SV2018005787A - 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas - Google Patents

3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas

Info

Publication number
SV2018005787A
SV2018005787A SV2018005787A SV2018005787A SV2018005787A SV 2018005787 A SV2018005787 A SV 2018005787A SV 2018005787 A SV2018005787 A SV 2018005787A SV 2018005787 A SV2018005787 A SV 2018005787A SV 2018005787 A SV2018005787 A SV 2018005787A
Authority
SV
El Salvador
Prior art keywords
compounds
oxo
prepare
dihidropiridazin
difenil
Prior art date
Application number
SV2018005787A
Other languages
English (en)
Inventor
Norbert Schmees
Ilona Gutcher
Horst Irlbacher
Benjamin Bader
Ulrike Röhn
Ludwig Zorn
Lars Röse
Detlef Stöckigt
Na Zhao
Michael Platten
Original Assignee
Bayer Pharma AG
Deutsches Krebsforschungszentrum Dkfz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Deutsches Krebsforschungszentrum Dkfz filed Critical Bayer Pharma AG
Publication of SV2018005787A publication Critical patent/SV2018005787A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCIÓN CUBRE COMPUESTOS DE 3-OXO-2,6-DIFENIL-2,3-DIHIDROPIRIDAZIN-4-CARBOXAMIDA DE FÓRMULA GENERAL (I): VER FÓRMULA, EN LA CUAL R1,R2,R3,R4,R5 Y R6 SON SEGÚN LO DEFINIDO EN LA PRESENTE INVENCIÓN, MÉTODOS PARA PREPARAR DICHOS COMPUESTOS, COMPUESTOS INTERMEDIOS ÚTILES PARA PREPARAR DICHOS COMPUESTOS, COMPOSICIONES Y COMBINACIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS Y LA UTILIZACIÓN DE DICHOS COMPUESTOS PARA MANUFACTURAR COMPOSICIONES FARMACÉUTICAS PARA EL TRATAMIENTO O PROFILAXIS DE EMFERMEDADES, EN PARTICULAR DEL CÁNCER O AFECCIONES CON RESPUESTAS INMUNES DESREGULADAS U OTROS TRANSTORNOS ASOCIADOS CON LA SEÑALIZACIÓN ABERRANTE DEL AHR COMO UN AGENTE ÚNICO O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS.
SV2018005787A 2016-05-25 2018-11-23 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas SV2018005787A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2016083308 2016-05-25
CN2017074408 2017-02-22

Publications (1)

Publication Number Publication Date
SV2018005787A true SV2018005787A (es) 2019-02-07

Family

ID=58745251

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2018005787A SV2018005787A (es) 2016-05-25 2018-11-23 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas

Country Status (27)

Country Link
US (1) US11040035B2 (es)
EP (1) EP3464248B1 (es)
JP (1) JP6964096B2 (es)
KR (1) KR20190009369A (es)
CN (1) CN109863140B (es)
AU (1) AU2017269870A1 (es)
BR (1) BR112018074185A2 (es)
CA (1) CA3025227A1 (es)
CL (1) CL2018003345A1 (es)
CO (1) CO2018012654A2 (es)
CR (1) CR20180556A (es)
CU (1) CU20180143A7 (es)
DO (1) DOP2018000256A (es)
EA (1) EA201892666A1 (es)
EC (1) ECSP18087725A (es)
IL (1) IL263046A (es)
MA (1) MA45087A (es)
MX (1) MX2018014443A (es)
NI (1) NI201800124A (es)
PE (1) PE20190509A1 (es)
PH (1) PH12018502472A1 (es)
SG (1) SG11201810366WA (es)
SV (1) SV2018005787A (es)
TN (1) TN2018000392A1 (es)
TW (1) TW201742859A (es)
UY (1) UY37256A (es)
WO (1) WO2017202816A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI759301B (zh) 2016-05-24 2022-04-01 美商安美基公司 聚乙二醇化卡非佐米化合物
JOP20190193A1 (ar) * 2017-02-09 2019-08-08 Bayer Pharma AG ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان
US11459312B2 (en) 2017-11-21 2022-10-04 Bayer Aktiengesellschaft Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides
EP3713931A1 (en) * 2017-11-21 2020-09-30 Bayer Aktiengesellschaft 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides
EA037978B1 (ru) * 2017-11-21 2021-06-18 Байер Акциенгезельшафт 2-гетероарил-3-оксо-2,3-дигидропиридазин-4-карбоксамиды для лечения злокачественного новообразования
WO2019101647A1 (en) * 2017-11-21 2019-05-31 Bayer Aktiengesellschaft 2-phenylpyrimidine-4-carboxamides as ahr inhibitors
BR112021003529A2 (pt) 2018-08-24 2021-05-18 Jaguahr Therapeutics Pte Ltd derivados de tetra-hidropiridopirimidina como moduladores de ahr
EP3843853A1 (en) 2018-08-31 2021-07-07 Jaguahr Therapeutics Pte Ltd Heterocyclic compounds as ahr modulators
CN109771437B (zh) * 2019-03-28 2023-03-17 西安交通大学医学院第一附属医院 三氟胸苷在制备治疗三阴性乳腺癌药物中的应用
EP3715471A1 (en) 2019-03-29 2020-09-30 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Ahr signature marker set
EP3721894A1 (en) 2019-04-10 2020-10-14 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof
EP4005637A4 (en) * 2019-07-29 2023-07-19 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
EP3835432A1 (en) 2019-12-10 2021-06-16 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer
CN114786674A (zh) * 2019-12-16 2022-07-22 拜耳公司 Ahr抑制剂和pd1抑制剂抗体的组合及其在癌症治疗中的用途
MX2022008532A (es) 2020-01-10 2022-09-09 Ikena Oncology Inc Inhibidores de hidrocarburo de arilo (ahr) y usos de estos.
WO2021173082A1 (en) 2020-02-26 2021-09-02 Jaguahr Therapeutics Pte Ltd Pyridopyrimidine derivatives useful in modulation of ahr signalling
MX2022011826A (es) * 2020-03-27 2022-10-18 Dong A St Co Ltd Derivados de aminopirimidina y su uso como moduladores del receptor de hidrocarburos de arilo.
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage
CN114181212B (zh) * 2020-09-15 2023-06-06 山东轩竹医药科技有限公司 哒嗪酮类AhR抑制剂
WO2022078356A1 (zh) * 2020-10-15 2022-04-21 山东轩竹医药科技有限公司 杂芳环类AhR抑制剂
CN114685426A (zh) * 2020-12-28 2022-07-01 苏州泽璟生物制药股份有限公司 磺酰胺类抑制剂及其制备方法和应用
CN118234710A (zh) * 2021-09-14 2024-06-21 元启(苏州)生物制药有限公司 2-芳基或杂芳基-3-氧代-4-甲酰胺-6-环-二氢吡嗪芳基烃受体调节剂和其在治疗疾病和病症中的用途
WO2024076300A1 (en) 2022-10-03 2024-04-11 Jaguahr Therapeutics Pte Ltd Compounds useful in modulation of ahr signalling

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4134467A1 (de) 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6469003B1 (en) * 1998-08-14 2002-10-22 Nihon Nohyaku Co., Ltd. Pyridazinone derivatives
US20030225081A1 (en) * 2000-09-18 2003-12-04 Satoshi Nagato Pyridazinones and triazinones and medicinal use thereof
FR2847253B1 (fr) 2002-11-19 2007-05-18 Aventis Pharma Sa Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
FR2847235B1 (fr) 2002-11-20 2005-07-08 Essilor Int Emballage de protection et de calage pour objets a contour circulaire
AR057986A1 (es) * 2005-11-21 2008-01-09 Japan Tobacco Inc Compuesto heterociclico y su uso farmaceutico
EP2328586A2 (en) 2008-05-20 2011-06-08 Cephalon, Inc. Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands
PE20100362A1 (es) 2008-10-30 2010-05-27 Irm Llc Derivados de purina que expanden las celulas madre hematopoyeticas
CN103179968B (zh) 2010-07-27 2017-10-03 波士顿大学管理委员会 作为癌症疗法的芳烃受体(AhR)调节剂
US20170173008A1 (en) 2014-03-19 2017-06-22 President And Fellows Of Harvard College Antimicrobial agents and screening methods

