MXPA01005681A - Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group - Google Patents

Abstract

Compounds having formula (I) wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon members, aryl, heteroaryl, halogen,-CN, -NO2, -CO2R6, -COR6, -OR6, -SR6, -SOR6, -SO2R6, -CONR7R8, -NR6N(R7R8), -N(R7R8) or W-Y-(CH2)n-Z provided that at least one of R1-R5 is not hydrogen;or R2 and R3, or R3 and R4, taken together to form a 3 to 7 membered heterocycloalkyl or 3 to 7 membered heteroaryl;R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl;R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together may form a 3 to 7 membered heterocycloalkyl;W is O, NR6, or is absent;Y is -(CO)- or-(CO2)-, or is absent;Z is alkyl of 1 to 4 carbon atoms,-CN, -CO2R6, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -SO2R6, SR6N(R7R8), -N(R7R8) or phenyl;G is aryl or fused bicyclic heteroaryl;X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J;J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl;and n is an integer from 1 to 6;useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and-7, and Kaposi herpesvirus.

Description

TIOUREAS CONTAINING ALPHA-METHYLBENCIL AND THE PHENYLENDIAMINE GROUP AS INHIBITORS OF THE HERPES VIRUS Background of the Invention Eight viruses that are members of the Herpesviridae family have been identified (reviewed in Roizman, B. 1996. Herpesviridae, p 2221-2230, in BN Fields, DM Knipe, and P. Howley (ed.)., Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadephia, PA). Each member of this family is characterized by a enveloped virus containing protein tegument and nucleocapsid, the latter of which hosts the relatively large double-stranded DNA genome of the viruses (eg, about 80-250 kilobases). Members of the alphaherpesvirus subfamily are neurotropic and include herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and varicella zoster virus (VZV). Human betaherpesviruses are cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7). The gammaherpesviruses are lymphotropic and include the Epstein-Barr virus (EBV) and the Kaposi herpesvirus (HHV-8). Each of these herpesviruses is causally related to human disease, including herpes labialis and herpes genitalis (HSV-1) and HSV-2 [Whitley, R. J. 1996. Herpes REF: 129642 Simpléx Viruses, p. 2297-2342. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, PA]; smallpox and chicken shingles (VZV [Arvin, A. 1996. Varicella-Zoster, pp. 2547-2585.In BN Fields, DM Knipe, and PM Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers Philadelphia, PA]); Infectious mononucleosis (EBV [Rickinson, AB and Kieff, E. 1996. Epstein-Barr Virus, pp. 2397-2446.In BN Fields, DM Knipe, and PM Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, PA]); pneumonia and retinitis (HCMV [(Britt, WJ and Alford, CA 1996. Cytomagalovirus, pp. 2493-2523, BN Fields, DM Knipe, and PM Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, PA]), sudden exanthema (HHV-6) [(Pellet, PE and Black, JB 1996. Human Herpesvirus 6, pp. 2586-2608.In BN Fields, DM Knipe, and PM Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, PA] and HHV-7 [Frenkel, N., and Roffman, E. 1996, Human Herpesvirus 7, p 2609-2622.In BN Fields, DM Knipe, and PM Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, PA]), and Kaposi's sarcoma (HHV-8 [Neipel, F., Albrecht, JC and Fleckenstein, B. 1997. Cell-homologous genes in the Kaposi sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? J. Virol 71: 4187-92, 1997].) The HCMV is considered in more detail below.After primary infection, herpes Viruses establish latency within the infected individual and remain there for the rest of their life. The periodic reactivation of the latent virus is clinically relevant. In the case of HSV, the reactivated virus can be transmitted to infants during birth, causing either skin or eye infection, infection of the central nervous system, or disseminated infection (eg, multiple organs or systems). Chicken shingles is the clinical manifestation of VZV reactivation. The treatment of HSV and VZV is generally with antiviral drugs such as acyclovir (Glaxo Wellcome), ganciclovir (Roche) and foscarnet (Asta) which target the viral encoded DNA polymerase. HCMV is a ubiquitous opportunistic pathogen that infects 50-90% of the adult population (Britt, W. J. and Alford, C. A. 1996. Cytomegalovirus, p. 2493-2523. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippicontt-Raven Publishers, Philadelphia, Pa. ). Primary infection with HCMV is usually asymptomatic, although heterophilic reactive mononucleosis has been observed. The virus is horizontally transmitted by sexual contact, breast milk, and saliva.

The intrauterine transmission of HCMV from the pregnant mother to the fetus occurs and is frequently the cause of a series of clinical consequences. The HCMV remains in a latent state within the infected person for the rest of his life. Cell-mediated immunity plays a central role in the control of reactivation from latency. The deteriorated cellular immunity leads to reactivation of latent HCMV in seropositive persons. HCMV disease is associated with deficient or immature cellular immunity. There are 3 main categories of people with HCMV disease (reviewed by Britt and Alford, 1996). (1) In immunocompromised patients (AIDS), HCMV is one of the two most common pathogens that cause clinical disease (the other one is Pneumocystis). The most common manifestation of HCMV in AIDS is retinitis, although infection of other organs including the adrenal glands, the lungs, the gastrointestinal tract, and the central nervous system are also frequently reported. 90% of patients with AIDS have active HCMV infection; 25-40% (approximately 85,000 patients in the United States) have life-threatening or sight-threatening HCMV disease.

HCMV is the cause of death in 10% of people with AIDS. (2) Due to the suppression of the immune system to reduce the risk of rejection to the graft, reactivation or reinfection by HCMV is common among patients with kidney, liver, heart, and allogeneic bone marrow transplants. Pneumonia is the most common HCMV disease in these patients, occurring in up to 70% of these transplant patients. (3) Congenital infection due to HCMV occurs in 1% of all births, approximately 40 K per year. Up to 25% of these infants are symptomatic for HCMV disease between the ages of 0 to 3 years. HCMV disease is progressive, causing mental retardation and neurological abnormalities in children. Recent studies suggest that treatment with anti-HCMV drugs can reduce morbidity in these children. Several antiviral drugs are currently marketed (Bron, DR Snoeck, and L. Lagneaux, 1996. New insights into the pathogenesis and treatment of cytomegalovirus, Exp. Opin Invest. Drugs 5: 337-344; Crumpacker, C. 1996. Ganciclovir, New Eng. J. Med. 335-721-729; Sachs, S. and F. Alrabiah, 1996. Novel herpes treatments: a review, Exp. Opin. Invest. Drugs 5: 169-183). These include: ganciclovir (Roche), a nucleoside analogue with hematopoietic cell toxicity; foscarnet (Astra), a pyrophosphate analog with nephrotoxicity; and cidofovir (Gilead), a nucleoside phosphonate with acute nephrotoxicity. Each of these drugs are directed to the DNA polymerase encoded by the virus, and are typically administered intravenously due to their low bioavailability and, as noted above, are the source of significant toxicity. The ganciclovir-resistant mutants that arise clinically are frequently cross-resistant with cidofovir. Therefore, there is a need for safer (for example less toxic), orally bioavailable antiviral drugs which are directed against novel viral targets. Phenylthioureas are discussed for use in a variety of pharmaceutical applications. Armistead, et al., WO 97/40028 teaches phenylureas and thioureas as inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH) which plays a role in viral replication diseases such as herpes. Widdowson et al. WO 96/25157 teaches the phenylurea and thiourea compounds of the following formula for the treatment of chemokine-mediated diseases, interleukin-8.

Morin, Jr. , and co-workers, U.S. Patent No. 5,593,993 teaches certain phenylthiourea compounds for the treatment of AIDS and the inhibition of HIV replication in related viruses. Therefore, an objective of this invention is to provide the compounds, and pharmaceutically acceptable salts thereof, for inhibiting and / or treating diseases associated with herpes viruses including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus , varicella zoster virus, human herpesvirus 6 and 7, and Kaposi herpesvirus.

Description of the invention In accordance with the present invention, the compounds having the formula are provided: wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 at 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -COR6, -OR6, -SR6, -SOR6, -S02R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3-7 membered heterocycloalkyl or a 3-7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cylcoalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together can forming a 3-7 membered heterocycloalkyl; W is oxygen, NR6, or is absent; And it is - (CO) - or (C02) - or it is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -C02R6, COR6, -C0NR7R8, -OCOR6, -NR6COR7, -OCONR6, -0R6, -SR6, -SOR6, -S02R6, SR6N (R7R8), -N (R7R8) or phenyl; G is aryl optionally substituted with one or more substituents selected from alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -CORβ, -0R6, -SR6, -SOR6, -S02R6, -C0NR7R8, - NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ; or G is a fused bicyclic heteroaryl; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to. 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6, or a pharmaceutically acceptable salt. In some preferred embodiments of the present invention, R1-R5 are independently, alkyl of 1 to 6 carbon atoms, halogen, perhaloalkyl of 1 to 6 carbon atoms, 0R6 or N (R7R8). Preferably, 1 to 3 of R1-R5 is not hydrogen. In still more preferred embodiments of the invention R 4 is halogen, cyano or trifluoromethyl. In some embodiments of the present invention G is substituted. In preferred embodiments of the invention, G is 2-fluorophenyl. In other preferred embodiments of the invention, G is benzofuran, isoquinoline or quinoline. In some embodiments of the present invention X is a bond, alkyl of 1 to 4 carbon atoms or CH (J) where J is alkyl of 1 to 6 carbon atoms. Preferably, when X is alkyl of 1 to 4 carbon atoms, said alkyl is straight chain alkyl. When X is CH (J), J is preferably methyl. Preferred compounds of the present invention are the following compounds, which include the pharmaceutical salts thereof N-. { - [3- (l-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-trifluoromethylbenzamide N- (4-fluoro-phenyl) -4-. { 3- [1- (4-fluoro-phenyl) -ethyl] -thiureido} -benzamide. Isoquinoline-1-carboxylic acid (4- [3- (4-fluoro-phenyl) -eti1] -thioureido.}. Phenyl) -amide, (4- [3- (1-benzofuran- 2-yl-ethyl-) thioureido] -phenyl} -amide of isoquinoline-1-carboxylic acid, (4-. {3- [1- (4-bromo-phenyl) -ethyl] -thioureido}. (1-phenyl) -aminoquin-1-carboxylic acid amide, isoquinoline-1-carboxylic acid (4- ({3- (1- (-cyano-phenyl) -ethyl) -thioureido} -phenyl) -amide Benzofuran-2-carboxylic acid (4- ({3- (1- (-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide, 4- [3- (1-benzofuran- 2-yl-ethyl) -thioureido] -phenyl.} - benzofuran-2-carboxylic acid amide(4- {3- [1- (bromo-phenyl) -ethyl] -thioureido} -phenyl) -amide of benzofuran-2-carboxylic acid, (4-. {3- 3- [l- (4-Cyano-phenyl) -ethyl] -thioureido.} - phenyl) -amide of benzofuran-2-carboxylic acid, (4-. {3- [l- (4-fluoro-phenyl) -ethyl] - isoquinoline-3-carboxylic acid, thioureido, phenyl) -amide,. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -isoquinoline-3-carboxylic acid amide, isoquinoline-3-carboxylic acid (4-. {3- [1- (4-cyano-phenyl) -ethyl] -thioureido,} -phenyl) -amide, ( 4- {3- (1- (4-bromo-phenyl) -ethyl] -thioureido} -phenyl) -amide of isoquinoline-3-carboxylic acid, (4-. {3- [1- ( quinoline-3-carboxylic acid, (4. {3. 3 [l- (4-fluoro-phenyl) -ethyl} -amine] -fluoro-phenyl) -eti] -thioureido. quinoline-4-carboxylic acid thioureido.}. phenyl) -amide, quinolinic acid (4- ({3- (1- (-fluoro-phenyl) -ethyl) -thioureido} -phenyl) -amide -6-carboxylic acid, quinoline-8-carboxylic acid (4- ({3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide, N- (4- {3- [l- (4-Fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -2-trifluoromethyl-1-benzamide, 2-cyano-N- (4-. {3- 3 [l- ( 4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -benzamide, N-. { 4- [3- (3-chloro-4-isobutoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- (3-fluoro-4-methoxy-phenyl) -thioureido] -phenyl} -benzamide, N- (4-. {3- [3-chloro- (2-methoxy-ethoxy) -phenyl] -thiureido}. phenyl) -2-fluoro-benzamide, 2-fluoro-N- . { - [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -benzamide, 2-fluoro-N-. { - [3- (-methoxy-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide, N-f 4- [3- (2-amino-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, N- (4-. {3- [l- (3-chloro-4-methoxy-phenyl) -ethyl] -thiureido}. Phenyl) -2-fluoro-benzamide, N -. { 4- [3- (5-chloro-2-hydroxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, N-β 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- (4-methyl-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide, (S) -N- (4- { 3- [1- (4-bro or -phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide, N- (4) - { 3- [(IR) -l- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide, 2-fluoro-N- (4- { 3- [2-methoxy-4- (2,2,2-trifluoroethoxy) -phenyl] -thioureido.} - phenyl) -benzamide, N-. { 4- [3- (2-amino-5-fluoro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, N- (4-. {3- [1- (4-dimethylsulfamoyl-phenyl) -ethyl] -thiureido}. Phenyl) -2-fluoro-benzamide, 2-fluoro-N - [4- (3- { L- [4- (piperidine-1-sulfonyl) -phenyl] -ethyl] -thioureido) -phenyl] -benzamide, N- (4-. {3- 3- [ 2,4-bis- (2, 2, 2-trifluoro-ethoxy) -phenyl] -thiureido.} - phenyl) -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- ((SS) -1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide, 2-fluoro-N-. { 4- [3- ((IR) -1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide, 2-fluoro-N-. { 4- [3- ((SS) -1-phenyl-ethyl) -thioureido] -phenyl} -benzamide, N- (4- { 3 - [(1R) -l- (-chloro-phenyl) -ethyl] -thioureido.} - phenyl) -2-benzamide, N- (4-. 3- [(1S) -l- (4-chloro-phenyl) -ethyl] -thioureido.] - phenyl) -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- ((IR) -1-phenyl-ethyl) -thioureido] -phenyl} -benzamide, N- (4-. {3- [1- (4-cyano-phenyl) -ethyl] -thiureido.} - phenyl) 2-methoxy-benzamide, N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-methoxy-benzamide, N- (4-. {3- [l- (bromo-phenyl) -ethyl] -thioureido}. Phenyl) -2-methoxy-benzamide, 3-cyano-N- (4- {3- [l- (4-fluoro-phenyl) -ethyl} -thioureido} -phenyl) -benzamide, N- (4-. {3- [l- (-fluoro-phenyl} ) -ethyl] -thioureido.}.-phenyl) -4-trifluoromethyl-1-benzamide, 4-cyano-N- (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} .phenyl) -benzamide, N- (4-. {3- [l- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide, N- (4- {3- 3- [(SS) -1- (4-bromo-phenyl) -ethyl] -thioureido.}.-Phenyl) -4-fluoro-benzamide, N- (4-. {3- [(1S ) -1- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-methoxy-benzamide, N- (4- { 3 - [(lR) -l- (4-bromo) -phenyl) -ethyl] -thiureido.}.-phenyl) -2-methoxy-benzamide, 2-fluoro-N- (4-y [(. {1- [2-fluoro-4- (trifluoromethyl) phenyl]] ethyl.}. amino) carbothioyl] amino.}. phenyl) -benzamide, (4-. {3- [(SS) -l- (4-bromo-phenyl) -ethyl] -thioureido] -phenyl) -isoquinoline-1-carboxylic acid amide(4- {3- [(1S) -1- (-bromo-phenyl) -ethyl] -thioureido} -phenyl) -amide of isoquinoline-3-carboxylic acid, (4- { 3 - [(ÍS) -1- (-chloro-phenyl) -et i 1] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid, (4-. {3- [1- (4 -fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid, and N-. { 4 - [( { [(LS) -l- (-cyanophenyl) -ethyl] -amino.} Carbothioyl) amino] phenyl} -l-phenyl) ethyl] amino} carbothioyl) aminojphenyl} -1-isoquinolinecarboxamide and the pharmaceutical salts thereof. Unless defined otherwise, the terms used herein have the following meanings. "Alkyl" as used herein refers to straight or branched chain lower alkyl of 1 to 6 carbon atoms. Exemplary alkyl groups include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tertbutyl, pentyl and hexyl. Alkenyl, as used herein, refers to straight or branched chain lower alkyl of 2 to 6 carbon atoms, containing at least one carbon-carbon double bond. The alkenyl includes the vinyl groups. Alkynyl, as used herein, refers to straight or branched chain lower alkyl of 2 to 6 carbon atoms containing at least one carbon-carbon triple bond. The alkyl, alkenyl and alkynyl groups of the present invention may be substituted or unsubstituted. Cycloalkyl refers to a saturated mono- or bicyclic ring system of 3 to 10 carbon atoms. Exemplary cycloalkyl groups include cyclopentyl, cyclohexyl and cycloheptyl. The cycloalkyl groups of the present invention may be substituted or unsubstituted. "Heterocycloalkyl" refers to a saturated 3- to 10-membered mono- or bicyclic ring system having 1 to 3 heteroatoms, selected from nitrogen, sulfur and oxygen, including but not limited to aziridinyl, azetidinyl, imidazolidinyl, morpholinyl, thiomorpholinyl, piperazinyl, pyrazolidinyl, piperidinyl, and pyrrolidinyl. The heterocycloalkyl groups of the present invention may be substituted or unsubstituted. Aryl, as used herein, refers to an aromatic mono- or bicyclic ring of 6 to 10 carbon atoms. Exemplary aryl groups include phenyl, naphthyl, and biphenyl. The aryl groups of the present invention may be substituted or unsubstituted. Heteroaryl, as used herein, refers to an aromatic mono- or bicyclic ring of 5 to 10 members having 1 to 3 heteroatoms selected from nitrogen, sulfur or oxygen including, but not limited to, thiazolyl, thiadiazolyl, oxazolyl, furyl, benzothiazolyl, benzotriazolyl, benzodioxyl, indazolyl, and benzofuryl. Preferred heteroaryls include quinolyl, isoquinolyl, naphthalenyl, benzofuranyl, benzothienyl, indolyl, pyridyl, pyrazinyl, thienyl, furyl, pyrrolyl, isoxazolyl, oxazolyl, isothiazolyl, thiazolyl, pyrazolyl, triazolyl, thiadiazolyl, and imidazolyl. The heteroaryl groups of the present invention may be substituted or unsubstituted.

Perhaloalkyl refers to an alkyl group of 1 to 6 carbon atoms in which three or more hydrogens are substituted by halogen. Phenyl, as used herein, refers to a 6-membered aromatic ring. Halogen, as used herein, refers to chlorine, bromine, iodine and fluorine. Unless otherwise limited, the substituents are unsubstituted and can include alkyl of 1 to 6 carbon atoms, cycloalkyl of 1 to 6 carbon atoms, heterocycloalkyl of 1 to 6 members, perhaloalkyl of 1 to 6 carbon atoms. carbon, amino, azido, hydroxyl, alkylamino, dialkylamino, aryl or heteroaryl. The number of carbon atoms refers to the number of carbons in the carbon backbone and does not include the carbon atoms that appear in substituents such as the alkyl or alkoxy substituents. Where the terms are used in combination, the definition for each individual part of the combination applies, unless otherwise defined. For example, alkylcycloalkyl is an alkylcycloalkyl group in which alkyl and cycloalkyl are as previously described.

The pharmaceutically acceptable salts are the acid addition salts which can be formed from a compound of the above general formula and a pharmaceutically acceptable acid such as phosphoric, sulfuric, hydrochloric, hydrobromic, citric, maleic, succinic, fumaric acids. , acetic, lactic, nitric, sulfonic, p-toluenesulfonic, methanesulfonic, and the like. The compounds of this invention contain a chiral center, providing various stereoisomeric forms of the compounds such as racemic mixtures as well as the individual optical isomers. In some preferred embodiments of the present invention, the compounds of the present invention are substantially pure optical isomers. By substantially pure optical isomer it is understood that the composition contains more than 75% of the desired isomer and can include no more than 25% of the unwanted isomer. In the most preferred embodiments, the pure optical isomer is more than 90% of the desired isomer. The individual isomers can be prepared directly or by asymmetric or stereospecific synthesis or by conventional separation of the optical isomers from the racemic mixture. The compounds of the present invention can be prepared by those skilled in the art of organic synthesis using the methods described below, which utilize reagents and readily available starting materials, unless otherwise described. The compounds of the present invention are thus prepared according to the following schemes. The novel compounds of the present invention are prepared according to the following reaction schemes. With reference to methods 31 (2 and 3, above) and 34 (4 and 5, below), the reaction of the appropriately substituted amines 2, wherein the substituents R? ~ R5, and X are as described above, with the appropriately substituted isothiocyanates 3, wherein the substituent G is as described above, either neat or in a suitable solvent such as tetrahydrofuran, acetonitrile, ethyl acetate, dichloromethane, or N, N-dimethylformamide provides the desired thioureas. Similarly, the reaction of the appropriately substituted isothiocyanates 4, wherein the substituents Ri-R5, and X are as described above, with the appropriately substituted anilines 5, wherein the substituent G is as described above, in a convenient solvent such like those listed above, it provides the desired thoureas.

Methods 31 and 34 Alternatively, the appropriately substituted thioureas 1 can be prepared as described by methods 32 and 33 by reacting the anilines 2 and 5, wherein R1-R5, and G are as described above, in the presence of either a molar equivalent of 1,1'-thiocarbonyldiimidazole or 1,1 '-carbonyldiimidazole in an appropriate solvent such as dichloromethane and tetrahydrofuran, or mixtures thereof or one molar equivalent of 1,1'-thiocarbonyl-di (1, 2,) triazole or 1,1 '-carbonyl-di (1, 2, 4) -triazole in an appropriate solvent such as dichloromethane and tetrahydrofuran, or mixtures thereof at room temperature.

Methods 32, 33 In certain cases, the subsequent chemical modification of the final thioureas was required. These methods, Methods 35-39 are summarized below.

The thioureas 1 wherein at least one substituent of R 1 -R 5 is 1-hydroxyethoxy or carboxy-methoxy, G is as defined above and X is equal to a bond, can be prepared from. the corresponding alkyl esters by alkaline hydrolysis with aqueous sodium or potassium hydroxide in a suitable solvent such as methanol, tetrahydrofuran or mixtures thereof, at room temperature, according to methods 35 and 36. Thioureas 1 wherein the unless a substituent of R1-R5 is 1-acyloxyethoxy or methanesulfonoxyethoxy, G is as defined above and X is equal to a bond, they can be prepared from the corresponding 1-hydroxyethoxy derivative by acylation with appropriate acylating agents such as benzoic acid chloride or methanesulfonic acid chloride in the presence of a suitable tertiary amine base such as triethylamine or diisopropylethylamine in a suitable solvent such as dichloromethane or the like at room temperature, according to methods 37 and 38. Thioureas 1 in wherein at least one substituent of R1-R5 is 1-aminoethoxy, G is as defined above and X is equal to a bond, can be prepared from the corresponding 1-methanesulfonoxy-ethoxy derivative by reaction with an appropriate secondary amine such as dimethylamine in a suitable solvent mixture such as tetrahydrofuran and water or the like, at room temperature according to method 39. Thioureas 1 wherein at least one substituent of R1-R5 is 1-aminoalkyl, G is as defined above and X is equal to a bond, can be prepared from the corresponding 1-azidoalkyl derivative by reaction with stannous chloride in a suitable solvent such as methanol, ethanol, or the like at room temperature according to method 40. The isothiocyanates 3 and 4 intermediates shown above in methods 31 and 34 are prepared according to method 41 (below) essentially in accordance with the Staab procedures, HA and Walther, G. Justus Liebigs Ann. Chem. 657, 104 (1962)) by reaction of the appropriately substituted amines 5 or 2, respectively, wherein R1-R5 and G are as described above and X is as defined above, with a molar equivalent of 1.1 '- thiocarbonyldiimidazole in a suitable solvent such as dichloromethane and tetrahydrofuran or mixtures thereof.

Method 41 Intermediates 2 and 5 can be prepared according to the following protocols: According to the methods 1A-1G, the amines 2, wherein R1-R5 are as defined above and X is as defined above, the amines 5 can be be prepared by reduction of appropriately substituted nitrobenzenes according to a variety of procedures known to those skilled in the art and described in RJ Lindsay, Comprehensive Organic Chemistry (ed.

Suthérland), Volume 2, Chapter 6.3.1, Aromatic Amines, 1979. Such procedures include the reduction of nitrobenzenes to form anilines after exposure to: a) iron powder and a strong acid, such as hydrochloric acid (Methods IA ) either pure or in alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; b) iron powder and glacial acetic acid (Method IB), either pure or in alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; c) iron powder and aqueous ammonium chloride (Method IC), either neat or in an alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; d) tin and a strong mineral acid, such as hydrochloric acid (Method ID), either neat or in an alcohol solvent such as methanol or ethanol, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; e) when R1-R5 are selected from chlorine, bromine, iodine, - (OS02) -CF3, or - (0S02) -1 (4-methylphenyl), by catalytic reduction such as with hydrogen and palladium on carbon (Method 1E) in a suitable solvent such as methanol, ethanol, or ethyl acetate, under one or more pressure atmospheres or; f) when R1-R5 and R9-R12 are selected from chlorine, bromine, iodine, - (0S02) -CF3, or - (0S02) -1 (4-methylphenyl), by catalytic reduction such as with cyclohexane and palladium on carbon (Method 1F) in an appropriate solvent such as methanol or ethanol, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; g) aqueous sodium hydrosulfite in alcohol solvent at temperatures ranging from room temperature to the reflux temperature of the solvent (Method 1G). Alternatively, according to Methods 3A-3C, the amines 2, where R1-R5 are as defined above and X is as defined above and the anilines 5, can be prepared by cleavage of the nitrogen bond of the aniline-carbon of the amide and the carbamate derivatives of these anilines, according to a variety of procedures known to those skilled in the art and described in Greene, Protective Groups in Organic Synthesis volume 2, Chapter 7, 1991, and references in this. Such procedures include: a) exposure of the suitably substituted arylamino-tert-butyl carbamates, to a strong acid such as trifluoroacetic acid (Method 3A) either neat or in a suitable solvent such as dichloromethane at temperatures between 0 ° C and the ambient temperature, or; b) exposure of the appropriately substituted arylamino- (2-trimethylsilylethyl) -carbamates to a source of fluoride ions such as tetrabutylammonium fluoride or potassium fluoride (Method 3B) in aqueous acetonitrile or tetrahydrofuran or mixtures thereof, at temperatures in the range from room temperature to the reflux temperature of the solvent, or; c) exposing appropriately substituted arylamino-trifluoroacetamides to a strong base, such as sodium or potassium hydroxide, or sodium or potassium carbonate in an alcohol solvent such as methanol or ethanol (Method 3C) at temperatures in the range from the ambient temperature to the reflux temperature of the solvent. Alternatively, according to Method 11, amines 2, where R1-R5 are as defined above, and X is as defined above, at least one substituent of R1-R5 is defined as vinyl, can be prepared by catalyzed coupling by palladium of a vinyl trialkyltin reagent, such as tributylvinyltin, with an appropriately substituted bromo- or iodo-aniline, for example 3-chloro-4-iodo-aniline, employing a palladium catalyst, such as tris (dibenzyl-idinacetone) -dipaladium , and a ligand, such as triphenylarsine in a suitable solvent, such as tetrahydrofuran or N-methylpyrrolidinone, at temperatures ranging from room temperature to the reflux temperature of the solvent, essentially according to the procedures of V. Fariña and GP Roth in Advances in Metal Organic Chemistry, Vol 5. 1-53, 1996 and references therein. Alternatively, according to method 42, the amines 2, wherein R1-R5 are as defined above and X is as defined above, and at least one substituent of R2 or R4 is defined as dialkylamino, can be prepared by catalyzed amination by palladium of an appropriately substituted 3- or 5-bromo- or iodo-aniline, for example 3-amino-5-bromobenzotrifluoride, by secondary amines under conditions employing a palladium catalyst, such as bis (dibenzyl idinacetone) palladium, and a ligand, such as tri-o-tolylphosphine, and at least two molar equivalents of a strong base, such as lithium bis (trimethylsilyl) amide in a sealed tube, in a suitable solvent such as tetrahydrofuran or toluene, at temperatures in the range from room temperature to 100 ° C essentially according to JF procedures Hartwig and J. Louie Tetrahedron Let ters 36 (21), 3609 (1995). Alternatively, according to Method 43, amines 2, where R1-R5 are as defined above and X is as defined above, and at least one substituent of R2 or R4 is defined as alkyl, can be prepared by catalyzed alkylation by palladium of an appropriately substituted 3- or 5-bromo- or iodo-aniline, for example 3-amino-5-bromobenzotrifluoride by alkenes under conditions employing a palladium catalyst such as the chloride complex [1,1'-bis (diphenylphosphino) ferrocene] palladium (II) -dichloromethane and in the presence of 9-borabicyclo [3.3. l] nonane and a suitable base such as aqueous sodium hydroxide in a suitable solvent such as tetrahydrofuran or the like at temperature in the range of from room temperature to the reflux temperature of the solvent. The acyl- and carbamoyl-amine derivatives used as starting materials in Methods 3A-3C can be prepared by derivatization of the corresponding amines as described in Methods 2A-2G according to a variety of procedures known to those skilled in the art. the technique and described in Greene, Protective Groups in Organic Synthesis volume 2, Chapter 7, 1991, and references therein. Such methods include: a) the reaction of an appropriately substituted amine with di-tert-butyl-dicarbonate (Method 2A) in the presence or absence of one or more molar equivalents of a tertiary amine such as triethylamine or N, N-diisopropylethylamine in a suitable solvent such as acetone, tetrahydrofuran, dimethylformamide, dichloromethane, and the like, at temperatures ranging from room temperature to the reflux temperature of the solvent, to produce the corresponding arylamino-tert-butyl carbamate or; b) the reaction of an aniline suitably substituted with l- [2- (trimethylsilyl) ethoxycarbonyl-oxy] benzotriazole (Method 2B) in the presence of a tertiary amine such as triethylamine or diisopropylethylamine in a suitable solvent such as dimethylformamide at room temperature to produce the corresponding arylamino- (2-trimethylsilyl) -carbamate, or; c) the reaction of an appropriately substituted aniline with a carboxylic acid chloride or acid anhydride (Method 2C) either neat or in an appropriate solvent such as tetrahydrofuran, dimethylformamide, dichloromethane, pyridine and the like, in the presence of one or more equivalents molars of a tertiary amine base such as triethylamine or N, N-diisopropylethylamine to produce the corresponding arylaminoamide, or; d) the reaction of an appropriately substituted nitroaniline with a carboxylic acid chloride (Method 2D) in the absence of one or more molar equivalents of a tertiary amine base such as triethylamine or N, N-diisopropylethylamine, either pure or in a solvent suitable such as tetrahydrofuran, 1,4-dioxane and the like at temperatures in the range from room temperature to the reflux temperature of the solvent, to produce the corresponding nitroarylaminoamide, or; e) the reaction of an appropriately substituted aniline with a carboxylic acid (Method 2E) in the presence of a coupling agent such as benzotriazol-1-yloxy-tris- (dimethylamino) -phosphonium hexafluorophosphate, 2- (lH-benzotriazole hexafluorophosphate -1-yloxy) -1,3,3-tetra-methyluronium, dicyclohexylcarbodiimide and the like, and in the presence of a tertiary amine such as triethylamine or diisopropylethylamine in a suitable solvent such as dichloromethane, dimethylformamide and the like, at room temperature for producing the corresponding arylaminoamide, or; f) the reaction of an appropriately protected aniline such as an arylamino-tert-butyl carbamate or the like in which at least one substituent of R? -R? 2 is defined as -WY- (CH2) nZ wherein W, Y , and Z are as defined above, with a carboxylic acid anhydride (Method 2F) in the presence of a suitable base such as pyridine in an appropriate solvent such as dichloromethane, dimethylformamide or the like, at temperatures in the range of 0 ° C to room temperature, to produce the corresponding carboxylic acid ester, or; g) the reaction of an appropriately substituted aniline in which at least one substituent of R1-R5 is defined as hydroxyl with di-tert-butyl-dicarbonate (Method 2G) is the absence of one or more molar equivalents of a tertiary amine such as triethylamine or N, N-diisopropylethylamine in a suitable solvent such as acetone, tetrahydrofuran, dimethylformamide, dichloromethane, and the like, at temperatures ranging from room temperature to the reflux temperature of the solvent, to produce the arylamino-tert-butyl- corresponding carbamate.

