DE4405178A1 (de) * 1994-02-18 1995-08-24 Hoechst Ag Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

Also Published As

Publication number Publication date
CA2226058C (en) 2008-01-29
ID19773A (id) 1998-07-30
SG71077A1 (en) 2000-03-21
JPH10212290A (ja) 1998-08-11
TR199800085A2 (xx) 1998-08-21
EP0856514A1 (en) 1998-08-05
UY24865A1 (es) 2000-12-29
NO310026B1 (no) 2001-05-07
HU9800138D0 (en) 1998-03-30
AU730147B2 (en) 2001-03-01
DK0856514T3 (da) 2001-09-17
EP0856514B1 (en) 2001-06-13
MA26470A1 (fr) 2004-12-20
AU5280998A (en) 1998-08-06
KR19980070900A (ko) 1998-10-26
ZA98570B (en) 1998-07-30
NO980332D0 (no) 1998-01-26
TW457238B (en) 2001-10-01
HUP9800138A3 (en) 1999-03-01
US6071925A (en) 2000-06-06
IL123036A (en) 2000-12-06
DE69800896D1 (de) 2001-07-19
GR3036523T3 (en) 2001-12-31
BR9800524A (pt) 2000-03-14
CN1113881C (zh) 2003-07-09
NO980332L (no) 1998-07-31
CN1191862A (zh) 1998-09-02
PT856514E (pt) 2001-10-31
HRP980043A2 (en) 1998-12-31
TR199800085A3 (tr) 1998-08-21
HRP980043B1 (en) 2001-12-31
CO4920223A1 (es) 2000-05-29
PE59999A1 (es) 1999-07-01
JP3292457B2 (ja) 2002-06-17
ES2158622T3 (es) 2001-09-01
EA199800108A1 (ru) 1998-10-29
NZ329627A (en) 1999-11-29
IL123036A0 (en) 1998-09-24
SI0856514T1 (en) 2001-08-31
CA2226058A1 (en) 1998-07-30
AR011576A1 (es) 2000-08-30
DE69800896T2 (de) 2002-03-28
CZ27398A3 (cs) 1998-08-12
KR100274107B1 (ko) 2000-12-15
YU2098A (sh) 2001-03-07
BR9800524B1 (pt) 2008-11-18
EA001357B1 (ru) 2001-02-26
ATE202105T1 (de) 2001-06-15
HUP9800138A2 (hu) 1998-09-28

Similar Documents

Publication Publication Date Title
PL324571A1 (en) 8-substituted derivatives of 1,3,8-triazaspiro[4,5]dekan-4-one, method of obtaining them and therapeutic agents containing such compounds
PL313433A1 (en) Derivatives of benzazepin-, benzoxazepin- and benzothiazepin-n-acetic acids, method of obtaining them and therapeutic agents containing such derivatives
PL311999A1 (en) Piperazine derivatives, therapeutic agents containing them and method of obtaining such derivatives
PL327532A1 (en) Derivatives of 5h-thiazole[3,2-a]pyrimidine, method of obtaining them and medicine containing such derivatives
PL330841A1 (en) Benzosulphonic derivatives, method of obtaining them and therapeutic agents containing such derivatives
PL312352A1 (en) 2,8-disubstituted quinazolinones, method of obtaining them and therapeutic agents containing such compounds
EG25852A (en) Teracyclic derivatives process of preparation
PL328719A1 (en) Pyrimido [5,4-d] pyrimidines, therapeutic agents containing such compounds, their application and method of obtaining such compounds
PL321201A1 (en) Derivatives of 4-hydroxypiepridine, method of obtaining them and therapeutic agents containing such derivatives
PL329440A1 (en) Derivatives of d-proline, method of obtaining them and therapeutic agent containing such compounds
GB2293383B (en) Method of preparing 1-N-ethylgentamicin derivatives
PL297716A1 (en) Benzimidazolyl derivatives, method of obtaining them and therapeutic agents containing such compounds
PL320952A1 (en) Cycloalkanon pyridines, method of obtaining and therapeutic agents containing them
PL317930A1 (en) Oxalydine compounds, method of obtaining them and therapeutic agents
PL316613A1 (en) Novel derivatives of piperazine, methods of obtaining them and agents containing such derivatives
PL324436A1 (en) Novel derivatives of oxazolydinone, method of obtaining them and therapeutic agents containing such compounds
PL328776A1 (en) Pyrimido [5,4-d] pyrimidines, therapeutic agents containing such compounds, their application and method of obtaining such compounds
PL330062A1 (en) Derivatives of 1,3,8-triaza-spiro[4,5]decan-4-one, method of obtaining them and therapeutic agents containing such derivatives
PL338143A1 (en) Derivatives acylpiperazinylpyrimidines, method of obtaining and drugs containing them
PL299260A1 (en) Biphenyl derivatives, therapeutic agents containing them and method of obtaining the sames
PL324825A1 (en) Derivatives of hydroximic acids, method of obtaining them and agents containing such derivatives
PL322802A1 (en) Derivatives of 10,13,15-trioxatricyclo[9.2.1.1]-pentadecanone, method of obtaining them and therapeutic agents containing such compounds
PL332382A1 (en) Derivatives of 1,2,3,4-tetrahydro-benzofuro [3,2-c] pyridine
PL312692A1 (en) New derivatives of dialkoxy-pyridinol-benzimidazole
GB2267089B (en) Cycloheptimidazole derivatives,method of manufacturing the same and therapeutic agents containing these compounds