SI2511282T1 - Nukleozidi uracil spirooksetana - Google Patents
Nukleozidi uracil spirooksetanaInfo
- Publication number
- SI2511282T1 SI2511282T1 SI201030667T SI201030667T SI2511282T1 SI 2511282 T1 SI2511282 T1 SI 2511282T1 SI 201030667 T SI201030667 T SI 201030667T SI 201030667 T SI201030667 T SI 201030667T SI 2511282 T1 SI2511282 T1 SI 2511282T1
- Authority
- SI
- Slovenia
- Prior art keywords
- spirooxetane nucleosides
- uracyl spirooxetane
- uracyl
- nucleosides
- spirooxetane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/503—Pyridazines; Hydrogenated pyridazines spiro-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09160215 | 2009-05-14 | ||
EP12176402.1A EP2511282B1 (en) | 2009-05-14 | 2010-05-11 | Uracyl Spirooxetane Nucleosides |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2511282T1 true SI2511282T1 (sl) | 2014-09-30 |
Family
ID=40823307
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201030667T SI2511282T1 (sl) | 2009-05-14 | 2010-05-11 | Nukleozidi uracil spirooksetana |
SI201030246T SI2430035T1 (sl) | 2009-05-14 | 2010-05-11 | Nukleozidi uracil spirooksetana |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201030246T SI2430035T1 (sl) | 2009-05-14 | 2010-05-11 | Nukleozidi uracil spirooksetana |
Country Status (39)
Country | Link |
---|---|
US (2) | US8481510B2 (sl) |
EP (2) | EP2511282B1 (sl) |
JP (2) | JP5778135B2 (sl) |
KR (1) | KR101806837B1 (sl) |
CN (1) | CN102439024B (sl) |
AP (1) | AP2783A (sl) |
AR (1) | AR076579A1 (sl) |
AU (1) | AU2010247439B2 (sl) |
BR (1) | BRPI1010579A2 (sl) |
CA (1) | CA2760329C (sl) |
CL (1) | CL2011002859A1 (sl) |
CO (1) | CO6440533A2 (sl) |
CR (1) | CR20120297A (sl) |
CY (2) | CY1114081T1 (sl) |
DK (2) | DK2430035T3 (sl) |
EA (1) | EA022084B1 (sl) |
EC (1) | ECSP11011461A (sl) |
ES (2) | ES2411086T3 (sl) |
HK (1) | HK1166326A1 (sl) |
HN (1) | HN2011003014A (sl) |
HR (2) | HRP20130554T1 (sl) |
IL (1) | IL215955A (sl) |
JO (1) | JO3027B1 (sl) |
ME (1) | ME01478B (sl) |
MX (1) | MX2011012027A (sl) |
MY (1) | MY157018A (sl) |
NI (1) | NI201100197A (sl) |
NZ (1) | NZ596073A (sl) |
PL (2) | PL2511282T3 (sl) |
PT (2) | PT2430035E (sl) |
RS (1) | RS52822B (sl) |
SG (1) | SG175981A1 (sl) |
SI (2) | SI2511282T1 (sl) |
SM (2) | SMT201300078B (sl) |
TW (1) | TWI461432B (sl) |
UA (1) | UA105790C2 (sl) |
UY (1) | UY32642A (sl) |
WO (1) | WO2010130726A1 (sl) |
ZA (1) | ZA201108309B (sl) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
JP5793084B2 (ja) | 2008-12-23 | 2015-10-14 | ギリアド ファーマセット エルエルシー | プリンヌクレオシドの合成 |
JO3027B1 (ar) | 2009-05-14 | 2016-09-05 | Janssen Products Lp | نيوكليوسيدات يوراسيل سبيرواوكسيتان |
ES2605433T3 (es) * | 2010-11-10 | 2017-03-14 | Janssen Products, L.P. | Fosforamidatos de espironucleósido oxetánico uracílico |
WO2012062870A1 (en) * | 2010-11-10 | 2012-05-18 | Janssen Products, Lp | Uracyl spirooxetane nucleoside phosphoramidates |
PT3042910T (pt) * | 2010-11-30 | 2019-04-16 | Gilead Pharmasset Llc | 2'-espiro-nucleósidos para utilização na terapia da hepatite c |