The nitrobenzene intermediates which are ultimately converted to amines 2 and 5 by the methods shown above in Methods 1A-1G, can be prepared according to methods 4A, 4C, 4E-4F. With reference to Methods 4A, 4C and 4E-4H, the nitrobenzene intermediates which are ultimately converted to the amines 2, R2 and R4 are as defined above and Rir 3 and / or R5 are defined as alkoxy, thioalkoxy, alkylsulfenyl , alkylsulfinyl, and dialkylamino, can be prepared by the nucleophilic displacement of nitrobenzenes appropriately substituted with 2-, 4-, and / or 6-fluoro-, chloro-, bromo-, iodo-, trifluoromethylsulfonyl-, or (-methylphenyl) sulfonyl , by methods which include the following: a) the reaction of the alcohols with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Method 4A) either pure or in an appropriate solvent such as tetrahydrofuran, dioxane, acetonitrile, N, N-dimethylformamide or dimethyl sulfoxide in the presence or absence of one or more molar equivalents of a base such as sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide, sodium hydride , potassium hydride, or the like, at temperatures ranging from room temperature to the reflux temperature of the solvent; b) reactions of the preformed sodium, lithium, or potassium phenoxides with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Method 4H) either pure or in an appropriate solvent such as tetrahydrofuran, dioxane , acetonitrile, N, N-dimethylformamide or dimethyl sulfoxide, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; c) the reaction of the ammonia, the primary or secondary amines with the appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Methods 4C, F) either pure or in an appropriate solvent, such as tetrahydrofuran, dioxane, acetonitrile, N, N-dimethylformamide or dimethyl sulfoxide, at temperatures ranging from room temperature to the reflux temperature of the solvent; d) the reaction of the preformed sodium, lithium, or potassium salts of amines with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles (Method 4G) in a suitable solvent such as tetrahydrofuran at temperatures in the range of 0 ° C to the reflux temperature of the solvent, or; e) the reaction of sodium sulphide with appropriately substituted 2- or 4-halo- or sulfonate esters of nitrobenzenes or benzonitriles, either pure or in an appropriate solvent such as tetrahydrofuran, dioxane, acetonitrile, N, N-dimethylformamide or sulfoxide of dimethyl, at temperatures ranging from room temperature to the reflux temperature of the solvent, followed by the addition of an alkyl halide directly to the reaction mixture (Method 4E). Alternatively, with reference to Methods 5C and 6, the nitrobenzene intermediates that are ultimately converted to the amines 2, wherein at least one substituent R1-R5 is defined as alkoxy, can be prepared from the corresponding substituted hydroxynithrobenzenes by methods which include the following: a) the reaction of the hydroxy nitrobenzene with an alkyl halide or dialkyl sulfonate ester (Method 5C) in the presence of a base, such as potassium carbonate, sodium carbonate, potassium hydroxide, hydroxide of sodium, potassium hydride, or sodium hydride, in a suitable solvent such as acetone, N, N-dimethylformamide, tetrahydrofuran or dimethyl sulfoxide, at temperatures ranging from room temperature to the reflux temperature of the solvent, or; b) the reaction of hydroxy nitrobenzene with an alkyl alcohol, triphenylphosphine, and a dialkylazadicarboxylate reagent (Method 6), such as diethylazocarboxylate, in an anhydrous aprotic solvent, such as diethyl ether or tetrahydrofuran at temperatures in the range of 0 ° C to the reflux temperature of the solvent, essentially according to the methods described by Mitsunobu, O. Synthesis 1981, I and references therein . In addition, with reference to Method 5A and 5E, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted. to amines 2, wherein at least one substituent R1-R5 is defined as alkoxy, can be prepared from the corresponding substituted hydroxyarylamino-tert-butyl carbamate by reaction with alkyl halides, trifluoronthanesulfonates, 4-methylbenzenesulfonates, dialkylsulfonate, carbonate of ethylene and the like, in the presence of a suitable base such as potassium carbonate in an appropriate solvent such as acetone, toluene, or N, N-dimethylformamide at temperatures ranging from room temperature to the reflux temperature of the solvent. Alternatively, with reference to Methods 7A-G, the nitrobenzene intermediates are ultimately converted to the amines 2, Ri and / or R3 is alkoxy, and R2 and / or R4 is a halogen, and X is equal to a bond, they can be prepared by standard halogenation reactions which include the following: a) the reaction of a 2- or 4-hydroxynitrobenzene with aqueous sodium hypochlorite (Methods 7A and 7B), at room temperature or; b) the reaction of a 2-hydroxy-4-methoxy- or 2,4-dimethoxynitrobenzene (Method 7C and 7D) with bromine in suitable solvent such as chloroform, dichloromethane, glacial acetic acid or the like in the presence or absence of silver trifluoroacetate at room temperature, or; c) the reaction of a 2-dimethoxynitrobenzene (Method 7E) with benzyltrimethylammonium dichloroiodate in the presence of anhydrous zinc chloride in a suitable solvent such as glacial acetic acid, at room temperature or; d) reacting 2-hydroxy-4-methoxynitrobenzene (Method 7F) with benzyltrimethylammonium dichloroiodate in the presence of sodium bicarbonate in a suitable solvent mixture such as dichloromethane and methanol, at room temperature or; e) the reaction of a 2-dimethoxynitrobenzene (Method 7G) with triflate of 3,5-dichloro-1-fluoropyridine in a suitable solvent such as tetrachloroethane, at a temperature in the range from room temperature to the reflux temperature of the solvent. With reference to Method 8, the nitrobenzene intermediates which are ultimately converted to amines 2, wherein R4 = CF3, and R? -R3 and Rs-R8 are as defined above, and X is equal to a bond, can to be prepared from the corresponding substituted 4-iodo-nitrobenzenes by reaction with trimethyl (trifluoromethyl) silane in the presence of cuprous iodide and potassium fluoride in a suitable solvent such as N, N-dimethylformamide or the like at a temperature in the range of the ambient temperature up to the reflux temperature of the solvent, in a sealed reaction vessel. With reference to Methods 19A and 19B, the nitrobenzene intermediates which are ultimately converted to the amines 2, wherein R4 = -HNC0CH2NR7R8 or -HNC0CH2SR6, and R? -R3 and R5 are as defined above and X is equal to a bond, can be prepared from the corresponding substituted 4- (N-chloroacetyl) -nitroaniline, by reaction with either a suitable secondary amine such as dimethylamine , morpholine, or the like in a suitable solvent such as mixtures of tetrahydrofuran and / or water at temperatures ranging from room temperature to the reflux temperature of the solvent or by reaction with an appropriate thiol in the presence of a suitable base such as carbonate of sodium or potassium or the like, in a suitable solvent such as tetrahydrofuran, 1,4-dioxane or the like at temperatures ranging from room temperature to the reflux temperature of the solvent. With reference to method 25, the nitrobenzene intermediates which are ultimately converted to the amines 2, wherein at least one substituent of R1-R5 is defined as triflate and X is equal to a bond, can be prepared from the corresponding phenol by reaction with trifluoromethanesulfonic anhydride in the presence of a tertiary amine such as triethylamine or diisopropylethylamine or the like, in a suitable solvent such as dichloromethane at temperatures in the range of 0 ° C to room temperature. With reference to Methods 9, 9B and 10, the carbamoylamine derivatives used as starting materials in Methods 3A-3C, which are ultimately converted to the amines 2, wherein at least one substituent R1-R5 is defined either such as alkylsulfenyl or alkylsulfinyl, can be prepared by reacting the corresponding 4-alkylthio-acylarylamino or carbamoylarylamino with an appropriate oxidizing agent such as dimethyloxirane or sodium periodate in a mixture of suitable solvents such as acetone and dichloromethane or water at room temperature. With reference to Method 12, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to the amines 2, wherein R4 is defined as 1-hydroxyethyl and R? ~ R3 and R5 are defined as described above and X is a bond, can be prepared by reacting the corresponding 4-vinylcarbamoylaniline with sodium borohydride in the presence of mercuric acetate in a suitable solvent such as tetrahydrofuran, 1,4-dioxane or the like and water at room temperature. With reference to Method 13, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to the amines 2, wherein R is defined as 2-hydroxyethyl and R? -R3 and R5 are defined as described above, and X is equal to a bond, can be prepared by reacting the corresponding 4-vinylcarbamoylaniline with sodium borohydride in the presence of glacial acetic acid in a suitable solvent such as tetrahydrofuran, 1,4-dioxane or the like, temperatures in the range from 0 ° C to room temperature. With reference to Method 14, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to Xas amines 2, wherein R4 is defined as 1-azidoethyl and R? ~ R3 and R5 are defined as described above, and X is defined as described above, can be prepared by reaction of the corresponding 4- (1-hydroxyethyl) -carbamoylaniline with hydrazoic acid in the presence of a dialkylazodicarboxylate such as diethylazodicarboxylate and triphenylphosphine in a mixture of suitable solvent such such as tetrahydrofuran and dichloromethane at temperatures in the range of 0 ° C to room temperature. With reference to Method 15, the carbamoylamine derivatives used as starting materials in methods 3A-3C which are ultimately converted to amines 2, wherein R 4 is defined as 3-dimethylaminoprop-1-ynyl and R 3 -R 3 and R 5 are as defined above, and X is as defined above, can be prepared by reaction of the corresponding 4-iodocarbamoylaniline with l-dimethylamino-2-propyne in a suitable tertiary amine solvent such as triethylamine or diisopropylethylamine in the presence of chloride of bis (triphenylphosphine) -palladium (II) and cuprous iodide at temperatures in the range from room temperature to the reflux temperature of the solvent. With reference to Method 16, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to the amines 2, wherein R4 is defined as 3-dimethylaminoacryloyl and R1-R3 and R5 are as defined above, and X is equal to a bond, can be prepared by reaction of the corresponding 4- (3-dimethylaminoprop-1-ynyl) carbamoylaniline with a suitable peracid such as 3-chloroperoxybenzoic acid in a suitable solvent mixture such as dichloromethane and methanol at temperatures in the range from 0 ° C to room temperature. With reference to Methods 17 and 18, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to the amines 2, wherein R 4 is defined to be either 4-isoxasol-5-yl or 4 - (lH-pyrazol-3-yl) and R1-R3 and R5 are as defined above and X is equal to a bond, they can be prepared by the reaction of the corresponding 4- (3-dimethylamino-acryloyl) carbamoylaniline either with hydroxylamine hydrochloride or hydrazine hydrate in a suitable solvent such as 1,4-dioxane or ethanol and the like at room temperature. With reference to Method 20, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to the amines 2, wherein R4 = -HNC02Z and R? -R3, R5 and Z are as defined above and X is equal to a bond, can be prepared by reacting the corresponding 4-aminocarbamoylaniline with 1, 1-carbonyl-di- (1, 2, 4) -triazole and an appropriately substituted alcohol in a suitable solvent mixture such such as tetrahydrofuran and dichloromethane and the like at temperatures in the range from room temperature to the reflux temperature of the solvent. With reference to Methods 26 and 30, the carbamoylamine derivatives used as starting materials in Methods 3A-3C which are ultimately converted to the amines, 2, wherein at least one substituent of R1-R5 is defined as dialkylamino and X is as defined above, can be prepared by reacting the appropriately substituted aldehydes in the presence of either sodium cyanoborohydride or hydrogen gas and 10% palladium on carbon in a suitable solvent such as water, methanol, tetrahydrofuran or toluene mixtures or similar, at room temperature.

With reference to Methods 27 and 28, amines 2 wherein at least one substituent of R1-R5 is defined as hydroxyl and X is as defined above, can be prepared by reaction of the corresponding ester such as acetate with an appropriate base such as sodium bicarbonate or sodium hydroxide in a suitable solvent mixture such as methanol-water mixtures at temperatures ranging from room temperature to the reflux temperature of the solvent. With reference to Method 29, the amines 2 wherein at least one substituent of R1-R5 is defined as 2-hydroxybenzamide and X is as defined above, can be prepared by the reaction of the corresponding N- (4-aminophenyl) phthalimide with lithium borohydride in a suitable solvent such as tetrahydrofuran, diethyl ether, or the like at room temperature. Intermediate amines 2 wherein R1-R5 are as defined above and X is equal to either -CH2- or - (CH2) 2- can be prepared by the following procedures: a) reduction of a benzo- or phenylacetonitrile suitably substituted with the borane-dimethylsulfide complex in a suitable solvent such as ethylene glycol dimethyl ether, tetrahydrofuran or the like, at temperatures ranging from room temperature to the reflux temperature of the solvent (Method 44); b) reduction under one or more atmospheres of hydrogen in the presence of a suitable catalyst such as 5% or 10% palladium on carbon and an acid such as 4-methyl-benzenesulfonic acid, hydrochloric acid, or the like in a suitable solvent such as ethylene glycol monomethyl ether, ethyl acetate, ethanol or the like, at room temperature (Method 50); c) reduction with lithium aluminum hydride in a suitable solvent such as tetrahydrofuran or diethyl ether at temperatures in the range of 0 ° C to room temperature (Method 51); The nitrated unsaturated precursors which are used as starting materials in Method 51 and are ultimately converted to amines 2, wherein R1-R5 are as defined above and X is equal to - (CH2) 2- can be prepared by reaction of a benzaldehyde appropriately substituted with nitromethane in the presence of ammonium acetate in a suitable solvent such as acetic acid at temperatures ranging from room temperature to the reflux temperature of the solvent (Method 53); The benzaldehydes, used as starting materials in Method 53, can be prepared by the reduction with diisobutylaluminum hydride of an appropriately substituted benzonitrile (Method 52). Substituted benzonitriles, used as starting materials in Method 52, can be prepared from the corresponding aryl bromide by reaction with copper cyanide in a suitable solvent such as N, N-dimethylformamide at temperatures ranging from room temperature to the reflux temperature of the solvent (Method 59). For the amines 2, wherein R1-R5 is as defined above and X is equal to either -0 (CH2) 2NH2 or -S (CH2) 2NH2, the required nitrile precursors can be prepared by the reaction of a phenol or thiophenol appropriately substituted with bromoacetonitrile in the presence of a suitable base such as potassium carbonate in an appropriate solvent such as acetone at room temperature according to Method 49. Alternatively, for amines 2, wherein R? ~ R5 are as defined above and X is equal to ~ (CH2) 3-, the nitrile precursors can be prepared essentially according to the procedure of Wilk, B. Synthetic Comm. 23, 2481 (1993), by reaction of a phenetanol appropriately substituted with acetone cyanohydrin and triphenylphosphine in the presence of a suitable azodicarboxylate such as diethyl azodicarboxylate in a suitable solvent such as diethyl ether or tetrahydrofuran or the like, at temperatures in the range of 0 ° C to room temperature (Method 54). Alternatively, intermediary amines 2, wherein R1-R5 are as defined above and X is equal to - (CH (CH3)) - can be prepared by acid or base catalyzed hydrolysis of the corresponding formamide using an appropriate acid catalyst such such as 6N hydrochloric acid or a suitable basic catalyst such sodium or potassium hydroxide 5N in an appropriate solvent mixture such as water and methanol or water and ethanol at temperatures ranging from room temperature to the reflux temperature of the solvent ( Method 46). The formamide precursors used as starting materials in Method 46 and which are ultimately converted to amines 2, are prepared according to Method 45 by treatment of an acetophenone appropriately substituted with ammonium formate, formic acid and formamide at temperatures in the range from room temperature to the reflux temperature of the solvent. Alternatively, the amines 2, wherein R1-R5 are as defined above and X is equal to - (CH (CH3)) - can be prepared by reduction of an appropriately substituted O-methyloxime in the presence of sodium borohydride and tetrachloride of zirconium in a suitable solvent such as tetrahydrofuran or diethyl ether at room temperature, Method 48 essentially according to the procedure of Itsuno, S., Sakurai, Y., Ito, K. Synthesis 1988, 995. The required O-methyl oximes may be prepared from the corresponding acetophenone by reaction with methoxylamine hydrochloride and pyridine in a suitable solvent such as ethanol or methanol at temperatures ranging from room temperature to the reflux temperature of the solvent (Method 47). The amines 2 for which R1-R5 are as defined above and X is equal to -CH (J) - where J is as defined above, can be prepared by reducing the appropriately substituted ketone by the methods described above ( Methods 45, 47 and 48). These required ketones, when not commercially available, can be prepared by reacting a suitably substituted benzaldehyde with an appropriate organometallic reagent such as phenyllithium, isopropylmagnesium bromide or ethylmagnesium bromide, or the like, in a suitable solvent such as ether diethyl or tetrahydrofuran at temperatures in the range of -78 ° C to 0 ° C (Method 57). The resulting alcohols can be oxidized to the corresponding ketone with an appropriate oxidizing agent such as chromium trioxide in aqueous sulfuric acid and acetone or pyridinium chlorochromate or pyridinium dichromate in an appropriate solvent such as dichloromethane or the like, at room temperature (Method 58 ). The intermediate anilines 5 can be prepared as previously described in Method 3A. Thus, the terbutyl ester of phenylcarbamic acid 6, G is as described above, with pure trichloroacetic acid at room temperature, followed by neutralization with aqueous sodium hydroxide, provides the desired anilines. The required carbamic acid esters 6, where G is as described above, are prepared as in Method 2C by reaction of the substituted acid chlorides, 8, where G is as described above, and the terbutyl esters of the acid 4 -aminophenylcarbamic acid 7 in the presence of triethylamine in a suitable solvent such as dichloromethane, dimethyl sulfoxide, or dimethylformamide or mixtures thereof. The carboxylic acid chlorides 8 are commercially available or prepared from the corresponding carboxylic acid by reaction with oxalyl chloride in a suitable solvent such as dichloromethane at room temperature.

Method 2C, 3A Alternatively, esters of carbamic acid 6, wherein G is as described above, are prepared as shown in method 2E by reaction of the substituted carboxylic acids 8a, wherein G is as described above, and the terbutyl esters of the 4-aminophenylcarbamic acid 7 appropriately substituted, in the presence of a coupling agent such as benzotriazol-1-yloxy-tris- (dimethylamino) phosphonium hexafluorophosphate, 2- (lH-benzotriazol-1-yloxy) -1, 1 hexafluorophosphate, 3, 3-tetramethyluronium, dicyclohexylcarbodoiimide or the like and in the presence of a tertiary amine base such as triethylamine or diisopropylethylamine in a suitable solvent such as dichloromethane, dimethylformamide and the like, at room temperature, to produce the corresponding arylaminoamide. The carboxylic acids 8a are commercially available or are prepared according to the methods of the literature. For example, when G is a substituted thiadiazole, the acid is available from the corresponding carboxylic acid ester by reaction with an appropriate base such as sodium or potassium hydroxide in a suitable solvent mixture such as methanol or ethanol and water. room temperature. When the carboxylic acid ester precursors which are ultimately converted to the acids 8 are not commercially available, they can be prepared by the methods known in the literature. For example, the esters of 5-substituted-1,2,3-thiadiazole-4-carboxylic acid can be prepared essentially according to the Caron process. M. J. Org. Chem. 51, 4075 (1986) and Taber, D.F., Ruckle R. E. J. Amer. Chem. Soc. 108, 7686 (1986). Thus, according to method 21, the treatment of an ester of beta-ketocarboxylic acid with 4-methylbenzenesulfonyl azide or methanesulfonyl azide or the like, in the presence of a tertiary amine base such as triethylamine or diisopropylethylamine in a suitable solvent such as acetonitrile provides the corresponding diazo-beta-ketocarboxylic acid ester. The treatment of this compound with 2,4-bis (4-methoxyphenyl) -1,3-dithia-2,4-diphosphetan-2,4-disulfide in a suitable solvent such as benzene or toluene or the like at temperatures in the range from room temperature to the reflux temperature of the solvent, gives the desired 5-substituted-1,2,3-thiadiazole-4-carboxylic acid ester. Alternatively, the esters of 4-substituted-1,2,3-thiadiazole-5-carboxylic acid can be prepared essentially according to the procedure of Shafiee, A., Lalezari, I., Yazdani, S., Shahbazian, FM Partovi, TJ Pharmaceutical Sci. 65, 304 (1976). Thus, according to methods 22 and 23, the reaction of an appropriately substituted beta-ketocarboxylic acid ester, in a suitable alcohol solvent such as methanol or ethanol with a semicarbazide hydrochloride in aqueous solution, at temperatures in the range from the ambient temperature to the reflux temperature of the solvent, in the presence of a suitable base such as pyridine, gives the corresponding semicarbazone derivative. Treatment of this compound with pure thionyl chloride at 0 ° C, followed by treatment with an excess aqueous solution of sodium bicarbonate gives the corresponding 4-substituted-l, 2,3-thiadiazole-5-carboxylic acid esters . The 4-carboalkoxythiazoles are prepared essentially according to the procedure of Scholkopf, U., Porsch, P., Lau, H. Liebigs Ann. Chem 1444 (1979). Thus, according to Method 55 and 56, the reaction of ethyl isocyanoacetate with the dimethylacetal of N, N-dimethylformamide in a suitable alcohol solvent, such as ethanol at room temperature, gives the ethyl ester of 3-dimethylamino acid -2-isocyanoacrylic corresponding. A solution of this compound in a suitable solvent such as tetrahydrofuran is treated with gaseous hydrogen sulfide in the presence of a suitable tertiary amine base such as triethylamine or diisopropylethylamine or the like at room temperature to give the corresponding 4-carboethoxythiazole. Additional thiazoles appropriately substituted can be prepared essentially according to the Bredenkamp procedure, M. W., Holzafel, C. W., van Zyl, W. J. Syn theti c Comm. 20, 2235 (1990). Suitable unsaturated oxazoles are prepared essentially according to the procedure of Henneke, K.H., Schollkopf, U., Neudecker, T. Liebigs Ann. Chem. 1979 (1979). The substituted oxazoles can be prepared essentially according to the procedures of Galeotti, N., Montagne, C, Poncet, J., Jouin, P. Tetrahedron Let t. 33, 2807 (1992) and Shin, C, Okumpura, K., Ito. A., Nakamura, Y. Chemistry Lett. 1305, (1994). The following specific examples are illustrative, but are not understood to be limiting of the present invention.

EXAMPLE 1 (METHOD ÍA) 4-methoxy-3-trifluoromethyl-phenylamine A suspension of 4-methoxy-3-trifluoromethyl-nitrobenzene (2.2 g) and iron powder (1.68 g) in 35 ml of ethanol and 15 ml of water is treated with a 0.42 ml solution of concentrated hydrochloric acid in 6 ml. of ethanol and 3 ml of water, and the mixture is heated to reflux for about 1 hour. The mixture is then cooled, filtered and concentrated under reduced pressure. The resulting oil is dissolved in ethyl acetate and extracted three times with 5% aqueous hydrochloric acid. The combined acid extracts are then cooled in an ice bath and made alkaline with solid potassium carbonate, then extracted with ethyl acetate. These organic extracts are washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated under reduced pressure, then passed through a short column of silica gel (ethyl acetate is used as the eluent) to provide the desired compound as an amber oil. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 2,6-dichlorobenzene-1,4-diamine 3-chloro-4-methylsulphane-phenylamine 2,6-dibromo-benzene-diamine 3-chloro- 4-trifluoromethyl-phenylamine 3-chloro-4-ethylsulfanyl-phenylamine 4-methoxy-3-trifluoromethyl-phenylamine 3,5-dichloro-4-methoxy-2-methy1-phenylamine 5-chloro-2-ethoxy-4-methoxy phenylalanine 5-chloro-4-ethoxy-2-methoxy-phenylalanine 5-iodo-2,4-dimethoxy-phenylamine 3,5-diiodo-2,4-dimethoxy-phenylamine 3,5-dibromo-2,4-dimethoxy- phenylamine 5-chloro-2-methoxy-4-methy1-phenylamine 2-chloro-N (1), N (1) -dimethyl-benzene-1, -diamine 3-chloro-4-piperidin-1-yl-phenylamine 3 -chloro-4-pyrrolidin-1-yl-phenylamine N (1) -benzyl-2-chloro-benzene-l, -diamine 3-chloro-4- (4-methyl-piperazin-1-yl) -phenylamine 2- chloro-N (l) -methyl-N (1) - (1-methyl-piperidin-4-yl) • benzene-1,4-diamine 2-chloro-N (1) -methyl- (1) - (l -methyl-pyrrolidin-3-yl) -benzene-1,4-diamine 2-chloro-N (1) -methyl-N (1) -f enyl-benzene-1,4-diamine N (1) - (1-benzyl-pyrrolidin-3-yl) -2-chloro-N (1) -methyl-benzene-1,4-diamine 2-chloro-N ( 1) -cyclopentyl-N (1) -methyl-benzene-1, -diamine 2- [(4-amino-2-chloro-phenyl) (2-hydroxy-ethyl) -amino] -ethanol 2-chloro-N ( 1) -hexyl-N (1) -methyl-benzene-1, -diamine 2-Chloro- (1) -isobutyl-N (1) -methyl-benzene-1,4-diamine 2- [(4-amino-2-chloro-phenyl) -methyl-amino] -ethanol 2-chloro-N (1) - (3-dimethylamino-propyl) -N (1) -methyl-benzene-1,4-diamine 2-chloro-N (1) - (2-dimethylamino-ethyl) -N (1) -methyl- benzene-1,4-diamine 2-chloro-N (l) - (2-dimethylamino-ethyl) -benzene-1,4-diamine N (1) - (1-benzyl-piperidin-4-yl) -2- chloro-benzene-1, -diamine ^ 2-chloro-N (1) - (2-methoxy-ethyl) -N (1) -methyl-benzene-1,4-diamine 2-chloro-N (1) - ( 3-dimethylamino-propyl) -benzene-1,4-diamine N (1) - (1-benzyl-pyrrolidin-3-yl) -2-chloro-benzene-1, -diamine 3-chloro-4- (l- methyl-piperidin-4-yloxy) -phenylamine 3-chloro-4- (2-dimethylamino-ethoxy) -phenylamine 3-chloro-4- (3-dimethylamino-propoxy) -phenylamine 3-chloro-4- (l-methyl) -pyrrolidin-3-yloxy) -phenylamine 3-chloro-4-cyclohexyloxy-phenylamine EXAMPLE 2 (METHOD IB) 4-bromo-2,4-dimethoxy-phenylamine A suspension of 4-bromo-2, -dimethoxy-nitrobenzene (0.48 g) and iron powder (0.42 g) in 10 ml of acetic acid and 10 ml of ethanol is heated at 120 ° C for about 5 hours. The mixture is then cooled, filtered, and concentrated under reduced pressure. Water is added and the mixture is cooled in an ice bath and neutralized with solid potassium carbonate and then extracted with dichloromethane. These organic extracts are washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, concentrated under reduced pressure, then subjected to chromatography on silica gel (20% ethyl acetate in hexanes is used as the eluent) to provide the desired compound as an amber oil.

