SK7702001A3 - Thiourea inhibitors of herpes viruses - Google Patents

Thiourea inhibitors of herpes viruses Download PDF

Info

Publication number
SK7702001A3
SK7702001A3 SK770-2001A SK7702001A SK7702001A3 SK 7702001 A3 SK7702001 A3 SK 7702001A3 SK 7702001 A SK7702001 A SK 7702001A SK 7702001 A3 SK7702001 A3 SK 7702001A3
Authority
SK
Slovakia
Prior art keywords
phenyl
carbon atoms
thioureido
chloro
ethyl
Prior art date
Application number
SK770-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Jonathan David Bloom
Kevin Joseph Curran
Martin Joseph Digrandi
Russell George Dushin
Stanley Albert Lang
Emily Boucher Norton
Adma Antonia Ross
Bryan Mark O'hara
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of SK7702001A3 publication Critical patent/SK7702001A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
SK770-2001A 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses SK7702001A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20856198A 1998-12-09 1998-12-09
PCT/US1999/028837 WO2000034238A1 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses

Publications (1)

Publication Number Publication Date
SK7702001A3 true SK7702001A3 (en) 2002-04-04

Family

ID=22775050

Family Applications (1)

Application Number Title Priority Date Filing Date
SK770-2001A SK7702001A3 (en) 1998-12-09 1999-12-06 Thiourea inhibitors of herpes viruses

Country Status (26)

Country Link
EP (1) EP1137632B1 (cs)
JP (1) JP2002531545A (cs)
KR (1) KR20010089559A (cs)
CN (1) CN1332725A (cs)
AR (1) AR033789A1 (cs)
AT (1) ATE272052T1 (cs)
AU (1) AU1934500A (cs)
BG (1) BG105583A (cs)
BR (1) BR9916086A (cs)
CA (1) CA2351403A1 (cs)
CZ (1) CZ20011957A3 (cs)
DE (1) DE69919023T2 (cs)
DK (1) DK1137632T3 (cs)
EA (1) EA200100634A1 (cs)
ES (1) ES2224733T3 (cs)
HU (1) HUP0104763A3 (cs)
ID (1) ID30287A (cs)
IL (1) IL143262A0 (cs)
NO (1) NO20012838L (cs)
NZ (1) NZ512108A (cs)
PL (1) PL348178A1 (cs)
PT (1) PT1137632E (cs)
SK (1) SK7702001A3 (cs)
TR (1) TR200101597T2 (cs)
WO (1) WO2000034238A1 (cs)
ZA (1) ZA200104144B (cs)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844367B1 (en) 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
ATE311366T1 (de) 2000-02-29 2005-12-15 Millennium Pharm Inc Benzamide und ähnliche inhibitoren vom faktor xa
DE10217518A1 (de) * 2002-04-19 2003-11-06 Bayer Ag Lactone
DE10222024A1 (de) * 2002-05-17 2003-11-27 Bayer Ag Lactame
DE10257786A1 (de) * 2002-12-11 2004-07-01 Bayer Healthcare Ag Oxazolidinone
PT2077995E (pt) 2006-11-02 2012-05-10 Millennium Pharm Inc Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
JP2014517847A (ja) * 2011-05-24 2014-07-24 ザ ウィスター インスティテュート エプスタイン・バー核抗原１の活性を調節する組成物および方法
WO2014070979A1 (en) * 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
WO2014070978A1 (en) * 2012-11-03 2014-05-08 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof
JP2024534270A (ja) * 2021-09-07 2024-09-18 上海齊魯制藥研究中心有限公司 ３ＣＬｐｒｏプロテアーゼ阻害剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU210683B (en) * 1990-06-18 1995-06-28 Sandoz Ag Process for producing n-benzyl-n1-(phenyl-alkyl)-thiourea derivatives and pharmaceutical compositions containing the same
JPH11503110A (ja) * 1995-02-17 1999-03-23 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体拮抗剤
GB9519270D0 (en) * 1995-09-21 1995-11-22 Sandoz Pharma Uk Organic compounds
EP0902782A1 (en) * 1996-04-23 1999-03-24 Vertex Pharmaceuticals Incorporated Urea derivatives as inhibitors of impdh enzyme

Also Published As

Publication number Publication date
JP2002531545A (ja) 2002-09-24
EA200100634A1 (ru) 2001-10-22
PL348178A1 (en) 2002-05-06
NZ512108A (en) 2003-09-26
EP1137632A1 (en) 2001-10-04
ES2224733T3 (es) 2005-03-01
BG105583A (en) 2001-12-29
EP1137632B1 (en) 2004-07-28
ATE272052T1 (de) 2004-08-15
ID30287A (id) 2001-11-15
ZA200104144B (en) 2002-08-21
IL143262A0 (en) 2002-04-21
DE69919023D1 (de) 2004-09-02
CN1332725A (zh) 2002-01-23
NO20012838L (no) 2001-08-08
BR9916086A (pt) 2001-09-04
HUP0104763A2 (hu) 2002-04-29
CZ20011957A3 (cs) 2001-10-17
DK1137632T3 (da) 2004-11-01
PT1137632E (pt) 2004-11-30
WO2000034238A1 (en) 2000-06-15
DE69919023T2 (de) 2005-07-28
AU1934500A (en) 2000-06-26
HUP0104763A3 (en) 2005-04-28
AR033789A1 (es) 2004-01-07
TR200101597T2 (tr) 2001-10-22
KR20010089559A (ko) 2001-10-06
CA2351403A1 (en) 2000-06-15
NO20012838D0 (no) 2001-06-08

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