MX2018014443A - 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas. - Google Patents

3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas.

Info

Publication number
MX2018014443A
MX2018014443A MX2018014443A MX2018014443A MX2018014443A MX 2018014443 A MX2018014443 A MX 2018014443A MX 2018014443 A MX2018014443 A MX 2018014443A MX 2018014443 A MX2018014443 A MX 2018014443A MX 2018014443 A MX2018014443 A MX 2018014443A
Authority
MX
Mexico
Prior art keywords
compounds
dihydropyridazine
diphenyl
oxo
preparing
Prior art date
Application number
MX2018014443A
Other languages
English (en)
Inventor
Schmees Norbert
Zorn Ludwig
Platten Michael
Bader Benjamin
Irlbacher Horst
GUTCHER Ilona
Roehn Ulrike
Roese Lars
Stoeckigt Detlef
Zhao Na
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MX2018014443A publication Critical patent/MX2018014443A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente invención cubre compuestos de 3-oxo-2,6-difenil-2,3-di hidropiridazin-4-carboxamida de fórmula general (I): (ver Fórmula) en la cual R1, R2, R3, R4, R5 y R6 son según lo definido en la presente invención, métodos para preparar dichos compuestos, compuestos intermedios útiles para preparar dichos compuestos, composiciones y combinaciones farmacéuticas que comprenden dichos compuestos y la utilización de dichos compuestos para manufacturar composiciones farmacéuticas para el tratamiento o profilaxis de enfermedades, en particular del cáncer o afecciones con respuestas inmunes desreguladas u otros trastornos asociados con la señalización aberrante del AHR, como un agente único o en combinación con otros ingredientes activos.
MX2018014443A 2016-05-25 2017-05-23 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas. MX2018014443A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016083308 2016-05-25
CN2017074408 2017-02-22
PCT/EP2017/062355 WO2017202816A1 (en) 2016-05-25 2017-05-23 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides

Publications (1)

Publication Number Publication Date
MX2018014443A true MX2018014443A (es) 2019-04-15

Family

ID=58745251

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014443A MX2018014443A (es) 2016-05-25 2017-05-23 3-oxo-2,6-difenil-2,3-dihidropiridazin-4-carboxamidas.

Country Status (27)

Country Link
US (1) US11040035B2 (es)
EP (1) EP3464248B1 (es)
JP (1) JP6964096B2 (es)
KR (1) KR20190009369A (es)
CN (1) CN109863140B (es)
AU (1) AU2017269870A1 (es)
BR (1) BR112018074185A2 (es)
CA (1) CA3025227A1 (es)
CL (1) CL2018003345A1 (es)
CO (1) CO2018012654A2 (es)
CR (1) CR20180556A (es)
CU (1) CU20180143A7 (es)
DO (1) DOP2018000256A (es)
EA (1) EA201892666A1 (es)
EC (1) ECSP18087725A (es)
IL (1) IL263046A (es)
MA (1) MA45087A (es)
MX (1) MX2018014443A (es)
NI (1) NI201800124A (es)
PE (1) PE20190509A1 (es)
PH (1) PH12018502472A1 (es)
SG (1) SG11201810366WA (es)
SV (1) SV2018005787A (es)
TN (1) TN2018000392A1 (es)
TW (1) TW201742859A (es)
UY (1) UY37256A (es)
WO (1) WO2017202816A1 (es)