EXAMPLE 3 (METHOD ÍC) (4-amino-2,6-dichloro-phenoxy) acetic acid tert-butyl ester A solution of 1 g of the terbutyl ester of (4-nitro-2,6-dichloro-phenoxy) -acetic acid in 17 ml of ethanol and 8.6 ml of water is treated with 0.861 g of iron powder and 86 mg of chloride of ammonium, and the mixture is heated to reflux for about 1 hour. The mixture is then filtered and concentrated under reduced pressure. The resulting oil is partitioned between water and ethyl acetate, and the organic phase is then washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to provide the desired compound as a pale yellow solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 4-chloro-benzene-1, 2-diamine N- (4-amino-2-chloro-phenyl) -acetamide (4-amino-2, 6- dichloro-phenoxy) -acetonitrile (4-amino-2,6-dichloro-phenoxy) -acetic acid (2-amino-4-chloro-5-methoxy-phenoxy) -acetonitrile (4-amino) methyl ester -2-chloro-5-methoxy-phenoxy) -acetic acid (4-amino-2-chloro-5-methoxy-phenoxy) -acetic acid terbutyl ester of (2-amino-4-chloro-5-methoxy) -phenoxy) -acetic N (1) -benzyl-4-chloro-5-methoxy-benzene-1,2-diamine N- (4-amino-2-chloro-phenyl) -2-fluoro-benzamide N- (4 -amino-5-chloro-2-hydroxy-phenyl) -acetamide N- (4-amino-5-chloro-2-hydroxy-phenyl) -2-fluoro-benzamide (4-amino-2-chloro-phenyl) - Furan-2-carboxylic acid amide (4-amino-2-chloro-phenyl) -carbamic acid ethyl ester N- (4-amino-5-chloro-2-methyl-phenyl) -acetamide N- (4-amino) -5-chloro-2-methyl-phenyl) - 2-Fluoro-benzamide (4-amino-5-chloro-2-methyl-phenyl) amide of furan-2-carboxylic acid N- (4-amino-3-chloro-phenyl) -2-fluoro-benzamide (4- amino-3-chloro-phenyl) -amide of furan-2-carboxylic acid N- (4-amino-2-chloro-phenyl) -2-dimethylamino-acetamide N- (4-amino-2-chloro-phenyl) - 2-piperidin-l-yl-acetamide N- (4-amino-2-chloro-phenyl) -2-morpholin-4-yl-acetamide N- (4-amino-2-chloro-phenyl) -methanesulfonamide N- ( 4-amino-2-chloro-phenyl) -benzamide N- (4-amino-2-chloro-phenyl) -2-diethylamino-acetamide N- (4-amino-2-chloro-phenyl) -2-piperidin-l-yl-acetamide N- (4-amino-2-chloro-phenyl) -2-azepane-l-yl-acetamide N- (4-amino-2-chloro-phenyl) -2- (2-methyl-piperidin-1-yl) -acetamide N- (4-amino-2-chloro-phenyl) -2- (3-methyl- piperidin-l-yl) -acetamide 3-chloro-benzene-l, 2-diamine 4-chloro-N, N-dimethyl-1-benzene-1,2-diamine EXAMPLE 4 (METHOD ID) 3, 5-dichloro-4-phenoxy-phenylamine To a suspension of 6.1 g of 3,5-dichloro-4-phenoxy-nitrobenzene and 12 g of tin powder, 60 ml of concentrated hydrochloric acid are added dropwise. 60 ml of ethanol are added and the mixture is heated to reflux for about 1 hour. The mixture is then cooled in an ice bath and made alkaline by the addition of solid sodium hydroxide. The resulting suspension is filtered through a pad of diatomaceous earth and extracted three times with ethyl acetate. The combined organic extracts are then washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to provide the desired product as a yellow solid. Recrystallization from ethyl acetate-hexanes gives the product as a pale yellow solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 1-furan-2-yl-ethylamine 3-chloro-4-isopropoxy-phenylamine 2-butoxy-5-chloro-methoxy-phenylamine 3,5-dichloro -2-methoxy-4-methyl-phenylamine 2-benzyloxy-5-chloro-methoxy-phenylamine 4-benzyloxy-5-chloro-2-methoxy-phenylamine 5-fluoro-2,4-dimethoxy-phenylamine ethyl acid ester (4-amino-2,6-dichloro-phenoxy) -acetic 3,5-dichloro-4-phenoxy-phenylamine 2- (4-amino-2-chloro-5-methoxy-phenoxy) -acetamide (4-amino- 2-Chloro-5-methoxy-phenoxy) -acetonitrile 2- (2-amino-4-chloro-5-methoxy-phenoxy) -ethanol 2- (4-amino-2-chloro-5-methoxy-phenoxy) -ethanol 4- (4-amino-2-chloro-5-methoxy-phenoxy) -butyronitrile-amino-2-chloro-5-methoxy-phenol 2-amino-4-chloro-5-methoxy-phenol 5-chloro-methoxy -2-morpholin-4-i1-phenylamine 4-chloro-5-methoxy-N (1), N (1) -dimethyl-benzene-1,2-diamine 5-chloro-4-methoxy-2-piperidin-1-yl-phenylamine 5-chloro-4-methoxy-2-pyrrolidin-1-yl-phenylamine 2 -chloro-N (1) -cyclohexy1-N (1) -methyl-benzene-1,4-diamine N (2) -benzyl-4-methoxy-benzene-l, 2-diamine 2- (4-amino-2 -chloro-phenoxy) -ethanol 2-chloro- (1) -cyclohexyl-N (1) -ethyl-benzene-1,4-diamine 4-butoxy-3-chloro-phenylamine (4-amino-2-chloro-phenoxy) ) -acetonitrile 2-chloro-N (1) - * - cyclohexyl-benzene-1, -diamine 2-chloro-N (1) -N (1) -dipropyl-benzene-1,4-diamine 3-chloro- (2,2,2-trifluoro-ethoxy) -phenylamine 3-chloro-4- (octahydro-quinolin-1-yl) -phenylamine N (l) -allyl-2-chloro-N (l) -cyclohexyl-benzene 1,4-diamine N- (4-amino-2-methoxy-5-methyl-phenyl) -2-fluoro-benzamide (4-amino-2-methoxy-5-methyl-phenyl) amide of furan-2-acid carboxylic N- (4-amino-naphthalen-1-yl) -2-fluoro-benzamide 3-chloro-N, N-dimethyl-1-benzene-1,2-diamine 3-chloro-propoxy-phenylamine 3-iodo- methoxy-phenylamine 3-chloro-2, -dimethoxy-aniline 3-bromo-4-methoxy-phenylamine 3-clo ro-4-ethoxy-phenylamine EXAMPLE 5 (METHOD 1E) Isobutyl ester of (4-amino-phenyl) -carbamic acid To a solution of 2.0 g of N- (4-nitro-phenyl) -isobutyrylamide in 100 ml of ethylene glycol monomethyl ether, 10% palladium on carbon (275 mg) is added. The mixture is hydrogenated for 2 hours at room temperature under a pressure of 2.19 kg / cm2 (30 psi) on a Parr hydrogenation apparatus. The catalyst is then removed by filtration through diatomaceous earth and the filtrate is evaporated to dryness under reduced pressure by azeotropic extraction three times with heptane. Trituration of the residue with heptane gives the desired product as a white solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 2-methyl-3H-benzoimidazol-5-ylamine N- (4-amino-phenyl) -formamide lH-benzoimidazole-5-ylamine isobutyl ester of the acid ( 4-amino-phenyl) -carbamic N- (4-amino-phenyl) -isobutyramide N- (5-amino-pyridin-2-yl) -2-methyl-benzamide (5-amino-pyridin-2-yl) - amide of furan-2-carboxylic acid N- (5-amino-pyridin-2-yl) -2-fluoro-benzamide [6- (2, 2, 2-trifluoroacetylamino) -pyridin-3-yl] butyl ester -carbamic N- (5-amino-pyridin-2-yl) -2,2, 2-trifluoro-acetamide (4-amino-benzyl) -carbamic acid terbutyl ester 2- (3,5-bis-trifluoromethyl-phenyl) ) -ethylamine l-tert-butyl-lH-imidazol-2-ylamine 3- (3-dimethylamino-propyl) -5-trifluoromethyl-phenylamine EXAMPLE 6 (METHOD 1F) N- (4-amino-2-methylphenyl) -2 -fluorobenzamide A mixture of 4.55 g of 2-fluoro-N- (2-methyl-4-nitrophenyl) benzamide, 30 ml of cyclohexene, 70 ml of ethanol, 30 ml of water and 3 g of 10% palladium ^ on mineral coal heat to reflux for 30 minutes. The mixture is filtered through diatomaceous earth and concentrated under reduced pressure. The resulting oil is dissolved in 50 ml of ethyl acetate and cooled to 4 ° C for 12 hours. Filtration provides the product as a burnt color solid. Using the above procedure and appropriate starting materials, the following compounds were prepared: N- (4-amino-2-methyl-phenyl) -acetamide 2-methyl-benzooxasol-6-ylamine N- (4-amino-3-methoxy) phenyl) -acetamide 2-Acetylamino-5-amino-benzoic acid N- (4-amino-phenyl) -acetamide [4- (3-Amino-benzoylamino) phenyl] carbamic acid terbutyl ester [4- ( 2-amino-benzoylamino) phenyl] carbamic N- (4-amino-2-cyano-phenyl) acetamide N- (4-amino-2,5-dimethoxy-phenyl) -2-fluoro-benzamide (4-amino-2) , 5-dimethoxy-phenyl) -amide of furan-2-carboxylic acid N- (4-amino-2-cyano-phenyl) -2-fluoro-benzamide (4-amino-2-methoxy-phenyl) -amide of the acid furan-2-carboxylic acid N- (4-amino-2-methoxy-phenyl) -2-fluoro-benzamide N- (4-amino-2-methoxy-5-methyl-phenyl) -acetamide N- (4-amino- 2-benzoyl-phenyl) -acetamide N- (4-amino-2-benzoyl-phenyl) -2-fluoro-benzamide (4-amino-2-benzoyl-phenyl) -amide of furan-2-carboxylic acid N- ( 4-amino-3-methyl-phenyl) -acetamide N- (4-amino-3-methyl-phenyl) -2-fluoro-benzamide (4-amino-3-methyl-phenyl) -amide of furan-2-carboxylic acid 5-amino-2- [(2 -fluorobenzoyl) amino] -N-phenylbenzamide (4-amino-2-phenylcarbamoyl-phenyl) amide of furan-2-carboxylic acid N- (4-amino-naphthalen-1-yl) -acetamide (4-amino-naphthalene) 1-yl) -amide of furan-2-carboxylic acid N- (4-amino-2-trifluoromethyl-phenyl) -acetamide (4-amino-2-cyano-phenyl) -amide of furan-2-carboxylic acid (4-amino) Furan-2-carboxylic acid -amino-2-trifluoromethyl-phenyl) -amide N- (4-amino-2-methyl-phenyl) -2-fluoro-benzamide (4-amino-2-methyl-phenyl) -amide of furan-2-carboxylic acid 5-amino-2- (2-fluoro-benzoylamino) -benzoic acid 5-amino-2- [(furan-2-carbonyl) -amino] -benzoic acid N- (4-amino- 2-cyano-phenyl) -2,2, 2-trifluoroacetamide N- (4-amino-3-methyl-phenyl) -2,6-difluoro-benzamide N- (4-amino-3-trifluoromethyl-phenyl) -acetamide N- (4-amino-3-trifluoromethyl-phenyl) -2-fluoro-benzamide N- (4-amino-2-trifluo romethyl-phenyl) -2,2,2-trifluoroacetamide N- (4-amino-2-methoxy-phenyl) -2,2,2-trifluoroacetamide N- (4-amino-2-trifluoromethyl-phenyl) -2-fluoro-N- (2-fluoro-benzoyl) -benzamide N- (4-amino-2-trifluoromethyl-phenyl) -2-fluoro-benzamide EXAMPLE 7 (METHOD 1G) N- (4-amino-2- chlorophenyl) -2-thiomorpholino-4-yl-acetamide A solution of N- (2-chloro-4-nitrophenyl) -2-thiomorpholino-4-yl-acetamide (3.02 g) in 200 ml of ethanol is added a solution of 12 g of sodium thiosulfate in 60 ml of water . The mixture is refluxed for 12 hours, cooled and poured into water. The mixture is then extracted with ethyl acetate. The ethyl acetate solution is washed twice with saturated aqueous sodium chloride, dried over anhydrous potassium carbonate, filtered through a pad of diatomaceous earth and concentrated under reduced pressure to give an oil. Toluene is added and the solution is cooled to give the desired product as a light orange crystalline solid. Using the above procedure and suitable starting materials, the following compounds were prepared: N- (4-amino-2 ^ chloro-phenyl) -2-thiomorpholino-4-yl-acetamide N- (4-amino-2-chloro- phenyl) -2-dipropylamino-acetamide EXAMPLE 8 (METHOD 2A) (3-Chloro-4-iodo-phenyl) -carbamic acid terbutyl ester To a solution of 10 g of 3-chloro-4-iodo-aniline in 40 ml of tetrahydrofuran containing 6.9 ml of diisopropylethylamine is added 8.6 g of diterbutyl dicarbonate and the mixture is heated to reflux. After about 15 hours, additional portions of diisopropylethylamine (6.9 ml) and di-tert-butyl dicarbonate (21 g) are added and heating is continued for about 24 hours. The solution is then cooled, concentrated under reduced pressure, diluted with ethyl acetate, and washed successively three times with 5% aqueous hydrochloric acid, then once with saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate and then concentrated under reduced pressure to provide the desired crude product as a brown oil. Crystallization is induced by the addition of hexanes, and the collected solid material is recrystallized from hexanes to give the desired product as a white solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: N '- (4-nitro-benzoyl) -hydrazinecarboxylic acid tertiary butyl ester (3-Chloro-4-iodo-phenyl) -carbamic acid tert-butyl ester (4-bromo-3-chloro-phenyl) -carbamic acid tertbutyl ester (3-Chloro-4-vinyl-phenyl) -carbamic acid terbutyl ester (3-Chloro-4-methylsufanyl-phenyl) -carbamic acid butyl ester (4-amino-3-chloro-phenyl) -butyl acid ester Carbamic acid (4-chloro-2-nitro-phenyl) -carbamic acid terbutyl ester (3-tert-Butoxycarbonylamino-5-chloro-phenyl) -carbamic acid tert-butyl ester (4-nitro-benzyl) -carbamic acid tert-butyl ester (3-Bromo-5-trifluoromethyl-phenyl) -carbamic acid terbutyl ester (2-amino-3-chloro-5-trifluoromethyl-phenyl) -carbamic acid butyl ester EXAMPLE 9 (METHOD 2B) 2-Trimethylsilanyl-ethyl ester of (3-chloro-4-vinyl-phenyl) -carbamic acid To a solution of 3.4 g of 3-chloro-4-vinyl-phenylamine in 44 ml of N, N-dimethylformamide containing 5.8 ml of diisopropylethylamine is added 7.1 g of l- [2- (trimethylsilyl) -ethoxycarbonyl-oxy] benzotriazole and the mixture is stirred at room temperature under an argon atmosphere for three days. The solution is then diluted with water and extracted three times with diethyl ester. The combined organic extracts are washed successively with water, with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue is chromatographed on silica gel (10% ethyl acetate in hexanes is used as the eluent) to provide the desired product as a yellow oil.

EXAMPLE 10 (METHOD 2C) [4- (2-Fluoro-benzoylamino) -phenyl] -carbamic acid terbutyl ester To a solution of 1.58 g of mono-N- (t-butoxycarbonyl) -1, -phenylenediamine and 1.50 ml of triethylamine in 25 ml of dichloromethane, 1.20 g of o-fluorobenzoyl chloride are added. A solid is immediately formed and filtered and washed with fresh solvent to produce a white solid, 1.90 g. Using the above procedure and the appropriate starting materials, the following compounds were prepared: N- (3-methoxy-4-nitro-phenyl) -acetamide N- (4-amino-phenyl) -isobutyrylamide 2,2, 2-trifluoro- N- (2-methoxy-4-nitro-phenyl) -acetamide tert-butyl ester of [4- (2-methyl-benzoylamino) -phenyl] -carbamic acid 2- (4-tert-butoxycarbonylamino-phenylcarbamoyl) -phenyl acid ester Acetic acid [4- (4-fluoro-benzoylamino) -phenyl] -carbamic acid terbutyl ester [4- (3-fluoro-benzoylamino) -phenyl] -carbamic acid [4- (2-fluoro]] terbutyl ester -benzoylamino) -phenyl] -carbamic acid terbutyl ester of [4- (2-methoxy-benzoylamino) -phenyl] -carbamic acid [4- (3-methoxy-benzoylamino) -phenyl] -carbamic acid tert-butyl ester [4- (2, 2-Dimethyl-propionylamino) -phenyl] -carbamic acid tert-butyl ester of [4- (2, 2-dimethyl-propionylamino) -phenyl] -carbamic acid tert-butyl ester [4- (2-bromo-acetylamino) -phenyl] -carbamic acid [4- (2, 2, 2-trifluoro-acetylamino) -phenyl] -carbamic acid tert-butyl ester of (4-benzoylamino-phenyl) acid -carbamic terbutyl ester of (4-methanesulfonylamino-phenyl) -carbamic acid terbutyl ester of (4-phenylacetylamino-phenyl) -carbamic acid terbutyl ester. { 4- [(thiophene-2-carbonyl) -amino] -phenyl} [4- (3-Nitro-benzoylamino) -phenyl] -carbamic acid terbutyl ester [4- (3-acetylamino-benzoylamino) -phenyl] -carbamic acid terbutyl ester of [4- (3- methanesulfonylamino-benzoylamino) -phenyl] -carbamic acid- [3 - [[[4 - [[(1, 1-dimethylethoxy) carbonyl] amino] -phenyl] amino] carbonyl] -phenyl] carbamate terbutyl ester of [4-] (2-trifluoromethyl-benzoylamino) -phenyl] -carbamic acid [4- (2,6-difluoro-benzoylamino) -phenyl] -carbamic acid [4- (2-chloro-benzoylamino) -phenyl] tert-butyl ester] -carbonate [4- (2-bromo-benzoylamino) -phenyl] -carbamic acid terbutyl ester of [4- (2-nitro-benzoylamino) -phenyl] -carbamic acid tert-butyl ester. { 4- [(benzo [b] thiophene-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(pyridine-4-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(naphthalene-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(naphthalene-1-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(3-bromo-thiophene-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(biphenyl-2-carbonyl) -amino] -phenyl} -carbamic acid N- (4-tert-butoxycarbonylamino-phenyl) -phthalamic acid [4- (2, 3-difluoro-benzoylamino) -phenyl] -carbamic acid terbutyl ester of [4- (2,5-difluoro]] [4- (2, -difluoro-benzoylamino) -phenyl] -carbamic acid [4- (2-acetylamino-benzoylamino) -phenyl] -carbamic acid tert-butyl ester of [4- (2, -difluoro-benzoylamino) -phenyl] -carbamic acid tert-butyl ester [4- (2-Methanesulfonylamino-benzoylamino) -phenyl] -carbamic acid [4- (2, 3, 4-trifluoro-benzoylamino) -phenyl] -carbamic acid terbutyl ester of [4- (2, 3 , 5, 6-pentafluoro-benzoylamino) -phenyl] -carbamic acid methyl ester of N- (4-tert-butoxycarbonylamino-phenyl) -isophthalamic acid 2-methylsulfanyl-N- [4- (2,2,2-trifluoro- acetylamino) -phenyl] -benzamide [4- (3-benzyloxy-benzoylamino) -phenyl] -carbamic acid [4- (3-butoxy-benzoylamino) -phenyl] -carbamic acid terbutyl ester [4- (3-benzyloxy) -phenyl] -carbamic acid ester acid terbutyl. { - [(5-difluoromethyl-furan-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(thiophene-3-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(5-methyl-furan-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(5-bromo-furan-2-carbonyl) -amino] -phenyl} -carbamic terbutyl ester of [4- (2-thiophen-2-yl-acetylamino) -phenyl] -carbamic acid tert-butyl ester of the acid (4-hexanoylamino-phenyl) -carbamic acid terbutyl ester. { [(pyridine-3-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(4-bromo-furan-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(furan-3-carbonyl) -amino] -phenyl} -carbamic terbutyl ester of (4-phenoxycarbonylamino-phenyl) -carbamic acid terbutyl ester. { 4- [(benzo [l, 3] dioxol-4-carbonyl) -amino] -phenyl} -carbonate [4- (3-trifluoromethoxy-benzoylamino) -phenyl] -carbamic acid terbutyl ester N- (2, 5-dimethoxy-4-nitro-phenyl) -2-fluoro-benzamide tert-butyl ester of the acid. { 4- [(furan-2-carbonyl) -amino] -phenyl} -carbamic terbutyl ester of [4- (2-phenoxy-acetylamino) phenyl] -carbamic acid terbutyl ester. { 4- [(5-nitro-furan-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(5-chloro-furan-2-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(3-methyl-furan-2-carbonyl) -amino] -phenyl} -carbamic terbutyl ester of [4- (2-methoxy-acetylamino) -phenyl] -carbamic acid terbutyl ester. { 4- [(4-furan-3-yl- [1,2, 3] thiadiazole-5-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(5-tert-butyl-furan-2-carbonyl) -amino] -phenyl} -carbamic N- [3-cyano-4- (2,2, 2-trifluoro-acetylamino) -phenyl] -2-fluoro-benzamide [3-cyano-4- (2,2,2-trifluoro-actylamino) - phenyl] -amide of furan-2-carboxylic acid N- (-acetylamino-2-cyano-phenyl) -2,2,2-trifluoro-acetamide 2,2,2-trifluoro-N- (4-nitro-2-) trifluoromethyl-phenyl) -acetamide N- (4-acetylamino-2-trifluoromethyl-phenyl) -2,2,2-trifluoroacetamide 2-fluoro-N- [4- (2,2,2-trifluoro-acetylamino) - 3-trifluoromethyl-phenyl] benzamide [4- (2, 2, 2-trifluoro-acetylamino) -3-trifluoromethyl-phenyl] -amide of furan-2-carboxylic acid 2-fluoro-N- (2-methyl-benzooxazole-6) -yl) -benzamide 4- (2-fluorobenzoylamino) -2-hydroxy-benzoic acid phenyl ester, terbutyl ester of the acid. { 4- [(isoxazole-5-carbonyl) -amino] -phenyl} -carbamic N- (4-acetylamino-2-methoxy-phenyl) -2,2,2-trifluoro-acetamide 2-fluoro-N- [3-methoxy-4- (2,2,2-trifluoro-acetylamino) - phenyl] benzamide 2-fluoro-N- (2-fluoro-benzoyl) -N- (4-nitro-2-trifluoromethyl-phenyl) benzamide tert-butyl ester of the acid. { 4- [(1H-pyrazole-4-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(lH-imidazole-4-carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { 4- [(5-methyl- [1,2,3] thiadyazole -carbonyl) -amino] -phenyl} -carbonate terbutyl ester of acid. { - [(5-furan-3-yl [1,2,3] thiadiazol-4-carbonyl) -amino] -phenyl} -carbamic 2,2, 2-trifluoro-N- (5-nitro-pyridin-2-yl) -acetamide tert-butyl ester of the acid. { 4- [(1-methyl-lH-pyrazol-4-amino] -phenyl] -carbamic acid 4- (2-fluorobenzoylamino) -2-hydroxy-benzoic acid methyl ester N- (5-chloro-2, 4-Dimethoxy-phenyl) -oxamic acid (4-amino-phenyl) -amide of isoxazole-5-carboxylic acid 2-fluoro-N- (4-nitro-benzyl) -benzamide 4-nitro-benzylamide of furan-2- acid carboxylic N- [3-chloro-5- (2,2,2-trifluoro-acetylamino) -phenyl] -2,2,2-trifluoroacetamide N- (3-amino-5-chloro-phenyl) -2, 2, 2-trifluoroacetamide [4- (2-Fluoro-benzoylamino) -benzyl] -carbamic acid terbutyl ester [4- (2,6-difluoro-benzoylamino) -benzyl] -carbamic acid terbutyl ester 2, 6 -difluoro-N- (4-nitro-benzyl) -benzamide tert-butyl ester of {4 - [(furan-2-carbonyl) -amino] -benzyl} -carbamic acid N- (3-amino-5-) Chloro-phenyl) -acetamide [4- (3-Chloro-benzoylamino) -phenyl] -carbamic acid terbutyl ester [4- (4-Chloro-benzoylamino) -phenyl] -carbamic acid terbutyl ester [4- (4-dimethylamino-benzoylamino) -phenyl] -carbamic acid (4-benzenesulfonylamino-phenyl) -carbamic acid terbutyl ester [4- (3-Trifluoromethyl-benzoylamino) -phenyl] -carbamic acid 2-terbutyl ester, 2,2-trifluoro-N- (5-nitro-pyrimidin-2-yl) -acetamide EXAMPLE 11 (2D METHOD) 2-chloro-N- (2-chloro-4-nitrophenyl) acetamide A solution of 19.0 g of 2-chloro-4-nitroaniline and 30 ml of chloroacetyl chloride in 150 ml of tetrahydrofuran is heated to reflux for 1 hour. The solution is cooled and concentrated under reduced pressure, giving a yellow, moist solid. 250 ml of ether are added and the yellow solid is collected. Using the above procedure and the appropriate starting materials, the following compounds were prepared: N- (4-nitro-3-trifluoromethyl-phenyl) -acetamide (2-Chloro-4-nitro-phenyl) -carbamic acid ethyl ester Acid 2 3-Nitro-benzoic acid (5-chloro-2-hydroxy-4-nitro-phenyl) -amide of furan-2-carboxylic acid (2-methyl-4-nitro-phenyl) -amide of furan-2 -carboxylic (2-methoxy-4-nitro-phenyl) -amide of furan-2-carboxylic acid N- (2-chloro-4-nitro-phenyl) -benzamide 2-methoxy-N- (4-nitro-phenyl) -acetamide N- (4-nitro-phenyl) -acrylamide N- (4-nitro-phenyl) -isobutyrylamide [4- (Acryloylamino) -phenyl] carbamic acid terbutyl ester (4-nitrophenyl) -isobutyl ester Carbamic acid (5-nitro-pyridin-2-yl) -amide [1,2,3] thiadiazole-4-carboxylic acid (5-nitro-pyridin-2-yl) -amide of furan-2-carboxylic acid 2-fluoro-N- (5-nitro-pyridin-2-yl) - N- (2-chloro-4-nitro-phenyl) -2-fluoro-benzamide (2, 5-dimethoxy-4-nitro-phenyl) -amide of furan-2-carboxylic acid N- (2-cyano-4) -nitro-phenyl) -2-fluoro-benzamide 2-fluoro-N- (2-methoxy-4-nitro-phenyl) -benzamide 2-methyl-N- (5-nitro-pyridin-2-yl) -benzamide ( 2-fluoro-N- (2-methoxy-5-methyl-4-nitro-phenyl) -benzamide N- (2-methoxy-5-methyl-4-nitro-phenyl) -amide of furan-2-carboxylic acid -benzoyl-4-nitro-phenyl) -acetamide N- (2-benzoyl-4-nitro-phenyl) -2-fluoro-benzamide (2-benzoyl-4-nitro-phenyl) -amide of furan-2-carboxylic acid N- (3-methyl-4-nitro-phenyl) -acetamide 2-fluoro-N- (3-methyl-4-nitro-phenyl) -benzamide (3-methyl-4-nitro-phenyl) -amide of furan -2-carboxylic acid 2-acetylamino-5-nitro-N-phenyl-benzamide 2- [(2-fluorobenzoyl) amino] -5-nitro-N-phenylbenzamide (4-nitro-2-phenylcarbamoyl) -amide of furan- 2-carboxy 2-fluoro-N- (4-nitro-naphthalen-1-yl) -benzamide (4-nitro-naphthalen-1-yl) -amide of furan-2-carboxylic acid N- (5-chloro-2-hydroxy) 4-nitro-phenyl) -acetamide N- (5-chloro-2-hydroxy-4-nitro-phenyl) -2-fluoro-benzamide (2-chloro-4-nitro-phenyl) -amide of furan-2 acid -carboxylic acid N- (4-nitro-2-trifluoromethyl-phenyl) -acetamide (2-cyano-4-nitro-phenyl) -amide of furan-2-carboxylic acid 2-fluoro-N- (4-nitro-2- 2-fluoro-N- (2-methyl-4-nitro-phenyl) -benzamide N- (5- trifluoromethyl-phenyl) -benzamide (4-nitro-2-trifluoromethyl-phenyl) -amide of furan-2-carboxylic acid Chloro-2-methyl-4-nitro-phenyl) -2-fluoro-benzamide (5-chloro-2-methyl-4-nitro-phenyl) -amide of furan-2-carboxylic acid 2- (2-fluoro- benzoylamino) -5-nitro-benzoic acid 2- [(furan-2-carbonyl) -amino] -5-nitro-benzoic acid N- (3-chloro-4-nitro-phenyl) -2-fluoro-benzamide (3- Chloro-4-nitro-phenyl) -amide of furan-2-carboxylic acid 2,6-difluoro-N- (3-methyl-4-nitro-phenyl) -benzamide 2-fluoro-N- (4-ni 3-trifluoromethyl-phenyl) -benzamide (4-nitro-3-trifluoromethyl-phenyl) -amide of furan-2-carboxylic acid 2-chloro-N- (2-chloro-4-nitro-phenyl) -acetamide N - (2-chloro-4-nitrophenyl) methanesulfonamide [3-methoxy-4- (2,2,2-trifluoro-acetylamino) -phenyl] -amide of furan-2-carboxylic acid N- (2-chloro-4-) nitro-phenyl) -2, 2, 2-trifluoroacetamide EXAMPLE 12 Terbutyl acid ester. { 4- [(4-phenyl- [1,2,3] thiadiazole-5-carbonyl) -amino] -phenyl} -carbamic A solution of 0.8 g of 1- (N-tert-butoxycarbonyl) -1,4-phenylenediamine and 0.7 g of 4-phenyl- [1,2,20] thiadiazole-5-carboxylic acid in 10 ml of dichloromethane is treated with 1.3 ml of triethylamine and 1.6 ml of benzotriazol-1-yloxy-tris (dimethylamino) -phosphonium hexafluorophosphate. After stirring at room temperature, the reaction is diluted with water and extracted with dichloromethane. The organic layer is washed with 0.5N hydrochloric acid, saturated sodium bicarbonate and water, then dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give the desired product. Using the above procedure and the appropriate starting materials, the following compounds were prepared: Acid terbutyl ester. { 4- [(lH-pyrrole-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(pyrazine-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(5-methyl-thiophene-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(1-methyl-lH-pyrrole-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(quinolin-8-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(benzofuran-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(isoquinolin-1-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(quinolin-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(pyridine-2-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(isoquinoline-4-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [([1, 2, 3] thiadiazole-4-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4 - [(1 H- [1,2, 3] triazole-4-carbonyl) -amino] -phenyl} -carbamic acid [4- (2-Methylsulfanyl-benzoylamino) phenyl] -carbamic acid terbutyl ester Terbutyl acid ester. { 4- [(quinoline-4-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(4-methyl- [1,2, 3] thiadiazole-5-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(4-phenyl- [1,2,3] thiadiazole-5-carbonyl) -amino] -phenyl} -carbamic Terbutyl acid ester. { 4- [(lH-indol-2-carbonyl) -amino] -phenyl} -carbamic acid [1, 2, 3] thiadiazole-4-carboxylic acid terbutyl ester, 4-nitro-benzylamide. { 4- [([1, 2, 3] thiadiazole-4-carbonyl) -amino] -benzyl} -carbamic 4- (4-tert-butoxycarbonylamino-phenylcarbamoyl) -phenyl ester of acetic acid terbutyl acid ester. { 4- [(quinolin-6-carbonyl) -amino] -phenyl} -carbamic EXAMPLE 13 (2F METHOD) Acetic acid 2- (4-tert-butoxycarbonylamino-2,6-dichloro-phenoxy) ethyl ester A solution of 0.85 g of the terbutyl ester of [3,5-dichloro-4- (2-hydroxy-ethoxy) -phenyl] -carbamic acid in 14 ml of pyridine is treated with 1.24 ml acetic anhydride and the mixture is stirred at room temperature for 15 hours. The solvent is removed under reduced pressure and the residue is dissolved in ethyl acetate. This solution is then washed twice with 5% aqueous hydrochloric acid, once with saturated aqueous sodium bicarbonate, and then with saturated aqueous sodium chloride. The solution is dried over anhydrous magnesium sulfate and the solvent is removed under reduced pressure to provide the desired product as a colorless oil. Using the above procedure and the appropriate starting materials, the following compounds were prepared: Phenylsulphane-acetonitrile 2- (4-tert-Butoxycarbonylamino-2,6-dichloro-phenoxy) -ethyl acetic acid ester EXAMPLE 14 (METHOD 2G) (3, 5-Dichloro-4-hydroxy-phenyl) -carbamic acid terbutyl ester To a solution of 9.5 g of 2,6-dichloro-4-aminophenol in 130 ml of tetrahydrofuran, 11.7 g of di-tert-butyl dicarbonate are added and the mixture is heated to reflux for about 15 hours. The solution is then cooled, concentrated under reduced pressure, diluted with ethyl acetate, and washed successively three times with 5% aqueous hydrochloric acid, then once with saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate, then concentrated under reduced pressure to provide the desired crude product. This material is then triturated with cold dichloromethane to provide the product as a white solid. Using the above procedure and the appropriate starting materials, the following compound was prepared: (3-amino-5-chloro-phenyl) -carbamic acid terbutyl ester EXAMPLE 15 (METHOD 3A) 3, 5-Dichloro-4-ethoxy-phenylamine ml of trifluoroacetic acid is added to 0.97 g of the 3,5-dichloro-4-ethoxy-phenyl) -carbamic acid terbutyl ester and the mixture is stirred for about 45 minutes at room temperature. Water is then added, and the mixture is cooled in an ice bath and alkalized with solid potassium carbonate. The solution is extracted three times with ethyl acetate and the combined organic phases are washed with saturated aqueous sodium chloride and then dried over anhydrous sodium sulfate. Concentration under reduced pressure and recrystallization from hexanes gives the desired product as a pale yellow crystalline solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 5-bromo-pyridin-3-ylamine 3-chloro-4-methanesulfoni-1-phenylamine N- (4-amino-phenyl) -2-methyl-benzamide Ester 2- (4-Amino-phenylcarbamoyl) -phenyl acetic acid N- (4-amino-phenyl) -4-fluoro-benzamide N- (4-amino-phenyl) -3-fluoro-benzamide N- (4-amino) -phenyl) -2-fluoro-benzamide N- (4-amino-phenyl) -2-methoxy-benzamide N- (4-amino-phenyl) -3-methoxy-benzamide N- (4-amino-phenyl) -4 -methoxy-benzamide N- (4-amino-phenyl) -2-phenyl-acetamide N- (4-amino-phenyl) -2,2-dimethyl-propionamide N- (4-amino-phenyl) -2,2, 2-trifluoro-acetamide (4-amino-phenyl) -amide of thiophene-2-carboxylic acid (4-amino-phenyl) -amide of lH-pyrrole-2-carboxylic acid N- (4-amino-phenyl) -3 -nitro-benzamide 3-acetylamino-N- (4-amino-phenyl) -benzamide N- (4-amino-phenyl) -3-dimethylamino-benzamide N- (4-amino-phenyl) -3-methanesulfonylamino-benzamide N - (4-Amino-phenyl) -2-trifluoromethyl-b N- (4-amino-phenyl) -2,6-difluoro-benzamide N- (4-amino-phenyl) -2-chloro-benzamide N- (4-amino-phenyl) -2-bromo-benzamide N- 5-Methyl-thiophene-2-carboxylic acid (4-amino-phenyl) -2-nitro-benzamide (4-amino-phenyl) -amide of pyrazine-2-carboxylic acid (4-amino-phenyl) -amide ( 4-amino-phenyl) -amide of quinoline-8-carboxylic acid (4-amino-phenyl) -amide of 1-methyl-lH-pyrrole-2-carboxylic acid (4-amino-phenyl) -amide of benzo acid [ b] thiophene-2-carboxylic acid (4-amino-phenyl) -amide of benzofuran-2-carboxylic acid N- (4-amino-phenyl) -isonicotinamide (4-amino-phenyl) -amide of naphthalene-2-carboxylic acid Naphthalene-1-carboxylic acid (4-amino-phenyl) -amide (4-amino-phenyl) -amide of isoquinoline-1-carboxylic acid (4-amino-phenyl) -amide of quinoline-2-carboxylic acid 3, 5-Dichloro-4-ethoxy-phenylamine-4-butoxy-3, 5-dichloro-phenylamine (4-amino-phenyl) -amide of isoquinoline-4-carboxylic acid (4-amino-phenyl) -amide of acid [1, 2, 3] t IH-1,2,3-triazole-4-carboxylic acid (4-amino-phenyl) -amide of 3-bromo-thiophene-2-carboxylic acid-4-carboxylic acid (4-amino-phenyl) -amide 4-benzyloxy-3, 5-dichloro-phenylamine 2- (4-amino-2,6-dichloro-phenoxy) -acetamide methyl ester of (4-amino-2,6-dichloro-phenoxy) -acetic acid ethyl ester of [3- (4-Amino-phenylcarbamoyl) -phenyl] -carbamic acid 2-amino-N- (4-amino-phenyl) -benzamide (4-amino-phenyl) -amide of biphenyl-2-carboxylic acid N- ( 4-amino-phenyl) -2, 3-difluoro-benzamide N- (4-amino-phenyl) -2,5-difluoro-benzamide N- (4-amino-phenyl) -2,4-difluoro-benzamide 2- acetylamino-N- (4-amino-phenyl) -benzamide N- (4-amino-phenyl) -2-methanesulfonylamino-benzamide N- (4-amino-phenyl) -2,3,4-trifluoro-benzamide N- (4-amino-phenyl) -2,3,4,5,6-pantafluoro-benzamide N- (4-amino-phenyl) ) -2-methanesulfanyl-benzamide 2- (4-Amino-2,6-dichloro-phenoxy) ethyl ester of acetic acid N- (4-amino-phenyl) -isophthalamic acid methyl ester N- (4-amino-) phenyl) -3-benzyloxy-benzamide N- (4-amino-phenyl) -3-butoxy-benzamide [3- (4-Amino-phenylcarbamoyl) -phenoxy] -acetic acid ethyl ester (4-amino-phenyl) -amide of pyridine-2-carboxylic acid (4-amino-phenyl) -amide of quinoline-4-carboxylic acid (4-amino-phenyl) -amide of 5-methyl-furan-2-carboxylic acid (4-amino-phenyl) 5-difluoromethyl-furan-2-carboxylic acid amide (4-amino-phenyl-amide of lH-indole-2-carboxylic acid (4-amino-phenyl) -amide of 4-methyl- [1,2, 3] thiadiazole-5-carboxylic acid (4-amino-phenyl) -amide of thiophene-3-carboxylic acid (4-amino-phenyl) -amide of 5-chloro-furan-2-carboxylic acid (4-amino-phenyl) -amide of 5-nitro-furan-2- acid N- (4-amino-phenyl) -2-thiophen-2-yl-acetamide (4-amino-phenyl) -amide of 3-methyl-furan-2-carboxylic acid (4-amino-phenyl) -amide 5-bromo-furan-2-carboxylic acid (4-amino-phenyl) -amide of 4-bromo-furan-2-carboxylic acid N- (4-amino-phenyl) -nicotinamide N- (4-aminophenyl) -3 4-phenyl- [1,2,3] thiadiazole-5-carboxylic acid furancarboxamide (4-amino-phenyl) -amide 3- (4-Amino-phenylcarbamoyl) -phenyl ester of acetic acid (4-amino- benzo [l, 3] dioxol-4-carboxylic acid phenyl) -amide N- (4-amino-phenyl) -3- (2-dimethylamino-ethoxy) -benzamide N- (4-amino-phenyl) -3- trifluoromethoxy-benzamide N- (4-amino-phenyl) -3- (2-morpholin-4-yl-ethoxy) -benzamide Hexyl ester of (4-amino-phenyl) -carbamic acid (4-amino-phenyl) -amide of furan-2-carboxylic acid phenyl ester of (4-amino-phenyl) -carbamic acid (4-amino-phenyl) -amide of hexanoic acid N- (4-amino-phenyl) -acrylamide N- (4-amino- phenyl) -2-methoxy-acetamide (4-am) 4-furan-3-yl- [1,2,3] thiadiazole-5-carboxylic acid (4-amino-phenyl) -amide of 5-tert-butyl-furan-2-carboxylic acid 3-furan-3-yl- [1,2,3] thiadiazole-5-carboxylic acid 5-Methyl- [1,2,3] thiadiazole-4-carboxylic acid chloro-4-methansulfinyl-phenylamine (4-amino-phenyl) -amide 2- (4-amino-2-chloro-phenyl) ethanol Ester 2 - (4-Amino-2-chloro-phenyl) carbamic acid-piperidin-1-yl-ethyl 5- (chloro-N, N-dimethyl-benzene-1,3-diamine 3- (2-methyl-butyl) - 5-trifluoromethyl-phenylamine 3-isobutyl-5-trifluoromethyl-phenylamine (4-aminomethyl-phenyl) -amide of furan-2-carboxylic acid N- (4-aminomethyl-phenyl) -2-fluoro-benzamide (4-aminomethyl- [1,2, 3] thiadiazole-4-carboxylic acid phenyl) -amide N- (4-aminomethyl-phenyl) -2,6-difluoro-benzamide (4-amino-phenyl) -amide of oxazole-4-acid carboxylic N- (4-amino-phenyl) -3-chloro-benzamide N- (4-amino-phenyl) -4-chloro-benzamide 4- (4-Amino-phenylcarbamoyl) -phenyl ester of acetic acid N- (4 -amino-phenyl) -4-dimethylamino-benzamide 1- (4-amino-phenyl) ) -3- (3,5-bis-trifluoromethyl) -phenyl) -thiourea N- (4-amino-phenyl) -2-iodo-benzamide N- (4-amino-phenyl) -3-trifluoromethyl-benzamide EXAMPLE 16 (METHOD 3B) 1- (4-amino-2-chloro-phenyl) -ethanol A 1M solution of tetrabutylammonium fluoride in 5.7 ml of tetrahydrofuran is added to the [3-chloro-4- (1-hydroxy-ethyl) -phenyl] -carbamic acid-2-trimethylsilyl-ethyl ester (0.5 g) and the mixture stir at room temperature for approximately 3.5 hours. The solution is then concentrated under reduced pressure, dissolved in a 1: 1 mixture of ethyl acetate and hexanes, washed successively with water and then with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure, followed by chromatography on silica gel (40% ethyl acetate in hexanes is used as the eluent) gives the product as an amber oil.

