SMT201400056B - Analoghi carba-nucleosidici per trattamento antivirale - Google Patents
Analoghi carba-nucleosidici per trattamento antiviraleInfo
- Publication number
- SMT201400056B SMT201400056B SM201400056T SM201400056T SMT201400056B SM T201400056 B SMT201400056 B SM T201400056B SM 201400056 T SM201400056 T SM 201400056T SM 201400056 T SM201400056 T SM 201400056T SM T201400056 B SMT201400056 B SM T201400056B
- Authority
- SM
- San Marino
- Prior art keywords
- carba
- nucleoside analogues
- antiviral treatment
- antiviral
- treatment
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 229940127073 nucleoside analogue Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15124809P | 2009-02-10 | 2009-02-10 | |
| PCT/US2010/023586 WO2010093608A1 (en) | 2009-02-10 | 2010-02-09 | Carba-nucleoside analogs for antiviral treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201400056B true SMT201400056B (it) | 2014-07-07 |
Family
ID=42333309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201400056T SMT201400056B (it) | 2009-02-10 | 2014-04-28 | Analoghi carba-nucleosidici per trattamento antivirale |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8012942B2 (uk) |
| EP (2) | EP2396340B1 (uk) |
| JP (2) | JP5746638B2 (uk) |
| KR (2) | KR101724759B1 (uk) |
| CN (1) | CN102348713B (uk) |
| AP (1) | AP2922A (uk) |
| AU (3) | AU2010213873B2 (uk) |
| BR (1) | BRPI1013643A2 (uk) |
| CA (1) | CA2751277C (uk) |
| CL (1) | CL2011001906A1 (uk) |
| CO (1) | CO6420354A2 (uk) |
| DK (1) | DK2396340T3 (uk) |
| EA (1) | EA025085B1 (uk) |
| ES (2) | ES2628842T3 (uk) |
| HK (1) | HK1163108A1 (uk) |
| HR (1) | HRP20140219T1 (uk) |
| IL (1) | IL214396A (uk) |
| MX (2) | MX345562B (uk) |
| NZ (1) | NZ594370A (uk) |
| PE (3) | PE20161067A1 (uk) |
| PL (1) | PL2396340T3 (uk) |
| PT (2) | PT2396340E (uk) |
| SG (1) | SG173186A1 (uk) |
| SI (1) | SI2396340T1 (uk) |
| SM (1) | SMT201400056B (uk) |
| UA (2) | UA112140C2 (uk) |
| WO (1) | WO2010093608A1 (uk) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| US8008264B2 (en) | 2008-04-23 | 2011-08-30 | Gilead Sciences, Inc. | 1′-substituted carba-nucleoside analogs for antiviral treatment |
| ME01528B (me) | 2009-09-21 | 2014-04-20 | Gilead Sciences Inc | POSTUPCI l INTERMEDIJERI ZA PROIZVODNJU 1'-CIJANOKARBANUKLEOZIDIH ANALOGA |
| AU2011282241B2 (en) | 2010-07-19 | 2015-07-30 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| EA025252B1 (ru) | 2010-07-22 | 2016-12-30 | Гайлид Сайэнсиз, Инк. | Способы и соединения для лечения вирусных инфекций paramyxoviridae |
| AP3699A (en) * | 2010-09-20 | 2016-05-31 | Gilead Sciences Inc | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| EP3042910B1 (en) | 2010-11-30 | 2019-01-09 | Gilead Pharmasset LLC | 2'-spiro-nucleosides for use in the therapy of hepatitis c |
| JP2014514295A (ja) | 2011-03-31 | 2014-06-19 | アイディニックス ファーマシューティカルズ インコーポレイテッド | ウイルス感染の治療のための化合物および薬学的組成物 |
| WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
| AR088441A1 (es) | 2011-09-12 | 2014-06-11 | Idenix Pharmaceuticals Inc | Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales |
| AR089650A1 (es) | 2011-10-14 | 2014-09-10 | Idenix Pharmaceuticals Inc | Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales |
| WO2013084165A1 (en) * | 2011-12-05 | 2013-06-13 | Medivir Ab | Hcv polymerase inhibitors |
| EP2812326A1 (en) | 2012-02-10 | 2014-12-17 | Lupin Limited | Antiviral compounds with a dibenzooxaheterocycle moiety |
| EP2852605B1 (en) | 2012-05-22 | 2018-01-31 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphate prodrugs for hcv infection |
| WO2013177219A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | D-amino acid compounds for liver disease |
| US9109001B2 (en) | 2012-05-22 | 2015-08-18 | Idenix Pharmaceuticals, Inc. | 3′,5′-cyclic phosphoramidate prodrugs for HCV infection |
