SMT201500322B - Derivati di tieno[2,3-d]pirimidina e loro uso per trattare l'aritmia - Google Patents
Derivati di tieno[2,3-d]pirimidina e loro uso per trattare l'aritmiaInfo
- Publication number
- SMT201500322B SMT201500322B SM201500322T SM201500322T SMT201500322B SM T201500322 B SMT201500322 B SM T201500322B SM 201500322 T SM201500322 T SM 201500322T SM 201500322 T SM201500322 T SM 201500322T SM T201500322 B SMT201500322 B SM T201500322B
- Authority
- SM
- San Marino
- Prior art keywords
- arithmia
- tenue
- pyrimidine
- treat
- derivatives
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105659.5A GB201105659D0 (en) | 2011-04-01 | 2011-04-01 | Compounds |
| PCT/GB2012/050710 WO2012131379A1 (en) | 2011-04-01 | 2012-03-29 | Thieno [2, 3 -d] pyrimidine derivatives and their use to treat arrhythmia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201500322B true SMT201500322B (it) | 2016-02-25 |
Family
ID=44071904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201500322T SMT201500322B (it) | 2011-04-01 | 2015-12-22 | Derivati di tieno[2,3-d]pirimidina e loro uso per trattare l'aritmia |
Country Status (42)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150307532A1 (en) * | 2012-11-20 | 2015-10-29 | The Royal Institution For The Advancement Of Learning/Mcgill University | Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase |
| JP7114076B2 (ja) | 2015-12-22 | 2022-08-08 | シャイ・セラピューティクス・エルエルシー | がん及び炎症性疾患の処置のための化合物 |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| JP7514005B2 (ja) * | 2017-06-21 | 2024-07-10 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物 |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH317906A (de) | 1953-09-16 | 1956-12-15 | Sandoz Ag | Verfahren zur Herstellung von 1-Amino-4-oxyanthrachinonsulfonsäuren |
| AU521790B2 (en) | 1977-05-23 | 1982-04-29 | Ici Australia Limited | Process for eradication of ticks |
| ZA782648B (en) | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
| DD226893A1 (de) | 1981-12-15 | 1985-09-04 | Ralf Boehm | Verfahren zur herstellung von arylaminosubstituierten thieno 2,3-d pyrimidinen |
| IL112566A (en) | 1994-02-10 | 2000-10-31 | Wyeth John & Brother Ltd | Substituted quinolinones and pharmaceutical compositions containing them |
| IL112568A0 (en) | 1994-02-10 | 1995-05-26 | Wyeth John & Brother Ltd | Substituted quinolines, their preparation and pharmaceutical compositions containing them |
| IL112569A (en) | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
| IL112567A (en) | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
| ATE227726T1 (de) | 1995-08-17 | 2002-11-15 | Takeda Chemical Industries Ltd | Thienopyrimidinderivate als endothelin antagonisten |
| NZ333870A (en) | 1996-07-26 | 2000-08-25 | Nissan Chemical Ind Ltd | 4-amino substituted chroman derivatives |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| RU2116309C1 (ru) | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
| US6333337B1 (en) | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| JP2002517385A (ja) | 1998-06-05 | 2002-06-18 | イカゲン インク． | カリウムチャネル阻害剤 |
| AU5444499A (en) | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Benzoxazine derivatives |
| US6194458B1 (en) | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| HUP0202690A3 (en) | 1999-09-17 | 2005-02-28 | Nissan Chemical Ind Ltd | Benzopyran derivative having antiarrhytmic activity |
| US6555574B1 (en) | 1999-09-24 | 2003-04-29 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| DE19947457A1 (de) | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| US6531495B1 (en) | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
| WO2001025224A1 (en) | 1999-10-05 | 2001-04-12 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| AU781365B2 (en) | 1999-12-21 | 2005-05-19 | Icagen, Inc. | Potassium channel inhibitors |
| EP1322619B1 (en) | 2000-09-20 | 2008-01-23 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10059418A1 (de) | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10060807A1 (de) | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10061876A1 (de) | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10104802A1 (de) | 2001-02-02 | 2002-08-08 | Merck Patent Gmbh | Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1) |
| JP2004525890A (ja) | 2001-02-02 | 2004-08-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ピラゾロ［４，３−ｄ］ピリミジンおよびエンドセリンレセプターアンタゴニストまたはチエノピリミジンおよびエンドセリンレセプターアンタゴニストを含む医薬製剤 |
| TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10121002A1 (de) | 2001-04-28 | 2002-11-14 | Aventis Pharma Gmbh | Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10128331A1 (de) | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| HUP0400362A3 (en) | 2001-06-25 | 2007-05-29 | Nissan Chemical Ind Ltd | Substituted benzopyran derivetives against arrhythmia |
| TW200307539A (en) | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| PL1641803T6 (pl) | 2003-06-11 | 2011-04-29 | Xention Ltd | Pochodne tienopirymidyny jako inhibitory kanału potasowego |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| ZA200600197B (en) * | 2003-07-02 | 2007-06-27 | Vertex Pharma | Pyrimidines useful as modulators of voltage-gated ion channels |
| RU2006128580A (ru) | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой |
| AU2005260077A1 (en) | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| JP5173429B2 (ja) | 2004-12-09 | 2013-04-03 | ゼンション・リミテッド | 化合物 |
| WO2007084815A2 (en) | 2006-01-19 | 2007-07-26 | Janssen Pharmaceutica, N.V. | Substituted thienopyrimidine kinase inhibitors |
| EP2043654A2 (en) | 2006-06-12 | 2009-04-08 | Vertex Pharmaceuticals, Inc. | Thienopyrimidines useful as modulators of ion channels |
| DE102009039893B4 (de) | 2009-09-03 | 2012-03-29 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Verwendung eines Brennstoffs in einem selbstunterhaltenden pulsierenden Sauerstoff-Brennstoff-Verbrennungsprozess |
-
2011
- 2011-04-01 GB GBGB1105659.5A patent/GB201105659D0/en not_active Ceased
-
2012
- 2012-03-29 PE PE2013002093A patent/PE20141021A1/es not_active Application Discontinuation
- 2012-03-29 RS RS20150833A patent/RS54458B1/sr unknown
- 2012-03-29 DK DK12718725.0T patent/DK2694518T3/en active
- 2012-03-29 ME MEP-2015-219A patent/ME02314B/me unknown
- 2012-03-29 SI SI201230406T patent/SI2694518T1/sl unknown
- 2012-03-29 EA EA201301111A patent/EA201301111A1/ru unknown
- 2012-03-29 PL PL12718725T patent/PL2694518T3/pl unknown
- 2012-03-29 MX MX2013011301A patent/MX335937B/es unknown
- 2012-03-29 ES ES12718725.0T patent/ES2558563T3/es active Active
- 2012-03-29 SG SG2013071147A patent/SG193578A1/en unknown
- 2012-03-29 BR BR112013025236A patent/BR112013025236A2/pt not_active IP Right Cessation
- 2012-03-29 CN CN201280016323.9A patent/CN103492392B/zh not_active Expired - Fee Related
- 2012-03-29 RU RU2013148627/04A patent/RU2013148627A/ru not_active Application Discontinuation
- 2012-03-29 MA MA36364A patent/MA35064B1/fr unknown
- 2012-03-29 WO PCT/GB2012/050710 patent/WO2012131379A1/en not_active Ceased
- 2012-03-29 EP EP12718725.0A patent/EP2694518B1/en active Active
- 2012-03-29 AP AP2013007198A patent/AP2013007198A0/xx unknown
- 2012-03-29 KR KR1020137028742A patent/KR20140023332A/ko not_active Ceased
- 2012-03-29 UA UAA201312693A patent/UA110131C2/ru unknown
- 2012-03-29 PH PH1/2013/501952A patent/PH12013501952A1/en unknown
- 2012-03-29 PT PT127187250T patent/PT2694518E/pt unknown
- 2012-03-29 CU CUP2013000124A patent/CU24173B1/es unknown
- 2012-03-29 JP JP2014501722A patent/JP5826374B2/ja not_active Expired - Fee Related
- 2012-03-29 HU HUE12718725A patent/HUE028438T2/en unknown
- 2012-03-29 CA CA2831493A patent/CA2831493A1/en not_active Abandoned
- 2012-03-29 AU AU2012235882A patent/AU2012235882B2/en not_active Ceased
- 2012-03-29 HR HRP20151340TT patent/HRP20151340T1/hr unknown
- 2012-03-29 US US14/008,776 patent/US9249155B2/en not_active Expired - Fee Related
- 2012-03-30 TW TW101111540A patent/TWI516265B/zh not_active IP Right Cessation
- 2012-03-30 AR ARP120101121A patent/AR088735A1/es unknown
-
2013
- 2013-09-19 ZA ZA2013/07085A patent/ZA201307085B/en unknown
- 2013-09-24 TN TNP2013000377A patent/TN2013000377A1/fr unknown
- 2013-09-26 GT GT201300225A patent/GT201300225A/es unknown
- 2013-09-26 CR CR20130488A patent/CR20130488A/es not_active Application Discontinuation
- 2013-09-27 CL CL2013002789A patent/CL2013002789A1/es unknown
- 2013-09-29 IL IL228555A patent/IL228555A0/en unknown
- 2013-09-30 NI NI201300100A patent/NI201300100A/es unknown
- 2013-10-23 EC ECSP13012988 patent/ECSP13012988A/es unknown
- 2013-10-24 CO CO13252150A patent/CO6801756A2/es active IP Right Grant
-
2015
- 2015-12-07 CY CY20151101110T patent/CY1117025T1/el unknown
- 2015-12-22 SM SM201500322T patent/SMT201500322B/it unknown
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