EXAMPLE 17 (METHOD 3C) N- (4-amino-3-cyanophenyl) -2-fluoro-benzamide g of potassium carbonate are added to a solution of 2.5 g of N- [3-cyano-4- (2, 2, 2-trifluoroacetylamino) -phenyl] -2-fluoro-benzamide in 270 ml of methanol and 16 ml of water, and the mixture is heated to reflux overnight. After removing the solvent under reduced pressure, the residue is suspended in water and extracted with dichloromethane. The organic extracts are combined, washed with water and then saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to provide the desired compound as a white solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: N- (4-amino-phenyl) -2-methanesulfinyl-benzamide N- (4-amino-3-cyano-phenyl) -2-fluoro-benzamide (4-amino-3-cyano-phenyl) -amide of furan-2-carboxylic acid N- (4-amino-3-cyano-phenyl) -acetamide (4-amino-3-trifluoromethyl-phenyl) -amide of the acid furan-2-carboxylic acid N- (4-amino-3-methoxy-phenyl) -acetamide N- (4-amino-3-methoxy-phenyl) -2-fluoro-benzamide (4-amino-3-methoxy-phenyl) -furan-2-carboxylic acid amide EXAMPLE 17 (METHOD 4A) 2-chloro-1-cyclohexyloxy-4-nitro-benzene 2. 9 g of cyclohexanol in 20 ml of dimethyl sulfoxide are added slowly to a flask containing 0. 90 g of potassium hydride (prewashed three times with hexanes) under an argon atmosphere and the solution is stirred for about 1 hour at room temperature. A solution of 1 g of 3-chloro-4-fluoro-nitrobenzene in 10 ml of dimethyl sulfoxide is added and the resulting dark red solution is then heated for about three hours at 100 degrees. The reaction mixture is then cooled, diluted with 300 ml of diethyl ether, and washed successively with saturated aqueous ammonium chloride, three times with water, then with saturated aqueous sodium chloride. The organic layer is then dried over anhydrous magnesium sulfate, the solvent is removed under reduced pressure, and the resulting oil is chromatographed on silica gel (5% ethyl acetate in hexanes which is used as the eluent) to provide the desired product as an orange solid.

EXAMPLE 18 (4C METHOD) (2-Chloro-4-nitro-phenyl) -methyl- (1-methyl-pyrrolidin-3-yl) -amine 1. 72 g of 3-chloro-4-fluoronitrobenzene and 1.72 g of N, N'-dimethyl-3-aminopyrrolidine are combined and stirred for approximately 24 hours. The mixture is then diluted with ethyl acetate, washed twice with water and once with saturated sodium chloride, and dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure, the residue is subjected to chromatography on silica gel (pure ethyl acetate followed by pure methanol is used as eluents) to provide the desired product as a yellow oil. Using the above procedure and the appropriate initiating materials, the following compounds were prepared: (2-chloro-4-nitro-phenyl) -dipropyl-amine 1- (2-chloro-4-nitro-phenyl) -piperidine 1- (2 -chloro-4-nitro-phenyl) -pyrrolidine (2-chloro-4-nitro-phenyl) -cyclohexyl-methylamine benzyl- (2-chloro-4-nitro-phenyl) -amine (2-chloro-4- nitro-phenyl) -methyl- (1-methyl-piperidin-4-yl) -amine (2-chloro-4-nitro-phenyl) -cyclohexyl-ethyl-amine (2-chloro-4-nitrophenyl) -cyclohexyl -amine (2-chloro-4-nitro-phenyl) -methyl- (1-methyl-pyrrolidin-3-yl) -amine (l-benzyl-pyrrolidin-3-yl) - (2-chloro-4-nitro) phenyl) -methyl-amine (2-chloro-4-nitro-phenyl) -cyclopentyl-methylamine 1- (2-chloro-4-nitro-phenyl) -decahydro-quinoline allyl- (2-chloro-4-nitro -phenyl) -cyclohexyl-amine 2- [(2-chloro-4-nitro-phenyl) - (2-hydroxy-ethyl) -amino] -ethanol (2-chloro-4-nitrophenyl) -isobutyl-methyl- amine (2-chloro-4-nitro-phenyl) -hexy-1-methyl-amine 2- [(2-chloro-4-nitro-phenyl) -methyl-amino] -ethanol N- (2-chloro-4-nitro) phenyl) -N, N ', N' -trimethyl-ethane-1,2-diamine N- (2-chloro-4-nitro-phenyl) -N, N ', N' -trimethyl-propan-1,3-diamine ( l-benzyl-piperidin-4-yl) - (2-chloro-4-nitro-phenyl) -amine N- (2-chloro-4-nitro-phenyl) -N *, N '-dimethyl-ethan-1, 2-diamine N- (2-chloro-nitro-phenyl) -NN '-dimethyl-propan-1,3-diamine (2-chloro-4-nitro-phenyl) - (2-methoxy-ethyl) -methylamine ( l-benzyl-pyrrolidin-3-yl) - (2-chloro-4-nitro-phenyl) -amine -? iperidin-l-yl-3-trifluoromethyl-benzonitrile dimethylamino-3-trifluoromethyl-benzonitrile 4- (4- methyl-piperazin-l-yl) -3-trifluoromethyl-benzonitrile EXAMPLE 19 (METHOD 4E) Butyl- (2-chloro-4-nitro-phenyl) thioether A solution of 5 g of 3-chloro-4-fluoro-nitrobenzene and 2.5 g of sodium sulfide in 30 ml of N, N-di-ethylformamide is stirred at room temperature for 1 hour and then treated with 12.6 g of 1 -yodobutane. The solvent is then removed under reduced pressure and the resulting residue is treated with ethyl acetate and hexanes to precipitate the inorganic salts. The solids are removed by filtration and the filtrate is reduced under reduced pressure. The resulting residue is then passed through hydrous magnesium silicate using dichloromethane as the eluent to provide the desired compound as a yellow solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared. l-Butylsulfanyl-2-chloro-4-nitro-benzene 2-Chloro-1-cyclohexylsulfanyl-4-nitro-benzene 2-chloro-1-nitro-benzene etilsulfañil- EXAMPLE 20 (METHOD 4F) (-chloro-5- methoxy-2-nitro-phenyl) -dimethyl-amine To a solution of 1 g of the 4-chloro-5-methoxy-2-nitro-phenyl ester of trifluoromethanesulfonic acid in 2 ml of tetrahydrofuran, dimethylamine (4.0 ml of a 40% strength aqueous solution) is added and the mixture is stirred at room temperature. room temperature for approximately 15 hours. The solution is then concentrated under reduced pressure and the residue is dissolved in ethyl acetate and then washed with water. The aqueous layer is extracted once with ethyl acetate and the combined organic layers are washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is triturated with hexanes to provide the desired product as a colorless solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: (4-chloro-2-nitro-phenyl) -dimethyl-amine 4- (4-chloro-5-methoxy-2-nitro-phenyl) -morpholine 4- (4-chloro-5-methoxy-2-nitro-phenyl) -dimethyl-amine 1- (4-chloro-5-methoxy-2-nitro-phenyl) -piperidine 1- (4-chloro-5-methoxy) -2-nitro-phenyl) -pyrrolidine benzyl- (4-chloro-5-methoxy-2-nitro-phenyl) -amine (2-chloro-6-nitro-phenyl) -dimethyl-amine EXAMPLE 21 (4G METHOD) (2-chloro-4-nitro-phenyl) -methyl-phenyl-amine The n-butyl lithium (12.3 ml of a 2.5 M solution in hexanes) is added dropwise to a solution of 3 g of N-methyl-aniline in 75 ml of tetrahydrofuran at 0 ° C. The mixture is allowed to warm slowly to room temperature and then cooled to 0 ° C and added by means of a cannula to a solution of 4.9 g of 3-chloro-4-fluoronitrobenzene in 35 ml of tetrahydrofuran which is maintained at room temperature. -78 ° C. After the addition, the reaction mixture is allowed to warm to room temperature over the course of 1 hour, and then concentrated under reduced pressure, quenched by the addition of saturated aqueous ammonium chloride, and extracted three times with ethyl acetate. The combined organic layers are washed three times with 5% aqueous hydrochloric acid, once with water, once with saturated aqueous sodium bicarbonate, once with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the residue is subjected to chromatography on silica gel (5% diethyl ether in hexanes which is used as eluent) to provide the desired product as a colorless oil.

EXAMPLE 22 (4H METHOD) 2, 6-dichloro-4-nitrophenol 14.86 g of 3, 4, 5-trichloronitrobenzene are added to a solution of 8.66 g of potassium phenoxide in 66 ml of diethylene glycol, and the mixture is heated to 160 ° C for about 15 hours. The resulting dark brown solution is cooled to room temperature, poured into 100 ml of cold water, and extracted twice with diethyl ether. The combined organic extracts are washed with water, with 10% aqueous sodium hydroxide, and then dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the resulting oil is distilled in a Kugelrohr apparatus to provide a yellow oil that solidifies upon standing. Recrystallization from ethanol-water gives the desired product as a pale yellow solid.

EXAMPLE 23 (METHOD 5A) Terbutyl ester of (3,5-dichloro-4-ethoxy-phenyl) -carbamic acid To a solution of 1 g of the terbutyl ester of (3,5-dichloro-4-hydroxy-phenyl) -carbamic acid and 1 g of potassium carbonate in 18 ml of acetone, 0.36 ml of ethyl iodide are added and the mixture stir for approximately 15 hours at room temperature. The solution is then filtered, concentrated under reduced pressure, and partitioned between ethyl acetate and water. The separated aqueous layer is subsequently extracted twice with ethyl acetate, and the combined organic extracts are successively washed with 10% aqueous sodium hydroxide, with water, and then dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gives the desired product as a burnt-colored solid. Using the above procedure and the appropriate initial materials, the following compounds were prepared: Terbutyl ester of (3,5-dichloro-4-ethoxy-phenyl) -carbamic acid Terbutyl ester of (4-butoxy-3,5-dichloro-phenyl) -carbamic acid Terbutyl acid ester ( 4-benzyloxy-3, 5-dichloro-phenyl) -carbamic acid ester (4-carbamoylmethoxy-3,5-dichloro-4-ethoxy-phenyl) -carbamic acid terbutyl ester of [3, 5-dichloro-4-] (2-nitrile-ethoxy) -phenyl] -carbamic acid ester (4-tert-butoxycarbonylamino-2,6-dichloro-phenoxy) -acetic acid methyl ester of 3-butoxy-benzoic acid methyl ester of 3-ter- butoxycarbonylmethoxy-benzoic acid 3-carbamoylmethoxy-benzoic acid methyl ester [4- (3-Carbamoylmethoxy-benzoylamino) -phenyl] -carbamic acid tert-butyl ester terbutyl ester. { 4- [3- (2-Chloro-ethoxy) -benzoylamino] -phenyl} -carbamic EXAMPLE 24 (METHOD 5C) (2,6-Dichloro-4-nitro-phenoxy) -acetic acid terbutyl ester To a solution of 2.5 g of 2,6-dichloro-4-nitrophenol and 3.3 g of potassium carbonate in 50 ml of dimethylformamide is added 10 ml of tert-butyl bromoacetate and the mixture is stirred at room temperature for two days. The solution is then poured into 500 ml of water, extracted three times with hexanes, and the combined organic extracts are washed with saturated aqueous ammonium chloride and then dried over anhydrous magnesium sulfate. Evaporation of the solvent under reduced pressure, followed by trituration of the resulting oil with hexanes gives the desired product as a white solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 3-dimethylamino-1- (4-nitro-phenyl) -propenone 2-chloro-1-isopropoxy-4-nitro-benzene 1,3-dichloro- 2-methoxy-4-methyl-5-nitro-benzene 1-chloro--ethoxy-2-methoxy-5-nitro-benzene 1-butoxy-chloro-5-methoxy-2-nitro-benzene l-chloro-2 -methoxy-5-nitro-4- (phenylmethoxy) benzene (CA name) l-chloro-4-methoxy-5-nitro-2- (phenylmethoxy (benzene (CA name)) terbutyl ester of (2,6-dichloro- 4-nitro-phenoxy) -acetic acid (2,6-dichloro-4-nitro-phenoxy) -acetonitrile 1-chloro-4-methoxy-2-methyl-5-nitro-benzene 2- (4-chloro-5-methoxy) -2-nitro-phenoxy) -acetamide 2- (2-chloro-5-methoxy-4-nitro-phenoxy) -acetamide (4-chloro-5-methoxy-2-nitro-phenoxy) -acetonitrile (2-chloro- 5-methoxy-4-nitro-phenoxy) -acetonitrile 4- (2-chloro-5-methoxy-4-nitro-phenoxy) -butyronitrile 2- (4-chloro-5-methoxy-2-nitro-phenoxy) -ethanol 2- (2-chloro-5-methoxy-4-nitro-phenoxy) -ethanol (2-clo) tert-butyl ester ro-5-methoxy-4-nitro-phenoxy) -acetic acid ester (2-chloro-5-methoxy-4-nitro-phenoxy) -acetic acid methyl ester (4-chloro-5-methoxy-2-) nitro-phenoxy) -acetic acid (4-Chloro-5-methoxy-2-nitro-phenoxy) -acetic acid (2-chloro-4-nitro-phenoxy) -acetonitrile 1-butoxy-2-chloro-4-butyl ester nitro-benzene 2-chloro-4-nitro-l- (2,2, 2-trifluoro-ethoxy) -benzene 2-chloro-4-nitro-1-propoxy-benzene 2-chloro-1-ethoxy-4-nitro benzene 1,3-diiodo-2,4-dimethoxy-5-nitro-benzene 1,3-dibromo-2,4-dimethoxy-5-nitro-benzene 3-chloro-2,4-dimethoxy-nitrobenzene EXAMPLE 25 ( METHOD 5E) [3,5-dichloro-4- (2-hydroxy-ethoxy) -phenyl] -carbamic acid terbutyl ester To a solution of 1 g of the terbutyl ester of (3,5-dichloro-4-hydroxy-phenyl) -carbamic acid and 0.55 g of potassium carbonate in 20 ml of toluene is added 1.6 g of ethylene carbonate and the mixture heat to reflux for 3 hours. To the cooled reaction mixture is added 50 ml of 2.5 M aqueous sodium hydroxide, and the separated organic layer is then washed successively with water, then with saturated aqueous sodium chloride, and then dried over anhydrous sodium sulfate. The solvent is then removed under reduced pressure and the resulting residue is subjected to chromatography on silica gel (30% ethyl acetate in hexanes which is used as the eluent) to provide the desired product as a white foam.

EXAMPLE 26 (METHOD 6) 3- (2-chloro-4-nitro-phenoxy) -1-methyl-pyrrolidine To a solution of 2 g of 2-chloro-4-nitrophenol in 60 ml of tetrahydrofuran, 2.3 g of l-methyl-3-pyrrolidinol, 6 g of triphenylphosphine, and 3.6 ml of diethylazocarboxylate are added, and the mixture is stirred at room temperature under an argon atmosphere for 1.5 hours. The solution is then concentrated under reduced pressure, diluted with ethyl acetate, washed successively with 10% aqueous sodium hydroxide, with water, saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed under evaporation under reduced pressure and the residue is subjected to chromatography on silica gel (ethyl acetate then 10% methanol in dichloromethane which is used as the eluent). The fractions of the combined product are then recrystallized from hexanes to provide the desired product as a yellow solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 4- (2-chloro-4-nitro-phenoxy) -1-methyl-piperidine 3- (2-chloro-4-nitro-phenoxy) -1 -methyl-pyrrolidine [2- (2-chloro-4-nitro-phenoxy) -ethyl] -dimethyl-amine [3- (2-chloro-4-nitro-phenoxy) -propyl] -dimethyl-amine EXAMPLE 27 (METHOD 7A) 2-chloro-3-methoxy-6-nitro-phenol and 2,4-dichloro-3-methoxy-6-nitro-phenol To a flask containing 0.5 g of 3-methoxy-6-nitrophenol is added aqueous sodium hypochlorite (5.25% aqueous solution, 21 ml) and the mixture is stirred at room temperature for approximately 24 hours. The mixture is then cooled in an ice bath, acidified by the addition of concentrated hydrochloric acid, then extracted twice with ethyl acetate. These organic extracts are dried over anhydrous magnesium sulfate, the solvent is removed by evaporation under reduced pressure, and the residue is subjected to chromatography on silica gel (15% acetone in hexanes which is used as the eluent) to provide the products. mono- and di-chlorinated as yellow solids. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 3-chloro-2-hydroxy-4-methoxy-nitrobenzene 3,5-dichloro-2-hydroxy-4-methoxy-nitrobenzene EXAMPLE 28 (METHOD 7B) 2,4-Dichloro-3-methyl-6-nitro-phenol To a solution of 5 g of 3-methyl-4-nitrophenol in 150 ml of water, aqueous sodium hypochlorite (5.25% aqueous solution, 230 ml) is added and the mixture is stirred at room temperature for about 15 hours. Additional aqueous sodium hypochlorite (5.25% aqueous solution, 230 ml) is added and the mixture is allowed to stir at room temperature for 2.5 days. The mixture is then cooled in an ice bath, acidified by the addition of concentrated hydrochloric acid, then extracted twice with ethyl acetate. These organic extracts are dried over anhydrous magnesium sulfate, the solvent is removed by evaporation under reduced pressure, and the residue is chromatographed on silica gel (ethyl acetate is used as the eluent) to provide the desired product as a solid. yellow. An analytically pure sample is obtained by a simple recrystallization from chloroform.

EXAMPLE 29 (METHOD 7C) l-bromo-2,4-dimethoxy-5-nitro-benzene To a solution of 0.50 g of 2,4-dimethoxy-nitrobenzene in 3 ml of chloroform, a solution of 0.23 g of bromine in 1 ml of chloroform is added dropwise, and the mixture is allowed to stir at room temperature for about 15 minutes. hours. An additional 0.15 g of bromine is added in 1 ml of chloroform, and the reaction is stirred for an additional 4 hours. The mixture is then poured into 5% aqueous sodium bisulfite and then extracted with chloroform. The combined organic extracts are then washed successively with 5% aqueous sodium bisulfite and then with saturated sodium chloride, and then dried over anhydrous sodium sulfate. Removal of the solvent under reduced pressure and recrystallization of the residue from the toluene gives the desired product as a yellow solid.

EXAMPLE 30 (METHOD 7D) 2, 4-dibromo-3-methoxy-6-nitro-phenol To a solution of 0.25 g of 5-methoxy-2-nitrophenol and 0.49 g of silver trifluoroacetate in 3 ml of glacial acetic acid, a solution of bromine (1.42 g) in 3 ml of glacial acetic acid is added dropwise and The mixture is stirred at room temperature for approximately 24 hours. The solution is then partitioned between ethyl acetate and water, and the organic layer is successively washed three times with 5% aqueous sodium bisulfite, three times with saturated aqueous sodium bicarbonate, and once with saturated aqueous sodium chloride. The organic layer is then dried over anhydrous magnesium sulfate and the solvent is removed under reduced pressure. The residue is chromatographed on silica gel (20% ethyl acetate in hexanes which is used as the eluent) then recrystallized from chloroform to provide the desired dibromo product as an orange solid.

EXAMPLE 31 (METHOD 7E) l-iodo-2, -dimethoxy-5-nitro-benzene To a solution of 1 g of 2,4-dimethoxy-nitrobenzene in 30 ml of glacial acetic acid, 1.90 g of benzyltrimethylammonium dichloroiodate and 1 g of anhydrous zinc chloride are added., and the mixture is stirred at room temperature under an argon atmosphere. An additional 0.4 g of benzyltrimethylammonium dichloroiodate is added after 5 hours, and again after 24 hours. An additional 0.5 g of zinc chloride and 15 ml of glacial acetic acid are added after 24 hours. The mixture is allowed to stir at room temperature for 3 days and is then filtered, diluted with 5% aqueous sodium bisulfite, and extracted three times with ethyl acetate. These combined organic extracts are washed successively with 5% aqueous sodium bisulfite, saturated aqueous sodium chloride, then dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the residue is triturated with hexanes to provide the desired product as a pale yellow solid.

EXAMPLE 32 (METHOD 7F) 2, 4-diiodo-3-methoxy-6-nitro-phenol To a solution of 0.25 g of 5-methoxy-2-nitrophenol in 15 ml of dichloromethane and 6 ml of methanol, 1.08 g of benzyltrimethylammonium dichloroiodate and 0.85 g of sodium bicarbonate are added, and the mixture is left stirring at room temperature. environment for 24 hours. The solution is then filtered, the filtrate is concentrated under reduced pressure, the residue is dissolved in ethyl acetate and then washed successively with 5% aqueous sodium bicarbonate, 5% aqueous sodium bisulfite, and saturated aqueous sodium chloride. . After drying over anhydrous magnesium sulfate, the solvent is removed by evaporation under reduced pressure and the residue is recrystallized from toluene to give the desired product as yellow needles.

EXAMPLE 33 (7G METHOD) 1-fluoro-2,4-dimethoxy-5-nitro-benzene To a solution of 1 g of 2,4-dimethoxy-nitrobenzene in 10 ml of tetrachloroethane is added 3,5-dichloro-1-fluoropyridinium triflate (85%, 5.07 g) and the mixture is heated to 120 ° C. 5 hours. Additional 3,5-dichloro-1-fluoropyridinium triflate (85%, 0.25 g) is added and heating is continued for 1 hour. The solution is then cooled to room temperature and passed over a column of silica gel (hexanes followed by 30% ethyl acetate in hexanes which is used as the eluent). The fractions containing the product are combined, evaporated under reduced pressure, and the residue is crystallized from hexanes to provide the desired product as a color-burned solid.

EXAMPLE 34 (METHOD 8) 3-chloro-4-trifluoromethyl-1-nitrobenzene A solution of 3-chloro-4-iodonitrobenzene (2.26 g), 5.68 g of trimethyl (trifluoromethyl) silane, 2.28 g of copper iodide, and 0.56 g of potassium fluoride in 8 ml of N, N-dimethylformamide is heated in a tube sealed at 80 ° C for 40 hours. The solution is then cooled, diluted with diethyl ether, filtered through diatomaceous earth, and the filtrate washed successively with water, with saturated aqueous sodium chloride, and then dried over anhydrous sodium sulfate. The solvent is removed under reduced pressure and the residue is subjected to chromatography on silica gel (1% diethyl ether in hexanes followed by 10% ethyl acetate in hexanes, which is used as the eluent), to provide the desired product. as a colorless oil.

EXAMPLE 35 (METHOD 9) (3-chloro-4-methanesulfinyl-phenyl) -carbamic acid terbutyl ester To a solution of 0.89 g of the (3-chloro-4-thiomethyl-phenyl) -carbamic acid terbutyl ester in 15 ml of dichloromethane at 0 ° C is added a solution of dimethyldioxirane (approximately 0.11 M in acetone, 34 ml) and The mixture is stirred at 0 ° C for 1 hour. The solvent is removed under reduced pressure and the residue is dissolved in dichloromethane, washed with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gave the desired product as an orange foam.

EXAMPLE 36 (METHOD 9B) [4- (2-Methylsulfinyl-benzoyl-ino-phenyl] -carbamic acid) butyl ester To a solution of 234 mg of the 2-methylsulfanyl-N- [4- (2,2,2-trifluoroacetylamino) -phenyl] -benzamide, a saturated solution of 5 ml of sodium periodate is added and the mixture is stirred by 12 hours. The purple mixture is poured into water, extracted with ethyl acetate, dried over anhydrous potassium carbonate and evaporated to yield a red solid, 101 mg. Using the above procedure and the appropriate starting materials, the following compounds were prepared: [4- (2-methanesulfinyl-benzoylamino) -phenyl] -carbamic acid terbutyl ester 2-methansulfinyl-N- [4- (2, 2, 2 -trifluoroacetylamino) -phenyl] -benzamide EXAMPLE 37 (METHOD 10) (3-Chloro-4-methanesulfonyl-phenyl) -carbamic acid terbutyl ester To a solution of 0.90 g of the (3-chloro-4-thiomethyl-phenyl) -carbamic acid terbutyl ester in 30 ml of dichloromethane at 0 ° C is added a solution of dimethyldioxirane (approximately 0.11 M in acetone, 80 ml) and The mixture is stirred at 0 ° C for 1 hour. The solvent is removed under reduced pressure and the residue is dissolved in dichloromethane, washed with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. Removal of the solvent under reduced pressure gives the desired product as an orange foam.

