CH530395A - Procédé de préparation de nouveaux lactames N-substitués - Google Patents
Procédé de préparation de nouveaux lactames N-substituésInfo
- Publication number
- CH530395A CH530395A CH200171A CH200171A CH530395A CH 530395 A CH530395 A CH 530395A CH 200171 A CH200171 A CH 200171A CH 200171 A CH200171 A CH 200171A CH 530395 A CH530395 A CH 530395A
- Authority
- CH
- Switzerland
- Prior art keywords
- preparation
- new
- substituted lactams
- lactams
- substituted
- Prior art date
Links
- 150000003951 lactams Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH530395A true CH530395A (fr) | 1972-11-15 |
Family
ID=9824325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH200171A CH530395A (fr) | 1970-02-13 | 1971-02-11 | Procédé de préparation de nouveaux lactames N-substitués |
Country Status (15)
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
| GB1583871A (en) * | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
| BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
| EP0005689B1 (fr) * | 1978-05-08 | 1981-03-18 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
| IT1141287B (it) * | 1979-06-13 | 1986-10-01 | Nattermann A & Cie | Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono |
| FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| EP0089900B1 (en) * | 1982-03-24 | 1985-12-27 | Prodes S.A. | New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
| US4804400A (en) * | 1986-09-12 | 1989-02-14 | Ciba-Geigy Corporation | N-phenyl-maleimides and herbicidal and plant growth regulating methods of use thereof |
| GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| TW544311B (en) * | 1998-08-06 | 2003-08-01 | Daiichi Seiyaku Co | Therapeutic or preventive agent for intractable epilepsies |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
| WO2002094787A1 (en) * | 2001-05-23 | 2002-11-28 | Ucb, S.A. | 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders |
| ATE410412T1 (de) * | 2001-08-10 | 2008-10-15 | Ucb Pharma Sa | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen |
| EP1435943B1 (en) * | 2001-10-08 | 2007-02-14 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidine derivatives for the preparation of a drug for treating dyskinesia |
| WO2004069796A2 (en) | 2003-02-03 | 2004-08-19 | Teva Pharmaceutical Industries Ltd. | Process for producing levetiracetam |
| ES2214147B1 (es) * | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
| CA2497062A1 (en) | 2004-02-18 | 2005-08-18 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
| CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| US20080146819A1 (en) * | 2005-03-10 | 2008-06-19 | Rubamin Limited | Process for Preparing Levetiracetam |
| WO2006128692A2 (en) | 2005-06-01 | 2006-12-07 | Ucb Pharma, S.A. | 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system |
| EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
| DK2346500T3 (en) | 2008-10-16 | 2017-07-17 | Univ Johns Hopkins | Methods and compositions for improving cognitive function |
| WO2010132693A2 (en) | 2009-05-13 | 2010-11-18 | Nektar Therapeutics | Oligomer-containing pyrrolidine compounds |
| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
| CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US11160785B2 (en) | 2013-03-15 | 2021-11-02 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| PL3431106T3 (pl) | 2014-01-21 | 2021-06-28 | Janssen Pharmaceutica Nv | Kombinacje zawierające pozytywne modulatory allosteryczne metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie |
| ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
| CN104059010A (zh) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法 |
| CN106591179B (zh) * | 2016-12-05 | 2018-07-03 | 长兴制药股份有限公司 | 甲基包囊菌及其在选择性拆分制备(S)-α-乙基-2-氧-1-吡咯烷乙酸盐上的应用 |
| RU2663899C1 (ru) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Способ получения 1-карбамоилметил-4-фенил-2-пирролидона |
| US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
| CN113979911A (zh) * | 2021-11-12 | 2022-01-28 | 汤斌 | 一种从大鲵肽中提取乙拉西坦的方法 |
| WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/xx not_active IP Right Cessation
- 1971-02-10 DK DK59571AA patent/DK137451B/da not_active IP Right Cessation
- 1971-02-10 YU YU306/71A patent/YU34876B/xx unknown
- 1971-02-10 BE BE762728A patent/BE762728R/xx active
- 1971-02-10 ES ES388135A patent/ES388135A2/es not_active Expired
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-10 FI FI383/71A patent/FI54916C/fi active
- 1971-02-11 DE DE2106418A patent/DE2106418C2/de not_active Expired
- 1971-02-11 CH CH200171A patent/CH530395A/fr not_active IP Right Cessation
- 1971-02-11 ZA ZA710877A patent/ZA71877B/xx unknown
- 1971-02-12 SU SU1893858A patent/SU508186A3/ru active
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1621307A patent/SU508185A3/ru active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/xx unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/ja active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI54916B (fi) | 1978-12-29 |
| BE762728R (fr) | 1971-08-10 |
| DE2106418C2 (de) | 1983-12-22 |
| FR2081508B2 (enrdf_load_stackoverflow) | 1975-06-06 |
| GB1309692A (en) | 1973-03-14 |
| FR2081508A2 (enrdf_load_stackoverflow) | 1971-12-03 |
| NL168830B (nl) | 1981-12-16 |
| CS167912B2 (enrdf_load_stackoverflow) | 1976-05-28 |
| SU508185A3 (ru) | 1976-03-25 |
| DK137451C (enrdf_load_stackoverflow) | 1978-07-24 |
| YU30671A (en) | 1979-10-31 |
| JPS53130656A (en) | 1978-11-14 |
| ES388135A2 (es) | 1973-05-01 |
| ZA71877B (en) | 1971-10-27 |
| MY7400072A (en) | 1974-12-31 |
| JPS5420491B2 (enrdf_load_stackoverflow) | 1979-07-23 |
| DK137451B (da) | 1978-03-06 |
| CS167911B2 (enrdf_load_stackoverflow) | 1976-05-28 |
| YU144578A (en) | 1982-10-31 |
| SU508186A3 (ru) | 1976-03-25 |
| NL7101697A (enrdf_load_stackoverflow) | 1971-08-17 |
| YU34876B (en) | 1980-04-30 |
| NL168830C (nl) | 1982-05-17 |
| FI54916C (fi) | 1979-04-10 |
| DE2106418A1 (de) | 1971-08-19 |
| JPS535301B1 (enrdf_load_stackoverflow) | 1978-02-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH530395A (fr) | Procédé de préparation de nouveaux lactames N-substitués | |
| CH436304A (fr) | Procédé de préparation de nouveaux lactames N-substitués | |
| CH485795A (fr) | Procédé pour la préparation de nouveaux polyamides | |
| CH525189A (fr) | Procédé de préparation de nouveaux cinnamamides substitués | |
| CH468425A (fr) | Procédé de préparation de nouveaux polyamides | |
| CH538474A (fr) | Procédé de préparation de nouvelles phényl-2-pyrrolidinones substituées | |
| CH518267A (fr) | Procédé de préparation de nouveaux aryloxy-acétamides basiques | |
| CH535227A (fr) | Procédé de préparation de bis-chromones | |
| CH532366A (fr) | Procédé de préparation de chocolat | |
| CH514543A (fr) | Procédé de préparation de nouveaux 5,8-dihydroxynaphtyloxyamino-propanols | |
| CH540922A (fr) | Procédé de préparation de 2-phényl-3-aminoacyl-benzo-thiazolines | |
| CH522577A (fr) | Procédé de préparation de 5-cyclohexadécène-1-one | |
| CH539023A (fr) | Procédé de préparation de nouveaux composés polyfluoroaminés | |
| CH517702A (fr) | Procédé de préparation de nouveaux peptides | |
| CH520641A (fr) | Procédé de préparation de nouveaux 2-benzylphénols | |
| CH485796A (fr) | Procédé de préparation de nouveaux polyamides | |
| CH537368A (fr) | Procédé de préparation de nouveaux composés polyfluor-aminés carboxylés | |
| OA03563A (fr) | Procédé de préparation de nouvelles pyrrolidines substituées. | |
| MC806A1 (fr) | Procédé de préparation de benzamides hétérocycliques nouveaux | |
| CH542231A (fr) | Procédé de préparation de nouveaux dérivés de la thiazolino-pyrimidino-5 | |
| CH541587A (fr) | Procédé de préparation de nouveaux copolymères | |
| CH525217A (fr) | Procédé de préparation de nouveaux acryloyl-2 benzimidazoles | |
| CH515290A (fr) | Procédé de préparation de nouveaux polyamides phosphores | |
| CH516504A (fr) | Procédé de préparation de nouveaux cyclopropanecarboxylates de benzyle substitué en position 3 | |
| CH540231A (fr) | Procédé pour la préparation de cyanamides substituées |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |