DK2511282T3 - Uracylspirooxetannukleosider - Google Patents
UracylspirooxetannukleosiderInfo
- Publication number
- DK2511282T3 DK2511282T3 DK12176402.1T DK12176402T DK2511282T3 DK 2511282 T3 DK2511282 T3 DK 2511282T3 DK 12176402 T DK12176402 T DK 12176402T DK 2511282 T3 DK2511282 T3 DK 2511282T3
- Authority
- DK
- Denmark
- Prior art keywords
- uracylspirooxetane
- nucleosides
- uracylspirooxetane nucleosides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09160215 | 2009-05-14 | ||
EP10718207A EP2430035B1 (en) | 2009-05-14 | 2010-05-11 | Uracyl spirooxetane nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2511282T3 true DK2511282T3 (da) | 2014-07-07 |
Family
ID=40823307
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10718207.3T DK2430035T3 (da) | 2009-05-14 | 2010-05-11 | Uracylspipooxetannukleosider |
DK12176402.1T DK2511282T3 (da) | 2009-05-14 | 2010-05-11 | Uracylspirooxetannukleosider |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10718207.3T DK2430035T3 (da) | 2009-05-14 | 2010-05-11 | Uracylspipooxetannukleosider |
Country Status (39)
Country | Link |
---|---|
US (2) | US8481510B2 (da) |
EP (2) | EP2511282B1 (da) |
JP (2) | JP5778135B2 (da) |
KR (1) | KR101806837B1 (da) |
CN (1) | CN102439024B (da) |
AP (1) | AP2783A (da) |
AR (1) | AR076579A1 (da) |
AU (1) | AU2010247439B2 (da) |
BR (1) | BRPI1010579A2 (da) |
CA (1) | CA2760329C (da) |
CL (1) | CL2011002859A1 (da) |
CO (1) | CO6440533A2 (da) |
CR (1) | CR20120297A (da) |
CY (2) | CY1114081T1 (da) |
DK (2) | DK2430035T3 (da) |
EA (1) | EA022084B1 (da) |
EC (1) | ECSP11011461A (da) |
ES (2) | ES2411086T3 (da) |
HK (1) | HK1166326A1 (da) |
HN (1) | HN2011003014A (da) |
HR (2) | HRP20130554T1 (da) |
IL (1) | IL215955A (da) |
JO (1) | JO3027B1 (da) |
ME (1) | ME01478B (da) |
MX (1) | MX2011012027A (da) |
MY (1) | MY157018A (da) |
NI (1) | NI201100197A (da) |
NZ (1) | NZ596073A (da) |
PL (2) | PL2430035T3 (da) |
PT (2) | PT2511282E (da) |
RS (1) | RS52822B (da) |
SG (1) | SG175981A1 (da) |
SI (2) | SI2511282T1 (da) |
SM (2) | SMT201300078B (da) |
TW (1) | TWI461432B (da) |
UA (1) | UA105790C2 (da) |
UY (1) | UY32642A (da) |
WO (1) | WO2010130726A1 (da) |
ZA (1) | ZA201108309B (da) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
JO3027B1 (ar) * | 2009-05-14 | 2016-09-05 | Janssen Products Lp | نيوكليوسيدات يوراسيل سبيرواوكسيتان |
WO2012062869A1 (en) * | 2010-11-10 | 2012-05-18 | Janssen Products, Lp | Uracyl spirooxetane nucleoside phosphoramidates |
PT2638054E (pt) * | 2010-11-10 | 2015-03-02 | Medivir Ab | Fosforamidatos de nucleósidos de uracilo espirooxetano |
AU2015252113B2 (en) * | 2010-11-30 | 2017-05-04 | Gilead Pharmasset Llc | Compounds |
AU2011336632B2 (en) * | 2010-11-30 | 2015-09-03 | Gilead Pharmasset Llc | Compounds |
JP6043338B2 (ja) * | 2011-04-13 | 2016-12-14 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス治療用の1’−置換ピリミジンn−ヌクレオシド類似体 |
AU2012358804B2 (en) * | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
HUE029038T2 (en) * | 2012-05-25 | 2017-01-30 | Janssen Sciences Ireland Uc | Uracil spirooxetan nucleosides |
RU2621709C2 (ru) * | 2013-03-08 | 2017-06-07 | Наньцзин Саньхоме Фармасьютикал Ко., Лтд. | Новое фосфорамидатное производное нуклеозида и его применение |
WO2014169278A1 (en) | 2013-04-12 | 2014-10-16 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of hcv |
WO2014194826A1 (zh) * | 2013-06-06 | 2014-12-11 | 南京圣和药业有限公司 | 三环稠杂环类核苷氨基磷酸酯化合物、其制备方法及应用 |
US20170165287A1 (en) * | 2013-11-28 | 2017-06-15 | Janssen Sciences Ireland Uc | Crystal form of a nucleoside inhibitor of hcv |
AU2016229966B2 (en) | 2015-03-06 | 2018-09-27 | Atea Pharmaceuticals, Inc. | Beta-D-2'-deoxy-2'alpha-fluoro-2'-beta-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment |
LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
DK3512863T3 (da) | 2016-09-07 | 2022-03-07 | Atea Pharmaceuticals Inc | 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus |
KR102592899B1 (ko) | 2017-02-01 | 2023-10-24 | 아테아 파마슈티컬즈, 인크. | C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염 |
JP2021521118A (ja) | 2018-04-10 | 2021-08-26 | アテア ファーマシューティカルズ, インコーポレイテッド | 肝硬変を伴うhcv感染患者の治療 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