EXAMPLE 38 (METHOD 11) 3-chloro-4-vinyl-phenylamine To a deoxygenated solution of 6.95 g of 3-chloro-4-iodo-aniline, 0.67 g of triphenylarsine, and 0.50 g of tris (dibenzylidene ketone) palladium (0) in 120 ml of tetrahydrofuran at 50 ° C is added 10 g of tributylvinyltin and the mixture is stirred for approximately 15 hours at 50 ° C under an argon atmosphere. The reaction is then cooled, filtered through diatomaceous earth, and the filtrate is evaporated to dryness under reduced pressure. The residue is dissolved in hexanes and then extracted three times with 5% aqueous hydrochloric acid. These aqueous acidic extracts are then alkalinized with solid potassium carbonate and extracted three times with ethyl acetate. These combined organic extracts are then washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and the solvent is removed under reduced pressure. The resulting residue is chromatographed on silica gel (hexanes and then 10% ethyl acetate in hexanes is used as the eluent) to provide the desired product as an amber oil.

EXAMPLE 39 (METHOD 12) [3-Clqro-4- (1-hydroxy-ethyl) -phenyl-carbamic acid 2-trimethylsilanyl ethyl ester 2. 6 g of the (3-chloro-4-vinyl-phenyl) -carbamic acid 2-trimethylsilanylethyl ester are added to a solution of mercuric acetate (3.48 g) in 7 ml of water and 5.25 ml of tetrahydrofuran, and the mixture is stirred for approximately 15 hours. 8.7 ml of 3 N aqueous sodium hydroxide and a 0.5 M solution of sodium borohydride are then added in 8.7 ml of 3 N aqueous sodium hydroxide, and the stirring is continued for 6. hours. The solution is then saturated with sodium chloride and extracted with ethyl acetate. The organic extracts are then washed with saturated aqueous sodium chloride and dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure, the residue is subjected to chromatography on silica gel (20% ethyl acetate in hexanes is used as the eluent) to provide the desired product as a white solid.

EXAMPLE 40 (METHOD 13) [3-Chloro-4- (2-hydroxy-ethyl) -phenyl] -carbamic acid terbutyl ester To a suspension with stirring of 0.45 g of sodium borohydride in 13 ml of tetrahydrofuranq at 0 ° C is added 0.75 ml of glacial acetic acid and the mixture is stirred at 0 ° C for 1 hour. The solution is then heated to room temperature and 1 g of the (3-chloro-4-vinyl-phenyl) -carbamic acid 2-trimethylsilylethyl ester is added. The reaction is stirred at room temperature for about 15 hours and then heated to reflux for about 20 hours. The mixture is then cooled and solutions of 0.80 ml of 5 N aqueous sodium hydroxide and 0.56 ml of 30% aqueous hydrogen peroxide are added. After stirring for an additional 15 hours the layers are separated, the aqueous layer is extracted three times with diethyl ether, and these organic extracts are dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the residue is subjected to chromatography on silica gel (40% ethyl acetate in hexanes is used as the eluent) to provide the desired product as an amber oil.

EXAMPLE 41 (METHOD 14) [4- (L-Azidoethyl) -3-chloro-phenyl] -carbamic acid 2-trimethylsilanyl ethyl ester To a solution of 1.25 g of the [3-chloro-4- (1-hydroxy-ethyl) -phenyl] -carbamic acid 2-trimethylsilanyl ester in 20 ml of tetrahydrofuran at 0 ° C under an argon atmosphere, add 2.6 g of triphenylphosphine, hydrazoic acid (approximately 2.5 molar equivalents in dichloromethane, prepared by the method of Fieser and Fieser, Reagen ts for Organic Syn thesis, Vol. 1, p 446, Wiley, New York) and 1.72 g of azodicarboxylate of diethyl After about 10 minutes, the solvent is removed under reduced pressure and the residue is subjected to chromatography on silica gel (5% ethyl acetate in hexanes is used as the eluent) to provide the desired product as a colorless oil.

EXAMPLE 42 (METHOD 15) [3-Chloro-4- (3-dimethylaminoprop-1-ynyl) -phenyl] -carbamic acid tertiary butyl ester To a deoxygenated solution of 10 g of the (3-chloro-4-iodo-phenyl) -carbamic acid terbutyl ester in 120 ml of triethylamine is added 2.82 g of 1-dimethylamino-2-ropin, 0.4 g of bis (triphenyl-phosphine) palladium (II) chloride, and 0.054 g of cuprous iodide. The mixture is stirred at room temperature under an argon atmosphere for about 6 hours and then briefly heated (approximately 10 minutes) to 60 ° C. The reaction mixture is then cooled, filtered through diatomaceous earth, and the solvent is removed by evaporation under reduced pressure. The residue is dissolved in ethyl acetate, washed three times with water, once with saturated aqueous sodium sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure, and the residue is subjected to chromatography on silica gel (80% ethyl acetate in hexanes is used as the eluent) to give the purified product as an amber oil which solidifies with the repose. Using the above procedure and the appropriate starting materials, the following compounds were prepared: [3-chloro-4- (3-dimethylamino-prop-1-ynyl) -phenyl] -carbamic acid [3- (4-methoxy)] terbutyl ester phenyl) -prop-2-ynyl] -dimethyl-amine 4- (3-dimethylamino-prop-1-ynyl) -benzonitrile dimethyl- [3- (4-nitro-phenyl) -prop-2-ynyl] -amine EXAMPLE 43 (METHOD 16) [3-Chloro-4- (3-dimethylamino-acryloyl) -phenyl] -carbamic acid terbutyl ester To an ice-cooled solution of 4 g of the [3-chloro-4- (3-dimethylamino-prop-1-yl) -phenyl] -carbamic acid terbutyl ester in 30 ml of dichloromethane, 2.34 g is added in small portions. of 3-chloroperoxybenzoic acid. After the reaction is stirred at 0 ° C for 20 minutes, the mixture is passed over twenty equivalents by weight of basic alumina (Brockmann Grade I, 150 mesh) and the N-oxide is eluted using a 5% methanol solution. % in dichloromethane. All fractions containing the desired amine N-oxide were combined and evaporated to dryness under reduced pressure. The residue is treated three times successively with small portions of methanol (approximately 50 ml) followed by evaporation to near dryness under reduced pressure, and the volume of the solution is adjusted to 250 ml by the addition of methanol. The methanolic solution of the N-oxide is then heated to reflux for about 15 hours, then cooled, and the solvent is evaporated to dryness under reduced pressure. The residue is purified by chromatography on silica gel (80% ethyl acetate in hexanes is used as the eluent) to give the desired product as a pale yellow solid.

EXAMPLE 44 (METHOD 17) (3-Chloro-4-isoxazol-5-yl-phenyl) -carbamic acid terbutyl ester A solution of 270 mg of the [3-chloro-4- (3-dimethylamino-acryloyl) -phenyl] -carbamic acid terbutyl ester in 3 ml of dioxane was treated with 122 mg of hydroxylamine hydrochloride and the mixture was stirred at room temperature. environment for 10 days. The mixture is diluted with ethyl acetate, washed successively with water, with 5% aqueous sodium bicarbonate, with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure and the resulting residue is subjected to chromatography on silica gel (33% ethyl acetate in hexanes which is used as the eluent) to provide the desired product as a colorless solid.

EXAMPLE 45 (METHOD 18) [3-Chloro-4- (lH-pyrazol-3-yl) -phenyl] -carbamic acid terbutyl ester A solution of 250 mg of the [3-chloro-4- (3-dimethylamino-acryloyl) -phenyl] -carbamic acid terbutyl ester in 1.25 ml of ethanol is treated with 0.25 ml of hydrazine hydrate and the mixture is stirred at room temperature. environment for 3 hours. The mixture is then diluted with 30 ml of diethyl ether, washed three times with water, once with saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure and the resulting residue is subjected to chromatography on silica gel (67% ethyl acetate in hexanes which is used as the eluent) to provide the desired product as an oil.

EXAMPLE 46 (METHOD 19A) N- (2-chloro-4-nitrophenyl) -2-thiomorpholino-4-yl-acetamide To a solution of 3.80 g of N- (chloroacetyl) -2-chloro-4-nitroaniline in 50 ml of tetrahydrofuran is added 10 ml of thiomorpholine and the solution is allowed to stand for 1 hour. This reaction mixture is poured into water and a pale yellow solid is collected and then recrystallized from hot 2-propanol to give a pale yellow crystalline solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: (4- {2- (Bis- (2-hydroxy-ethyl) -amino] -acetylamino} -phenyl} - tert-butyl ester Carbamic acid [4- (2-dimethylamino-acetylamino) -phenyl] -carbamic acid terbutyl ester. { 4- [3- (2-dimethylamino-ethoxy) -benzoylamino] -phenyl} -carbonate terbutyl ester of acid. { 4- [3- (2-morpholin-4-yl-ethoxy) -benzoylamino] -phenyl} -carbamic N- (2-chloro-4-nitro-phenyl) -2-dimethylamino-acetamide N- (2-chloro-4-nitro-phenyl) -2-piperidin-l-yl-acetamide N- (2-chloro) -4-nitro-phenyl) -2-morpholin-4-yl-acetamide N- (2-chloro-4-nitro-phenyl) -2-dipropylaminoacetamide N- (2-chloro-4-nitro-phenyl) - 2-thiomorpholin-4-yl-acetamide N- (2-chloro-4-nitro-phenyl) -2-diethylamino-acetamide N- (2-chloro-4-nitro-phenyl) -2-pyrrolidin-1-yl-acetamide 2-azepane-l-yl-N- (2-chloro-4-nitro-phenyl) -acetamide N- (2-chloro-4-nitro-phenyl) -2- (2-methyl-piperidin-1-yl) -acetamide N- (2-chloro-4-nitro-phenyl) -2- (3-methyl- piperidin-1-yl) -acetamide N- (2-chloro-4-nitro-phenyl) -2- (4-methyl-piperidin-1-yl) -acetamide EXAMPLE 47 (METHOD 19B) N- (2-chloro-4-nitrophenyl) -2- (2-dimethylaminoethylsulfanyl) acetamide To a solution of 3.01 g of N- (chloroacetyl) -2-chloro-4-nitroaniline in 100 ml of N, N-dimethylformamide is added 6.0 g of powdered sodium carbonate and 6.0 g of 2-dimethylaminoethanethiol hydrochloride. The mixture is stirred for 1 hour at 25 ° C, poured into water and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous potassium carbonate and concentrated under reduced pressure to give an oil. The oil is crystallized from toluene-hexanes (3: 1) to produce a pale yellow crystalline solid.

EXAMPLE 48 (METHOD 20) 2-piperidin-1-yl-ethyl ester of (4-tert-butoxycarbonylamino-2-chloro-phenyl) -carbamic acid To a suspension of 4.0 g of 1, 1-carbonyl-di- (1, 2, 4) -triazole in 40 ml of dichloromethane, a solution of 5 g of the terbutyl ester of the acid (4-amino-3-chloro) is added. phenyl) -carbamic acid in 45 ml of dichloromethane dropwise in 20 minutes. The reaction is stirred at room temperature for 30 minutes, at which point a precipitate forms. To this mixture is added 6.6 ml of piperidinetanol and 20 ml of tetrahydrofuran, which is added to maintain homogeneity. After heating to reflux overnight, the reaction is cooled and then poured into water, the organic layer is separated and then washed with saturated aqueous sodium chloride. The solution is dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain a crude oil which is purified by chromatography on silica gel (5% methanol in dichloromethane, which is used as the eluent) to give the desired product as a white foam.

EXAMPLE 49 (METHOD 21) 5-Phenyl- [1, 2, 3] thiadiazole-4-carboxylic acid methyl ester A solution of 1.1 g of ethyl benzoylacetate in 10 ml of acetonitrile is treated with 1.3 g of the 4-methylbenzenesulfinyl azide and 1.6 g of triethylamine. After stirring overnight at room temperature, the reaction is concentrated under reduced pressure and the resulting crude product is dissolved in ethyl acetate and washed with 1 N sodium hydroxide. The organic layer is then dried over anhydrous magnesium sulfate, it is filtered and concentrated under reduced pressure to produce a yellow oil. This oil is collected in dichloromethane and filtered through a pad of hydrous magnesium silicate, eluting with dichloromethane to give the partially purified diazoketone as a colorless oil. A sample of the above diazoketone (1.2 g) is dissolved in 25 ml of toluene and treated with 2.8 g of 2,4-bis (4-methoxyphenyl) -1,3-dithia-2, -diphosphetan-2, 4- disulfide and the reaction is heated to reflux. After 3 hours, the reaction is cooled to room temperature, loaded onto a pad of silica gel and eluted with dichloromethane. After removing the solvent under reduced pressure, the resulting oil is purified by chromatography on silica gel (30% diethyl ether in petroleum ether as the eluent), and then recrystallized from hexanes to give the desired product like pale yellow needles. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 5-phenyl- [1, 2, 3] thiadiazole-4-carboxylic acid ethyl ester 5-methyl- [1,2,3-methyl ester ] thiadiazole-carboxylic acid EXAMPLE 50 Semicarbazide of ethyl benzoylacetate . 0 g of ethyl benzoylacetate are dissolved in ml of methanol and add rapidly to a warm solution of 29 g of semicarbazide hydrochloride in 130 ml of water. To this is added 4.1 g of pyridine and after heating to reflux for 5 minutes, the reaction mixture is cooled to -20 ° C overnight. The resulting solid semicarbazone is collected by filtration, washed with water and then with diethyl ether to give the desired product as white crystals. Using the above procedure and the appropriate starting materials, the following compounds were prepared: (Z) -3- [aminocarbonyl) hydrazone] -4,4,4-trifluorobutanoate ethyl ester 3 - [(Z) -2- (aminocarbonyl) hydrazono] -3-phenylpropanoic acid 3 - [(E) -2- (aminocarbonyl) hydrazono] -3- (3-furyl) propanoic acid ethyl ester EXAMPLE 51 5-Phenyl- [1, 2, 3] thiadiazole-5-carboxylic acid ethyl ester A solution of 2.5 g of the semicarbazone of ethyl benzoylacetate in 5 ml of pure thionyl chloride is stirred at 0 ° C for 1 hour. 25 ml of dichloromethane are then added, the excess thionyl chloride is slowly destroyed with saturated aqueous sodium bicarbonate. The precipitate formed with the quenching is removed by filtration and the filtrate is extracted with dichloromethane. The combined organic extracts are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Chromatography on silica gel (50% hexanes in dichloromethane is used as the eluent) gives the desired product as a colorless oil. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 4-methyl- [1,2,3] thiadiazole-5-carboxylic acid methyl ester 4-phenyl- [1, 2, 3 ] thiadiazole-5-carboxylic acid 4-furan-3-yl- [1,2,3] thiadiazole-5-carboxylic acid ethyl ester EXAMPLE 52 4-Methyl- [1,2,3] thiadiazole-5-carboxylic acid 1. 7 g of the methyl ester of the acid. 4-Methyl- [1, 2, 3] thiadiazole-5-carboxylic acid is dissolved in 15 ml of methanol and treated with 16 ml of 1 N sodium hydroxide. After stirring at room temperature for 1 hour, the reaction is treated. with 1.5 ml of concentrated hydrochloric acid and concentrated under reduced pressure. The resulting turbid aqueous layer is extracted twice with diethyl ether and the combined organic layers are dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the desired compound as a white powder. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 3-ethoxycarbonylmethoxy-benzoic acid 5-furan-3-yl- [1,2,3] thiadiazole-4-carboxylic acid thiazole-4-carboxylic acid 4-methyl- [1,2,3] thiadiazole-5-carboxylic acid 5-methyl- [1,2,3] thiadiazole-4-carboxylic acid EXAMPLE 53 (METHOD 25) 4-chloro-5-methoxy-2-nitro-phenyl ester of trifluoro-methanesulfonic acid To a solution of 6.5 g of 4-chloro-5-methoxy-2-nitro-phenol in 150 ml of dichloromethane at 0 ° C. under an atmosphere of argon, 10 g of triethylamine and then a solution of 13.5 g of anhydride are added. trifluoromethanesulfonic acid in 30 ml of dichloromethane. The solution is stirred at 0 ° C for 10 minutes, and then diluted with dichloromethane and washed successively with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride. After drying over anhydrous sodium sulfate, the solvent is removed by evaporation under reduced pressure and the residue is dissolved in a solution of 20% dichloromethane in hexanes and passed through a short column of hydrous magnesium silicate ( 20% dichloromethane in hexanes as the eluent). The fractions containing the product are combined and the solvents are removed by evaporation under reduced pressure to give the desired product as a yellow oil. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 4-chloro-5-methoxy-2-nitrophenyl ester of trifluoromethanesulfonic acid 4-chloro-2-nitro-phenyl ester of trifluoro-methanesulfonic acid ester 2 -chloro-6-nitro-phenyl of trifluoro-methanesulfonic acid EXAMPLE 4 (METHOD 26) [- (3-dimethylamino-benzoylamino) -phenyl] -carbamic acid terbutyl ester A solution of 404 mg of the [- (3-amino-benzoylamino) -phenyl] -carbamic acid terbutyl ester, 240 mg of sodium cyanoborohydride, 3 drops of acetic acid and ml of 0% aqueous formaldehyde in 14 ml of tetrahydrofuran -methanol 1: 2, stirred for 14 minutes, and then poured into saturated aqueous sodium bicarbonate and then extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous potassium carbonate and concentrated under reduced pressure to give a solid which is recrystallized from acetonitrile to give a pale pink crystalline solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: [- (3-dimethylamino-benzoylamino) -phenyl] -carbamic acid (3-bromo-4-trifluoromethyl-phenyl) -dimethyl-amine N-butyl ester - (3-chloro-4-dimethylamino-phenyl) -acetamide EXAMPLE 55 (METHOD 27) N- (4-aminophenyl) -2-hydroxybenzamide To a solution of 580 mg of 2- (4-aminophenylcarbamoyl) phenyl in 10 ml of methanol is added 2 ml of saturated sodium bicarbonate and 3 ml of water. The mixture is heated at 80 ° C for 30 minutes, then it is poured into saturated aqueous sodium chloride, and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give an oil which is then triturated with diethyl ether to provide the desired product as a white solid.

EXAMPLE 56 (METHOD 28) [4- (3- (Hydroxybenzoylamino) phenyl) carbamic acid terbutyl ester To a solution of 4.34 g of 3- (4-aminophenylcarbamoyl) -phenyl acetate in 75 ml of methanol is added 25 ml of 0.1 N aqueous sodium hydroxide and 25 ml of tetrahydrofuran. This solution is heated at 40 ° C for 30 minutes, then cooled, poured into 1 M hydrochloric acid and extracted with ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white solid, which is further purified by trituration with diethyl ether.

EXAMPLE 57 (METHOD 29) N- (4-aminophenyl) -2-hydroxymethylbenzamide To a solution of 332 mg of N- (4-aminophenyl) pphthalimide in 4 ml of tetrahydrofuran is added 1 g of lithium borohydride and the mixture is stirred for 1 hour at 25 ° C. The mixture is poured into water and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a white foam, which when triturated with diethyl ether gives the desired product as a white powder.

EXAMPLE 58 (METHOD 30) (3-chloro-5-diemthylamino-phenyl) -carbamic acid terbutyl ester To a solution of 0.32 g of the terbutyl ester of (3-amino-5-chloro-phenyl) -carbamic acid in 10 ml of toluene is added aqueous formaldehyde (37%, 1.5 ml) then 10% palladium on carbon (0.50 g). ) and the mixture is stirred under a hydrogen atmosphere for approximately 15 hours. The solution is then filtered through diatomaceous earth and the filtrate is concentrated under reduced pressure. The residue is chromatographed on silica gel (50% dichloromethane in hexanes which is used as the eluent) to provide the desired product as a white solid.

EXAMPLE 59 (METHOD 35) N- (4-. {3 [3, 5-dichloro-4- (2-hydroxy-ethoxy) -phenyl] -thioureido} - phenyl) -acetamide To a solution of 0.16 g of ester 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} Ethyl acetic acid in a 1: 1 mixture of tetrahydrofuran and 2.5 ml of methanol is added 1 ml of 1 N aqueous sodium hydroxide and the mixture is stirred for about 2 hours at room temperature. The solution is then poured into 3 ml of 2 M aqueous hydrochloric acid, extracted into ethyl acetate, and the extracts are dried over anhydrous sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is triturated with diethyl ether to provide the desired product as a white solid.

EXAMPLE 60 (METHOD 36) acid. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetic To a solution of 0.29 g of the ethyl ester of the acid. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetic in a 1: 1 mixture of tetrahydrofuran and 4 ml of methanol is added 2 ml of 1 N aqueous sodium hydroxide and the mixture is stirred for about 2 hours at room temperature. The solution is then poured into 5 ml of 2 M aqueous hydrochloric acid, extracted into ethyl acetate, and the extracts are dried over anhydrous sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is triturated with diethyl ether to provide the desired product as a white solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: acid. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetic acid. { 2- [3- (4-acetylamino-phenyl) -thioureido] -4-chloro-5-methoxy-phenoxy} -acetic acid. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2-chloro-5-methoxy-phenoxy} -acetic EXAMPLE 61 (METHOD 37) ester 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -benzoic acid ethyl To a solution cooled with ice of 0.20 g of N- (4-. {3- [3,5-dichloro-4- (2-hydroxy-ethoxy) -phenyl] -thioureido}. Phenyl] -acetamide in 2 ml of pyridine and 0.5 ml of tetrahydrofuran are add 0.08 g of benzoyl chloride and the mixture is stirred at 0 ° C for 1.5 hours.The mixture is then diluted with ethyl acetate, washed successively twice with 2% aqueous hydrochloric acid, once with aqueous sodium chloride After drying the solvent under reduced pressure, the residue is subjected to chromatography on silica gel (5% methanol in dichloromethane which is used as the eluent) and the fractions containing The product is combined, evaporated under reduced pressure, and the residue is crystallized from acetone-hexanes to provide the desired product as a white powder.

EXAMPLE 62 (METHOD 38) ester 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -methyl methanesulfonic acid To an ice-cooled solution of 0.20 g of N- (4. {3- [3, 5-dichloro-4- (2-hydroxy-ethoxy) -phenyl] -thioureido.} - phenyl) acetamide in 2 g. ml of pyridine and 0.5 ml of tetrahydrofuran is added 0.11 g of methanesulfonyl chloride and the solution is stirred at 0 ° C for 45 minutes. The reaction mixture is diluted with ethyl acetate, washed successively twice with 2% aqueous hydrochloric acid, once with saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. After removing the solvents by evaporation under reduced pressure, the resulting residue is recrystallized from acetone-hexanes to give the desired product as a white powder.

EXAMPLE 63 (METHOD 39) N- (4- { 3- [3,5-dichloro-4- (2-dimethylamino-ethoxy) -phenyl] -thioureido}. -phenyl) -acetamide To a solution of 0.33 g of ester 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichlorophenoxy} of methanesulfonic acid in 6 ml of tetrahydrofuran is added dimethylamine (8.8 M, 0.5 ml) and the mixture is stirred at room temperature for 5 days. The reaction mixture is then diluted with ethyl acetate, then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. After removal of the solvent under reduced pressure, the residue is subjected to chromatography on silica gel (pure methanol is used as the eluent). The fractions containing the combined product are evaporated under reduced pressure and the residue is recrystallized from acetonitrile to provide the desired product as a white powder. Using the above procedure and the appropriate starting materials, the following compounds were prepared: N- (4-. {3- [3,5-dichloro-4- (2-dimethylamino-ethoxy) -phenyl] -thioureido}. -phenyl) -acetamide ester 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -benzoic acid ethyl EXAMPLE 64 (METHOD 40) (4- {3- [4- (1-amino-ethyl) -3-chloro-phenyl] -thioureido} -phenyl) -furan-2-carboxylic acid amide To a solution of 0.25 g of tin (II) chloride dihydrate in 2.5 ml of methanol is added 0.22 g of (4- {3 - [4- (1-azido-ethyl) -3-chloro-phenyl] - thioureido.}. phenyl) -amide of furan-2-carboxylic acid and the solution is stirred for approximately 15 hours at room temperature. The solution is then diluted with ethyl acetate, washed successively with saturated aqueous sodium bicarbonate, then with saturated aqueous sodium chloride, then dried over anhydrous sodium sulfate. After removal of the solvent by evaporation under reduced pressure, the residue is subjected to chromatography on silica gel (8% methanol in dichloromethane containing 1% triethylamine which is used as the eluent) to provide the desired product as a solid. yellow.

