SMT201500322B - Derivati di tieno[2,3-d]pirimidina e loro uso per trattare l'aritmia - Google Patents
Derivati di tieno[2,3-d]pirimidina e loro uso per trattare l'aritmiaInfo
- Publication number
- SMT201500322B SMT201500322B SM201500322T SM201500322T SMT201500322B SM T201500322 B SMT201500322 B SM T201500322B SM 201500322 T SM201500322 T SM 201500322T SM 201500322 T SM201500322 T SM 201500322T SM T201500322 B SMT201500322 B SM T201500322B
- Authority
- SM
- San Marino
- Prior art keywords
- arithmia
- tenue
- pyrimidine
- treat
- derivatives
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105659.5A GB201105659D0 (en) | 2011-04-01 | 2011-04-01 | Compounds |
| PCT/GB2012/050710 WO2012131379A1 (en) | 2011-04-01 | 2012-03-29 | Thieno [2, 3 -d] pyrimidine derivatives and their use to treat arrhythmia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201500322B true SMT201500322B (it) | 2016-02-25 |
Family
ID=44071904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201500322T SMT201500322B (it) | 2011-04-01 | 2015-12-22 | Derivati di tieno[2,3-d]pirimidina e loro uso per trattare l'aritmia |
Country Status (42)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2922858A4 (en) * | 2012-11-20 | 2016-06-15 | Univ Mcgill | THIENOPYRIMIDININHIBITORS OF FARNESYL AND / OR GERANYL GERANYL PYROPHOSPHATE SYNTHASE |
| SG11201804901WA (en) | 2015-12-22 | 2018-07-30 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| EA201992780A1 (ru) | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
| US12391705B2 (en) | 2018-12-19 | 2025-08-19 | Shy Therapeutics, Llc | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
Family Cites Families (50)
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| CH317906A (de) | 1953-09-16 | 1956-12-15 | Sandoz Ag | Verfahren zur Herstellung von 1-Amino-4-oxyanthrachinonsulfonsäuren |
| US4196207A (en) | 1977-05-23 | 1980-04-01 | Ici Australia Limited | Process for controlling eradicating or preventing infestations of animals by Ixodid ticks |
| AU521790B2 (en) | 1977-05-23 | 1982-04-29 | Ici Australia Limited | Process for eradication of ticks |
| DD226893A1 (de) | 1981-12-15 | 1985-09-04 | Ralf Boehm | Verfahren zur herstellung von arylaminosubstituierten thieno 2,3-d pyrimidinen |
| IL112566A (en) | 1994-02-10 | 2000-10-31 | Wyeth John & Brother Ltd | Substituted quinolinones and pharmaceutical compositions containing them |
| IL112567A (en) | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
| IL112568A0 (en) | 1994-02-10 | 1995-05-26 | Wyeth John & Brother Ltd | Substituted quinolines, their preparation and pharmaceutical compositions containing them |
| IL112569A (en) | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
| EP0846119B1 (en) | 1995-08-17 | 2002-11-13 | Takeda Chemical Industries, Ltd. | Thienopyrimidine derivatives, their production and use as endothelin antagonists |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| CZ24499A3 (cs) | 1996-07-26 | 1999-05-12 | Nissan Chemical Industries, Ltd. | Derivát chromanu a farmaceutický prostředek, který ho obsahuje |
| US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| RU2116309C1 (ru) | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
| US6333337B1 (en) | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| EP1082315A1 (en) | 1998-06-05 | 2001-03-14 | Icagen, Inc. | Potassium channel inhibitors |
| AU5444499A (en) | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Benzoxazine derivatives |
| US6194458B1 (en) | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| CA2383583C (en) | 1999-09-17 | 2009-04-07 | Nissan Chemical Industries, Ltd. | Benzopyran derivative |
| EP1214307B1 (en) | 1999-09-24 | 2004-04-07 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| DE19947457A1 (de) | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| US6531495B1 (en) | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
| US6677371B1 (en) | 1999-10-05 | 2004-01-13 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| AU781365B2 (en) | 1999-12-21 | 2005-05-19 | Icagen, Inc. | Potassium channel inhibitors |
| AU2002212969B2 (en) | 2000-09-20 | 2006-07-06 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10059418A1 (de) | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10060807A1 (de) | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10061876A1 (de) | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10104802A1 (de) | 2001-02-02 | 2002-08-08 | Merck Patent Gmbh | Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1) |
| JP2004525890A (ja) | 2001-02-02 | 2004-08-26 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ピラゾロ［４，３−ｄ］ピリミジンおよびエンドセリンレセプターアンタゴニストまたはチエノピリミジンおよびエンドセリンレセプターアンタゴニストを含む医薬製剤 |
| TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10121002A1 (de) | 2001-04-28 | 2002-11-14 | Aventis Pharma Gmbh | Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10128331A1 (de) | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| EP1401823B1 (en) | 2001-06-25 | 2005-10-05 | Nissan Chemical Industries, Ltd. | Substituted benzopyran derivatives against arrhythmia |
| TW200307539A (en) | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| ES2324536T7 (es) * | 2003-06-11 | 2012-03-16 | Xention Limited | Derivados de tenopirimidina como inhibidores de los canales de potasio. |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| ZA200600197B (en) * | 2003-07-02 | 2007-06-27 | Vertex Pharma | Pyrimidines useful as modulators of voltage-gated ion channels |
| EP1701961A1 (en) | 2004-01-06 | 2006-09-20 | Taisho Pharmaceutical Co., Ltd | Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group |
| MXPA06015223A (es) | 2004-06-29 | 2007-11-09 | Amgen Inc | Furanopirimidinas. |
| ATE476434T1 (de) | 2004-12-09 | 2010-08-15 | Xention Ltd | Thienopyridinderivate als kaliumkanalinhibitoren |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| US20080108611A1 (en) | 2006-01-19 | 2008-05-08 | Battista Kathleen A | Substituted thienopyrimidine kinase inhibitors |
| WO2007146284A2 (en) | 2006-06-12 | 2007-12-21 | Vertex Pharmaceuticals Incorporated | Thienopyrimidines useful as modulators of ion channels |
| DE102009039893B4 (de) | 2009-09-03 | 2012-03-29 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Verwendung eines Brennstoffs in einem selbstunterhaltenden pulsierenden Sauerstoff-Brennstoff-Verbrennungsprozess |
-
2011
- 2011-04-01 GB GBGB1105659.5A patent/GB201105659D0/en not_active Ceased
-
2012
- 2012-03-29 UA UAA201312693A patent/UA110131C2/ru unknown
- 2012-03-29 PT PT127187250T patent/PT2694518E/pt unknown
- 2012-03-29 ES ES12718725.0T patent/ES2558563T3/es active Active
- 2012-03-29 SI SI201230406T patent/SI2694518T1/sl unknown
- 2012-03-29 EP EP12718725.0A patent/EP2694518B1/en active Active
- 2012-03-29 AP AP2013007198A patent/AP2013007198A0/xx unknown
- 2012-03-29 CA CA2831493A patent/CA2831493A1/en not_active Abandoned
- 2012-03-29 PH PH1/2013/501952A patent/PH12013501952A1/en unknown
- 2012-03-29 RS RS20150833A patent/RS54458B1/sr unknown
- 2012-03-29 RU RU2013148627/04A patent/RU2013148627A/ru not_active Application Discontinuation
- 2012-03-29 PE PE2013002093A patent/PE20141021A1/es not_active Application Discontinuation
- 2012-03-29 AU AU2012235882A patent/AU2012235882B2/en not_active Ceased
- 2012-03-29 CN CN201280016323.9A patent/CN103492392B/zh not_active Expired - Fee Related
- 2012-03-29 HR HRP20151340TT patent/HRP20151340T1/hr unknown
- 2012-03-29 EA EA201301111A patent/EA201301111A1/ru unknown
- 2012-03-29 JP JP2014501722A patent/JP5826374B2/ja not_active Expired - Fee Related
- 2012-03-29 PL PL12718725T patent/PL2694518T3/pl unknown
- 2012-03-29 HU HUE12718725A patent/HUE028438T2/en unknown
- 2012-03-29 SG SG2013071147A patent/SG193578A1/en unknown
- 2012-03-29 CU CUP2013000124A patent/CU24173B1/es unknown
- 2012-03-29 DK DK12718725.0T patent/DK2694518T3/en active
- 2012-03-29 WO PCT/GB2012/050710 patent/WO2012131379A1/en not_active Ceased
- 2012-03-29 BR BR112013025236A patent/BR112013025236A2/pt not_active IP Right Cessation
- 2012-03-29 KR KR1020137028742A patent/KR20140023332A/ko not_active Ceased
- 2012-03-29 US US14/008,776 patent/US9249155B2/en not_active Expired - Fee Related
- 2012-03-29 MX MX2013011301A patent/MX335937B/es unknown
- 2012-03-29 MA MA36364A patent/MA35064B1/fr unknown
- 2012-03-29 ME MEP-2015-219A patent/ME02314B/me unknown
- 2012-03-30 TW TW101111540A patent/TWI516265B/zh not_active IP Right Cessation
- 2012-03-30 AR ARP120101121A patent/AR088735A1/es unknown
-
2013
- 2013-09-19 ZA ZA2013/07085A patent/ZA201307085B/en unknown
- 2013-09-24 TN TNP2013000377A patent/TN2013000377A1/fr unknown
- 2013-09-26 GT GT201300225A patent/GT201300225A/es unknown
- 2013-09-26 CR CR20130488A patent/CR20130488A/es not_active Application Discontinuation
- 2013-09-27 CL CL2013002789A patent/CL2013002789A1/es unknown
- 2013-09-29 IL IL228555A patent/IL228555A0/en unknown
- 2013-09-30 NI NI201300100A patent/NI201300100A/es unknown
- 2013-10-23 EC ECSP13012988 patent/ECSP13012988A/es unknown
- 2013-10-24 CO CO13252150A patent/CO6801756A2/es active IP Right Grant
-
2015
- 2015-12-07 CY CY20151101110T patent/CY1117025T1/el unknown
- 2015-12-22 SM SM201500322T patent/SMT201500322B/it unknown
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