SV2002000132A - Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-[2-(piperidin-1-il)etoxi]fenoxi) -2-(4-metoxifenil)benzo[b]tiofeno ref. x-11357. - Google Patents

Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-[2-(piperidin-1-il)etoxi]fenoxi) -2-(4-metoxifenil)benzo[b]tiofeno ref. x-11357.

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Publication number
SV2002000132A
SV2002000132A SV2000000132A SV2000000132A SV2002000132A SV 2002000132 A SV2002000132 A SV 2002000132A SV 2000000132 A SV2000000132 A SV 2000000132A SV 2000000132 A SV2000000132 A SV 2000000132A SV 2002000132 A SV2002000132 A SV 2002000132A
Authority
SV
El Salvador
Prior art keywords
phenoxi
etoxi
hydroxi
piperidin
thiophen
Prior art date
Application number
SV2000000132A
Other languages
English (en)
Inventor
Julie Kay Bush
Preston Charles Conrad
Merlyn Gerard Flom
Wayne Douglas Luke
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2002000132A publication Critical patent/SV2002000132A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P3/06—Antihyperlipidemics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

EL HIDRATO CRISTALINO DEL CLORHIDRATO DE 6-HIDROXI-3-(4-[2-(PIPERIDIN-1-IL)ETOXI]FENOXI)-2-(4-METOXIFENIL)BENZO[B] TIOFENO (F-I)QUE TIENE UN MODELO DE DIFRACCON DE RAYOS X QUE COMPRENDE LOS SIGUIENTES PICOS: 7,9± O,2,10,7± O,2, 14,9 ± 0,2 15,9 ± 0,2, 18,3 0,2, Y 20,6 ± 0,2º EN 20; CUANDO SE OBTIENE A PARTIR DE UNA FUENTE DE RADIACION DE COBRE
SV2000000132A 1999-07-29 2000-07-28 Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-[2-(piperidin-1-il)etoxi]fenoxi) -2-(4-metoxifenil)benzo[b]tiofeno ref. x-11357. SV2002000132A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14628699P 1999-07-29 1999-07-29
US14757099P 1999-08-06 1999-08-06
US14977399P 1999-08-19 1999-08-19

Publications (1)

Publication Number Publication Date
SV2002000132A true SV2002000132A (es) 2002-06-07

Family

ID=27386379

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2000000132A SV2002000132A (es) 1999-07-29 2000-07-28 Una nueva forma cristalina de clorhidrato de 6-hidroxi-3-(4-[2-(piperidin-1-il)etoxi]fenoxi) -2-(4-metoxifenil)benzo[b]tiofeno ref. x-11357.

Country Status (45)

Country Link
EP (1) EP1204656A2 (es)
JP (1) JP2001064277A (es)
KR (1) KR100697177B1 (es)
CN (1) CN1138770C (es)
AR (1) AR031073A1 (es)
AT (1) AT502318A1 (es)
AU (1) AU6335600A (es)
BE (1) BE1013411A3 (es)
BR (1) BR0003209A (es)
CA (1) CA2314682A1 (es)
CO (1) CO5180570A1 (es)
CZ (1) CZ299311B6 (es)
DE (1) DE10036854A1 (es)
DK (1) DK200001151A (es)
DZ (1) DZ3060A1 (es)
FI (1) FI20001722A (es)
FR (1) FR2796944B1 (es)
GB (1) GB2352717A (es)
GR (1) GR1004084B (es)
HK (1) HK1035370A1 (es)
HR (1) HRP20000503B1 (es)
HU (1) HUP0003001A2 (es)
ID (1) ID27078A (es)
IL (1) IL137553A (es)
IT (1) IT1318660B1 (es)
LT (1) LT4790B (es)
LU (1) LU90617B1 (es)
LV (1) LV12623B (es)
MD (1) MD2336G2 (es)
MX (1) MXPA00007461A (es)
MY (1) MY128764A (es)
NL (1) NL1015821C2 (es)
NO (1) NO20003879L (es)
PE (1) PE20010385A1 (es)
PL (1) PL341749A1 (es)
PT (1) PT102502A (es)
RO (1) RO121851B1 (es)
SE (1) SE0002792L (es)
SG (1) SG91296A1 (es)
SI (1) SI20426A (es)
SV (1) SV2002000132A (es)
TR (1) TR200002206A2 (es)
TW (1) TWI276437B (es)
UA (1) UA72885C2 (es)
WO (1) WO2001009116A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2208384T3 (es) * 1999-07-29 2004-06-16 Eli Lilly And Company Forma cristalina de clorhidrato de 6 hidroxi-3-(4-(2-(piperidin-1-il)-etoxi)-fenoxi)2--(4-metoxifenil)-benzo(b)tiofeno.
EP1757291A3 (en) * 2000-05-08 2009-07-15 Eli Lilly & Company Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
US7122203B2 (en) 2000-05-08 2006-10-17 Eli Lilly And Company Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
DZ3376A1 (fr) * 2000-05-08 2001-11-15 Lilly Co Eli Formulations stabilisees de 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene et sels de ces composes
EP1157996A1 (de) * 2000-05-23 2001-11-28 JENAPHARM GmbH Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on
BR0114792A (pt) * 2000-10-20 2003-08-12 Lilly Co Eli Composto cristalino, anidro, não solvatado, de cloridreto de 6-hidróxi-3-(-4-[2-piperidin-1-il)-etóxi]-fenóxi)-2-(4-metóx i-fenil)-benzol[b]tiofeno (f-v), formulação farmacêutica, processo para preparar um composto, e uso de um composto
US6921827B2 (en) 2000-11-27 2005-07-26 Eli Lilly And Company Process for preparing 3-aryl-benzo{b} thiophenes
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
ES2349798T3 (es) * 2004-07-22 2011-01-11 Eli Lilly And Company Hidrato variable cristalino de la sal hemisuccinato de (s)-6-(4-(2-((3-(9h-carbazol-4-iloxi)-2-hidroxipropil)amino)-2-metilpropil)fenoxi)-3-piridinocarboxamida.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE44597A1 (es) * 1995-02-28 1997-10-13 Lilly Co Eli Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos
US5510357A (en) 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
ZA9710262B (en) * 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.