EXAMPLE 65 (METHOD 41) [1, 2, 3] thiadiazole-4-carboxylic acid (4-isothiocyanato-phenyl) amide To an ice-cooled solution of 7.28 g of 1,1-thiocarbonyldiimidazole in 50 ml of tetrahydrofuran is added 9 g of [1,2,3] -thiadiazole-4-carboxylic acid (4-amino-phenyl) amide in 100 ml of tetrahydrofuran. After about one hour the solvent is removed by evaporation and the residue is dissolved in ethyl acetate. Diethyl ether is added to precipitate the crude product, which is then collected by filtration, dissolved in dichloromethane, and passed through a plug of hydrous magnesium silicate. After removal of the solvents, the residue is recrystallized from ethyl acetate-hexanes to give the desired product as a light yellow solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 2-fluoro-N- (4-isothiocyanato-phenyl) -benzamide (4-isothiocyanato-phenyl) -amide of furan-2-carboxylic acid (4- isothiocyanato-phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid (4-isothiocyanato-phenyl) -amide of thiazole-4-carboxylic acid EXAMPLE 66 (METHOD 42) N, N-dimethyl-5-trifluoromethyl-benzene-1,3-diamine To a solution of 1 g of 3-amino-5-bromo-benzotrifluoride in 2 ml of degassed tetrahydrofuran with argon, 0.15 g of bis- (tri-o-tolylphosphino) palladium, a solution of dimethylamine in tetrahydrofuran (2 M) are added. , 4.2 ml), and a solution of bis (trimethylsilyl) amide in tetrahydrofuran (1 M, 10.4 ml). The reaction mixture is heated in a sealed vessel at 100 ° C for about 2.5 hours to complete the reaction. The mixture is then cooled to room temperature, quenched by the addition of water, and diluted with ethyl acetate. The product is extracted three times in 5% aqueous hydrochloric acid, and the combined acid extracts are then alkalized with cooling by the addition of 5 N aqueous sodium hydroxide. This basic solution is then extracted with ethyl acetate, and these organic extracts The combined extracts are washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and evaporated to dryness under reduced pressure. The resulting residue is chromatographed on silica gel (20-30% ethyl acetate in hexanes is used as the eluent) to provide the desired product as a lightly dyed solid. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 3- (4-methyl-piperazin-1-yl) -5-trifluoromethyl-phenylamine 3-morpholin-4-i1-5-trifluoromethyl-phenylamine 3- piperidin-l-yl-5-trifluoromethyl-phenylamine 3-piperidin-l-yl-5-trifluoromethyl-phenylamine 3-pyrrolidin-l-yl-5-trifluoromethyl-phenylamine N, N-dimethyl-5-trifluoromethyl-1-benzene , 3-diamine N-isobutyl-N-methyl-5-trifluoromethyl-1-benzene-1,3-diamine N-buty1-N-methy1-5-trifluoromethyl-1-benzene-1,3-diamine EXAMPLE 67 (METHOD 43) (3-isobutyl-5-trifluoromethyl-phenyl) -carbamic acid terbutyl ester To a sealed tube containing 5 ml of tetrahydrofuran which is capped with a rubber stopper and cooled in a dry ice-acetone bath, isobutylene is bubbled for approximately 5 minutes. A solution of 9-borabicyclo [3.3.1] nonane in tetrahydrofuran (0.5 M, 11 ml) is added, the container is sealed with a Teflon plug, heated slowly to room temperature and maintained at room temperature for approximately 2.5 hours. The mixture is then cooled again in a dry ice-acetone bath, the Teflon lid is replaced with a rubber stopper, and argon is bubbled through the vent mixture to remove the excess isobutylene. A solution of 1.7 g of the (3-bromo-5-trifluoromethyl-phenyl) -carbamic acid terbutyl ester in 12 ml of tetrahydrofuran is added, followed by 0.12 g of the [1,1'-bis (diphenylphosphino) chloride complex. -ferrocene] palladium (II) -dichloromethane and then 3 N aqueous sodium hydroxide. The vessel is again sealed with the Teflon plug and then heated to 65 ° C for about 15 hours. The mixture is then cooled to room temperature, diluted with hexanes, washed with water, saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure. The resulting oil is subjected to chromatography on silica gel (5% ethyl acetate in hexanes which is used as the eluent) to provide the desired product as a white powder. Using the above procedure and the appropriate starting materials, the following compounds were prepared: [3- (2-methyl-butyl) -5-trifluoromethyl-phenyl] -carbamic acid terbutyl ester (3-isobutyl-5-) trifluoromethyl-phenyl) -carbamic EXAMPLE 68 (METHOD 44) 2- (3,5-dichloro-phenylsulfanyl) -ethylamine To a solution of 1.2 g of (3,5-dichlorophenylthio) acetonitrile in 3.0 ml of ethylene glycol dimethyl ether was added 0.61 ml of the dimethyl sulfur-borane complex and the mixture was heated to reflux for 0.5 hour. The reaction is cooled in an ice bath and 2.0 ml of water and 2.0 ml of concentrated hydrochloric acid are added. This mixture is heated to reflux for 0.5 hours. The clear solution is then cooled and basified with 5 N sodium hydroxide and extracted with ether. The ether extract is dried over potassium carbonate, filtered and concentrated to give 1.0 g of a colorless oil. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 2- (3-bromo-phenylsulfanyl) -ethylamine 2- (4-bromo-phenoxy) -ethylamine 2- (4-iodo-phenoxy) -ethylamine 2 - (3,4-dichloro-phenoxy) -ethylamine 2- (3,4-chloro-phenylsulfane) -ethylamine 2- (3,4-dichloro-phenylsulfanyl) -ethylamine 3- (4-bromo-phenyl) -propylamine 2 - (2-fluoro-phenoxy) -ethylamine 2- (2-chloro-phenoxy) -ethylamine 2- (3-bromo-phenoxy) -ethylamine 2- (3-fluoro-phenoxy) -ethylamine 2- (3-iodo- phenoxy) -ethylamine 2- (3,5-dichloro-phenylsulfanyl) -ethylamine 2-phenylsulfanyl-ethylamine 1- (2-chloro-phenyl) -ethylamine EXAMPLE 69 (METHOD 45) N- (l-naphthalen-2-yl-ethyl) -formamide A mixture of 3.0 g of 2-acetylnaphylene, 11.0 g of ammonium formate, 3.3 ml of formic acid, and 3.5 ml of formamide is heated at 190 ° C for 3 hours. The mixture is cooled, poured into water and extracted with ether. The ether extract was dried with anhydrous potassium carbonate, filtered and concentrated to give a yellow oil, which is crystallized from toluene-hexanes to give a white solid, 1.97 g. Using the procedure and the appropriate starting materials, the following compounds were prepared: N- [1- (4-fluoro-phenyl) -2-methyl-propyl] -formamide N- (l-naphthalen-2-yl-ethyl) - formamide EXAMPLE 70 (METHOD 46) 1- (2-naphthyl) ethylamine A mixture of 1.12 g of the N- (1-naphthalen-2-yl-ethyl) -formamide, 10 ml of ethanol and 10 ml of 5 N sodium hydroxide is heated at reflux for 1 hour. The solution is cooled, poured into water and extracted with ether. The ether solution is dried with anhydrous potassium carbonate, filtered and concentrated to give the product (0.95 g) as a pale yellow oil. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 1- (3-trifluoromethyl-phenyl) -ethylamine 1- (4-fluoro-phenyl) -2-methyl-propylamine [3- (1-amino- ethyl) -phenyl] -dimethyl-amine 3- (1-amino-ethyl) -benzonitrile EXAMPLE 71 (METHOD 47) 1- (3-trifluoromethyl-phenyl) -ethanone O-methyl-oxime 2. 33 g of methoxylamine hydrochloride were added to a solution of 1.5 g of 3 '- (trifluoromethyl) -acetophenone in 20 ml of ethanol and 2 ml of pyridine. The solution is heated to reflux for 45 minutes. The reaction mixture is then cooled, concentrated under reduced pressure and partitioned between water and ethyl acetate. The aqueous layer is extracted with ethyl acetate. The combined organic layers are washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the desired product as a colorless oil (1.61 g). Using the above procedure and the appropriate starting materials, the following compounds were prepared: 3,5-bis-trifluoromethyl-benzaldehyde oxime O-methyl-oxime of 1- (4-fluoro-phenyl) -propan-1-one O -methyl-oxime of the 1- (2-chloro-phenyl) -ethanone O-methyl-oxime of the 1- (3-bromo-phenyl) -ethanone O-methyl-oxime of the 1- (3-chloro-phenyl) ) -etanone O-methyl-oxime of the 1-p-tolyl-ethanone O-methyl-oxime of the 1- (4-fluoro-phenyl) -pentan-1-one O-methyl-oxime of the 1- (4 -fluoro-phenyl) -2-phenyl-ethanone O-methyl-oxime of the 1-o-tolyl-ethanone O-methyl-oxime of the 1-m-tolyl-ethanone O-methyl-oxime of the 1- (2-phenyl-ethanone) -fluoro-phenyl) -ethanone 3- (1-methoxyimino-ethyl) -benzonitrile 4- (1-methoxyimino-ethyl) -benzonitrile O-methyl-oxime of 1- (4-methoxy-phenyl) -ethanone O-methyl -Oxima of 1- (2-methoxy-phenyl) -ethanone O-methyl-oxime of 1- (4-dimethylamino-phenyl) -ethanone O-methyl-oxime of 1- (2-trifluoromethyl-phenyl) - Ethanone O-methyl-oxime of 1- (3-methoxy-phenyl) -ethanone Om ethyl-oxime of 1- (3-trifluoromethyl-phenyl) -ethanone O-methyl-oxime of 1- (4-trifluoromethyl-phenyl) -ethanone O-methyl-oxime of l-furan-2-yl-ethanone O-methyl-oxime of the l-pyridin-4-yl-ethanone O-methyl-oxime of the 1- (l-methyl-lH-pyrrol-2-yl) -ethanone O-methyl-oxime of the 1-thiophen -3-yl-ethanone O-methyl-oxime of the (4-fluoro-phenyl) -phenyl-methanone O-methyl-oxime of the 1- (4-methoxyphenyl) ethanone O-methyl-oxime of the 1- (3 -chloro-4-methoxy-phenyl) -ethanone 4- (1-methoxyimino-ethyl) -benzenesulfonamide 4- (1-methoxyimino-ethyl) -N, N-dimethyl-benzenesulfonamide O-methyl-oxime of 1- [4 - (piperidin-1-sulfonyl) phenyl] -ethanone 4- (1-methoxyimino-ethyl) -N, N-dipropyl-benzenesulfonamide 2-fluoro-N- [4- (1-methoxyimino-ethyl) -phenyl] -benzamide O-methyl-oxime of the 1- (3,5-bis-trifluoromethyl-phenyl) -ethanone O-methyl-oxime of the 1- [4- (lH-imidazol-1-yl) phenyl] -1-ethanone O -methyl oxime of 1- [4- (trifluoromethyl) phenyl] -1-ethanone O-methyl-oxime of 1- [1,1'-biphenyl] -4-yl-l-ethanone O -methyl-oxime of 1- (4-methylphenyl) -1-ethanone O-methyl-oxime of 1- [4-fluoro-3- (trifluoromethyl) phenyl] ethanone O-benzyl oxime of l- [3,5 - is (trifluoromethyl) phenyl] ethanone O-methyl-oxime of 1- [4-chloro-3- (trifluoromethyl) phenyl] ethanone O-methyl-oxime of 1- [3-fluoro-5- (trifluoromethyl) phenyl] ] ethanone O-methyl-oxime of 1- [2-fluoro-4- (trifluoromethyl) phenyl] ethanone O-methyl-oxime of 1- [2-fluoro-5- (trifluoromethyl) phenyl] ethanone O-methyl- Oxima of 1- (2,4-dichlorophenyl) ethanone O-methyl-oxime of 1- (2,4-dichlorophenyl) ethanone O-methyl-oxime of 1- (2,4-dimethylphenyl) ethanone O-methyl -lime of l- [2,4-bis (trifluoromethyl) phenyl] ethanone O-methyl-oxime of the 1- (3-bromophenyl) ethanone O-methyl-oxime of the 1- (3-methylphenyl) ethanone O- Methyl-oxime of l- [4- (4-morpholin) phenyl] ethanone. O-methyl-oxime of the 1- (2-chloro-4-fluorophenyl) ethanone O-methyl-oxime of the 1- (4-bromo-2-fluorophenyl) ethanone O-methyl-oxime of the 1- (3, -diflurophenyl) ethanone O-methyl-oxime of l- [3- (trifluoromethyl) phenyl] ethanone O-methyl-oxime of l- [2- (trifluoromethyl) phenyl] ethanone O-methyl-oxime of 1- ( 2, 4-difluorophenyl) ethanone .O-methyl-oxime of 1- [3-fluoro-4- (trifluoromethyl) phenyl] ethanone O-methyl-oxime of 1- (3,4-dichlorophenyl) ethanone O-methyl -Oxima of 1- (4-fluoro-2- (trifluoromethyl) phenyl] ethanone O-methyl-oxime of 1- (3-chloro-4-fluorophenyl) ethanone O-methyl-oxime of 1- (4- chloro-3-fluorophenyl) ethanone O-methyl-oxime of the 1- (2, 5-difluorophenyl) ethanone O-methyl-oxime of the 1- (2-bromo-4-fluorophenyl) ethanone O-methyl-oxime of the 1- (3,4-dibromophenyl) ethanone O-methyl-oxime of 1- (2-bromophenyl) ethanone EXAMPLE 72 (METHOD 48) 1- (2-trifluoromethyl-phenyl) -ethylamine 1.17 g of sodium borohydride are slowly added to a flask containing 1.8 g of zirconium tetrachloride in 27 ml of tetrahydrofuran. A solution of 1.34 g of the O-methyl-oxime of the 1- (2-trifluoromethyl-phenyl) -ethanone in 7.7 ml of tetrahydrofuran is added and the resulting solution is stirred at 25 ° C for 12 hours. The reaction mixture is then cooled to 0 ° C and 16 ml of water are added slowly. The excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1 N hydrochloric acid. The aqueous layer (acid) is made alkaline with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). Using the above procedure and the appropriate starting materials, the following compounds were prepared: 1- (3-methoxy-phenyl) -ethylamine 1- (4-fluoro-phenyl) -propylamine-1-naphthalen-2-yl-ethylamine 4- (1-Amino-ethyl) -benzonitrile 1- (4-trifluoromethyl-phenyl) -ethylamine 1- (4-methoxy-phenyl) -ethylamine l-prop-2-ynyl-pyrrolidine 1- (2-methoxy-phenyl) - ethylamine 1-m-toly1-ethylamine 1- (2-bromo-phenyl) -ethylamine 1-o-tolyl-ethylamine C- (4-fluoro-phenyl) -C-phenyl-methylamine 1- (4-fluoro-phenyl) -pentylamine 1- (4-fluoro-phenyl) -2-phenyl-ethylamine 1- (2-trifluoromethyl-phenyl) -ethylamine 1- (3-bromo-phenyl) -ethylamine 1- (3-chloro-phenyl) -ethylamine [4- (1-amino-ethyl) -phenyl] -dimethyl-amine 1- (l-methyl-lH-pyrrol-2-yl) -ethylamine l-thiophen-3-yl-ethylamine 1- [3,5-bis ( trifluoromethyl) phenyl] propylamine 1- [3,5-bis (trifluoromethyl) phenyl] -1-butanamine - [3,5-bis (trifluoromethyl) phenyl] butylamine 1- [3,5-bis- (trifluoromethyl) phenyl] - 1-pentanamine 1- (4-methylphenyl) ethane amine 1- [3- (trifluoromethyl) phenyl] ethylampa 1- [4- (trifluoromethyl) phenyl] ethylamine 1- [4-methylphenyl) ethanamine 1- (3-methylphenyl) ethanamine 1- [3,4-dichlorophenyl) ethanamine 1 - (2-bromo-phenyl) -ethylamine 1- (2-trifluoromethyl-phenyl) -ethylamine 1- (3-bromo-phenyl) -ethylamine 1- (3-chloro-4-methoxy-f-enyl) -ethylampate 4 - (1-amido-ethyl) -N, N-dimet i 1-benzene sulfonamide 1- [4- (piperidip-1-sulfopyl) -phenyl] -ethylamine l-qui-olin-6-yl-ethylamine 1- (3,5-bis-trifluoromethyl-phenyl) -ethylamine 4- [(SS) -1-aminoethyl] bepzonitrile (S) -alpha-methyl-3,5-bis (trifluoromethyl) -benzenemethanamine (S) -alpha-methyl-3,5-bis (trifluoromethyl) -benzenemethanamine 1-biphenyl-4-yl- ethylamine 1-4-fluoro-phenyl) -ethylamine 1-4-fluoro-3- (trifluoromethyl) phenyl] ethanamine 1-4-chloro-3- (trifluoromethyl) phenyl] ethanamine N- 4- [(IR) -1- aminoethyl] phenyl} -1,2, 3-thiadiazole-4-carboxamide N- 4- [(1S) -l-aminoethyl] phenyl} -1, 2, 3-thiadiazole-4-carboxamide-3-fluoro-5- (trifluoromethyl) phenyl] ethylamine 1- 2 -fluoro-4- (trifluoromethyl) phenyl] ethylamine 1- 2 -fluoro-5- (trifluoromethyl) ) phenyl] ethylamine 1- 2, 4-d? chlorophenyl) ethylamine 1- 2, 4-dimethylphenyl) ethylamine 1- 2,4-bis (trifluoromethyl) phenyl] ethylamine 1- 2-chloro-4-fluorophenyl) ethylamine 1- 3,4-difluorophenyl) ethylamine 1-4-bromo-2-fluorophenyl) ethylamine 1- 3-fluorophenyl) ethylamine 1- 2, -difluorophenyl) ethylamine 1- 3-fluoro-4- (trifluoromethyl) phenyl] ethylamine 1-4 -fluoro-2- (trifluoromethyl) phenyl] ethylamine 1- 3-chloro-4-fluorophenyl) ethylamine 1- (4-chloro-3-fluorophenyl) ethylamine 1- (3,4-dibromophenyl) ethylamine 1- (2-bromo) -4-fluorophenyl) ethanamine-1- (2-bromo-4-fluorophenyl) ethylamine EXAMPLE 73 (METHOD 49) (2-fluoro-5-trifluoromethyl-phenoxy) -acetonitrile A solution of 25 g of 2-fluoro-5-trifluoromethylphenol in 0.55 liters of acetone grade reagent is treated with 7.7 g of solid potassium carbonate followed by the rapid addition of 10 ml of pure bromoacetonitrile. The heterogeneous mixture is stirred vigorously for about 20 hours after which it is poured into water and extracted into diethyl ether. The combined ether extracts are washed with saturated sodium chloride and dried over anhydrous potassium carbonate. Filtration and concentration under reduced pressure gives a pale orange solid which is then subjected to chromatography on silica gel, eluting with dichloromethane, to give the desired product as a white solid (28.3 g). Using the above procedure and the appropriate starting materials, the following compounds were prepared: (3-bromo-phenylsulfanyl) -acetonitrile (3-chloro-phenylsulfane) -acetonitrile (4-iodo-phenoxy) -acetonitrile (3-trifluoromethyl-phenylsulfane) -acetonitrile (3,5-dichloro-phenylsulfane) -acetonitrile (3,4-dichloro-phenylsulfane) -acetonitrile (3, -dichloro-phenoxy) -acetonitrile (2-fluoro-phenoxy) -acetonitrile (3-fluoro-phenoxy) -acetonitrile (2-chloro-phenoxy) -acetonitrile (3-bromo-phenoxy) -acetonitrile (2-fluoro-5-trifluoromethyl-phenoxy) -acetonitrile (3-iodo-phenoxy) -acetonitrile (4-bromo-phenoxy) - acetonitrile METHOD 74 (METHOD 50) 3-Fluoro-5-trifluoromethylphenethylamine tosylate A solution of 2.5 g of 3-fluoro-5-trifluoromethylphenylacetonitrile and 2.34 g (12.3 mmol) of p-toluenesulfonic acid in 75 ml of ethylene glycol monomethyl ether is hydrogenated 3 hours at room temperature at 2.92 kg / cm2 (40 psi) , using 200 mg of 10% palladium on carbon, as a catalyst. The catalyst is filtered and the solvent is evaporated to half the volume. After rest, the salt of p-toluenesulfonic acid of 3-fluoro-5-trifluoromethylphenethylamine crystallizes. The white crystals, 4.26 g (91%) are collected by filtration. Using the above procedure and the appropriate starting materials, the following compounds were prepared: 2- (3,5-difluoro-phenyl) -ethylamine 2- (4-trifluoromethyl-phenyl) -ethylamine 2- (3,4-difluoro-phenyl) ) -ethylamine 2- (2-fluoro-phenyl) ethylamine 2- (3-fluoro-5-trifluoromethyl-phenyl) -ethylamine 2- (2-fluoro-3-trifluoromethyl-phenyl) -ethylamine 2- (2, 4-) bis-trifluoromethyl-phenyl) -ethylamine 2- (4-fluoro-3-trifluoromethyl-phenyl) -ethylamine EXAMPLE 75 (METHOD 51) (4-aminomethyl-2-trifluoromethyl-phenyl) -dimethyl-amine A solution of 0.35 g of 4-dimethylamino-3-trifluoromethylbenzonitrile in 2 ml of tetrahydrofuran is slowly added to a suspension of lithium-aluminum hydride (0.1 g) in 2 ml of tetrahydrofuran at 0 ° C and stirred under an atmosphere of Argon for 2 hours. While it is at 0 ° C, 0.1 ml of water is slowly added, followed by 0.1 ml of 5% sodium hydroxide and 0.3 ml of water. The resulting gray solid is filtered and washed with tetrahydrofuran. The filtrates are collected and concentrated under reduced pressure and the resulting oil is chromatographed on silica gel (15% methanol in methylene chloride which is used as the eluent) to give the desired product as a pale orange oil (0.164). g). Using the above procedure and the appropriate starting materials, the following compounds were prepared: -piperidin-1-yl-3-trifluoromethyl-1-benzylamine (4-aminomethyl-2-trifluoromethyl-phenyl) -dimethylamine 4- (4-methyl-piperazine- 1-yl) -3-trifluoromethyl-benzylamine (3-aminomethyl-5-trifluoromethyl-phenyl) -dimethylamine [3- (2-amino-ethyl) -5-trifluoromethyl-phenyl] -dimethyl-amine [4- (2- amino-ethyl) -2-methyl-phenyl] -dimethyl-amine EXAMPLE 76 (METHOD 52) 3-dimethylamino-5-trifluoromethyl-benzaldehyde Diisobutylaluminium hydride (10 ml of a 1M solution in methylene chloride) is added dropwise to a solution of 3-dimethylamino-5-trifluoromethylbenzonitrile (1.06 g) in 25 ml of methylene chloride at 0 ° C and the mixture It is stirred for 2 hours. While still at 0 ° C, a saturated aqueous solution of 8 ml of potassium sodium tartrate is added slowly, and the solution is stirred for 1.5 hours. The reaction mixture is then extracted with ethyl acetate, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to provide the desired product as a yellow solid (0.97 g). Using the above procedure and the appropriate starting materials, the following compounds were prepared: 3-dimethylamino-5-trifluoromethyl-benzaldehyde 4-dimethylamino-3-methyl-benzaldehyde EXAMPLE 9 (METHOD 53) Dimethyl- [3- 2-nitro-vinyl) -5-trifluoromethyl-phenyl] -amine 0.4 (3 g of nitromethane is added to a solution of 0.885 g of 3-dimethylamino-5-trifluoromethylbenzaldehyde and 0.339 g of ammonium acetate in 3.4 ml of acetic acid and the solution is heated at 110 ° C for 6 hours. The reaction medium was cooled to 0 ° C and a solid was formed which was filtered and washed with water-acetic acid 1: 1. This solid was recrystallized from ethanol to give the desired product as a red solid 0.39 g). Using the above procedure and the appropriate starting materials, the following compounds were prepared: dimethyl- [3- 2-nitro-vinyl) -5-trifluoromethyl-phenyl] -amine dimethyl- [2-methyl-4-2-nitro-vinyl] ) -phenyl] -amine EXAMPLE (8 METHOD 54) 3-4-bromo-phenyl) -propionitrile .2 g of diethylazodicarboxylate are added dropwise to a solution of 2.01 g of 4-bromo-phenethyl alcohol and (.9 g of triphenylphosphine in 16 ml of diethyl ether at 0 ° C. The reaction mixture was stirred for 10 minutes and a solution of 2.6 g of acetone cyanohydrin in 10 ml of diethyl ether was added. 5 minutes at 0 ° C and then at 25 ° C for 12 hours.The reaction mixture is then filtered, and washed with diethyl ether.The filtrate is concentrated under reduced pressure and subjected to chromatography on silica gel (10%). of ethyl acetate-hexanes is used as the eluent) to provide the desired product as a pale yellow oil (2.04 g).

EXAMPLE 79 (METHOD 55) 3-Dimethylamino-2-isocyanoacrylic acid ethyl ester To a solution of 5.0 g of ethyl isocyanoacetate in 100 ml of ethanol is added 6.5 g of the N, N-dimethylformamide dimethylacetal dropwise with stirring in 10 minutes. The reaction is stirred for 24 hours and the ethanol is evaporated. The resulting oil is passed through magnesium silicate using 50% ethyl acetate-hexanes as eluent. The solvents are removed and the resulting oil is crystallized from ethyl acetate-hexanes to produce light yellow needles, 3.0 g.

EXAMPLE 80 (METHOD 56) 4-carboethoxythiazole A solution of 1.0 g of the ethyl ester of 3-dimethylamino-2-isocyanoacrylic acid and 3.0 g of triethylamine in 30 ml of tetrahydrofuran is treated with gaseous hydrogen sulfide until all the initial material is consumed. The mixture is concentrated to an oil and purified by column chromatography using silica and 25% ethyl acetate-hexanes as the eluent. 0.61 g of the purified material is isolated as an oil.

