MX345562B - Analogos de carba-nucleosido para tratamiento antiviral. - Google Patents

Analogos de carba-nucleosido para tratamiento antiviral.

Info

Publication number
MX345562B
MX345562B MX2014007180A MX2014007180A MX345562B MX 345562 B MX345562 B MX 345562B MX 2014007180 A MX2014007180 A MX 2014007180A MX 2014007180 A MX2014007180 A MX 2014007180A MX 345562 B MX345562 B MX 345562B
Authority
MX
Mexico
Prior art keywords
carba
nucleoside analogs
antiviral treatment
pyrimidin
treatment
Prior art date
Application number
MX2014007180A
Other languages
English (en)
Inventor
Cho Aesop
U Kim Choung
Butler Thomas
Xu Jie
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42333309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX345562(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX345562B publication Critical patent/MX345562B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a ribosidas de tieno[3,4-d]pirimidin-7-ilo y furo[3,4-d]pirimidin-7-ilo, fosfatos de ribosida y profármacos de los mismos, así como intermediarios y métodos de preparación. Los compuestos, composiciones y métodos proporcionados son útiles para el tratamiento de infecciones de virus Flaviviridae.
MX2014007180A 2009-02-10 2010-02-09 Analogos de carba-nucleosido para tratamiento antiviral. MX345562B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15124809P 2009-02-10 2009-02-10
PCT/US2010/023586 WO2010093608A1 (en) 2009-02-10 2010-02-09 Carba-nucleoside analogs for antiviral treatment

Publications (1)

Publication Number Publication Date
MX345562B true MX345562B (es) 2017-02-03

Family

ID=42333309

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011008409A MX2011008409A (es) 2009-02-10 2010-02-09 Análogos de carba-nucléosido para tratamiento antiviral.
MX2014007180A MX345562B (es) 2009-02-10 2010-02-09 Analogos de carba-nucleosido para tratamiento antiviral.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2011008409A MX2011008409A (es) 2009-02-10 2010-02-09 Análogos de carba-nucléosido para tratamiento antiviral.

Country Status (26)

Country Link
US (1) US8012942B2 (es)
EP (2) EP2396340B1 (es)
JP (2) JP5746638B2 (es)
KR (2) KR101834707B1 (es)
CN (1) CN102348713B (es)
AP (1) AP2922A (es)
AU (3) AU2010213873B2 (es)
BR (1) BRPI1013643A2 (es)
CA (1) CA2751277C (es)
CL (1) CL2011001906A1 (es)
CO (1) CO6420354A2 (es)
DK (1) DK2396340T3 (es)
EA (1) EA025085B1 (es)
ES (2) ES2628842T3 (es)
HR (1) HRP20140219T1 (es)
IL (1) IL214396A (es)
MX (2) MX2011008409A (es)
NZ (1) NZ594370A (es)
PE (3) PE20161067A1 (es)
PL (1) PL2396340T3 (es)
PT (2) PT2396340E (es)
SG (1) SG173186A1 (es)
SI (1) SI2396340T1 (es)
SM (1) SMT201400056B (es)
UA (2) UA112140C2 (es)
WO (1) WO2010093608A1 (es)

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Also Published As

Publication number Publication date
CL2011001906A1 (es) 2012-03-30
ES2453078T3 (es) 2014-04-03
JP2012517444A (ja) 2012-08-02
AU2010213873A1 (en) 2011-09-01
PE20160858A1 (es) 2016-09-03
UA110093C2 (uk) 2015-11-25
EP2719701B1 (en) 2017-04-05
CA2751277A1 (en) 2010-08-19
AP2922A (en) 2014-05-31
HRP20140219T1 (hr) 2014-04-11
AU2017202413B2 (en) 2018-09-13
UA112140C2 (uk) 2016-07-25
EA201190110A1 (ru) 2012-02-28
SMT201400056B (it) 2014-07-07
AU2015238785A1 (en) 2015-10-29
PT2719701T (pt) 2017-06-29
AU2017202413A1 (en) 2017-05-04
KR101834707B1 (ko) 2018-03-05
US8012942B2 (en) 2011-09-06
IL214396A (en) 2014-07-31
EP2396340B1 (en) 2013-12-18
NZ594370A (en) 2014-01-31
SI2396340T1 (sl) 2014-04-30
AU2015238785B2 (en) 2017-02-16
US20100203015A1 (en) 2010-08-12
BRPI1013643A2 (pt) 2016-04-19
CN102348713A (zh) 2012-02-08
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EP2719701A1 (en) 2014-04-16
PL2396340T3 (pl) 2014-05-30
WO2010093608A1 (en) 2010-08-19
MX2011008409A (es) 2011-10-21
JP5951690B2 (ja) 2016-07-13
AU2010213873B2 (en) 2015-07-09
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IL214396A0 (en) 2011-09-27
CN102348713B (zh) 2015-12-02
CO6420354A2 (es) 2012-04-16
CA2751277C (en) 2018-10-30
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KR20110116046A (ko) 2011-10-24
PE20120257A1 (es) 2012-03-29
JP2014185183A (ja) 2014-10-02
ES2628842T3 (es) 2017-08-04
JP5746638B2 (ja) 2015-07-08
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PT2396340E (pt) 2014-03-26
EP2396340A1 (en) 2011-12-21
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AP2011005818A0 (en) 2011-08-31

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