SU508185A3 - Способ получени -замещенных лактамов - Google Patents

Способ получени -замещенных лактамов

Info

Publication number
SU508185A3
SU508185A3 SU1621307A SU1621307A SU508185A3 SU 508185 A3 SU508185 A3 SU 508185A3 SU 1621307 A SU1621307 A SU 1621307A SU 1621307 A SU1621307 A SU 1621307A SU 508185 A3 SU508185 A3 SU 508185A3
Authority
SU
USSR - Soviet Union
Prior art keywords
oxopyrrolidino
dimethyl
acetamide
methyl
ethanol
Prior art date
Application number
SU1621307A
Other languages
English (en)
Russian (ru)
Inventor
Оноре Люсьен Мишель Струббе Жозеф
Арман Ленц Раймон
Original Assignee
Юньон Шимик-Шемиш Бедрижвен (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юньон Шимик-Шемиш Бедрижвен (Фирма) filed Critical Юньон Шимик-Шемиш Бедрижвен (Фирма)
Application granted granted Critical
Publication of SU508185A3 publication Critical patent/SU508185A3/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2632-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/272-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SU1621307A 1970-02-13 1971-02-12 Способ получени -замещенных лактамов SU508185A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB697870A GB1309692A (en) 1970-02-13 1970-02-13 N-substituted lactams

Publications (1)

Publication Number Publication Date
SU508185A3 true SU508185A3 (ru) 1976-03-25

Family

ID=9824325

Family Applications (2)

Application Number Title Priority Date Filing Date
SU1621307A SU508185A3 (ru) 1970-02-13 1971-02-12 Способ получени -замещенных лактамов
SU1893858A SU508186A3 (ru) 1970-02-13 1971-02-12 Способ получени -замещенных лактамов

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU1893858A SU508186A3 (ru) 1970-02-13 1971-02-12 Способ получени -замещенных лактамов

Country Status (15)

Country Link
JP (2) JPS535301B1 (enrdf_load_stackoverflow)
BE (1) BE762728R (enrdf_load_stackoverflow)
CH (1) CH530395A (enrdf_load_stackoverflow)
CS (2) CS167911B2 (enrdf_load_stackoverflow)
DE (1) DE2106418C2 (enrdf_load_stackoverflow)
DK (1) DK137451B (enrdf_load_stackoverflow)
ES (1) ES388135A2 (enrdf_load_stackoverflow)
FI (1) FI54916C (enrdf_load_stackoverflow)
FR (1) FR2081508B2 (enrdf_load_stackoverflow)
GB (1) GB1309692A (enrdf_load_stackoverflow)
MY (1) MY7400072A (enrdf_load_stackoverflow)
NL (1) NL168830C (enrdf_load_stackoverflow)
SU (2) SU508185A3 (enrdf_load_stackoverflow)
YU (2) YU34876B (enrdf_load_stackoverflow)
ZA (1) ZA71877B (enrdf_load_stackoverflow)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2663899C1 (ru) * 2017-07-19 2018-08-13 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Способ получения 1-карбамоилметил-4-фенил-2-пирролидона

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1045043B (it) * 1975-08-13 1980-04-21 Isf Spa Derivati pirrolidinici
GB1583871A (en) 1976-10-19 1981-02-04 Ucb Sa Anti-aggregants
BE864269A (fr) * 1977-03-03 1978-06-16 Parke Davis & Co Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
ATE27T1 (de) * 1978-05-08 1981-04-15 Ucb Sa Lactam-n-essigsaeuren und ihre amide, verfahren zu ihrer herstellung und heilmittel, die sie enthalten
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
FR2515179A1 (fr) * 1981-07-24 1983-04-29 Hoffmann La Roche Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
EP0089900B1 (en) * 1982-03-24 1985-12-27 Prodes S.A. New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
DE3420193A1 (de) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
US4804400A (en) * 1986-09-12 1989-02-14 Ciba-Geigy Corporation N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof
GB8827389D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide
AR020115A1 (es) * 1998-08-06 2002-04-10 Daiichi Seiyaku Co Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos
GB0004297D0 (en) * 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
US6686477B2 (en) 2000-09-29 2004-02-03 Eastman Chemical Company Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same
EP1395560A1 (en) * 2001-05-23 2004-03-10 Ucb, S.A. 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
ES2314090T3 (es) 2001-08-10 2009-03-16 Ucb Pharma S.A. Compuestos de oxopirrolidina, preparacion de dichos compuestos y uso de los mismos en la fabricacion de levetiracetam y sus analogos.
ATE353645T1 (de) * 2001-10-08 2007-03-15 Ucb Sa Verwendung von 2-oxo-1-pyrrolidin-derivaten zur herstellung eines arzneimittels zur behandlung von dyskinesia
CN1802352A (zh) 2003-02-03 2006-07-12 特瓦制药工业有限公司 制备左乙拉西坦的方法
ES2214147B1 (es) * 2003-02-28 2005-10-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
CA2497062A1 (en) 2004-02-18 2005-08-18 Dr. Reddy's Laboratories Limited Preparation of amino acid amides
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
US20080146819A1 (en) * 2005-03-10 2008-06-19 Rubamin Limited Process for Preparing Levetiracetam
ES2441178T3 (es) 2005-06-01 2014-02-03 Ucb Pharma, S.A. Derivados de 2-oxo-1-pirrolidina, procedimientos para prepararlos y el uso terapéutico de los mismos sobre el sistema nervioso central
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
DK2346500T3 (en) 2008-10-16 2017-07-17 Univ Johns Hopkins Methods and compositions for improving cognitive function
US8785661B2 (en) 2009-05-13 2014-07-22 Nektar Therapeutics Oligome-containing pyrrolidine compounds
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
JP6082250B2 (ja) 2010-02-09 2017-02-15 ザ・ジョンズ・ホプキンス・ユニバーシティー 認知機能を改善するための方法および組成物
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144801A1 (en) 2013-03-15 2014-09-18 Agenebio Inc. Methods and compositions for improving cognitive function
US10806717B2 (en) 2013-03-15 2020-10-20 The Johns Hopkins University Methods and compositions for improving cognitive function
MY203464A (en) 2014-01-21 2024-06-28 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
KR20200126026A (ko) 2014-01-21 2020-11-05 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
CN104059010A (zh) * 2014-06-12 2014-09-24 浙江华海药业股份有限公司 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法
CN106591179B (zh) * 2016-12-05 2018-07-03 长兴制药股份有限公司 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用
US11384050B1 (en) 2021-02-03 2022-07-12 Vitaworks Ip, Llc Method for preparing levetiracetam and intermediates thereof
CN113979911A (zh) * 2021-11-12 2022-01-28 汤斌 一种从大鲵肽中提取乙拉西坦的方法
EP4572852A1 (en) 2022-08-19 2025-06-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2663899C1 (ru) * 2017-07-19 2018-08-13 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" Способ получения 1-карбамоилметил-4-фенил-2-пирролидона

Also Published As

Publication number Publication date
JPS5420491B2 (enrdf_load_stackoverflow) 1979-07-23
BE762728R (fr) 1971-08-10
FI54916B (fi) 1978-12-29
FI54916C (fi) 1979-04-10
DE2106418C2 (de) 1983-12-22
DE2106418A1 (de) 1971-08-19
FR2081508B2 (enrdf_load_stackoverflow) 1975-06-06
YU34876B (en) 1980-04-30
DK137451C (enrdf_load_stackoverflow) 1978-07-24
MY7400072A (en) 1974-12-31
GB1309692A (en) 1973-03-14
NL7101697A (enrdf_load_stackoverflow) 1971-08-17
ES388135A2 (es) 1973-05-01
JPS535301B1 (enrdf_load_stackoverflow) 1978-02-25
ZA71877B (en) 1971-10-27
NL168830C (nl) 1982-05-17
YU30671A (en) 1979-10-31
FR2081508A2 (enrdf_load_stackoverflow) 1971-12-03
YU144578A (en) 1982-10-31
NL168830B (nl) 1981-12-16
SU508186A3 (ru) 1976-03-25
CH530395A (fr) 1972-11-15
CS167912B2 (enrdf_load_stackoverflow) 1976-05-28
JPS53130656A (en) 1978-11-14
CS167911B2 (enrdf_load_stackoverflow) 1976-05-28
DK137451B (da) 1978-03-06

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