MX9705562A - Sintesis mejorada de ciclopropilacetileno. - Google Patents

Sintesis mejorada de ciclopropilacetileno.

Info

Publication number
MX9705562A
MX9705562A MX9705562A MX9705562A MX9705562A MX 9705562 A MX9705562 A MX 9705562A MX 9705562 A MX9705562 A MX 9705562A MX 9705562 A MX9705562 A MX 9705562A MX 9705562 A MX9705562 A MX 9705562A
Authority
MX
Mexico
Prior art keywords
cyclopropylacetylene
improved synthesis
temperature
pentyne
quenched
Prior art date
Application number
MX9705562A
Other languages
English (en)
Other versions
MXPA97005562A (es
Inventor
Andrew S Thompson
Edward G Corley
Martha Huntington
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX9705562A publication Critical patent/MX9705562A/es
Publication of MXPA97005562A publication Critical patent/MXPA97005562A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se prepara ciclopropilacetileno mezclando una base fuerte y 5-halo-1-pentino en un solvente aprotico; la temperatura se deje aumentar de 0 a 150 degree C y esta temperatura se mantiene por lo menos durante 15 minutos; después, la mezcla de reaccion se extingue con una fuente de protones.
MXPA/A/1997/005562A 1995-01-23 1996-01-19 Sintesis mejorada de ciclopropilacetileno MXPA97005562A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08376611 1995-01-23
US08/376,611 US5663467A (en) 1995-01-23 1995-01-23 Synthesis of cyclopropylacetylene
PCT/US1996/000628 WO1996022955A1 (en) 1995-01-23 1996-01-19 Improved synthesis of cyclopropylacetylene

Publications (2)

Publication Number Publication Date
MX9705562A true MX9705562A (es) 1997-10-31
MXPA97005562A MXPA97005562A (es) 1998-07-03

Family

ID=

Also Published As

Publication number Publication date
HUP9800849A2 (hu) 1999-01-28
FI973086A (fi) 1997-07-22
CZ234997A3 (cs) 1998-02-18
EA199700139A1 (ru) 1997-12-30
WO1996022955A1 (en) 1996-08-01
GR3032200T3 (en) 2000-04-27
CA2210577A1 (en) 1996-08-01
YU3696A (sh) 1998-11-05
JPH10512880A (ja) 1998-12-08
ES2140062T3 (es) 2000-02-16
CN1169137A (zh) 1997-12-31
DK0805790T3 (da) 2000-05-01
AU4657496A (en) 1996-08-14
NZ301206A (en) 1998-11-25
CN1056824C (zh) 2000-09-27
FI973086A0 (fi) 1997-07-22
JP3107829B2 (ja) 2000-11-13
DE69605282T2 (de) 2000-07-13
ATE186903T1 (de) 1999-12-15
KR19980701577A (ko) 1998-05-15
HUP9800849A3 (en) 2001-01-29
SK99997A3 (en) 1998-05-06
EA000074B1 (ru) 1998-06-25
HRP960029A2 (en) 1997-08-31
BR9606782A (pt) 1997-12-30
AR000771A1 (es) 1997-08-06
AU692674B2 (en) 1998-06-11
EP0805790A1 (en) 1997-11-12
DE69605282D1 (en) 1999-12-30
US5663467A (en) 1997-09-02
EP0805790B1 (en) 1999-11-24
HRP960029B1 (en) 2000-12-31

Similar Documents

Publication Publication Date Title
EA199700139A1 (ru) Усовершенствованный синтез циклопропилацетилена
JPS51138704A (en) Method and apparatus for producing synthetic fuel from solid waste
DE69627381D1 (de) Vefahren zur herstellung von erythrmycinderivate
CA2182521A1 (en) Method for Reproducing in Vitro the Proteolytic Activity of the NS3 Protease of Hepatitis C Virus (HCV)
HUT54119A (en) Process for producing antiinflammatory aminophenol derivatives
MY111493A (en) Method for preparing copper-containing hydrogenation reaction catalyst and method for producing alcohol.
DE69213227D1 (de) Herstellung von zementmörteltrockenmischung
EP0252431A3 (en) Process for the preparation of n-fluorsulfon amides
AU5267386A (en) Process for preparing vinyl-tri-(tertiary-substituted) alkoxysilanes
DK0508352T3 (da) Fremgangsmåde til fremstilling af 2-azabicyclo(2.2.1)hept-5-en-3-on
CA2112918A1 (en) Process for the Preparation of Aluminoxanes
CA2009400A1 (en) Cold setting reaction resin mixture and use thereof
BR8600260A (pt) Processo para a preparacao de triacetoxissilanas a partir de tris(amino)silanas
NO871573L (no) Fremgangsmaate for fremstilling av peptider.
AU544962B2 (en) Synthesis of prostaglandin analogues
ATE231104T1 (de) Verfahren zur herstellung von gasförmigem wasserstoffbromid und vorrichtung zu dessen durchführung
MY121092A (en) Preparation of tetrahydrofuran
JPS5653627A (en) Hydroxylation of short chain fatty mono and diolefin
PT97742A (pt) Processo para efectuar a combustao de um combustivel aquoso num motor de combustao interna
MY125164A (en) Method for purifying hexamethylenediamine in mixtures of hexamethylenediamine and an unsaturated cyclic imine
AU2657188A (en) Improved process for synthesis of 5 alpha-cholest-8 (14)-en-3 beta-ol-15-one and other 15-oxygenated sterols
JPS56147799A (en) Transition of vinylsteroid
JPS53119832A (en) Preparation of p-phenylenediamine
JPS5346901A (en) Preparation of carbon monoxide for synthetic raw material use
SU1203855A1 (ru) Способ получения метилового эфира n-(2-амино-5-бром-бензгидрил)-глицина

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees