SK99997A3 - Improved synthesis of cyclopropylacetylene - Google Patents
Improved synthesis of cyclopropylacetylene Download PDFInfo
- Publication number
- SK99997A3 SK99997A3 SK999-97A SK99997A SK99997A3 SK 99997 A3 SK99997 A3 SK 99997A3 SK 99997 A SK99997 A SK 99997A SK 99997 A3 SK99997 A3 SK 99997A3
- Authority
- SK
- Slovakia
- Prior art keywords
- temperature
- reaction mixture
- butyllithium
- cyclopropylacetylene
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
- C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
- C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
- C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/376,611 US5663467A (en) | 1995-01-23 | 1995-01-23 | Synthesis of cyclopropylacetylene |
| PCT/US1996/000628 WO1996022955A1 (en) | 1995-01-23 | 1996-01-19 | Improved synthesis of cyclopropylacetylene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK99997A3 true SK99997A3 (en) | 1998-05-06 |
Family
ID=23485719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK999-97A SK99997A3 (en) | 1995-01-23 | 1996-01-19 | Improved synthesis of cyclopropylacetylene |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5663467A (da) |
| EP (1) | EP0805790B1 (da) |
| JP (1) | JP3107829B2 (da) |
| KR (1) | KR19980701577A (da) |
| CN (1) | CN1056824C (da) |
| AR (1) | AR000771A1 (da) |
| AT (1) | ATE186903T1 (da) |
| AU (1) | AU692674B2 (da) |
| BR (1) | BR9606782A (da) |
| CA (1) | CA2210577A1 (da) |
| CZ (1) | CZ234997A3 (da) |
| DE (1) | DE69605282T2 (da) |
| DK (1) | DK0805790T3 (da) |
| EA (1) | EA000074B1 (da) |
| ES (1) | ES2140062T3 (da) |
| FI (1) | FI973086A (da) |
| GR (1) | GR3032200T3 (da) |
| HR (1) | HRP960029B1 (da) |
| HU (1) | HUP9800849A3 (da) |
| NZ (1) | NZ301206A (da) |
| SK (1) | SK99997A3 (da) |
| WO (1) | WO1996022955A1 (da) |
| YU (1) | YU3696A (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998004535A1 (en) * | 1996-07-26 | 1998-02-05 | Du Pont Pharmaceuticals Company | A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors |
| US5955627A (en) * | 1996-12-16 | 1999-09-21 | Kuraray Co., Ltd. | Process for the preparation of cyclopropylacetylene derivatives |
| ZA9711256B (en) | 1996-12-16 | 1999-06-15 | Du Pont Merck Pharma | Asymmetric synthesis of benzoxazinones |
| AU5521498A (en) * | 1996-12-16 | 1998-07-15 | Du Pont Pharmaceuticals Company | An improved synthesis of cyclopropylacetylene |
| US5932726A (en) * | 1996-12-16 | 1999-08-03 | Dupont Pharmaceuticals Company | Asymmetric synthesis of benzoxazinones |
| US5965729A (en) | 1997-02-05 | 1999-10-12 | Merck & Co., Inc. | Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent |
| PL197740B1 (pl) * | 1997-02-05 | 2008-04-30 | Merck & Co Inc | Postać krystaliczna I (-)-6-chloro-4-cyklopropyloetynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu i sposób krystalizacji postaci I (-)-6-chloro-4-cyklopropylo-etynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu |
| EP0973708A1 (de) | 1997-03-07 | 2000-01-26 | Basf Aktiengesellschaft | Verbessertes verfahren zur herstellung von cyclopropylacetylen |
| CA2285000A1 (en) * | 1997-04-07 | 1998-10-15 | Dupont Pharmaceuticals Company | Asymmetric synthesis of benzoxazinones via new intermediates |
| AR011731A1 (es) * | 1997-05-16 | 2000-08-30 | Merck & Co Inc | Un proceso de reaccion de adicion enantioselectiva eficiente utilizando un reactivo de organozinc. |
| KR20010022443A (ko) | 1997-07-31 | 2001-03-15 | 블레어 큐. 퍼거슨 | 시클로프로필아세틸렌의 제조 방법 |
| US6072094A (en) * | 1997-08-06 | 2000-06-06 | Merck & Co., Inc. | Efficient synthesis of cyclopropylacetylene |
| WO1999007657A1 (en) * | 1997-08-06 | 1999-02-18 | Merck & Co., Inc. | Efficient synthesis of cyclopropylacetylene |
| EP0922686B1 (de) * | 1997-12-10 | 2002-02-06 | Lonza A.G. | Verfahren zur Herstellung von Ethinylcyclopropan |
| KR100350752B1 (ko) * | 1998-02-06 | 2002-08-28 | 가부시키가이샤 구라레 | 시클로프로필아세틸렌 유도체의 제조방법 |
| US5952537A (en) | 1998-03-13 | 1999-09-14 | Wiley Organics, Inc. | Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium |
| UA72207C2 (uk) | 1998-04-07 | 2005-02-15 | Брістол- Майєрс Сквібб Фарма Компані | Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення |
| US20010014352A1 (en) | 1998-05-27 | 2001-08-16 | Udit Batra | Compressed tablet formulation |
| US6235957B1 (en) | 1998-06-29 | 2001-05-22 | Dupont Pharmaceuticals Company | Process for the preparation of cyclopropylacetylene |
| WO2000018706A1 (en) | 1998-10-01 | 2000-04-06 | Du Pont Pharmaceuticals Company | Process for the preparation of cyclopropylacetylene |
| US6288297B1 (en) | 1998-10-01 | 2001-09-11 | Dupont Pharmaceuticals Company | Process for the preparation of cyclopropylacetylene |
| GB2355724A (en) * | 1999-10-28 | 2001-05-02 | Merck & Co Inc | Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid) |
| GB2355988A (en) | 1999-10-28 | 2001-05-09 | Merck & Co Inc | Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate |
| US8080655B2 (en) * | 2009-07-20 | 2011-12-20 | Apotex Pharmachem Inc. | Methods of making efavirenz and intermediates thereof |
| EP2471783A1 (en) | 2010-12-23 | 2012-07-04 | Esteve Química, S.A. | Novel polymorphic form of efavirenz |
| CN103254087B (zh) * | 2013-06-07 | 2015-03-18 | 郑州大学 | 依非韦伦中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU578293A1 (ru) * | 1972-02-04 | 1977-10-30 | Институт Органической Химии Имени Н.Д.Зелинского Ан Ссср | Способ получени циклопропилацетилена |
| SU555079A1 (ru) * | 1976-01-30 | 1977-04-25 | Институт органической химии им.Н.Д.Зелинского АН СССР | Способ получени циклопропилацетилена |
| SU572445A1 (ru) * | 1976-04-05 | 1977-09-15 | Институт Органической Химии Имени Н.Д. Зелинского Ан Ссср | Способ получени циклопропилацетилена |
-
1995
- 1995-01-23 US US08/376,611 patent/US5663467A/en not_active Expired - Fee Related
-
1996
- 1996-01-19 JP JP08522919A patent/JP3107829B2/ja not_active Expired - Fee Related
- 1996-01-19 KR KR1019970704969A patent/KR19980701577A/ko active IP Right Grant
- 1996-01-19 WO PCT/US1996/000628 patent/WO1996022955A1/en active IP Right Grant
- 1996-01-19 DE DE69605282T patent/DE69605282T2/de not_active Expired - Fee Related
- 1996-01-19 CZ CZ972349A patent/CZ234997A3/cs unknown
- 1996-01-19 SK SK999-97A patent/SK99997A3/sk unknown
- 1996-01-19 CN CN96191577A patent/CN1056824C/zh not_active Expired - Fee Related
- 1996-01-19 EA EA199700139A patent/EA000074B1/ru not_active IP Right Cessation
- 1996-01-19 AU AU46574/96A patent/AU692674B2/en not_active Ceased
- 1996-01-19 CA CA002210577A patent/CA2210577A1/en not_active Abandoned
- 1996-01-19 HU HU9800849A patent/HUP9800849A3/hu unknown
- 1996-01-19 AT AT96902153T patent/ATE186903T1/de not_active IP Right Cessation
- 1996-01-19 ES ES96902153T patent/ES2140062T3/es not_active Expired - Lifetime
- 1996-01-19 EP EP96902153A patent/EP0805790B1/en not_active Expired - Lifetime
- 1996-01-19 NZ NZ301206A patent/NZ301206A/en unknown
- 1996-01-19 BR BR9606782A patent/BR9606782A/pt not_active Application Discontinuation
- 1996-01-19 DK DK96902153T patent/DK0805790T3/da active
- 1996-01-22 AR ARP960101100A patent/AR000771A1/es unknown
- 1996-01-22 YU YU3696A patent/YU3696A/sh unknown
- 1996-01-22 HR HR960029A patent/HRP960029B1/xx not_active IP Right Cessation
-
1997
- 1997-07-22 FI FI973086A patent/FI973086A/fi unknown
-
1999
- 1999-12-21 GR GR990403286T patent/GR3032200T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10512880A (ja) | 1998-12-08 |
| CN1169137A (zh) | 1997-12-31 |
| JP3107829B2 (ja) | 2000-11-13 |
| ES2140062T3 (es) | 2000-02-16 |
| EA199700139A1 (ru) | 1997-12-30 |
| FI973086A0 (fi) | 1997-07-22 |
| WO1996022955A1 (en) | 1996-08-01 |
| EP0805790A1 (en) | 1997-11-12 |
| KR19980701577A (ko) | 1998-05-15 |
| FI973086A (fi) | 1997-07-22 |
| MX9705562A (es) | 1997-10-31 |
| BR9606782A (pt) | 1997-12-30 |
| AR000771A1 (es) | 1997-08-06 |
| DE69605282D1 (en) | 1999-12-30 |
| AU692674B2 (en) | 1998-06-11 |
| HRP960029A2 (en) | 1997-08-31 |
| US5663467A (en) | 1997-09-02 |
| HRP960029B1 (en) | 2000-12-31 |
| AU4657496A (en) | 1996-08-14 |
| HUP9800849A3 (en) | 2001-01-29 |
| YU3696A (sh) | 1998-11-05 |
| EP0805790B1 (en) | 1999-11-24 |
| DK0805790T3 (da) | 2000-05-01 |
| ATE186903T1 (de) | 1999-12-15 |
| DE69605282T2 (de) | 2000-07-13 |
| GR3032200T3 (en) | 2000-04-27 |
| CA2210577A1 (en) | 1996-08-01 |
| NZ301206A (en) | 1998-11-25 |
| HUP9800849A2 (hu) | 1999-01-28 |
| CZ234997A3 (cs) | 1998-02-18 |
| CN1056824C (zh) | 2000-09-27 |
| EA000074B1 (ru) | 1998-06-25 |
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