SMT201600275B - Composti eterociclici utili come inibitori di pdk1 - Google Patents

Composti eterociclici utili come inibitori di pdk1

Info

Publication number
SMT201600275B
SMT201600275B SM201600275T SM201600275T SMT201600275B SM T201600275 B SMT201600275 B SM T201600275B SM 201600275 T SM201600275 T SM 201600275T SM 201600275 T SM201600275 T SM 201600275T SM T201600275 B SMT201600275 B SM T201600275B
Authority
SM
San Marino
Prior art keywords
pdk1
inhibitors
heterocyclic compounds
useful heterocyclic
useful
Prior art date
Application number
SM201600275T
Other languages
English (en)
Italian (it)
Inventor
Joseph Arndt
Timothy Chan
Kevin Guckian
Gnanasambandam Kumaravel
Wen-Cherng Lee
Edward Yin-Shiang Lin
Daniel Scott
Lihong Sun
Jermaine Thomas
Vloten Kurt Van
Deping Wang
Lei Zhang
Daniel Erlanson
Original Assignee
Millennium Pharm Inc
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Sunesis Pharmaceuticals Inc filed Critical Millennium Pharm Inc
Publication of SMT201600275B publication Critical patent/SMT201600275B/it

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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