ECSP18087725A - 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas - Google Patents
3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidasInfo
- Publication number
- ECSP18087725A ECSP18087725A ECSENADI201887725A ECDI201887725A ECSP18087725A EC SP18087725 A ECSP18087725 A EC SP18087725A EC SENADI201887725 A ECSENADI201887725 A EC SENADI201887725A EC DI201887725 A ECDI201887725 A EC DI201887725A EC SP18087725 A ECSP18087725 A EC SP18087725A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- diphenyl
- oxo
- preparing
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
- C07D237/16—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención cubre compuestos de 3oxo2,6difenil2,3dihidropiridazin4carboxamida de fórmula general (I): en la cual R1, R2, R3, R4, R5 y R6 son según lo definido en la presente invención, métodos para preparar dichos compuestos, compuestos intermedios útiles para preparar dichos compuestos, composiciones y combinaciones farmacéuticas que comprenden dichos compuestos y la utilización de dichos compuestos para manufacturar composiciones farmacéuticas para el tratamiento o profilaxis de enfermedades, en particular del cáncer o afecciones con respuestas inmunes desreguladas u otros trastornos asociados con la señalización aberrante del AHR, como un agente único o en combinación con otros ingredientes activos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016083308 | 2016-05-25 | ||
CN2017074408 | 2017-02-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP18087725A true ECSP18087725A (es) | 2018-11-30 |
Family
ID=58745251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI201887725A ECSP18087725A (es) | 2016-05-25 | 2018-11-23 | 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas |
Country Status (27)
Country | Link |
---|---|
US (1) | US11040035B2 (es) |
EP (1) | EP3464248B1 (es) |
JP (1) | JP6964096B2 (es) |
KR (1) | KR20190009369A (es) |
CN (1) | CN109863140B (es) |
AU (1) | AU2017269870A1 (es) |
BR (1) | BR112018074185A2 (es) |
CA (1) | CA3025227A1 (es) |
CL (1) | CL2018003345A1 (es) |
CO (1) | CO2018012654A2 (es) |
CR (1) | CR20180556A (es) |
CU (1) | CU20180143A7 (es) |
DO (1) | DOP2018000256A (es) |
EA (1) | EA201892666A1 (es) |
EC (1) | ECSP18087725A (es) |
IL (1) | IL263046A (es) |
MA (1) | MA45087A (es) |
MX (1) | MX2018014443A (es) |
NI (1) | NI201800124A (es) |
PE (1) | PE20190509A1 (es) |
PH (1) | PH12018502472A1 (es) |
SG (1) | SG11201810366WA (es) |
SV (1) | SV2018005787A (es) |
TN (1) | TN2018000392A1 (es) |
TW (1) | TW201742859A (es) |
UY (1) | UY37256A (es) |
WO (1) | WO2017202816A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI759301B (zh) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
JOP20190193A1 (ar) | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان |
PT3580211T (pt) * | 2017-11-21 | 2021-02-01 | Deutsches Krebsforsch | 2-heteroaril-3-oxo-2,3-di-hidropiridazina-4-carboxamidas para o tratamento de cancro |
CA3082856A1 (en) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides |
WO2019101643A1 (en) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides |
WO2019101647A1 (en) * | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-phenylpyrimidine-4-carboxamides as ahr inhibitors |
CN112739698A (zh) | 2018-08-24 | 2021-04-30 | 捷豹治疗有限公司 | 作为ahr调节剂的四氢嘧啶衍生物 |
US20210395242A1 (en) | 2018-08-31 | 2021-12-23 | Jaguahr Therapeutics Pte Ltd | Heterocyclic compounds as ahr modulators |
CN109771437B (zh) * | 2019-03-28 | 2023-03-17 | 西安交通大学医学院第一附属医院 | 三氟胸苷在制备治疗三阴性乳腺癌药物中的应用 |
EP3715471A1 (en) * | 2019-03-29 | 2020-09-30 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Ahr signature marker set |
EP3721894A1 (en) | 2019-04-10 | 2020-10-14 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof |
JPWO2021020362A1 (es) * | 2019-07-29 | 2021-02-04 | ||
EP3835432A1 (en) | 2019-12-10 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer |
AU2020403801A1 (en) * | 2019-12-16 | 2022-06-02 | Bayer Aktiengesellschaft | Combination of an AhR-inhibitor and an PD1-inhibitor antibody and its use in the treatment of cancer |
MX2022008532A (es) | 2020-01-10 | 2022-09-09 | Ikena Oncology Inc | Inhibidores de hidrocarburo de arilo (ahr) y usos de estos. |
CN115244048A (zh) | 2020-02-26 | 2022-10-25 | 捷豹治疗有限公司 | 可用于调节AhR信号传导的吡啶并嘧啶衍生物 |
MX2022011826A (es) * | 2020-03-27 | 2022-10-18 | Dong A St Co Ltd | Derivados de aminopirimidina y su uso como moduladores del receptor de hidrocarburos de arilo. |