Also Published As

Publication number Publication date
MD20000162A (en) 2001-04-30
SE0002792D0 (sv) 2000-07-28
GB0018641D0 (en) 2000-09-13
HK1035370A1 (en) 2001-11-23
FR2796944A1 (fr) 2001-02-02
CN1288007A (zh) 2001-03-21
MD2336F2 (en) 2003-12-31
CA2314682A1 (en) 2001-01-29
MXPA00007461A (es) 2004-07-16
HUP0003001A2 (hu) 2002-04-29
NL1015821C2 (nl) 2002-01-03
LV12623B (en) 2001-07-20
AR031073A1 (es) 2003-09-10
WO2001009116A2 (en) 2001-02-08
ITMI20001759A0 (it) 2000-07-28
BE1013411A3 (fr) 2001-12-04
AU6335600A (en) 2001-02-19
IL137553A0 (en) 2001-07-24
SI20426A (sl) 2001-06-30
BR0003209A (pt) 2001-03-20
TR200002206A2 (tr) 2001-03-21
CO5180570A1 (es) 2002-07-30
MD2336G2 (ro) 2004-06-30
IT1318660B1 (it) 2003-08-27
CN1138770C (zh) 2004-02-18
PT102502A (pt) 2001-01-31
DE10036854A1 (de) 2001-03-01
FI20001722A0 (fi) 2000-07-28
NO20003879L (no) 2001-01-30
HRP20000503A2 (en) 2001-06-30
ITMI20001759A1 (it) 2002-01-28
LV12623A (en) 2001-03-20
AT502318A1 (de) 2007-02-15
KR20010049916A (ko) 2001-06-15
FI20001722A (fi) 2001-01-30
JP2001064277A (ja) 2001-03-13
GB2352717A (en) 2001-02-07
IL137553A (en) 2005-09-25
SE0002792L (sv) 2001-01-30
KR100697177B1 (ko) 2007-03-21
LU90617B1 (fr) 2001-06-15
SG91296A1 (en) 2002-09-17
LT2000076A (lt) 2001-02-26
GR20000100265A (el) 2001-03-30
ID27078A (id) 2001-02-22
NL1015821A1 (nl) 2001-01-30
IE20000605A1 (en) 2001-04-04
LT4790B (lt) 2001-05-25
FR2796944B1 (fr) 2003-01-31
DK200001151A (da) 2001-01-30
HRP20000503B1 (en) 2008-04-30
UA72885C2 (uk) 2005-05-16
CZ20002716A3 (en) 2001-05-16
MY128764A (en) 2007-02-28
CZ299311B6 (cs) 2008-06-18
PE20010385A1 (es) 2001-04-06
PL341749A1 (en) 2001-02-12
NO20003879D0 (no) 2000-07-28
WO2001009116A3 (en) 2001-05-17
TWI276437B (en) 2007-03-21
HU0003001D0 (en) 2000-10-28
DZ3060A1 (fr) 2004-05-22
GR1004084B (el) 2002-12-11
EP1204656A2 (en) 2002-05-15
RO121851B1 (ro) 2008-06-30

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