CA3174825A1 (en) * | 2020-04-14 | 2021-10-21 | Janssen Pharmaceuticals, Inc. | Spirocyclic nucleoside analogues for the treatment of hepatitis e |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1355916B1 (en) * | 2001-01-22 | 2007-01-10 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
CA2571079A1 (en) * | 2004-06-24 | 2006-02-02 | Merck & Co., Inc. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
EP1928475B1 (en) * | 2005-08-15 | 2018-05-23 | Riboscience LLC | Antiviral phosphoramidates of 4'-c-azido-substituted pronucleotides |
JP2009526850A (ja) * | 2006-02-14 | 2009-07-23 | メルク エンド カムパニー インコーポレーテッド | Rna依存性rnaウイルス感染を治療するためのヌクレオシドアリールホスホルアミデート |
PA8852101A1 (es) * | 2008-12-08 | 2010-07-27 | Medivir Ab | Nucleótidos uracil ciclopropílicos |
JO3027B1 (ar) * | 2009-05-14 | 2016-09-05 | Janssen Products Lp | نيوكليوسيدات يوراسيل سبيرواوكسيتان |
-
2010
- 2010-05-04 JO JOP/2010/0138A patent/JO3027B1/ar active
- 2010-05-11 CA CA2760329A patent/CA2760329C/en active Active
- 2010-05-11 EP EP12176402.1A patent/EP2511282B1/en active Active
- 2010-05-11 SG SG2011082757A patent/SG175981A1/en unknown
- 2010-05-11 PL PL10718207T patent/PL2430035T3/pl unknown
- 2010-05-11 ME MEP-2013-47A patent/ME01478B/me unknown
- 2010-05-11 DK DK10718207.3T patent/DK2430035T3/da active
- 2010-05-11 PT PT121764021T patent/PT2511282E/pt unknown
- 2010-05-11 NZ NZ596073A patent/NZ596073A/xx not_active IP Right Cessation
- 2010-05-11 SI SI201030667T patent/SI2511282T1/sl unknown
- 2010-05-11 MY MYPI2011005445A patent/MY157018A/en unknown
- 2010-05-11 WO PCT/EP2010/056438 patent/WO2010130726A1/en active Application Filing
- 2010-05-11 PL PL12176402T patent/PL2511282T3/pl unknown
- 2010-05-11 PT PT107182073T patent/PT2430035E/pt unknown
- 2010-05-11 DK DK12176402.1T patent/DK2511282T3/da active
- 2010-05-11 ES ES10718207T patent/ES2411086T3/es active Active
- 2010-05-11 AU AU2010247439A patent/AU2010247439B2/en not_active Ceased
- 2010-05-11 EP EP10718207A patent/EP2430035B1/en active Active
- 2010-05-11 AP AP2011005958A patent/AP2783A/xx active
- 2010-05-11 US US13/319,735 patent/US8481510B2/en active Active
- 2010-05-11 JP JP2012510269A patent/JP5778135B2/ja not_active Expired - Fee Related
- 2010-05-11 RS RS20130213A patent/RS52822B/en unknown
- 2010-05-11 SI SI201030246T patent/SI2430035T1/sl unknown
- 2010-05-11 MX MX2011012027A patent/MX2011012027A/es active IP Right Grant
- 2010-05-11 BR BRPI1010579A patent/BRPI1010579A2/pt active Search and Examination
- 2010-05-11 CN CN201080021188.8A patent/CN102439024B/zh active Active
- 2010-05-11 EA EA201171406A patent/EA022084B1/ru not_active IP Right Cessation
- 2010-05-11 KR KR1020117029826A patent/KR101806837B1/ko active IP Right Grant
- 2010-05-11 ES ES12176402.1T patent/ES2477598T3/es active Active
- 2010-05-12 TW TW099115051A patent/TWI461432B/zh not_active IP Right Cessation
- 2010-05-13 AR ARP100101670A patent/AR076579A1/es unknown
- 2010-05-14 UY UY0001032642A patent/UY32642A/es unknown
- 2010-11-05 UA UAA201112920A patent/UA105790C2/uk unknown
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2011
- 2011-10-26 IL IL215955A patent/IL215955A/en not_active IP Right Cessation
- 2011-10-27 CO CO11145588A patent/CO6440533A2/es not_active Application Discontinuation
- 2011-11-11 ZA ZA2011/08309A patent/ZA201108309B/en unknown
- 2011-11-11 NI NI201100197A patent/NI201100197A/es unknown
- 2011-11-14 HN HN2011003014A patent/HN2011003014A/es unknown
- 2011-11-14 CL CL2011002859A patent/CL2011002859A1/es unknown
- 2011-11-14 EC EC2011011461A patent/ECSP11011461A/es unknown
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2012
- 2012-05-30 CR CR20120297A patent/CR20120297A/es unknown
- 2012-07-18 HK HK12107046.5A patent/HK1166326A1/xx unknown
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2013
- 2013-03-15 US US13/836,465 patent/US8933052B2/en active Active
- 2013-05-22 CY CY20131100408T patent/CY1114081T1/el unknown
- 2013-06-18 HR HRP20130554AT patent/HRP20130554T1/hr unknown
- 2013-07-04 SM SM201300078T patent/SMT201300078B/xx unknown
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2014
- 2014-06-26 HR HRP20140605AT patent/HRP20140605T1/hr unknown
- 2014-06-30 SM SM201400085T patent/SMT201400085B/xx unknown
- 2014-07-01 CY CY20141100491T patent/CY1115383T1/el unknown
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2015
- 2015-07-06 JP JP2015135001A patent/JP2015180692A/ja not_active Withdrawn
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