| AR091156A1 (es) | 2012-05-25 | 2015-01-14 | Jansen R & D Ireland | Nucleosidos de espirooxetano de uracilo |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| AU2013329521B2 (en) | 2012-10-08 | 2018-04-19 | Centre National De La Recherche Scientifique | 2'-chloro nucleoside analogs for HCV infection |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| US20150037282A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| WO2015127848A1 (zh) * | 2014-02-27 | 2015-09-03 | 四川海思科制药有限公司 | 一种取代的氨基磷酸酯类衍生物、其制备方法及其应用 |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| TWI687432B (zh) | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| US20190022116A1 (en) | 2014-12-26 | 2019-01-24 | Emory University | N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto |
| GEP20237502B (en) | 2015-03-06 | 2023-04-25 | Atea Pharmaceuticals Inc | B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| WO2016178876A2 (en) * | 2015-05-01 | 2016-11-10 | Cocrystal Pharma, Inc. | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
| EA038141B1 (ru) | 2015-09-16 | 2021-07-13 | Джилид Сайэнс, Инк. | Способы лечения вирусных инфекций arenaviridae и coronaviridae |
| CN106083962B (zh) * | 2016-06-08 | 2018-12-18 | 成都倍特药业有限公司 | 一种具有环磷酰胺结构的化合物及其制备方法 |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| SG11201901457TA (en) | 2016-09-07 | 2019-03-28 | Atea Pharmaceuticals Inc | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| IL288737B (en) | 2017-02-01 | 2022-09-01 | Atea Pharmaceuticals Inc | Hemisulfate nucleotide salt for treatment of hepatitis c virus |
| JP6824434B2 (ja) | 2017-03-14 | 2021-02-03 | ギリアード サイエンシーズ， インコーポレイテッド | ネココロナウイルス感染を処置する方法 |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
| CA3077489A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| GB2581936B (en) | 2017-12-07 | 2021-02-10 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| TW202012001A (zh) | 2018-04-10 | 2020-04-01 | 美商亞堤製藥公司 | C型肝炎病毒(hcv)感染硬化之患者的治療 |
| KR20210121105A (ko) * | 2019-02-01 | 2021-10-07 | 얀센 바이오파마, 인코퍼레이트. | 항바이러스 뉴클레오시드 및 이의 유도체 |
| AU2021214911A1 (en) | 2020-01-27 | 2022-07-21 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
| US11701372B2 (en) | 2020-04-06 | 2023-07-18 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs |
| JP2023528810A (ja) | 2020-05-29 | 2023-07-06 | ギリアード サイエンシーズ， インコーポレイテッド | レムデシビル治療方法 |
| TWI819321B (zh) | 2020-06-24 | 2023-10-21 | 美商基利科學股份有限公司 | 1'-氰基核苷類似物及其用途 |
| EP4204421B1 (en) | 2020-08-27 | 2024-05-15 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| EP4320128A1 (en) | 2022-03-02 | 2024-02-14 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2083580T3 (es) | 1990-06-13 | 1996-04-16 | Arnold Glazier | Profarmacos de fosforo. |
| US6312662B1 (en) * | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| EP1225899A2 (en) | 1999-11-04 | 2002-07-31 | Virochem Pharma Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| HUP0301112A3 (en) | 2000-02-18 | 2005-04-28 | Shire Biochem Inc Laval | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| WO2002032920A2 (en) | 2000-10-18 | 2002-04-25 | Pharmasset Limited | Modified nucleosides for treatment of viral infections and abnormal cellular proliferation |
| EP2360166A1 (en) | 2001-01-22 | 2011-08-24 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
| US20040006002A1 (en) | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| AT410792B (de) * | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| EP1809301B1 (en) | 2004-09-14 | 2019-11-06 | Gilead Pharmasset LLC | 2-fluoro-2-alkyl-substituted d-ribonolactone intermediates |
| KR20070100237A (ko) * | 2004-10-29 | 2007-10-10 | 바이오크리스트 파마수티컬즈, 인코퍼레이티드 | 치료용 푸로피리미딘 및 티에노피리미딘 |
| WO2006121820A1 (en) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
| WO2007027248A2 (en) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | 3', 5' - cyclic nucleoside analogues for treatment of hcv |
| US8148349B2 (en) | 2006-12-20 | 2012-04-03 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| CA2673649A1 (en) | 2007-01-05 | 2008-07-17 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
| EP2114980B1 (en) | 2007-01-12 | 2012-06-27 | BioCryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| ES2393038T3 (es) | 2007-05-10 | 2012-12-18 | Biocryst Pharmaceuticals, Inc. | Compuestos de tretrahidrofuro[3,4-D]dioxolano para su utlilización en el tratamiento de las infecciones víricas y del cáncer |
| WO2010036407A2 (en) * | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