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TWI759301B (zh) 2016-05-24 2022-04-01 美商安美基公司 聚乙二醇化卡非佐米化合物
JOP20190193A1 (ar) * 2017-02-09 2019-08-08 Bayer Pharma AG ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان
EP3713931A1 (en) * 2017-11-21 2020-09-30 Bayer Aktiengesellschaft 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides
WO2019101647A1 (en) * 2017-11-21 2019-05-31 Bayer Aktiengesellschaft 2-phenylpyrimidine-4-carboxamides as ahr inhibitors
PT3580211T (pt) * 2017-11-21 2021-02-01 Deutsches Krebsforsch 2-heteroaril-3-oxo-2,3-di-hidropiridazina-4-carboxamidas para o tratamento de cancro
EP3713922A1 (en) * 2017-11-21 2020-09-30 Bayer Aktiengesellschaft Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides
CA3110402A1 (en) 2018-08-24 2020-02-27 Jaguahr Therapeutics Pte Ltd Tetrahydropyridopyrimidine derivatives as ahr modulators
KR20210053911A (ko) 2018-08-31 2021-05-12 재규어 테라퓨틱스 피티이 리미티드 Ahr 조절제로서의 헤테로사이클릭 화합물
CN109771437B (zh) * 2019-03-28 2023-03-17 西安交通大学医学院第一附属医院 三氟胸苷在制备治疗三阴性乳腺癌药物中的应用
EP3715471A1 (en) * 2019-03-29 2020-09-30 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Ahr signature marker set
EP3721894A1 (en) 2019-04-10 2020-10-14 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof
WO2021020362A1 (ja) * 2019-07-29 2021-02-04 武田薬品工業株式会社 複素環化合物
EP3835432A1 (en) 2019-12-10 2021-06-16 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer
KR20220128622A (ko) * 2019-12-16 2022-09-21 바이엘 악티엔게젤샤프트 Ahr-억제제 및 pd1-억제제 항체의 조합물 및 암 치료에서의 그의 용도
CN115190799A (zh) 2020-01-10 2022-10-14 医肯纳肿瘤学公司 Ahr抑制剂及其用途
CN115244048A (zh) 2020-02-26 2022-10-25 捷豹治疗有限公司 可用于调节AhR信号传导的吡啶并嘧啶衍生物
MX2022011826A (es) * 2020-03-27 2022-10-18 Dong A St Co Ltd Derivados de aminopirimidina y su uso como moduladores del receptor de hidrocarburos de arilo.
US11911376B2 (en) 2020-03-30 2024-02-27 The Regents Of The University Of Colorado Methods for preventing and treating retinal damage
CN114181212B (zh) * 2020-09-15 2023-06-06 山东轩竹医药科技有限公司 哒嗪酮类AhR抑制剂
WO2022078356A1 (zh) * 2020-10-15 2022-04-21 山东轩竹医药科技有限公司 杂芳环类AhR抑制剂
CN114685426A (zh) * 2020-12-28 2022-07-01 苏州泽璟生物制药股份有限公司 磺酰胺类抑制剂及其制备方法和应用
TW202320777A (zh) * 2021-09-14 2023-06-01 中國大陸商元啟（蘇州）生物製藥股份有限公司 芳基烴受體調節劑及其用於治療疾病及病症之用途
WO2024076300A1 (en) 2022-10-03 2024-04-11 Jaguahr Therapeutics Pte Ltd Compounds useful in modulation of ahr signalling

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Also Published As

Publication number Publication date
BR112018074185A2 (pt) 2019-03-06
CL2018003345A1 (es) 2019-03-15
DOP2018000256A (es) 2019-02-15
CN109863140B (zh) 2023-02-21
SV2018005787A (es) 2019-02-07
TW201742859A (zh) 2017-12-16
TN2018000392A1 (en) 2020-06-15
KR20190009369A (ko) 2019-01-28
IL263046A (en) 2018-12-31
EP3464248A1 (en) 2019-04-10
SG11201810366WA (en) 2018-12-28
AU2017269870A1 (en) 2018-12-06
ECSP18087725A (es) 2018-11-30
EA201892666A1 (ru) 2019-08-30
CR20180556A (es) 2019-04-23
PE20190509A1 (es) 2019-04-10
PH12018502472A1 (en) 2019-09-23
NI201800124A (es) 2019-04-29
US20200237757A1 (en) 2020-07-30
CA3025227A1 (en) 2017-11-30
CO2018012654A2 (es) 2018-12-14
UY37256A (es) 2018-01-02
CU20180143A7 (es) 2019-07-04
JP2019516744A (ja) 2019-06-20
MA45087A (fr) 2021-05-26
US11040035B2 (en) 2021-06-22
WO2017202816A1 (en) 2017-11-30
CN109863140A (zh) 2019-06-07
EP3464248B1 (en) 2021-09-08
JP6964096B2 (ja) 2021-11-10

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