US11911376B2 (en) | 2020-03-30 | 2024-02-27 | The Regents Of The University Of Colorado | Methods for preventing and treating retinal damage |
CN114181212B (zh) * | 2020-09-15 | 2023-06-06 | 山东轩竹医药科技有限公司 | 哒嗪酮类AhR抑制剂 |
WO2022078356A1 (zh) * | 2020-10-15 | 2022-04-21 | 山东轩竹医药科技有限公司 | 杂芳环类AhR抑制剂 |
CN114685426A (zh) * | 2020-12-28 | 2022-07-01 | 苏州泽璟生物制药股份有限公司 | 磺酰胺类抑制剂及其制备方法和应用 |
WO2023043753A1 (en) * | 2021-09-14 | 2023-03-23 | Allianthera (Suzhou) Biopharmaceutical Co., Ltd. | 2-aryl or heteroaryl-3-oxo-4-carbamide-6-cyclic-dihydropyrazine aryl hydrocarbon receptor modulators and their use in the treatment of diseases and disorders |
WO2024076300A1 (en) | 2022-10-03 | 2024-04-11 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO2000009488A1 (fr) | 1998-08-14 | 2000-02-24 | Nihon Nohyaku Co., Ltd. | Derives de pyridazinone |
KR100770327B1 (ko) | 2000-09-18 | 2007-10-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피리다지논 및 트리아지논 화합물류 및 그들의 의약 용도 |
FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
FR2847235B1 (fr) | 2002-11-20 | 2005-07-08 | Essilor Int | Emballage de protection et de calage pour objets a contour circulaire |
AR057986A1 (es) * | 2005-11-21 | 2008-01-09 | Japan Tobacco Inc | Compuesto heterociclico y su uso farmaceutico |
EP2328586A2 (en) | 2008-05-20 | 2011-06-08 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
CN107648216B (zh) | 2010-07-27 | 2021-03-30 | 波士顿大学管理委员会 | 作为新型癌症疗法的芳烃受体(AhR)调节剂 |
WO2015143164A1 (en) | 2014-03-19 | 2015-09-24 | President And Fellows Of Harvard College | Antimicrobial agents and screening methods |
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2017
- 2017-05-23 CA CA3025227A patent/CA3025227A1/en active Pending
- 2017-05-23 AU AU2017269870A patent/AU2017269870A1/en not_active Abandoned
- 2017-05-23 TN TNP/2018/000392A patent/TN2018000392A1/en unknown
- 2017-05-23 US US16/303,539 patent/US11040035B2/en active Active
- 2017-05-23 CR CR20180556A patent/CR20180556A/es unknown
- 2017-05-23 CN CN201780046149.5A patent/CN109863140B/zh active Active
- 2017-05-23 PE PE2018003109A patent/PE20190509A1/es unknown
- 2017-05-23 MA MA045087A patent/MA45087A/fr unknown
- 2017-05-23 EP EP17724833.3A patent/EP3464248B1/en active Active
- 2017-05-23 JP JP2018561224A patent/JP6964096B2/ja active Active
- 2017-05-23 MX MX2018014443A patent/MX2018014443A/es unknown
- 2017-05-23 WO PCT/EP2017/062355 patent/WO2017202816A1/en unknown
- 2017-05-23 SG SG11201810366WA patent/SG11201810366WA/en unknown
- 2017-05-23 KR KR1020187037050A patent/KR20190009369A/ko not_active Application Discontinuation
- 2017-05-23 CU CU2018000143A patent/CU20180143A7/es unknown
- 2017-05-23 BR BR112018074185-0A patent/BR112018074185A2/pt not_active IP Right Cessation
- 2017-05-23 EA EA201892666A patent/EA201892666A1/ru unknown
- 2017-05-24 UY UY0001037256A patent/UY37256A/es not_active Application Discontinuation
- 2017-05-25 TW TW106117299A patent/TW201742859A/zh unknown
-
2018
- 2018-11-15 IL IL263046A patent/IL263046A/en unknown
- 2018-11-23 DO DO2018000256A patent/DOP2018000256A/es unknown
- 2018-11-23 CL CL2018003345A patent/CL2018003345A1/es unknown
- 2018-11-23 NI NI201800124A patent/NI201800124A/es unknown
- 2018-11-23 PH PH12018502472A patent/PH12018502472A1/en unknown
- 2018-11-23 EC ECSENADI201887725A patent/ECSP18087725A/es unknown
- 2018-11-23 CO CONC2018/0012654A patent/CO2018012654A2/es unknown
- 2018-11-23 SV SV2018005787A patent/SV2018005787A/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20190009369A (ko) | 2019-01-28 |
EP3464248B1 (en) | 2021-09-08 |
CR20180556A (es) | 2019-04-23 |
CA3025227A1 (en) | 2017-11-30 |
PE20190509A1 (es) | 2019-04-10 |
CN109863140B (zh) | 2023-02-21 |
EP3464248A1 (en) | 2019-04-10 |
US11040035B2 (en) | 2021-06-22 |
TW201742859A (zh) | 2017-12-16 |
JP2019516744A (ja) | 2019-06-20 |
WO2017202816A1 (en) | 2017-11-30 |
EA201892666A1 (ru) | 2019-08-30 |
SG11201810366WA (en) | 2018-12-28 |
CN109863140A (zh) | 2019-06-07 |
CO2018012654A2 (es) | 2018-12-14 |
CU20180143A7 (es) | 2019-07-04 |
SV2018005787A (es) | 2019-02-07 |
BR112018074185A2 (pt) | 2019-03-06 |
MA45087A (fr) | 2021-05-26 |
UY37256A (es) | 2018-01-02 |
TN2018000392A1 (en) | 2020-06-15 |
NI201800124A (es) | 2019-04-29 |
MX2018014443A (es) | 2019-04-15 |
PH12018502472A1 (en) | 2019-09-23 |
DOP2018000256A (es) | 2019-02-15 |
US20200237757A1 (en) | 2020-07-30 |
IL263046A (en) | 2018-12-31 |
AU2017269870A1 (en) | 2018-12-06 |
JP6964096B2 (ja) | 2021-11-10 |
CL2018003345A1 (es) | 2019-03-15 |
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