HRP960029B1 - Improved synthesis of cyclopropylacetylene - Google Patents

Improved synthesis of cyclopropylacetylene

Info

Publication number
HRP960029B1
HRP960029B1 HR960029A HRP960029A HRP960029B1 HR P960029 B1 HRP960029 B1 HR P960029B1 HR 960029 A HR960029 A HR 960029A HR P960029 A HRP960029 A HR P960029A HR P960029 B1 HRP960029 B1 HR P960029B1
Authority
HR
Croatia
Prior art keywords
cyclopropylacetylene
improved synthesis
synthesis
improved
Prior art date
Application number
HR960029A
Other languages
English (en)
Inventor
S Thompson Andrew
G Corley Edward
Huntington Martha
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP960029A2 publication Critical patent/HRP960029A2/hr
Publication of HRP960029B1 publication Critical patent/HRP960029B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/02—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/04—Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C07C1/26—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms
    • C07C1/30—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero-atoms by splitting-off the elements of hydrogen halide from a single molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR960029A 1995-01-23 1996-01-22 Improved synthesis of cyclopropylacetylene HRP960029B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/376,611 US5663467A (en) 1995-01-23 1995-01-23 Synthesis of cyclopropylacetylene

Publications (2)

Publication Number Publication Date
HRP960029A2 HRP960029A2 (en) 1997-08-31
HRP960029B1 true HRP960029B1 (en) 2000-12-31

Family

ID=23485719

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960029A HRP960029B1 (en) 1995-01-23 1996-01-22 Improved synthesis of cyclopropylacetylene

Country Status (23)

Country Link
US (1) US5663467A (da)
EP (1) EP0805790B1 (da)
JP (1) JP3107829B2 (da)
KR (1) KR19980701577A (da)
CN (1) CN1056824C (da)
AR (1) AR000771A1 (da)
AT (1) ATE186903T1 (da)
AU (1) AU692674B2 (da)
BR (1) BR9606782A (da)
CA (1) CA2210577A1 (da)
CZ (1) CZ234997A3 (da)
DE (1) DE69605282T2 (da)
DK (1) DK0805790T3 (da)
EA (1) EA000074B1 (da)
ES (1) ES2140062T3 (da)
FI (1) FI973086A0 (da)
GR (1) GR3032200T3 (da)
HR (1) HRP960029B1 (da)
HU (1) HUP9800849A3 (da)
NZ (1) NZ301206A (da)
SK (1) SK99997A3 (da)
WO (1) WO1996022955A1 (da)
YU (1) YU3696A (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2260922A1 (en) * 1996-07-26 1998-02-05 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
ZA9711256B (en) 1996-12-16 1999-06-15 Du Pont Merck Pharma Asymmetric synthesis of benzoxazinones
US5932726A (en) * 1996-12-16 1999-08-03 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones
AU5521498A (en) * 1996-12-16 1998-07-15 Du Pont Pharmaceuticals Company An improved synthesis of cyclopropylacetylene
US5955627A (en) * 1996-12-16 1999-09-21 Kuraray Co., Ltd. Process for the preparation of cyclopropylacetylene derivatives
US5965729A (en) * 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
EP0975609B1 (en) * 1997-02-05 2010-10-27 Merck Sharp & Dohme Corp. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
CA2283118A1 (en) 1997-03-07 1998-09-17 Basf Aktiengesellschaft Improved process for preparing cyclopropylacetylene
CN1251582A (zh) * 1997-04-07 2000-04-26 杜邦药品公司 经由新中间体不对称合成苯并噁嗪酮类化合物
US6015926A (en) * 1997-05-16 2000-01-18 Merck & Co., Inc. Efficient enantioselective addition reaction using an organozinc reagent
PL338455A1 (en) * 1997-07-31 2000-11-06 Du Pont Pharm Co Metho dof obtaining cyclopropyl acetylene
US6072094A (en) * 1997-08-06 2000-06-06 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
JP2001513518A (ja) * 1997-08-06 2001-09-04 メルク エンド カムパニー インコーポレーテッド シクロプロピルアセチレンの効率的な合成
ES2170990T3 (es) * 1997-12-10 2002-08-16 Lonza Ag Procedimiento para la preparacion de etinil-ciclopropano.
KR100350752B1 (ko) * 1998-02-06 2002-08-28 가부시키가이샤 구라레 시클로프로필아세틸렌 유도체의 제조방법
US5952537A (en) * 1998-03-13 1999-09-14 Wiley Organics, Inc. Preparation of cycloalkylacetylene compounds using dialkylaminomagnesium halide or bis(dialkylamino)magnesium
UA72207C2 (uk) * 1998-04-07 2005-02-15 Брістол- Майєрс Сквібб Фарма Компані Фармацевтична композиція ефавіренцу з добавкою дезінтегруючих агентів у вигляді швидкорозчинних капсул або таблеток та спосіб її виготовлення
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
WO2000018706A1 (en) 1998-10-01 2000-04-06 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
GB2355724A (en) * 1999-10-28 2001-05-02 Merck & Co Inc Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid)
GB2355988A (en) 1999-10-28 2001-05-09 Merck & Co Inc Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
US8080655B2 (en) * 2009-07-20 2011-12-20 Apotex Pharmachem Inc. Methods of making efavirenz and intermediates thereof
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN103254087B (zh) * 2013-06-07 2015-03-18 郑州大学 依非韦伦中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU578293A1 (ru) * 1972-02-04 1977-10-30 Институт Органической Химии Имени Н.Д.Зелинского Ан Ссср Способ получени циклопропилацетилена
SU555079A1 (ru) * 1976-01-30 1977-04-25 Институт органической химии им.Н.Д.Зелинского АН СССР Способ получени циклопропилацетилена
SU572445A1 (ru) * 1976-04-05 1977-09-15 Институт Органической Химии Имени Н.Д. Зелинского Ан Ссср Способ получени циклопропилацетилена

Also Published As

Publication number Publication date
EP0805790B1 (en) 1999-11-24
BR9606782A (pt) 1997-12-30
ATE186903T1 (de) 1999-12-15
HUP9800849A3 (en) 2001-01-29
DK0805790T3 (da) 2000-05-01
KR19980701577A (ko) 1998-05-15
HUP9800849A2 (hu) 1999-01-28
DE69605282T2 (de) 2000-07-13
CN1056824C (zh) 2000-09-27
SK99997A3 (en) 1998-05-06
AU4657496A (en) 1996-08-14
FI973086A (fi) 1997-07-22
ES2140062T3 (es) 2000-02-16
US5663467A (en) 1997-09-02
HRP960029A2 (en) 1997-08-31
NZ301206A (en) 1998-11-25
JP3107829B2 (ja) 2000-11-13
AR000771A1 (es) 1997-08-06
CZ234997A3 (cs) 1998-02-18
MX9705562A (es) 1997-10-31
YU3696A (sh) 1998-11-05
WO1996022955A1 (en) 1996-08-01
GR3032200T3 (en) 2000-04-27
CN1169137A (zh) 1997-12-31
EA000074B1 (ru) 1998-06-25
JPH10512880A (ja) 1998-12-08
DE69605282D1 (en) 1999-12-30
AU692674B2 (en) 1998-06-11
EA199700139A1 (ru) 1997-12-30
EP0805790A1 (en) 1997-11-12
FI973086A0 (fi) 1997-07-22
CA2210577A1 (en) 1996-08-01

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Legal Events

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Payment date: 20010122

Year of fee payment: 6

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Effective date: 20020123