AU2015252113B2 (en) * | 2010-11-30 | 2017-05-04 | Gilead Pharmasset Llc | Compounds |
WO2012142523A2 (en) * | 2011-04-13 | 2012-10-18 | Gilead Sciences, Inc. | 1'-substituted pyrimidine n-nucleoside analogs for antiviral treatment |
CA2860234A1 (en) * | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
EA027929B1 (ru) | 2012-05-25 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Нуклеозиды на основе урацила и спирооксетана |
BR112015020472B1 (pt) * | 2013-03-08 | 2021-01-19 | Nanjing Sanhome Pharmaceutical Co., Ltd. | composto de fosforamidato de nucleosídeo, composição farmacêutica e uso do mesmo |
BR112015025716A2 (pt) | 2013-04-12 | 2017-07-18 | Achillion Pharmaceuticals Inc | pró-fármacos de nucleosídeo submetidos a deutério úteis para o tratamento de hcv |
WO2014194826A1 (zh) * | 2013-06-06 | 2014-12-11 | 南京圣和药业有限公司 | 三环稠杂环类核苷氨基磷酸酯化合物、其制备方法及应用 |
US20170165287A1 (en) * | 2013-11-28 | 2017-06-15 | Janssen Sciences Ireland Uc | Crystal form of a nucleoside inhibitor of hcv |
UA124966C2 (uk) | 2015-03-06 | 2021-12-22 | Атеа Фармасеутікалс, Інк. | <font face="Symbol">b</font>-D-2'-ДЕЗОКСИ-2'-<font face="Symbol">a</font>-ФТОР-2'-<font face="Symbol">b</font>-C-ЗАМІЩЕНІ-2-МОДИФІКОВАНІ-N<sup>6</sup>-ЗАМІЩЕНІ ПУРИНОВІ НУКЛЕОТИДИ ДЛЯ ЛІКУВАННЯ ВИКЛИКАНИХ HCV ЗАХВОРЮВАНЬ |
LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
EP3865136A1 (en) | 2016-09-07 | 2021-08-18 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for corona virus treatment |
KR20230151050A (ko) | 2017-02-01 | 2023-10-31 | 아테아 파마슈티컬즈, 인크. | C형 간염 바이러스를 치료하기 위한 뉴클레오티드 헤미-술페이트 염 |
TW202012001A (zh) | 2018-04-10 | 2020-04-01 | 美商亞堤製藥公司 | C型肝炎病毒(hcv)感染硬化之患者的治療 |
US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
CN115443138A (zh) * | 2020-04-14 | 2022-12-06 | 杨森制药公司 | 用于治疗戊型肝炎的螺环核苷类似物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057287A2 (en) * | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
US20070265222A1 (en) * | 2004-06-24 | 2007-11-15 | Maccoss Malcolm | Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection |
CA2618335C (en) * | 2005-08-15 | 2015-03-31 | F.Hoffmann-La Roche Ag | Antiviral phosphoramidates of 4'-substituted pronucleotides |
AU2007215114A1 (en) * | 2006-02-14 | 2007-08-23 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
PA8852101A1 (es) * | 2008-12-08 | 2010-07-27 | Medivir Ab | Nucleótidos uracil ciclopropílicos |
JO3027B1 (ar) * | 2009-05-14 | 2016-09-05 | Janssen Products Lp | نيوكليوسيدات يوراسيل سبيرواوكسيتان |
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2010
- 2010-05-04 JO JOP/2010/0138A patent/JO3027B1/ar active
- 2010-05-11 PT PT107182073T patent/PT2430035E/pt unknown
- 2010-05-11 KR KR1020117029826A patent/KR101806837B1/ko active IP Right Grant
- 2010-05-11 DK DK10718207.3T patent/DK2430035T3/da active
- 2010-05-11 WO PCT/EP2010/056438 patent/WO2010130726A1/en active Application Filing
- 2010-05-11 BR BRPI1010579A patent/BRPI1010579A2/pt active Search and Examination
- 2010-05-11 PT PT121764021T patent/PT2511282E/pt unknown
- 2010-05-11 US US13/319,735 patent/US8481510B2/en active Active
- 2010-05-11 CN CN201080021188.8A patent/CN102439024B/zh active Active
- 2010-05-11 SI SI201030667T patent/SI2511282T1/sl unknown
- 2010-05-11 SG SG2011082757A patent/SG175981A1/en unknown
- 2010-05-11 CA CA2760329A patent/CA2760329C/en active Active
- 2010-05-11 MX MX2011012027A patent/MX2011012027A/es active IP Right Grant
- 2010-05-11 AU AU2010247439A patent/AU2010247439B2/en not_active Ceased
- 2010-05-11 AP AP2011005958A patent/AP2783A/xx active
- 2010-05-11 SI SI201030246T patent/SI2430035T1/sl unknown
- 2010-05-11 ME MEP-2013-47A patent/ME01478B/me unknown
- 2010-05-11 PL PL12176402T patent/PL2511282T3/pl unknown
- 2010-05-11 EA EA201171406A patent/EA022084B1/ru not_active IP Right Cessation
- 2010-05-11 RS RS20130213A patent/RS52822B/en unknown
- 2010-05-11 DK DK12176402.1T patent/DK2511282T3/da active
- 2010-05-11 ES ES10718207T patent/ES2411086T3/es active Active
- 2010-05-11 ES ES12176402.1T patent/ES2477598T3/es active Active
- 2010-05-11 NZ NZ596073A patent/NZ596073A/xx not_active IP Right Cessation
- 2010-05-11 EP EP12176402.1A patent/EP2511282B1/en active Active
- 2010-05-11 PL PL10718207T patent/PL2430035T3/pl unknown
- 2010-05-11 JP JP2012510269A patent/JP5778135B2/ja not_active Expired - Fee Related
- 2010-05-11 EP EP10718207A patent/EP2430035B1/en active Active
- 2010-05-11 MY MYPI2011005445A patent/MY157018A/en unknown
- 2010-05-12 TW TW099115051A patent/TWI461432B/zh not_active IP Right Cessation
- 2010-05-13 AR ARP100101670A patent/AR076579A1/es unknown
- 2010-05-14 UY UY0001032642A patent/UY32642A/es unknown
- 2010-11-05 UA UAA201112920A patent/UA105790C2/uk unknown
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2011
- 2011-10-26 IL IL215955A patent/IL215955A/en not_active IP Right Cessation
- 2011-10-27 CO CO11145588A patent/CO6440533A2/es not_active Application Discontinuation
- 2011-11-11 NI NI201100197A patent/NI201100197A/es unknown
- 2011-11-11 ZA ZA2011/08309A patent/ZA201108309B/en unknown
- 2011-11-14 EC EC2011011461A patent/ECSP11011461A/es unknown
- 2011-11-14 HN HN2011003014A patent/HN2011003014A/es unknown
- 2011-11-14 CL CL2011002859A patent/CL2011002859A1/es unknown
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2012
- 2012-05-30 CR CR20120297A patent/CR20120297A/es unknown
- 2012-07-18 HK HK12107046.5A patent/HK1166326A1/xx unknown
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2013
- 2013-03-15 US US13/836,465 patent/US8933052B2/en active Active
- 2013-05-22 CY CY20131100408T patent/CY1114081T1/el unknown
- 2013-06-18 HR HRP20130554AT patent/HRP20130554T1/hr unknown
- 2013-07-04 SM SM201300078T patent/SMT201300078B/xx unknown
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2014
- 2014-06-26 HR HRP20140605AT patent/HRP20140605T1/hr unknown
- 2014-06-30 SM SM201400085T patent/SMT201400085B/xx unknown
- 2014-07-01 CY CY20141100491T patent/CY1115383T1/el unknown
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2015
- 2015-07-06 JP JP2015135001A patent/JP2015180692A/ja not_active Withdrawn
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