-
2010
- 2010-02-09 CA CA2751277A patent/CA2751277C/en not_active Expired - Fee Related
- 2010-02-09 KR KR1020117020990A patent/KR101724759B1/ko active IP Right Grant
- 2010-02-09 ES ES13194605.5T patent/ES2628842T3/es active Active
- 2010-02-09 MX MX2014007180A patent/MX345562B/es unknown
- 2010-02-09 SG SG2011054798A patent/SG173186A1/en unknown
- 2010-02-09 EP EP10704068.5A patent/EP2396340B1/en active Active
- 2010-02-09 US US12/702,957 patent/US8012942B2/en active Active
- 2010-02-09 JP JP2011549324A patent/JP5746638B2/ja not_active Expired - Fee Related
- 2010-02-09 EA EA201190110A patent/EA025085B1/ru not_active IP Right Cessation
- 2010-02-09 PT PT107040685T patent/PT2396340E/pt unknown
- 2010-02-09 NZ NZ594370A patent/NZ594370A/en not_active IP Right Cessation
- 2010-02-09 WO PCT/US2010/023586 patent/WO2010093608A1/en active Application Filing
- 2010-02-09 PT PT131946055T patent/PT2719701T/pt unknown
- 2010-02-09 AU AU2010213873A patent/AU2010213873B2/en not_active Ceased
- 2010-02-09 PE PE2016000564A patent/PE20161067A1/es not_active Application Discontinuation
- 2010-02-09 UA UAA201506736A patent/UA112140C2/uk unknown
- 2010-02-09 BR BRPI1013643A patent/BRPI1013643A2/pt active Search and Examination
- 2010-02-09 EP EP13194605.5A patent/EP2719701B1/en active Active
- 2010-02-09 AP AP2011005818A patent/AP2922A/xx active
- 2010-02-09 PL PL10704068T patent/PL2396340T3/pl unknown
- 2010-02-09 PE PE2011001464A patent/PE20120257A1/es active IP Right Grant
- 2010-02-09 DK DK10704068.5T patent/DK2396340T3/en active
- 2010-02-09 MX MX2011008409A patent/MX2011008409A/es active IP Right Grant
- 2010-02-09 KR KR1020177008719A patent/KR101834707B1/ko active IP Right Grant
- 2010-02-09 SI SI201030554T patent/SI2396340T1/sl unknown
- 2010-02-09 CN CN201080011690.0A patent/CN102348713B/zh not_active Expired - Fee Related
- 2010-02-09 PE PE2016000758A patent/PE20160858A1/es not_active Application Discontinuation
- 2010-02-09 ES ES10704068.5T patent/ES2453078T3/es active Active
- 2010-09-02 UA UAA201110568A patent/UA110093C2/uk unknown
-
2011
- 2011-08-02 IL IL214396A patent/IL214396A/en not_active IP Right Cessation
- 2011-08-09 CL CL2011001906A patent/CL2011001906A1/es unknown
- 2011-08-26 CO CO11109501A patent/CO6420354A2/es active IP Right Grant
-
2012
- 2012-04-05 HK HK12103428.2A patent/HK1163108A1/xx unknown
-
2014
- 2014-03-10 HR HRP20140219AT patent/HRP20140219T1/hr unknown
- 2014-04-28 SM SM201400056T patent/SMT201400056B/xx unknown
- 2014-07-07 JP JP2014139374A patent/JP5951690B2/ja not_active Expired - Fee Related
-
2015
- 2015-10-06 AU AU2015238785A patent/AU2015238785B2/en not_active Ceased
-
2017
- 2017-04-12 AU AU2017202413A patent/AU2017202413B2/en not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SMT201400056B (it) | Analoghi carba-nucleosidici per trattamento antivirale | |
| SMT201700091B (it) | ANALOGHI CARBA-NUCLEOSIDlCI2'-FLUORO SOSTITUITI PER TRATTAMENTO ANTIVIRALE | |
| LTPA2018013I1 (lt) | Antivirusinė terapija | |
| HK1216750A1 (zh) | ' - 用於抗病毒治療的 '替代咔核苷類似物 | |
| SMT201600351B (it) | Composti antivirali | |
| BR112013008017A2 (pt) | análogos de carba-nucleosídeo 2-flúor substituídos para tratamento antiviral | |
| DK2576534T3 (da) | 1-Substitueret-carba-nukleosid prodrugs til antiviral behandling | |
| BRPI0911269A2 (pt) | análogos de halicondrina b | |
| DK2398483T3 (da) | Oxyntomodulinanaloge | |
| GB0900914D0 (en) | Antiviral agents | |
| BRPI0922508A2 (pt) | Análogos de nucleosídeo | |
| DK2511282T3 (da) | Uracylspirooxetannukleosider | |
| BRPI0910534A2 (pt) | terapia antiviral | |
| ITPD20090053U1 (it) | Paradordi per banchine | |
| IT1396620B1 (it) | Analoghi chimerici | |
| GB0905485D0 (en) | Antiviral therapy | |
| FI20095951A0 (fi) | Kaasusumutinkotelo | |
| FR2947339B1 (fr) | Granulometre perfectionne | |
| DE112010004152A5 (de) | Stabilisiervorrichtung | |
| FR2942717B1 (fr) | Nouvel agent antiviral | |
| ITCT20090003U1 (it) | Telepass -2 per non udenti | |
| TH110486B (th) | เดือย | |
| ES1070801Y (es) | Muleta ortopedica | |
| TH115379B (th) | ไพราโซโล-ควินาโซลีน(pyrazolo-quinazolines) | |
| GB0908952D0 (en) | Antiviral therapy |