TJ244R3 - (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment - Google Patents

(-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Info

Publication number
TJ244R3
TJ244R3 TJ94000128A TJ94000128A TJ244R3 TJ 244 R3 TJ244 R3 TJ 244R3 TJ 94000128 A TJ94000128 A TJ 94000128A TJ 94000128 A TJ94000128 A TJ 94000128A TJ 244 R3 TJ244 R3 TJ 244R3
Authority
TJ
Tajikistan
Prior art keywords
oxathiolan
pyrimidin
hydroxymethyl
fluoro
amino
Prior art date
Application number
TJ94000128A
Other languages
English (en)
Inventor
Gervais Dionne
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10699340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TJ244(R3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Priority to TJ94000128A priority Critical patent/TJ244R3/xx
Publication of TJ244R3 publication Critical patent/TJ244R3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167—Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
TJ94000128A 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment TJ244R3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TJ94000128A TJ244R3 (en) 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919116601A GB9116601D0 (en) 1991-08-01 1991-08-01 1,3-oxathiolane nucleoside analogues
PCT/CA1992/000321 WO1993003027A1 (en) 1991-08-01 1992-07-24 1,3-oxathiolane nucleoside analogues
TJ94000128A TJ244R3 (en) 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Publications (1)

Publication Number Publication Date
TJ244R3 true TJ244R3 (en) 1999-11-24

Family

ID=10699340

Family Applications (1)

Application Number Title Priority Date Filing Date
TJ94000128A TJ244R3 (en) 1991-08-01 1994-12-15 (-)-4-Amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(111)-pyrimidin-2-one mixture of its enantiomers method of its preparation method of treatment

Country Status (41)

Country Link
US (2) US5538975A (ko)
EP (2) EP1155695B1 (ko)
JP (1) JP2960778B2 (ko)
KR (1) KR100242454B1 (ko)
CN (5) CN1034810C (ko)
AP (1) AP321A (ko)
AT (2) ATE227720T1 (ko)
AU (1) AU659668B2 (ko)
BG (1) BG61693B1 (ko)
CA (2) CA2114221C (ko)
CZ (1) CZ283765B6 (ko)
DE (2) DE69232845T2 (ko)
DK (2) DK1155695T3 (ko)
EE (1) EE03002B1 (ko)
EG (1) EG20193A (ko)
ES (2) ES2335968T3 (ko)
FI (1) FI940435A (ko)
GB (1) GB9116601D0 (ko)
GE (1) GEP20002094B (ko)
HK (2) HK1008672A1 (ko)
HN (1) HN1997000118A (ko)
HU (2) HUT70030A (ko)
IL (1) IL102616A (ko)
MA (1) MA22919A1 (ko)
MD (1) MD1434C2 (ko)
MX (1) MX9204474A (ko)
NO (3) NO300842B1 (ko)
NZ (1) NZ243637A (ko)
OA (1) OA09883A (ko)
PH (1) PH30983A (ko)
PT (2) PT526253E (ko)
RS (1) RS49993B (ko)
RU (1) RU2126405C1 (ko)
SG (1) SG68541A1 (ko)
SK (1) SK280131B6 (ko)
TJ (1) TJ244R3 (ko)
TN (1) TNSN92070A1 (ko)
TW (2) TW366347B (ko)
WO (1) WO1993003027A1 (ko)
YU (1) YU49259B (ko)
ZA (1) ZA925668B (ko)

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Also Published As

Publication number Publication date
CA2682254C (en) 2012-02-21
BG61693B1 (bg) 1998-03-31
GB9116601D0 (en) 1991-09-18
CN101074228A (zh) 2007-11-21
NO2005017I1 (no) 2005-09-05
NO940322L (no) 1994-03-21
OA09883A (en) 1994-09-15
RS49993B (sr) 2008-09-29
BG98616A (bg) 1995-03-31
RU2126405C1 (ru) 1999-02-20
HU9400285D0 (en) 1994-05-30
SK10494A3 (en) 1994-12-07
AP9200414A0 (en) 1992-07-31
DE69232845D1 (de) 2002-12-19
US5538975A (en) 1996-07-23
GEP20002094B (en) 2000-05-10
FI940435A0 (fi) 1994-01-28
HU211333A9 (en) 1995-11-28
PT1155695E (pt) 2010-02-02
CZ283765B6 (cs) 1998-06-17
ZA925668B (en) 1993-04-28
TW366347B (en) 1999-08-11
JPH07500317A (ja) 1995-01-12
ATE227720T1 (de) 2002-11-15
MA22919A1 (fr) 1993-04-01
EE03002B1 (et) 1997-06-16
CN100542535C (zh) 2009-09-23
SK280131B6 (sk) 1999-08-06
CZ20394A3 (en) 1994-07-13
MD950114A (en) 1996-06-28
CA2114221A1 (en) 1993-02-18
NZ243637A (en) 1995-03-28
EP0526253A1 (en) 1993-02-03
YU72303A (sh) 2006-05-25
YU49259B (sh) 2004-12-31
NO300842B1 (no) 1997-08-04
WO1993003027A1 (en) 1993-02-18
FI940435A (fi) 1994-01-28
US5618820A (en) 1997-04-08
NO2008009I1 (no) 2008-06-30
SG68541A1 (en) 1999-11-16
KR100242454B1 (ko) 2000-03-02
CN1302612A (zh) 2001-07-11
DK0526253T3 (da) 2003-03-17
EP0526253B1 (en) 2002-11-13
CN101066970A (zh) 2007-11-07
TNSN92070A1 (fr) 1993-06-08
DE69233776D1 (de) 2009-12-31
CN1070191A (zh) 1993-03-24
PH30983A (en) 1997-12-23
EP1155695A1 (en) 2001-11-21
EG20193A (en) 1997-10-30
MX9204474A (es) 1993-12-01
NO940322D0 (no) 1994-01-31
DE69232845T2 (de) 2003-04-24
AU2340892A (en) 1993-03-02
ATE448787T1 (de) 2009-12-15
HK1008672A1 (en) 1999-05-14
AP321A (en) 1994-02-28
CA2682254A1 (en) 1993-02-18
CN1074924C (zh) 2001-11-21
HN1997000118A (es) 1999-11-12
CA2114221C (en) 2009-12-22
DK1155695T3 (da) 2010-04-06
EP1155695B1 (en) 2009-11-18
PT526253E (pt) 2003-03-31
CN1034810C (zh) 1997-05-07
HK1038189A1 (en) 2002-03-08
MD1434B2 (en) 2000-03-31
YU74992A (sh) 1995-12-04
TWI232217B (en) 2005-05-11
HUT70030A (en) 1995-09-28
AU659668B2 (en) 1995-05-25
IL102616A0 (en) 1993-01-14
ES2186667T3 (es) 2003-05-16
JP2960778B2 (ja) 1999-10-12
NO2005017I2 (no) 2007-10-01
MD1434C2 (ro) 2000-12-31
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