Also Published As

Publication number Publication date
US11040035B2 (en) 2021-06-22
TN2018000392A1 (en) 2020-06-15
TW201742859A (zh) 2017-12-16
CO2018012654A2 (es) 2018-12-14
SG11201810366WA (en) 2018-12-28
IL263046A (en) 2018-12-31
EA201892666A1 (ru) 2019-08-30
UY37256A (es) 2018-01-02
ECSP18087725A (es) 2018-11-30
NI201800124A (es) 2019-04-29
DOP2018000256A (es) 2019-02-15
CU20180143A7 (es) 2019-07-04
MA45087A (fr) 2021-05-26
BR112018074185A2 (pt) 2019-03-06
CA3025227A1 (en) 2017-11-30
US20200237757A1 (en) 2020-07-30
CN109863140A (zh) 2019-06-07
CN109863140B (zh) 2023-02-21
MX2018014443A (es) 2019-04-15
PH12018502472A1 (en) 2019-09-23
PE20190509A1 (es) 2019-04-10
AU2017269870A1 (en) 2018-12-06
JP6964096B2 (ja) 2021-11-10
JP2019516744A (ja) 2019-06-20
EP3464248B1 (en) 2021-09-08
CR20180556A (es) 2019-04-23
WO2017202816A1 (en) 2017-11-30
EP3464248A1 (en) 2019-04-10
CL2018003345A1 (es) 2019-03-15
KR20190009369A (ko) 2019-01-28

Similar Documents

Publication Publication Date Title
SV2018005787A (es) 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas
CL2019002255A1 (es) 2-heteroaril-3-oxo-2,3-dihidropiridazin-4-carboxamidas.
DOP2019000110A (es) 1,2,4–triazolonas 2,4,5–trisustituidas
CO2019000386A2 (es) Compuestos heterocíclicos como inmunomoduladores
UY37460A (es) 1,2,4-triazolonas con anelación en 4 y 5
PH12020500500A1 (en) Pyrazolopyrimidinone compounds and uses thereof
CL2019001292A1 (es) Nuevos derivados de quinolina.
SV2017005461A (es) Benzamidas sustituidas con 1,3-tiazol-2-ilo
CL2018001685A1 (es) Compuestos heterociclicos como inmuno moduladores.
CL2018000150A1 (es) Compuestos útiles como inmunomoduladores (divisional de solicitud 201600508)
CL2020000301A1 (es) Nuevos derivados de quinolina.
CO2018004968A2 (es) 2,4-dihidroxi-nicotinamidas como agonistas del receptor de apelina (apj)
UY37789A (es) Nuevos derivados de azaquinolina
UY37971A (es) Derivados de indol macrocíclicos sustituidos
CL2019001092A1 (es) Tratamientos de combinación que comprenden la administración de imidazopirazinonas.
UY37832A (es) Dihidrooxadiazinonas
EA201892822A1 (ru) Новые антибактериальные соединения
UY37250A (es) Derivados macrocíclicos de indol
NO20180002A1 (en) Aminobenzisoxazole compounds as agonists of A7-nicotinic acetylcholine receptors
UY37973A (es) Derivados de indol macrocíclicos
DOP2020000100A (es) Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3
UY35600A (es) "composiciones farmacéuticas que comprenden compuestos derivados de triazolopiridina y métodos para prepararlas"
CR20190028A (es) Compuestos heterocíclicos como inmunomoduladores
UY37032A (es) Compuestos de heteroarilbenzimidazol