EXAMPLE 81 (METHOD 34) N-. { 4- [3- (5-chloro-2, -dimethoxy-phenyl) -ureido] -phenyl} -2- fluoro-benzamide A suspension of 0.43 g of N- (4-amino-phenyl) -2-fluoro-benzamide in 4 ml of acetonitrile is treated with 0.40 g of 5-chloro-2,4-dimethoxyphenylisocyanate. The mixture becomes a solution and left to stand for 12 hours. A white solid is formed and collected by filtration (0.79 g) .- [M + H] 444. Using the above procedure and the appropriate starting materials, the following compounds were prepared: Ex. M + H NAME OF THE COMPOUND No. 81 445 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -ureido] -phenyl} -2-fluoro-benzamide 82 441 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -ureido] -phenyl} -2-methyl-benzamide 83 435. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -ureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 84 443. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -ureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 85 453 N-. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -ureido] -phenyl} -2-fluoro-benzamide 86 409. { 4- [3- (3, 5-dichloro-phenyl) -ureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 87 486 N-. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -ureido] -phenyl} -2-fluoro-benzamide 88 458. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -ureido] -phenyl} -amide of furan-2-carboxylic acid 89 476. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -ureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 90 423. { 4- [3- (3,4-dichloro-benzyl) -ureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide EXAMPLE 91 (METHOD 31) N- (5-. {[[( { (ÍS) -1- [3,5-bis (trifluoromethyl) phenyl] ethyl} amino) -carbothioyl] amino.} -2-pyridinyl) -1 , 3-thiazole-4-carboxamide A mixture of 0.36 g of N- (5-isothiocyanato-2-pyridinyl) -1,3-thiazole-4-carboxamide and 0.36 g of (S) -alpha-methyl-3,5-bis (trifluoromethyl) -benzenemethanamine, it is heated with 10 ml of acetonitrile until all solids dissolve. The solution is left to stand for 12 hours. A white solid is formed and collected by filtration (0.40 g). [M + H] 520. Using the above procedure and the appropriate starting materials, the following compounds were prepared: Example M + H COMPOUND NAME No. 92 506 [3-Chloro-5- (3. {4- [([1,2,3] thiadiazole -carbonyl) -amino] phenyl tert-butyl ester Thioureido) phenyl] carbamic 93 409 1- (5-Chloro-2,4-dimethoxy-phenyl) -3- (4-morpholin-4-yl-phenyl) -thiourea 94 370 1- (5-chloro- 2,4-dimethoxy-phenyl) -3- (4-methylsulfanyl-phenyl) -thiourea 95 338 1- (5-chloro-2,4-dimethoxy-phenyl) -3-p-tolyl-thiourea 96 414 Acid. { 4- [3- (5-Chloro-2,4-dimethoxy-phenyl) -thioureido] -phenylsulphane} -acetic 97 384 l- (5-chloro-2,4-dimethoxy-phenyl) -3- [4- (2-hydroxy-ethoxy) -phenyl] -thiourea 98 340 1- (5-chloro-2,4- dimethoxy-phenyl) -3- (4-hydroxy-phenyl) -thiourea 99 395 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] phenyl} -N-methyl-acetamide 100 381 N-. { 3- [3- (5-chloro-2,4-diemtoxy-phenyl) -thioureido] -phenyl-acetamide 101 411 Ethyl ester of the acid. { 4- [3- (5-Chloro-2, 4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamic 102 319 1- (2,4-dimethoxy-phenyl) -3- (4-methoxy-phenyl) -thiourea 103 346 N-. { 4- [3- (2, 4-dimethoxy-phenyl) -thioureido] phenyl} - acetamide 104 316 N-. { 4- [3- (4-methoxy-phenyl) -thioureido] phenyl} - acetamide 105 316 N-. { 4- [3- (2-methoxy-phenyl) -thioureido] phenyl} - acetamide 106 351 N-. { 4- [3- (3-chloro-4-methoxy-phenyl) -thioureido] phenyl} -acetamide 107 351 N-. { 4- [3- (5-chloro-2-methoxy-phenyl) -thioureido] phenyl} -acetamide 108 371 N-. { 4- [3- (3, 5-dichloro-4-hydroxy-phenyl) -thioureido] phenyl} -acetamide 109 385 N-. { 4- [3- (3, 5-dichloro-4-methoxy-phenyl) -thioureido] phenyl} -acetamide 110 381 N-. { 4- [3- (4-chloro-2,5-dimethoxy-phenyl) -thioureido] phenyl} -acetamide 111 389 N-. { 4- [3- (2-Chloro-5-trifluoromethyl-phenyl) -thioureido] phenyl} -acetamide 112 389 N-. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] phenyl} -acetamide 113 422 4- [3- (4-Acetylamino-phenyl) -thioureido] -3-hydroxy-phenyl ester of benzoic acid 114 457 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-methy1-benzamide 115 501 Ester 2-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamoil} -acetic acid acetic 116 461 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -4-fluoro-benzamide 117 461 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3-fluoro-benzamide 118 461 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 119 473 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-methoxy-benzamide 120 473 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3-methoxy-benzamide 121 473 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -4-methoxy-benzamide 122 443 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 123 417 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -metansulfonamide 124 331 N-. { 4- [3- (3-nitro-phenyl) -thioureido] -phenyl} - acetamide 125 339 l- (3-chloro-4-methoxy-phenyl) -3- (3-nitro-phenyl) -thiourea 126 337 N-. { 4- [3- (5-chloro-2-hydroxy-phenyl) -thioureido] -phenyl} -acetamide 127 439 Tert-butyl acid ester. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamic 128 351 N-. { 4- [3- (3-chloro-4-hydroxy-5-methyl-phenyl) -thioureido] -phenyl} -acetamide 129 385 N-. { 4- [3- (3, 5-dichloro-4-hydroxy-2-methyl-phenyl) -thioureido] -phenyl} -acetamide 130 318 N-. { 4- [3- (2, 4-dihydroxy-phenyl) -thioureido] -phenyl} -acetamide 131 414 N-. { 4- [3- (2, 4-dimethoxy-5-trifluoromethyl-phenyl) thioureido] -phenyl} -acetamide 132 332 N-. { 4- [3- (2-hydroxy-4-methoxy-phenyl) -thioureido] phenyl} -acetamide 133 465 N-. { 4- [3- (3,5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} -4-fluoro-benzamide 134 500 3-acetylamino-N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 135 488 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3-nitro-benzamide 136 486 N-. { 4- [3- (5-chloro-2, -dimethoxy-phenyl) -thioureido] -phenyl} -3-dimethylamino-benzamide 137 536 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3-methansulfonyl-amino-benzamide 138 511 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-trifluoro-methyl-benzamide 139 459 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-hydroxy-benzamide 140 479 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2, 6-difluoro-benzamide 141 477 2-chloro-N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 142 522 2-bromo-N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 143 488 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-nitro-benzamide 144 445. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} - pyrazine-2-carboxylic acid amide 145 463. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 5-Methyl-thiophene-2-carboxylic acid amide 146 494 (4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl] -amide of quinoline-8- carboxylic 147 446. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -l-methyl-lH-pyrrole-2-carboxylic acid amide 148 369 1- (5-chloro-2, -dimethoxy-phenyl) -3- (2-nitro-phenyl) -thiourea 149 369 1- (5- chloro-2,4-dimethoxy-phenyl) -3- (4-nitro-phenyl) -thiourea 150-425 N-. { 4- [3- (5-bromo-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 151 376 N-. { 4- [3- (3,4,5-trimethoxy-phenyl) -thioureido] -phenyl} -acetamide 152 399 N-. { 4- [3- (3,5-dichloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} -acetamide 153 499. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} benzo [b] thiophene-2-carboxylic acid amide 154 483. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzofuran-2-carboxylic acid amide 155 444 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} - isonicotinamide 156 493. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} Naphthalene-2-carboxylic acid amide 157 493. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} Naphthalene-1-carboxylic acid amide 158 494. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -isoquinoline-1-carboxylic acid amide 159 494. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -quinoline-2-carboxylic acid amide 160 444 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -nicotinamide 161 478 Phenyl ester of acid. { 4- [3- (5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -phenyl} - amidecarbamic acid of 5-nitro-furan-2-carboxylic acid 162 459. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} - 163 467. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 5-chloro-furan-2-carboxylic acid amide 164 439 Isobutyl acid ester. { 4- [3- (5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamic 165 397 Methyl acid ester. { 4- [3- (5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamic 166 433. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -furan-3-carboxylic acid amide 167 447. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 3-methyl-furan-2-carboxylic acid amide 168 512. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 5-bromo-furan-2-carboxylic acid amide 169 512. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 4-bromo-furan-2-carboxylic acid amide 170 433. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 171 467 Hexyl ester of acid. { 4- [3- (5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamic 172 494. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} Isoquinoline-4-carboxylic acid amide 173 451 (4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl] -amide of [1, 2, 3] thiadiazole acid 4-carboxylic acid 174 434. {4 - [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -amide of 1H- [1,2,3] triazole- 4-carboxylic acid 175 528. {4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -amide of 3-bromo-thiophene-2-carboxylic acid 176 399 N - { 4- [3- (3,5-dichloro-4-ethoxy-phenyl) -thioureido] -phenyl} -acetamide 177 427 N- { 4- [3- (4-butoxy-3 , 5-dichloro-phenyl) -thioureido] -phenyl.}. -acetamide 178 461 N- { 4- [3- (4-benzyloxy-3,5-dichloro-phenyl) -thioureido] -phenyl}. -acetamide 179 381 N- { 4- [3- (3-Chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl.}. -acetamide 180 530 (3-. {4 - [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenylcarbamoyl.] - phenyl) -carbamic acid 181 458 2-amino-N- { 4- [3- (5-chloro -2, 4-dimethoxy-phenyl) -thioureido] -phenyl.}. -benzamid to 182 519. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -Biphenyl-2-carboxylic acid amide183 469 l- (5-Chloro-2,4-dimethoxy-phenyl) -3- [4- (1,3-dioxo-1,3-dihydro-isoindol-2-yl) -phenyl] -thiourea 184 487 Acid N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -phthalmic 185 473 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-hydroxy-methyl-benzamide 186 479 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2, 3-difluoro-benzamide 187 479 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2, 5-difluoro-benzamide 188 479 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2, 4-difluoro-benzamide 189 500 2-acetylamino-N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 190 441 1- (5-chloro-2,4-dimethoxy-phenyl) -3- (6-OXO-5,6-dihydro-phenanthridin-2-yl) -thiourea 191 536 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-methansulfonylaminobenzamide 192 497 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2, 3, 4-trifluoro-benzamide 193 533 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2, 3,4,5, 6-pentafluorobenzamide 194 489 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-methyl-sulfañil-benzamida 195 431. { 4- [3- (5-chloro-2, -dimethoxy-phenyl) -ureido] -phenyl} 5-methyl-furan-2-carboxylic acid amide 196 467. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -ureido] -phenyl} 5-difluoromethyl-furan-2-carboxylic acid amide 197 472 N-. { 4- [3- (5-iodo-2, -dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 198 364 N-. { 4- [3- (5-fluoro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 199 365 N-. { 4- [3- (5-chloro-2-methoxy-4-phenyl) -thioureido] -phenyl} -acetamide 200 459. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 201 455. { 4- [3- (3, 5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 202 392 N-. { 4- [3- (3-chloro-4-diethylamino-phenyl) -thioureido] -phenyl} -acetamide 203 432 N-. { 4-. { 3- [3-chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido} -phenyl} -acetamide 204 506. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2-chloro-phenyl} -amide of 1-hydroxy-naphthalene-2-carboxylic acid 205 406 N-. { 4- [3- (3-chloro-4-morpholin-4-yl-phenyl) -thioureido] -phenyl} -acetamine 206 443 l- (5-chloro-2,4-dimethoxy-phenyl) -3- (3-chloro-4-morpholin-4-yl-phenyl) -thiourea 207 372 l- (5-chloro-2, 4-dimethoxy-phenyl) -3- (5-chloro-2-methyl-phenyl) -thiourea 208 501 Methyl ester of N- acid. { 4- [3- (5-chloro-2, -dimethoxy-phenyl) -thioureido] -phenyl} -isophthalmic 209 487 N- acid. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -isophthalamic 210 549 3-benzyloxy-N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 211 434 N-. { 4- [3- (5-Chloro-2-methoxy-4- (4-nitrile-butoxy) -phenyl] -thioureido}.-Pheny1-acetamide 212 406 N- { 4- [3- (5- chloro-2-methoxy-4- (2-nitrile-ethoxy) -phenyl) -thioureido.} - phenyl) -acetamide 213 406 N-. { 4- [3- (5-chloro-4-methoxy-2- (2-nitrile-ethoxy) -phenyl] -thioureido}. Phenyl) -acetamide 214 411 N-. { 4- [3- (5-Chloro-2- (2-hydroxy-ethoxy) -4-methoxy-phenyl] -thioureido.} - phenyl) -acetamide 215 411 N- (4-. {3- 3- [5 -chloro-4- (2-hydroxy-ethoxy) -2-methoxy-phenyl] -thioureido.} - phenyl) -acetamide 216 481 Tert-butyl ester of the acid. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2-chloro-5-methoxy-phenoxy} -acetic 217 439 Methyl acid ester. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2-chloro-5-methoxy-phenoxy} - acetic 218 481 Ter-butyl acid ester. { 2- [3- (4- Acetylamino-phenyl) -thioureido] -4-chloro-5-methoxy} -acetic 219 515 4-butoxy-N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzamide 220 505 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-methan-sulfinyl-benzamide 221 545 Ethyl (3- {4- [3- (5-chloro-2, -dimethoxy-phenyl) -thioureido] -phenylcarbamoyl} - phenoxy) -acetic acid ethyl ester 222 517 Acid (3-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenylcarbamoyl.} - phenoxy) -acetic 223 367 N-. { 4- [3- (5-chloro-hydroxy-2-methoxy-phenyl) -thioureido] -phenyl} -acetamide 224 444. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -pyridine-2-carboxylic acid amide 225 494. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -quinoline-4-carboxylic acid amide 226 436 N-. { 4- [3- (5-Chloro-4-methoxy-2-morpholin-4-yl-phenyl) -thioureido] -f -enyl} -acetamide 227 394 N-. { 4- [3- (5-chloro-2-dimethylamino-4-methoxy-phenyl) -thioureido] -phenyl} -acetamide 228 420 N-. { 4- [3- (5-Chloro-4-methoxy-2-pyrrolidin-1-yl-phenyl) -thioureido] -f-enyl} -acetamide 229 434 N-. { 4- [3- (5-Chloro-4-methoxy-2-piperidin-1-yl-phenyl) -thioureido] -phenyl} -acetamide 230 405. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 231 415 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 232 427 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -3-methoxy-benzamide 233 387. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 234 411 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -2-methyl-benzamide 235 433 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -2,6-difluoro-benzamide 236 398 (4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -amide of pyridine-2-carboxylic acid 237 502. { 4- [3- (3-Chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido.} -phenyl] -amide of [1,2,3] thiadiazole-4-carboxylic acid 238 512 N- (4- { 3- [3-chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido}.-Phenyl) -2-f-luoro-benzamide 239 404 N-. { 4- [3- (3-chloro-4-piperidin-yl-phenyl) -thioureido] -phenyl} -acetamide 240 364 N-. { 4- [3- (3-chloro-4-dimethylamino] -phenyl) -thioureido] -phenyl} -acetamide 241 426 N-. { 4- [3- (4-benzylamino-3-chloro-phenyl) -thioureido] -phenyl} -acetamide 242 390 N-. { 4- [3- (3-chloro-4-pyrrolidin-yl-phenyl) -thioureido] -phenyl} -acetamide 243 419 N- (4-. {3- [3-chloro-4- (4-methyl-piperazin-1-yl) -phenyl] -thioureido}. -phenyl) -acetamide 244 469 N-. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 245 422 N-. { 4- [3- (2-benzylamino-4-methoxy-phenyl) -thioureido] -phenyl} -acetamide 246 484 (furan-2-carboxylic acid 4-chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido.}. phenyl) -amide 247 508 N- (4- { 3- [3-chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido}.-Phenyl.} -2-methyl-benzamide 248 530 N- (4-. {3- [3-chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido}. Phenyl) -2,6-difluoro-benzamide 249 495 (4 -. {3 - [3-Chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido} -phenyl) -amide of pyridine-2-carboxylic acid 250 524 N- (4-. 3- [3-chloro-4- (cyclohexyl-methyl-amino) -phenyl] -thioureido}. -phenyl) -3-methoxy-benzamide 251 376 N- (4-. {3- [3-chloro-4- (2-nitrile-ethoxy) -phenyl] -thioureido}. Phenyl) -acetamide 252-393 N-. { 4- [3- (4-sec-butoxy-3-chloro-phenyl) -thioureido] -phenyl} -acetamide 253 501 Ester 3-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl-carbamoyl} -acetic acid 254 459 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3-hydroxy-benzamide 255 487. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -benzo [l, 3] -dioxol-4-carboxylic acid amide 256 527 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3-trifluoro-methoxy-benzamide 257 530 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3- (2-dimethylamino-ethoxy) -benzamide 258 572 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -3- (2-morpholin-4-yl-ethoxy) -benzamide 259 406 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-cyano-phenyl} -acetamide 260 521 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2,5-dimethoxy-phenyl} -2-fluorobenzamide 261 441 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2,5-dimethoxy-phenyl} -acetamide 262 527 2- Acid. { 4- (3- (4-acetylamino-phenyl) -thioureido] -2-chloro-phenoxy] -5-chloro-benzenesulfonic acid 263 562 2- {4- [3- (4-acetylamino-phenyl)} -thioureido] -2-chloro-phenoxy] -4,5-dichloro-benzenesulfonic acid 264 527. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 4-phenyl- [1,2,3] thiadiazole-5-carboxylic acid amide 265 381 N- (4-. {3- [3-chloro-4- (2-hydroxy-ethoxy) -phenyl] - thioureido.}. phenyl) -acetamide 266-393 N-. { 4- [3- (4-butoxy-3-chloro-phenyl) -thioureido] -phenyl} -acetamide 267 446 N- (4-. {3- [3-chloro-4-cyclohexyl-ethyl-amino) -phenyl] -thioureido} -phenyl) -acetamide 268 365 N-. { 4- [3- (3-chloro-4-ethoxy-phenyl) -thioureido] -phenyl} -acetamide 269 427 N-. { 4- [3- (4-benzyloxy-3-chloro-phenyl) -thioureido] phenyl} -acetamide 270 317 Tert-butyl acid ester. { 4- [(3-methyl-furan-2-carbonyl) -amino] -phenyl} -carbámico 271 456 N-. { 4- [3- (2-benzylamino-5-chloro-4-methoxy-phenyl) -thioureido] -phenyl} -acetamide 272 420 N-. { 4- [3- (3-chloro-4-dipropylamino-phenyl) -thioureido] -phenyl} -acetamide 273-458 N- (4-. {3- [4- (allyl-cyclohexyl-amino) -3-chloro-phenyl] -thioureido}. phenyl) -acetamide 274-411 N-. { 4- [3- (5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -2-methoxy-phenyl} -acetamide 275 415 N-. { 2-Chloro-4- [3- (5-chloro-2, -dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 276 493. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2,5-dimethoxy-phenyl} -amide of furan-2-carboxylic acid 277 486 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-cyano-phenyl} -2-fluoro-benzamide 278 495 N-. { 2-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 279 465. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 5-methyl- [1,2,3] thiadiazole-4-carboxylic acid amide 280 517. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 5-furan-3-yl- [1,2,3] thiadiazole-4-carboxylic acid amide 281 527. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} 5-phenyl- [1,2,3] thiadiazole-4-carboxylic acid amide 282-458 N- (4-. {3- [3-chloro-4- (octahydro-quinolin-1-yl) -phenyl] -thioureido} -phenyl) -acetamide 283 458 N- [5- [[ [(5-Chloro-2,4-dimethoxyphenyl) amino] -thioxomethyl] amino] -2-pyridinyl] -2-methylbenzamide 284 434. { 5- [3- (5-Chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-2-yl} -amide of furan-2-carboxylic acid 285 425 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methoxy-5-methyl-phenyl} -acetamide 286 505 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methoxy-5-methyl-phenyl} -2-fluorobenzamide 287 477. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methoxy-5-methyl-phenyl} -furan 2-carboxylic acid amide 288 517. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -amide of 4-furan-3-yl- [1,2,3] thiadiazole-5-carboxylic acid 289 462 N-. { 5- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-2-yl} -2-fluoro-benzamide 290 384 N-. { 4- [3- (4-methoxy-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -acetamide 291 394 N-. { 4- [3- (3-chloro-4- [(2-hydroxy-ethyl) -methylamino] -phenyl] -thioureido) -phenyl] -acetamide 292 485 N-. { 2-Benzoyl-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 293 565 N-. { 2-Benzoyl-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 294 537. { 2-Benzoyl-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 295 475 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-methyl-phenyl} -2-fluoro-benzamide 296 447. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-methyl-phenyl} -amide of furan-2-carboxylic acid 297 395 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-methyl-1-phenyl} -acetamide 298 435 N- [4- (3 { 3-chloro-4- [(3-dimethylamino-propyl) -methyl-amino] -phenyl} -.-thioureido) -phenyl] -acetamide 299 418 N -. { 4- [3- (3-chloro-4-cyclohexylamino-phenyl) -thioureido] -phenyl} -acetamide 300 421 N- [4- (3- { 3-chloro-4- [(dimethylamino-ethyl) -methylamino] -phenyl] -thioureido) -phenyl] -acetamide 301 580 5- [[[(5-Chloro-2,4-dimethoxyphenyl) amino] -thioxomethyl] amino] -2- [(2-fluorobenzoyl) amino] -phenyl-benzamide 302 552. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-phenylcarbamoyl-phenyl} -amide of furan-2-carboxylic acid 303 491 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methoxy-phenyl} -2-fluoro-benzamide 304 463. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methoxy-phenyl} -amide of furan-2-carboxylic acid 305 449 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-trifluoromethyl-phenyl} -acetamide 306 458. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-cyano-phenyl} -amuran of furan-2-carboxylic acid 307 467. { 2-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 308 501. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-trifluoromethyl-phenyl} -amide of furan-2-carboxylic acid 309 395 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methyl-phenyl} -acetamide 310 475 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methyl-phenyl} -2-fluoro-benzamide 311 447. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methyl-phenyl} -furan-2-carboxylic acid amide 312 378 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} -acetamide 313 408 Ethyl ester of acid. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2-chloro-phenyl} -carbamic 314 382 N-. { 5- [3- (5-Chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-2-yl} -acetamide 315 509 N- (4-. {3- [4- (l-benzyl-piperidin-4-ylamino) -3-chloro-phenyl] -thioureido}. -phenyl.}. -acetamide 316 407 N - (4- { 3- [3-chloro-4- (2-dimethylamino-ethylamino) -phenyl] -thioureido}. -phenyl) -acetamide 317 408 N- [4- (3-. {3 -chloro-4- [(2-methoxy-ethyl) -methylamino] -phenyl] -thioureido] -phenyl] -acetamide 318 421 N- (4-. {3- [3-chloro-4-dimethylamino-propylamino) -phenyl] -thioureido} phenyl) -acetamide 319 495 N- (4-. {3- [4- (l-benzyl-pyrrolidin-3-ylamino) -3-chloro-phenyl] -thioureido}. -phenyl.}. -acetamide 320 483 (5-chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-hydroxy-phenyl] -amide of furan-2-carboxylic acid 321 431 N- {.5-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-hydroxy-phenyl}. -acetamide 322 511 (5H, HH-benzo [e] pyrrolo [1,2-a] [1,4] diazepin-10-yl) - (2-chloro-4-imidazol-1-yl-phenyl) -metanone 323 451. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-5-carboxylic acid amide 324 483. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -naphthalene-1-yl} -furan-2-carboxylic acid amide 325 511 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -naphthalen-1-yl} -2-fluoro-benzamide 326 429 N-. { 5-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methyl-phenyl} -acetamide 327 509 N-. { 5-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methyl-phenyl} -2-fluoro-benzamide 328 4.81. { 5-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -2-methyl-f-enyl} -furan-2-carboxylic acid amide 329 431 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -naphthalen-1-i1} -acetamide 330 416. { 4- [3- (3-chloro-2,4-dimethylamino-phenyl) -thioureido] -phenyl} furan-2-carboxylic acid amide 331 561 [4- (3. {4 - [(1-benzyl-pyrrolidin-3-yl) -methylamino] -3-chloro-phenyl] -thioureido) - phenyl] -amide of furan-2-carboxylic acid 332 513 N- [4- (3. {3-chloro-4- [methyl- (1-methyl-pyrrolidin-3-yl) -amino] -phenyl} -thioureido) -phenyl] -2-fluorobenzamide 333 463 N-. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} -2,6-difluoro-benzamide 334-420 N- (4-. {3- [3-chloro-4- (l-methyl-pyrrolidin-3-yloxy) -phenyl] -thioureido} -phenyl) - acetamide 335 434 N- (4-. {3- [3-chloro-4- (l-methyl-piperidin-4-yloxy) -phenyl) -thioureido} phenyl) -acetamide 336 422 N- (4-. {3- [3-chloro-4- (3-dimethylamino-propoxy) -phenyl] -thioureido}. phenyl) -acetamide 337 425 2-acetylamino acid -5- [3- (5-Chloro-2,4-dimethoxy-phenyl) -thioureido] -benzoic acid 338 505 5- [3- (5-Chloro-2-dimethoxy-phenyl) -thioureido] -2- (2-fluorobenzoylamino) -benzoic acid 339 477 5- [3- (5-Chloro-2,4-dimethoxy-phenyl) -thioureido] -2- [(furan-2-carbonyl) -amino] -benzoic acid 340 545 N - [4- (3- { 3-Chloro-4- [methyl- (l-methyl-piperidin-4-yl) -amino] -phenyl] -.-thioureido) -phenyl] -2,6-difluoro -benzamide 341 503 [4- (3. {3-Chloro-4- [methyl- (1-methyl-pyrrolidin-3-yl) -amino] -phenyl] -thioureido) -phenyl] -amide [1,2,3] thiadiazole-4-carboxylic acid 342 443 N-. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -phenyl} -2-methyl-benzamide 343 408 N- (4-. {3- [3-chloro-4- (2-dimethylamino-ethoxy) -phenyl] -thioureido}. -phenyl) -acetamide 344 499 [4- Furan-2-carboxylic acid (3- {3-chloro-4- [methyl- (1-methyl-piperidin-4-yl) -amino] -phenyl} -thioureido) -phenyl] -amide 419 N-. { 4- [3- (3-chloro-4-cyclohexyloxy-phenyl) -thioureido] -phenyl} -acetamide 346 440 N-. { 4- [3- (3-chloro-2,4-dimethylamino-phenyl) -thioureido] -phenyl} -2-methyl-benzamide 347 493 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-methyl-phenyl} -2,6-difluorobenzamide 348 462 N-. { 4- [3- (3-chloro-4-dimethylamino-phenyl) -thioureido] -phenyl} -2,6-difluoro-benzamide 349 531 N- [4- (3. {3-chloro-4- [methyl- (1-methyl-pyrrolidin-3-yl) -amino] -phenyl}. thioureido) -phenyl] -2,6-difluoro-benzamide 350 427. { 4- [3- (3-chloro-4-dimethylamino-phenyl) -thioureido] -phenyl} - pyridine-2-carboxylic acid amide 351 430. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -phenyl} pyridine-2-carboxylic acid amide 352 428. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} pyridine-2-carboxylic acid amide 353 417. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 354 496 [4- (3- { 3-chloro-4- [methyl- (1-methyl-pyrrolidin-3-yl) -amino] -phenyl) -thioureido) - phenyl] -amide of pyridine-2-carboxylic acid 355 495 N-. { 3-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 356 467. { 3-Chloro-4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 357 515 N-. { 4- [3- (3-chloro-4-cyclohexylsulfanyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 358 449 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-trifluoromethyl-phenyl} -acetamide 359 529 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-trifluoromethyl-phenyl} -2-fluorobenzamide 360 421 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} 2-dimethylaminoacetamide 361 473 (4-. {3- [3-chloro-4- (2-dimethylamino-acetylamino) -phenyl] -thioureido} -phenyl) -amide of furan-2 -carboxílico 362 501 N-. { 4- [3- (3-chloro-4- (2-dimethylamino-acetylamino) -phenyl] -thioureido}. Phenyl) -2-fluorobenzamide 363 461 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} -2-piperidin-1-yl-acetamide 364 541 N- (4-. {3- [3-chloro-4- (2-piperidin-1-yl-acetylamino) -phenyl] -thioureido} -phenyl ) -2-fluoro-benzamide 365 513 (4-. {3- [3-chloro-4- (2-piperidin-1-yl-acetylamino) -phenyl] -thioureido} -phenyl} -amide of furan-2-carboxylic acid 366 463 N- { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} -2-morpholin-4-yl-acetamide 367 543 N- (4-. {3- [3-chloro-4- (2-morpholin-4-yl-acetylamino) -phenyl] -thioureido}. Phenyl) -2-fluorobenzamide 368 515 (4- {3 - [3-chloro-4- (2-morpholin-4-yl-acetylamino) -phenyl] -thioureido} -phenyl} -amide of furan-2-carboxylic acid 369 414 N- { 4- [3- (3-chloro-4-methanesulfonylamino-phenyl) -thioureido] -phenyl-acetamide 370 494 N- { 4- [3- (3-chloro-4-methanesulfonylamino-phenyl) -thioureido ] -phenyl.} -2-fluoro-benzamide 371 466. {4 - [3- (3-chloro-4-methanesulfonylamino-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 372 481 N- { 4- [3- (4-acetylamino-feni l) -thioureido] -2- chloro-phenyl} -2- (2-dimethylamino-ethylsulfane) -acetamide 373 561 N- [4- (3. {3-chloro-4- [2- (2-dimethylamino-ethylsulfanyl) -acetylamino] -phenyl} - thioureido) -phenyl] -2-fluoro-benzamide 374 585 N- [4- (3. {4 - [(l-benzyl-pyrrolidin-3-yl) -methylamino] -3-chloro-phenyl} - thioureido) -phenyl] -2- methyl-benzamide 375 523 N- [4- (3. {3-chloro-4- [methyl- (1-methyl-piperidin-4-yl) -amino] -f-enyl .}. -thioureido) -phenyl] -2-methyl-benzamide 376 510 [4- (3 { 3-chloro-4- [methyl- (1-methyl-piperidin-4-yl) -amino] - Phenyl-2-carboxylic acid phenyl] -ioureido) -phenyl] -amide 377 347 N-. { 4- [3- (3-chloro-4-vinyl-phenyl) -thioureido] -phenyl} -acetamide 378 441. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -amide 379 452. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -amid of pyridine-2-carboxylic acid 380 487 N-. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -2,6-difluoro-benzamide 381 486 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-cyano-phenyl} -2-fluoro-benzamide 382 458. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-cyano-phenyl} -amide of furan-2-carboxylic acid 383 406 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-cyano-phenyl} -acetamide 384 395 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -2-methyl-isothioureido] -phenyl} -acetamide 385 396 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -2-methyl-isothioureido] -phenyl} -acetamide 386 461 N-. { 4- [3- (3-chloro-4-ethylsulfanyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 387 489 N-. { 4- [3- (4-Butylsulfanyl-3-chloro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 388 411 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-methoxy-phenyl} -acetamide 389 491 N-. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-methoxy-phenyl} -2-fluoro-benzamide 390 463. { 4- [3- (5-chloro-2, -dimethoxy-phenyl) -thioureido] -3-methoxy-phenyl} -furan-2-carboxylic acid amide 391 531 (4-. {3- [3-chloro-4- (2-piperidin-1-yl-acetylamino) -phenyl] -thioureido} -phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 392 481 N-. { 4- [3- (3-chloro-4-methanesulfinyl-phenyl) -thioureido] -phenyl} -2, 6-difluoro-benzamide 393 497 N-. { 4- [3- (3-chloro-4-methanesulfonyl-phenyl) -thioureido] -phenyl} -2, 6-difluoro-benzamide 394 459 N-. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -2-methyl-phenyl} -2-fluoro-benzamide 395 429 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -2- methyl-phenyl} -2-fluoro-benzamide 396 533 [4- (3-. {2- (3-Chloro-4- [2- (2-dimethylamino-ethylsulfanyl) -acetylamino] -phenyl] -thioureido) 'phenyl] -furan-2-carboxylic acid amide 397 458 N-. { 4- [3- (4-acetylamino-3-chloro-phenyl) - thioureido] -phenyl} -2-fluoro-benzamide 398 460 Ethyl ester [2-chloro-4- (3- {4- [(furan-2-carbonyl) -amino] -phenyl} -thioureido) -phenyl] - carbamic 399 488 Ethyl acid ester (2-chloro-4- { 3- [- (2-fluoro-benzoylamino) -phenyl] -thioureido}.-phenyl] carbamic acid 400 440 N- { 4- [ 3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl) -benzamide 401 520 N-. { 4- [( { [4- (benzoylamino) -3-chloro-phenyl] -amino} -thioxomethyl) -amino] -phenyl} -2-fluorobenzamide 402 529 N-. { 4- [3- (5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -2-trifluoromethyl-phenyl} -2-fluorobenzamide 403 492. { 4- [3- (4-benzoylamino-3-chloro-phenyl) -thioureido] -phenyl} furan-2-carboxylic acid amide 404 416 N-. { 4- [3- (4-amino-3-chloro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 405 479 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} -2-thiomorpholin-4-yl-acetamide 406 531 (4- {3- [3-chloro-4- (2-thiomorpholin-4-yl-acetylamino) -phenyl] -thioureido} -phenyl) -amide of furan-2-carboxylic acid 407 559 N- (4-. {3- [3-chloro-4- (2-thiomorpholin-4-yl-acetylamino) -phenyl] -thioureido}. Phenyl) -2-fluorobenzamide 408 461 N -. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -2-methyl-phenyl} -2-fluoro-benzamide 409 430. { 4- [3- (4-acetylamino-3-chloro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 410 477 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -chlorophenyl} -2-dipropyl-amino-acetamide 411 529 (4-. {3- [3-chloro-4- (2-dipropylamino-acetylamino) -phenyl) -thioureido} phenyl) -amide of furan-2-carboxylic acid 412 449 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} -2-diethylamino-acetamide 413 501 (4-. {3- [chloro-4- (2-diethylamino-acetylamino) -phenyl] -thioureido} -phenyl) -amide of furan-2-carboxylic acid 414 529 N-. { 4- [3- (3-chloro-4- (2-diethylamino-acetylamino) -phenyl] -thioureido.} - phenyl) -2-fluoro-benzamide 415 447 N-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-phenyl} -2-pyrrolidin-1-yl-acetamide 416 499 (4-. {3- [3-chloro-4- (2-pyrrolidin-1-yl-acetylamino) -phenyl] -thioureido} -phenyl) - Furan-2-carboxylic acid amide 417 -527 N- (4-. {3- [3-chloro-4- (2-pyrrolidin-1-yl-acetylamino) -phenyl] -thioureido} -phenyl) - 2-fluorobenzamide 418 475 N-. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -3-methoxy-phenyl} -2-fluoro-benzamide 419 v 445 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -3-methoxy-phenyl} -2-fluoro-benzamide 420 477 N-. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -3-methoxy-phenyl} -2-fluoro-benzamide 421 388 (4- [3- (4-amino-3-chloro-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 422 527 (4- {3- [4- (2-azepan-l-yl-acetylamino) -3-chloro-phenyl] -thioureido} -phenyl) -amide of furan-2-carboxylic acid 423 555 N- (4- { 3- [4- (2-azepan-l-yl-acetylamino) -3-chloro-phenyl] -thioureido}. -phenyl.} -2-fluoro-benzamide 424 527 [4- (3- { 3-Chloro-4- [2- (2-methyl-piperidin-1-yl) -acetylamino] -phenyl] -thioureido) -phenyl] -amide furan-2-carboxylic acid 425 555 N- [4- (3. {3-Chloro-4- [2- (2-methyl-piperidin-yl) -acetylamino] -phenyl} -thioureido) -phenyl ] -2-Fluorobenzamide 426 339 [4- (3-pyridin-2-yl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 427 339 [4- (3-pyridin-4-yl-thioureido ) -phenyl] -amide of furan-2-carboxylic acid 428 367 2-fluoro-N- [4- (3-pyridin-3-yl-thioureido]) - phenyl] -benzamide 429 339 [4- (3-pyridine -3-yl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 430 353. { 4- [3- (3-Amino-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 431 406. { 4- [3- (3-trifluoromethyl-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 432 380 2-fluoro-N- [4- (3-m-tolyl-thioureido) -phenyl] -benzamide 433 434 2-fluoro-N-. { 4- [3- (3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide 434 381 N-. { 4- [3- (3-Amino-phenyl) -thioureido] -phenyl} -2- fluoro-benzamide 435 388. { 4- [3- (3-amino-5-chloro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 436 352 [4- (3-m-tolyl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 437 416 N-. { 4- [3- (2-amino-5-chloro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 438 571 2-piperidin-1-yl-ethyl ester of (2-chloro-4-. {3- [4- (2-fluoro-benzoylamino) -phenyl] -thioureido}. -phenyl) -carbamic acid 439 543 2-piperidin-1-ethyl-ethyl ester of [2-chloro-4- (3- {4- [(furan-2-carbonyl) amino] -phenyl} - thioureido) -phenyl] -carbamic 440 388. { 4- [3- (2-amino-5-chloro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 441 363. { 4- [3- (3-cyano-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 442 416 N-. { 4- [3- (3-amino-5-chloro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 443 367 2-fluoro-N- [4- (3-pyridin-2-yl-thioureido) -phenyl] -benzamide 444 367 2-fluoro-N- [4- (3-pyridin-4 -yl-thioureido) -phenyl] -benzamide 445 374. { 4- [3- (6-chloro-pyridin-3-yl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 446 388. { 4- [3- (2-amino-3-chloro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 447 496. { 4- [3- (3-hydrazinocarbonyl-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 448 410 2-fluoro-N- (4-. {3- [3- (l-hydroxy-ethyl) -phenyl] -thioureido} -phenyl) -benzamide 449 414 . { 4- [3- (3-Hydrazincarbonyl-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 450 399. { 4- [3- (3-isopropyl-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 451 380. { 4- [3- (3-isopropyl-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 452 409 2-fluoro-N-. { 4- [3- (3-isopropyl-phenyl) -thioureido] -phenyl} -benzamide 453 381. { 4- [3- (3-cyano-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 454 410 N-. { 4- [3- (3-dimethylamino-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 455 381. { 4- [3- (3-dimethylamino-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 456 370 [[(2,3-thiadiazole-4-carboxylic acid [4- (3-m-tolyl-thioureido) -phenyl] -amide] -amide 457 424. { 4- [3- (3-trifluoromethyl-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 458 479 N-. { 3-Chloro-4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 459 449 N-. { 3-chloro-4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 460 481 N-. { 3-Chloro-4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 461 391 N-. { 4- [3- (3-cyano-phenyl) -thioureido] -phenyl} -2- fluoro-benzamide 462 395. { 4- [3- (3-acetylamino-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 463 424 2-fluoro-N-. { 4- [3- (3-hydrazinocarbonyl-phenyl) -thioureido] -phenyl} benzamide 464-400 (4-. {3- [3- (1-hydroxy-ethyl) -phenyl] -thioureido.} - phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 465 434 N-. { 4- [3- (2-amino-3-chloro-phenyl) -thioureido] -phenyl} -2,6-difluoro-benzamide 466 406 (4- [3- (3-amino-5-chloro-phenyl) -thioureido] -phenyl] -amide of [1, 2, 3] thiadiazole-4 -amide. carboxylic acid 467 398 { 4- [3- (3, 5-dimethoxy-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 468 416 { 4- [3- (3, 5-dimethoxy-phenyl) -thioureido] -phenyl.} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 469 454 5- (3- {4- [(furan-2-carbonyl) -amino] -phenyl} -thioureido) -isophthalic acid dimethyl ester 470 434. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -amidoxazole-5-carboxylic acid amide 471 392. { 4- [3- (6-chloro-pyridin-3-yl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 472 382 (4- { 3- [3- (l-hydroxy-ethyl) -phenyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 473 368 (4- [3- (3-methoxy-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 474 354 { 4- [3- (3-hydroxy-phenyl) - thoureido] -phenyl.} - furan-2-carboxylic acid amide 475 382 2-fluoro-N- { 4- [3- (3-hydroxy-phenyl) -thioureido] -phenyl} - benzamide 476 396 2-fluoro-N- { 4- [3- (3-hydroxymethyl-phenyl) -thioureido] -phenyl.}. -benzamide 477 423 N- { 4- [3- (3-acetylamino-phenyl ) -thioureido] -phenyl.} -2-fluoro-benzamide 478 413. {4- [3- (3-acetylamino-phenyl) -thioureido] -phenyl} -amide of the acid [1, 2, 3 ] thiadiazole-4-carboxylic acid 479 400 { 4- [3- (3-dimethylamino-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 480 340 [4- (3-pyrimidin-4-yl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 481 378. { 4- [3- (lH-indazol-5-yl) -thioureido] -phenyl} furan-2-carboxylic acid amide 482 395 [4- (3-benzothiazol-5-yl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 483 406 2-fluoro-N-. { 4- [3- (lH-indazol-5-yl) -thioureido] -phenyl} -benzamide 484 424 N- [4- (3-benzothiazol-5-yl-thioureido) -phenyl] -2-fluoro-benzamide 485 473 Dimethyl acid ester 5- (3-. {4- [([1, 2,3] thiadiazole-4-carbonyl) -amino] -phenyl.} - thioureido) -isophthalic acid 486 442 (4-. {3- [4- (l-azido-ethyl) -3-chloro-phenyl] - furan-2-carboxylic acid thioureido.}. phenyl) -amide 487 396 2-fluoro-N-. { 4- [3- (3-methoxy-phenyl) -thioureido] -phenyl} -benzamide 488 368. { 4- [3- (3-hydroxymethyl-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 489 416. { 4- [3- (5-chloro-2-dimethylamino-phenyl) -thioureido] -f-enyl} -amide of furan-2-carboxylic acid 490 444 N-. { 4- [3- (5-chloro-2-dimethylamino-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 491 506 [3-chloro-5- (3- {4- [([1]] -butyl acid ester, 2,3] thiadiazole-4-carbonyl) -amino-phenyl} thioureido) -phenyl] -carbamic acid 492 470 N- (4-. {3- (1-azido-ethyl) -3-chloro-phenyl] -thioureido}. -phenyl) -2-fluoro-benzamide 493 337 [4- (lH-thiazol [5, -b] pyridin-2-ylidenamino-phenyl] -amide of furan-2-carboxylic acid 494 378. { 4- [3- (lH-benzoimidazol-5-yl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 495 392. { 4- [3- (2-methyl-lH-benzoimidazol-5-yl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 496 406 N-. { 4- [3- (lH-benzoimidazol-5-yl) -thioureido] -phenyl} -2-fluoro-benzamide 497 420 2-fluoro-N-. { 4- [3- (2-methyl-lH-benzoimidazol-5-yl) -thioureido] -phenyl} -benzamide 498 452. { 5- [3- (5-Chloro-2, -dimethoxy-phenyl) -thioureido] -pyridin-2-yl} [1, 2, 3] thiadiazole-4-carboxylic acid amide 499 445 (5- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-2-yl}. pyridine-2-carboxylic acid amide 500 434 (4- [3- (5-chloro-2-dimethylamino-phenyl) -thioureido] -f-enyl] -amide of [1,2,3] thiadiazole-4 -amide -carboxylic acid 501 484 (4-. {3- [4- (2-amino-pyrimidin-4-yl) -3-chloro-phenyl] -thioureido} -phenyl) -amide of the acid [1,2, 3] thiadiazole-4-carboxylic acid 502-494 N- (4-. {3- [4- (2-amino-pyrimidin-4-yl) -3-chloro-phenyl] -thioureido} -phenyl) -2 -fluoro-benzamide 503 434 (4- [3- (3-Chloro-2-dimethylamino-phenyl) -thioureido] -phenyl} -amide of [1,2,3] thiadiazole-4-carboxylic acid 504 462 N-. 4- [3- (3-chloro-2-dimethylamino-phenyl) -thioureido] -phenyl.} -2,6-difluoro-benzamide 505 416 (4- [3- (3-chloro-2-dimethylamino-phenyl) - thioureido] -phenyl.} - furan-2-carboxylic acid amide 506 445. {6- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-3-yl} - pyridine-2-carboxylic acid amide 507 462 N-. {6- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-3-yl.} -2 -fluoro-benzamide 508 482. { 4- [3- (3-iodo-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 509 413. { 4- [3- (3-tert-butyl-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 510 387. { 4- [3- (3-chloro-benzyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 511 415 N-. { 4- [3- (3-chloro-benzyl) -thioureido] -phenyl} -2- fluoro-benzamide 512 434 (6- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -pyridin-3-yl} -amide of furan-2-carboxylic acid 513 435 {1,4- [3- (3-bromo-phenyl) -thioureido] -phenyl} -amide of [1,2,3] thiadiazole-4-carboxylic acid 514 452 { 6- [3- ( 5-chloro-2, 4-dimethoxy-phenyl) -thioureido] -pyridin-3-yl.} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 515 426 { 5- [3- (1,3,5-dichloro-phenyl) -thioureido] -pyridin-2-yl.} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 516 474 { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 517 502 N-. {4- [3- (3,5-bis-trifluoromethyl-phenyl) -thioureido ] -phenyl.} -2-fluoro-benzamide 518 450 N- { 4- [3- (4-amino-3,5-dichloro-phenyl) -thioureido] -phenyl} -2-fluoro- benzamide 519 539 N- {4- [3- (4-amino-3,5-dibromo-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 520 392 { 4- [3- (5-chloro-pyridin-3-yl) -thioureido] -phenyl}. [1, 2, 3] thiadiazole-4-carboxylic acid 521 529. { 4- [3- (4-amino-3,5-dibromo-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 522 434. { 4- [3- (3-chloro-5-dimethylamino-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 523 444 N-. { 4- [3- (3-chloro-5-dimethylamino-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 524 416 (4- [3- (3-chloro-5-dimethylamino-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 525 436. 3- [5-Bromo-pyridin-3-yl) -thioureido] -phenyl] -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 526 379. { 4- [3- (lH-benzotriazol-5-yl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 527 425 N-. { 4- [3- (lH-benzotriazol-5-yl) -thioureido] -phenyl} -2,6-difluoro-benzamide 528 388 N- [4- ( { [2- (3-Chloro-phenyl) -hydrazino] -thioxomethyl] -amino) -phenyl] -furan-2-carboxamide 529 416 N- [4- ( { [2- (3-Chloro-phenyl) -hydrazino] -thioxomethyl] -amino) -phenyl] -2-fluoro-benzamide 530 456. { 4- [3- (2-amino-3-chloro-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 531 513 N-. { 4- [3- (3-bromo-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 532 503. { 4- [3- (3-bromo-5-trifluoromethyl-phenyl) -thioureido] -phenyl} [1,2,3] thiadiazole-4-carboxylic acid amide 533 374 O- (3-chloro-phenyl) acid ester. { 4- [(furan-2-carbonyl) -amino] -phenyl} -thiocarbamic 534 474. { 4- [3- (2-amino-3-chloro-5-trifluoromethyl-phenyl) -thioureido] -phenyl} [1,2,3] thiadiazole-4-carboxylic acid amide 535 508. { 4- [3- (3-piperidin-1-yl-5-trifluoromethyl-phenyl) -thioureido] -phenyl} [1,2,3] thiadiazole-4-carboxylic acid amide 536 380 N- [4- (3-benzyl-thioureido) -phenyl] -2-fluoro-benzamide 537 439. { 4- [3- (3,4-dichloro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 538 449 N-. { 4- [3- (3,4-dichloro-benzyl) -thioureido] -phenyl} 2-Fluoro-benzamide 539 370 [1,2,3] thiadiazole-carboxylic acid [4- (3-benzyl-thioureido) -phenyl] -amide] -amide 540 424 N- [4- (3-benzo [l, 3] dioxol-5-ylmethyl-thioureido) -phenyl] -2-fluoro-benzamide 541 414 [4- (3-benzo [l, 3] dioxol-5-ylmethyl-thioureido] -phenyl] -amide of the acid [1 , 2, 3] thiadiazole-4-carboxylic acid 542 506 (4- [3- (3, 5-bis-trifluoromethyl-benzyl) -thioureido] -phenyl} -amide of [1,2,3] thiadiazole- 4-carboxylic acid 543 516 N- { 4- [3- (3,5-bis-trifluoromethyl-benzyl) -thioureido] -phenyl} -2-fluoro-benzamide 544 352 [4- (3-benzyl- Thuran-2-carboxylic acid thioureido) -phenyl] -amide 545 421. {furan-2-carboxylic acid furan-2-carboxylic acid 546 396 [4- (3-benzo [1, 3] dioxol-5-ylmethyl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 547 488. { 4- [3- (3, 5-bis-trifluoromethyl-benzyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 548 503. { 4- [3- (4-bromo-3-trifluoromethyl) -phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 549 529 N-. { 4- [3- (3-bromo-trifluoromethoxy-phenyl) -thioureido] -phenyl} -2-Fluoro-benzamide 550 519 ([1,2,3] thiadiazole-4-carboxylic acid 4- [3- (3-bromo-4-trifluoromethoxy-phenyl) -thioureido] -phenyl} -amide. 473. {4 - [3- (3-Chloro-4-trifluoromethylsulfanyl-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 552 412 2-fluoro-N- (4-. { 3- [2- (3-fluoro-phenyl) -ethyl] -thioureido}. Phenyl) -benzamide 553 412 2-fluoro-N- (4-. {3- [2- (4-fluoro- phenyl) -ethyl] -thioureido.}.-phenyl) -benzamide 554 402 (4-. {3- [2- (3-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of the acid [1, 2, 3] thiadiazole-4-carboxylic acid 555 402 (4-. {3- [2- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl} -amide [ 1, 2, 3] thiadiazole-4-carboxylic acid 556 495 (4-. {3- [3- (2-methyl-butyl) -5-trifluoromethyl-phenyl] -thioureido} -phenyl) - [1,2,3] thiadiazole-4-carboxylic acid amide 557 481. {4- [3- (3-isobutyl-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -amide [1] , 2,3] thiadiazole-carboxylic acid 558 523 (4 - { 3- [3- (4-methyl-piperazin-1-yl) -5-trifluoromethyl-phenyl] -thioureido} [1,2,3] thiadiazole-4-carboxylic acid phenyl) -amine 559 510. { 4- [3- (3-morpholin-4-yl-5-trifluoro-methyl-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 560 494. { 4- [3- (3-pyrrolidin-1-yl-5-trifluoro-methyl-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid 561 384 (4-. {3- [4-fluoro-phenyl] -ethyl] -thioureidoamide} phenyl) furan-2-carboxylic acid amide 562 419 (4-. {3- [2- (3-Chloro-phenyl) -ethyl] -thioureido.} - phenyl) -amide [1, 2] , 3] thiadiazole-4-carboxylic acid 563 429 N- (4-. {3- [2- (3-chloro-phenyl) -ethyl] -thioureido} - phenyl) -2-fluoro-benzamide 564 401 ( 4- {3- [2- (3-chloro-phenyl) -ethyl] -thioureido} - phenyl) -amide of furan-2-carboxylic acid 565 402 (4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 566 504 2 -fluoro-N- { 4- [3- (3-pyrrolidin-1-yl-5-trifluoromethyl-phenyl) -thioureido] -phenyl} - benzamide 567 477 N-. { 4- [3- (3-dimethylamino-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 568 520 2-fluoro-N-. { 4- [3- (3-morpholin-4-yl-5-trifluoromethyl-phenyl) -thioureido] -phenyl} benzamide 569 533 2-fluoro-N- (4-. {3- [3- (4-methyl-piperazin-1-yl) -5- trifluoromethyl-phenyl) -thioureido} phenyl) -benzamide 570 518 2-fluoro-N-. { 4- [3- (3-piperidin-l-yl-5-trifluoromethyl-phenyl) -thioureido] -phenyl} - benzamide 571 468. { 4- [3- (3-dimethylamino-5-trifluoromethyl-phenyl) -thioureido] -phenyl} [1,2,3] thiadiazole-4-carboxylic acid amide 572 405. { 4- [3- (3-chloro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 573 384 (4-. {3- [2- (3-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -amide furan-2-carboxylic acid 574 366 [4- (3-phenethyl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 575 384 [4- (3-phenethyl-thioureido) -phenyl] -amide of the acid [1,2,3] thiadiazole-4-carboxylic acid 576 394 2-fluoro-N- [4- (3-phenethyl-thioureido) -phenyl] -benzamide 577 505 2-fluoro-N- (4- { 3- [3- (2- methyl-butyl) -5- trifluoromethyl-phenyl] -thioureido.} - phenyl) -benzamide 578 491 2-fluoro-N-. { 4- [3- (3-isobutyl-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide 579 388. { 4- [3- (3, 5-difluoro-benzyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 580 416 N-. { 4- [3- (3, 5-difluoro-benzyl) -thioureido] -phenyl} -2-fluoro-benzamide 581 406. { 4- [3- (3, 5-difluoro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 582 421. { 4- [3- (3, 5-dichloro-benzyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 583 449 N-. { 4- [3- (3, 5-dichloro-benzyl) -thioureido] -phenyl} - 2-fluoro-benzamide 584 439. { 4- [3- (3, 5-dichloro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 585 438. { 4- [3- (3-fluoro-5-trifluoromethyl-benzyl) -thioureido] -phenyl} -amuran of furan-2-carboxylic acid 586 466 2-fluoro-N-. { 4- [3- (3-fluoro-5-trifluoromethyl-benzyl) -thioureido] -phenyl} -benzamide 587 456. { 4- [3- (3-fluoro-5-trifluoromethyl-benzyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 588 384. { 4- [3- (1-phenyl-ethyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 589 394 2-fluoro-N-. { 4- [3- (1-phenyl-ethyl) -thioureido] -phenyl} -benzamide 590 366. { 4- [3- (1-phenyl-ethyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 591 412 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. -phenyl) -benzamide 592 384 . { 4- [3- (1- (4-Fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 593 413 N-. { 4- [3- (l-tert-butyl-lH-imidazol-2-yl) -thioureido] -phenyl} -2-fluoro-benzamide 594 510 (4-. {3- [3- (isobutyl-methyl-amino) -5-trifluoromethyl-phenyl] -thioureido}. Phenyl) -amide [1, 2, 3] thiadiazole-4-carboxylic acid 595 510 (4-. {3- [3- (3-hydroxy-pyrrolidin-1-yl) -5-trifluoromethyl-phenyl] -thioureido}. Phenyl) -amide [1, 2, 3] thiadiazole-4-carboxylic acid 596 520 2-fluoro-N-. { 4- [3- (3- (isobutyl-methyl-amino) -5-trifluoromethyl-phenyl] -thioureido.} - phenyl) -benzamide 597 510 (4-. {3- [3- (butyl-methyl- amino) -5-trifluoromethyl-phenyl] -thioureido.} - phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 598 520 N- (4-. {3- [3- (butyl) -methyl-amino) -5- trifluoromethyl-phenyl] -thioureido.} - phenyl) -2-fluoro-benzamide 599 520 (4-. {3- [2- (3,5-bis-trifluoromethyl-phenyl) [1,2,3] thiadiazole-4-carboxylic acid thioureido.}. phenyl) -amide 600 442. { 4- [3- (4-fluoro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 601 522. { 4- [3- (4-piperidin-1-yl-3-trifluoro-methyl-benzyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 602 482. { 4- [3- (4-dimethylamino-3-trifluoromethyl-benzyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 603 381 (4-. {3- [2- (4-amino-phenyl) -ethyl] -thioureido} - phenyl) -amide furan-2-carboxylic acid 604 445 (4- { 3- [2- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 605 380 { 4- [3- (2-p-tolyl-ethyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 606 463 (4-. {3- [2- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -amide [1, 2, 3] ] thiadiazole-4-carboxylic acid 607 396 (4- {3- [2- (3-methoxy-phenyl) -ethyl] -thioureido} - phenyl) -amide of furan-2-carboxylic acid 608 403 (4 - [3- (l-tert-butyl-lH-imidazol-2-yl) -thioureido] -f-enyl] -amide of [1,2,3] thiadiazole-4-carboxylic acid 609 384. - [3- (l-tert-butyl-lH-imidazol-2-yl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 610 492 N- { 4- [3- (4 -dimethylamino-3-trifluoromethyl-benzyl) -thioureido] -phenyl.} -2-fluoro-benzamide 611 427 (4-. {3- [2- (3,4-dimethoxy-phenyl) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 612 380 { 4- [3- (3-phenyl-propyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 613 399. { 4- [3- (3-phenyl-propyl) -thioureido] -phenyl} -amide of acid [1, 2, 3] thiadiazole-4-carboxylic acid 614 502 (4-. {3- [2- (3,5-bis-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide of furan -2- carboxylic 615 550. { 4- [3- (4-iodo-3-trifluoromethyl-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-carboxylic acid 616 532 2-fluoro-N- amide. { 4- [3- (4-piperidin-1-yl-3-trifluoromethyl-benzyl) -thioureido] -phenyl} - benzamide 617 537 (4-. {3- [4- (4-methyl-piperazin-1-yl) -3-trifluoromethyl-benzyl] -thioureido}. phenyl) -amide [1, 2, 3] thiadiazole-4-carboxylic acid 618 482. { 4- [3- (3-dimethylamino-5-trifluoromethyl-benzyl) -thioureido] -phenyl} - [1,, 3] thiadiazole-4-carboxylic acid amide 619 488. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureidomethyl] -phenyl} -furan-2-carboxylic acid amide 620 421. { 4- [3- (3, 5-dichloro-phenyl) -thioureidomethyl] -phenyl} -furan-2-carboxylic acid amide621 421. { 4- [3- (3, 4-dichloro-phenyl) -thioureidomethyl] -phenyl} -furan-2-carboxylic acid amide 622 455. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido-methyl] -phenyl} -amide of furan-2-carboxylic acid 623 466 2-fluoro-N-. { 4- [3- (4-fluoro-3-trifluoromethyl-benzyl) -thioureido] -phenyl} -benzamide 624 456 (4- [3- (4-fluoro-3-trifluoromethyl-benzyl) -thioureido] -phenyl] -amide of [1,2,3] thiadiazole-carboxylic acid 625 410 2-fluoro- N- {4- [3- (2-phenoxy-ethyl) -thioureido] -phenyl} -benzamide 626 382. {4- [3- (2-phenoxy-ethyl) -thioureido] -phenyl} - furan-2-carboxylic acid 627 400. {4- [3- (2-phenoxy-ethyl) -thioureido] -phenyl} -amide [1, 2, 3] thiadiazole-4 -amide. -carboxylic 628 409 2-fluoro-N- { 4- [3- (3-phenyl-propyl) -thioureido] -phenyl} -benzamide 629 425 { 4- [3- (5-trifluoromethyl- pyridin-3-yl) -thioureido] -phenyl.} - [1,2,3] thiadiazole-4-carboxylic acid 630 439 -4- [3- (3,4-dichloro-phenyl) -thioureido-methyl] ] - [1, 2, 3] thiadiazole-4-carboxylic acid phenyl] -amide of 4,331,473 { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureidomethyl] -phenyl} - amide. .-[1,2,3] thiadiazole-4-carboxylic acid 632 381 2-fluoro-N- [4- (3-pyridin-3-ylmethyl-thioureido) -phenyl] -benzamide 633 353 [4- ( 3-pi Rutin-3-ylmethyl-thioureido) -phenyl] -amide of furan-2-carboxylic acid 634 371 [4- (3-pyridin-3-ylmethyl-thioureido) -phenyl] -amide [1, 2, 3] thiadiazole-4-carboxylic acid 635 439. { 4- [3- (3,5-dichloro-phenyl) -thioureido-methyl] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 636-492 N-. { 4- [3- (3-dimethylamino-5-trifluoromethyl-benzyl) -thioureido] -phenyl} 2-Fluoro-benzamide 637 415 (4- {3- [2- (3-methoxy-phenyl) -ethyl] -thioureido} - phenyl) -amide of [1, 2, 3] thiadiazole- 4- carboxylic 638 399. { 4- [3- (2-p-tolyl-ethyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid amide 639 445 (4-. {3- [2- (3,4-dimethoxy-phenyl) -ethyl-thioureido} - phenyl) -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 640 506. { 4- [3- (3,5-bis-trifluoromethyl-phenyl) -thioureidomethyl] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide 641 516 N-. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureidomethyl] -phenyl} -2-fluoro-benzamide 642 449 N-. { 4- [3- (3, 5-dichloro-phenyl) -thioureidomethyl] -phenyl} -2-fluoro-benzamide 643 449 N-. { 4- [3- (3, 4-dichloro-phenyl) -thioureidomethyl] -phenyl} -2-fluoro-benzamide 644 448. { 4- [3- (3-acetylamino-5-chloro-phenyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid amide 645 453 (4-. {3- [2- (3,4-dichloro-phenyl) -ethyl] -thioureido} - phenyl) - [1, 2, 3] thiadiazole-4-carboxylic acid amide 646 413. { 4- [3- (1-methyl-3-phenyl-propyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid 647 463 (4-. {3- [1- (4-bromo-phenyl) -ethyl] -thioureido] -phenyl] -amide acid amide. [1, 2, 3] thiadiazole-4-carboxylic acid 648 413. { 4- [3- (4-phenyl-butyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid 649 397 [1- (3, 3-indan-1-yl-thioureido) -phenyl] -amide [1,2,3] thiadiazole-4 -amide] Carboxylic 650 400. { 4- [3- (2-methoxy-benzyl) -thioureido] -phenyl} - [1, 2,3] thiadiazole-4-carboxylic acid amide 651 415 (4-. {3- [2- (2-methoxy-phenyl) -ethyl] -thioureido} - phenyl) -amide [1, 2, 3] thiadiazole-4-carboxylic acid 652 415 (4-. {3- [2- (4-methoxy-phenyl) -ethyl] -thioureido.} - phenyl) -amide [1] , 2,3] thiadiazole-4-carboxylic acid 653 506 N- (4-. {3- [2- (3-dimethylamino-5-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -2- Fluorobenzamide 654 510 (4- {3- [3- (3-dimethylamino-propyl) -5-trifluoromethyl-phenyl] -thioureido} - phenyl) -amide of [1,2,3] thiadiazole -4-carboxylic 655 417. { 4- [3- (2-phenylsulfanyl-ethyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 656 427 2-fluoro-N-. { 4- [3- (2-phenylsulfanyl-ethyl) -thioureido] -phenyl} -benzamide 657 399. { 4- [3- (2-phenylsulfanyl-ethyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 658 381 2-fluoro-N- [4- (3-pyridin-4-ylmethyl-thioureido) -phenyl] -benzamide 659 353 [4- (3-pyridin-4-ylmethyl- thoureido) -phenyl] -amide of furan-2-carboxylic acid 660 371 [4- (3-pyridin-4-ylmethyl-thioureido) -phenyl] -amide of acid [1, 2, 3] thiadiazole-4-carboxylic acid 661 506 2-fluoro-N-. { 4- [3- (3-iodo-benzyl) -thioureido] -phenyl} -benzamide 662 478. { 4- [3- (3-iodo-benzyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 663 496. { 4- [3- (3-iodo-benzyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid amide 664 479 N- (4-. {3- [2- (3,5-dichloro-phenoxy) -ethyl] -thioureido}. phenyl) -2-fluoro-benzamide 665 451 (4-. {3- [2- (3,5-dichloro-phenoxy) -ethyl] -thioureido.} - phenyl) -amide of furan-2-acid carboxylic 666 445 N- (4- { 3- [2- (3-chloro-phenoxy) -ethyl] -thioureido.} - phenyl.} -2-fluoro-benzamide 667 417 (4- { 3 - [2- (3-chloro-phenoxy) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 668 435 (4- {3- [2- (3-chloro-phenoxy) -ethyl] -thioureido} -phenyl] -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 669 466 2 -fluoro-N- { 4- [3- (2-fluoro-5-trifluoromethyl-benzyl) -thioureido] -phenyl} -benzamide 670 438 { 4- [3- (2-fluoro-5 -trifluoromethyl-benzyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 671 456 (4- [3- (2-fluoro-5-trifluoromethyl-benzyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid 672 416 N- { 4- [3- (3, -difluoro-benzyl) -thioureido] -phenyl} -2- fluoro-benzamide 673 amide 452 N- (4-. {3- [2- (4-dimethylamino-3-methyl-phenyl) -ethyl-thioureido} -phenyl) -2-fluoro-benzamide 674 496 (4- { 3 [1,2,3] thiadiazole-4-carboxylic acid [2- (3-dimethylamino-5-trifluoromethyl-phenyl) -ethyl] -thioureido.]. Phenyl) -amide. - [3- (3,4-difluoro-benzyl) -thioureido] -phenyl] -amide of furan-2-carboxylic acid 676 406 { 4- [3- (3,4-difluoro-benzyl) - thioureido] -phenyl.} - acid amide [1, 2, 3] thiadiazole-4-carboxylic acid 677 433 N-. { 4- [3- (3-chloro-4-fluoro-benzyl) -thioureido; phenyl } -2,7-Fluoro-benzamide 678 495 (4- {3- [2- (3-bromo-phenylsulfanyl) -ethyl] -thioureido} -phenyl) -amide of [i, 2,3] thiadiazole- 4-carboxylic acid 679 477 (4-. {3- [2- (3-bromo-phenylsulfanyl) -ethyl] -thioureido} -phenyl) -amide of furan-2-carboxylic acid 680 505 N- (4- {. 3- 3- [2- (3-bromo-phenylsulfanyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 681 493 (4-. {3- [2- (3-bromo- 4-methoxy-phenyl) -ethyl] -thioureido.} - phenyl)} [1,2,3] thiadiazole-4-carboxylic acid (682-493) (4-. {3- [2- (5-bromo-2-methoxy-phenyl) -ethyl] -thioureido] -phenyl acid. ) - [1,2,3] thiadiazole -carboxylic acid 683 419 (4-. {3- [2- (2-chloro-phenyl) -ethyl] -thioureido] -phenyl] -amide [1, 2, 3] thiadiazole-4-carboxylic acid 684 402 (4-. {3- [2- (2-fluoro-phenyl) -ethyl] -thioureido} - phenyl} -amide acid [1, 2, 3] thiadiazole-4-carboxylic acid 685 419 (4-. {3- [2- (4-chloro-phenyl) -ethyl] -thioureido.} - phenyl) -amide [1] 2,3] thiadiazole-4-carboxylic acid 686 475 (4- [3- (3, 3-diphenyl-propyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 687,547 2-fluoro-N- (4-. {3- [4- (4-methyl-piperazin-1-yl) -3-trifluoromethyl-benzyl] -thioureido} -phenyl) -benzamide 688 469 ( 4- [3- (2- (3, 5-dichloro-phenoxy) -ethyl] -thioureido.} - phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 689 423. { 4- [3- (3-chloro-4-fluoro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 690 427. { [1, 2, 3] thiadiazole-4-carboxylic acid [3- (4-tert-butyl-benzyl) -thioureido] -phenyl) -amide. 691 399 (4- [3- (3, 5-dimethyl-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 692 442 (4- {3- [2- (4-dimethylamino-3-methyl-phenyl) -ethyl] -thioureido} -phenyl) -amide of [1,2,3] thiadiazole-4 -amide. carboxylic acid 693 479 (4-. {3- [2- (4-bromo-phenoxy) -ethyl] -thioureido.} - phenyl) -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 694 526 (4- {3- [2- (4-iodo-phenoxy) -ethyl] -thioureido} - phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 695 489 N- ( 4- { 3- [2- (4-bromo-phenoxy) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 696 536 2-fluoro-N-. { 4-. { 3- [2- (4-iodo-phenoxy) -ethyl] -thioureido} phenyl) -benzamide 697 461 (4-. {3- [2- (4-bromo-phenoxy) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 698 508 (4- { 3- [2- (4-iodo-phenoxy) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 699 408. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - oxazole-4-carboxylic acid amide 700 424. { 4- [3- (3,5-dichloro-phenyl) -thioureido] -phenyl} - thiazole-4-carboxylic acid amide 701 491. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureido] -phenyl} -thiazole-4-carboxylic acid amide 702 408. { 4- [3- (3, 5-dichloro-phenyl) -thioureido] -phenyl} Oxazole-4-carboxylic acid amide 703 469 (4-. {3- [2- (3,4-dichloro-phenoxy) -ethyl] -thioureido} - phenyl) -amide [1, 2] , 3] thiadiazole-4-carboxylic acid 704 424. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - thiazole-4-carboxylic acid amide 705 458 (4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido) -phenyl} -thiazole-4-carboxylic acid amide 706 400. { 4- [3- (2-phenylaminol-ethyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 707 453 (4- {3- [2- (2, -dichloro-phenyl) -ethyl] -thioureido} -phenyl) -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 708 452 (4- {3- [2- (3-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 709 453 (4- [1, 2, 3] thiadiazole-4-carboxylic acid 710 485 (4-. 2- (2,6-dichloro-phenyl) -ethyl] -thioureido.} - phenyl) -amide. [1,2,3] thiadiazole-4-carboxylic acid {7,3-dichloro-phenylsulfanyl) -ethyl] -thioureido}. {[3- [2- (2-fluoro-5-trifluoromethyl-phenylsulfanyl) -ethyl] -thioureido} -phenyl) -amide of [1, 2, 3] thiadiazole-4-carboxylic acid 712 668 N- (4- (3- [3-chloro-5- (3- { 4- [([1, 2, 3] thiadiazole-4-carbonyl) -amino] -phenyl] -.-thioureido) -phenyl] - thioureido.} - phenyl) - [1,2,3] thiadiazole-4-carboxamide 713 413 (4-. {3- [2- (4-ethyl-phenyl) -ethyl] -thioureido} - [1, 2, 3] thiadiazole-4-carboxylic acid phenyl) -amide 714 442 { 4- [3- (4-chloro-3-trif luoromethyl-phenyl) -thioureido] -phenyl} Oxazole-4-carboxylic acid amide 715 475. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureido] -phenyl} Oxazole-4-carboxylic acid 716 420 (4-. {3- [2- (3,4-difluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of the acid [1, 2] , 3] thiadiazole-4-carboxylic acid 717 452 (4-. {3- [2- (4-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide [1,2,3] thiadiazole-4-carboxylic acid 718 435 (4-. {3- [2- (3,4-dichloro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of furan-2-carboxylic acid 719 463 N- (4-. {3- [2- (3,4-dichloro-phenyl) -ethyl] -thioureido} - phenyl) -2-fluoro-benzamide 720 420 (4- { 3 - [1,2,3-thiadiazole-4-carboxylic acid] -221-412 2-fluoro-N- (2- (3, 5-difluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide. - { 3- [2- (2-fluoro-phenyl) -ethyl] -thioureido.}.-Phenyl) -benzamide 722 429 (4- { 3- [2- (4-nitro-phenyl) - ethyl] -thioureido.} - phenyl) -amide of [1,2,3] thiadiazole-4-carboxylic acid 723 399. { 4- [3- (1-methyl-2-phenyl-ethyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 724 437 N-. { 4- [3- (4-tert-butyl-benzyl) -thioureido] -phenyl} - 2-fluoro-benzamide 725 409 N-. { 4- [3- (3, 5-dimethyl-benzyl) -thioureido] -phenyl} - 2-fluoro-benzamide 726 400. { 4- [3- (2-hydroxy-l-phenyl-ethyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid 727 409-2-fluoro-N- amide. { 4- [3- (l-methyl-phenyl-ethyl) -thioureido] -phenyl} -benzamide 728 399. { 4- [3- (l-methyl-phenyl-ethyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 729 405. { 4- [3- (2-chloro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 730 388. { 4- [3- (2-fluoro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 731 438. { 4- [3- (3-trifluoromethyl-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 732 388. { 4- [3- (3-fluoro-benzyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid 733 435 (4-. {3- [2- (2-chloro-phenoxy) -ethyl] -thioureido] -phenyl] -amide acid amide. [1, 2, 3] thiadiazole-4-carboxylic acid 734 479 (4-. {3- [2- (3-bromo-phenoxy) -ethyl] -thioureido] -phenyl) -amide [1, 2] , 3] thiadiazole-4-carboxylic acid 735 418 (4-. {3- [2- (2-fluoro-phenoxy) -ethyl] -thioureido} phenyl] -amide [1, 2, 3] thiadiazole-4-carboxylic acid 736 418 (4- {3- [2- (3-fluoro-phenoxy) -ethyl] -thioureido} - phenyl) -amide of [1, 2, 3] thiadiazole-4 -amide - [1,2,3] thiadiazole- (3- ({3- (2- (2-fluoro-5-trifluoromethyl-phenoxy) -ethyl] -thioureido} -phenyl) -amide. 4-carboxylic acid 738 384 (4- {3- [2- (2-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -amide of furan-2-carboxylic acid 739 435. { 4- [3- (4-bromo-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 740 374. { 4- [3- (4-fluoro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 741 388. { 4- [3- (4-fluoro-benzyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 742 405. { 4- [3- (4-chloro-benzyl) -thioureido] -phenyl} [1, 2, 3] thiadiazole-4-carboxylic acid amide 743 449 (4-. {3- [4-bromo-benzyl] -thioureido] -phenyl]} -amide of acid [1, 2,3] thiadiazole-4-carboxylic acid 744 * 332 N- (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -acetamide 745 438. { 4- [3- (3,4-dichloro-benzyl) -thioureido] -phenyl} - thiazole-4-carboxylic acid amide 746 455 (4- [3- (2-fluoro-5-trifluoromethyl-benzyl) -thioureido] -phenyl} -amide of thiazole-4-carboxylic acid 747 426. 4- [3- (4-tert-Butyl-benzyl) -thioureido] -phenyl} -amide of thiazole-4-carboxylic acid 748 374 { 4- [3- (2-fluoro-phenyl) -thioureido ].]. phenyl.} - [1, 2, 3] thiadiazole-4-carboxylic acid 749 374. {4- [3- (3-fluoro-phenyl) -thioureido] -phenyl] -amide. [1, 2, 3] thiadiazole-4-carboxylic acid amide 750 526 (4-. {3- [2- (3-iodo-phenoxy) -ethyl] -thioureido} - phenyl) -amide [1, 2, 3] thiadiazole-4-carboxylic acid 751 409 N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl-thioureido} - phenyl) -2-phenyl- acetamide 752 425 N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -2-methoxy-benzamide 753 425 N- (4-. 3- [1- (4-fluoro-phenyl) -ethyl] -thioureido.] - phenyl) -3-methoxy-benzamide 754 425 N- (4-. {3- [1- (4-fluoro-phenyl) ) -ethyl] -thioureido.}. - phenyl) -4-methoxy-benzamide 755 429 2-chloro -N- (4- { 3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} phenyl) -benzamide 756 429 4-chloro-N- (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -benzamide 757 453 Ester 4- ( 4- {3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido} - phenyl) -carbamoyl) -phenylic acid of acetic acid 758 394 N- (4-. {3- 3- [1 - (4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -benzamide 759 395 N- (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} phenyl) -isonicotinamide 750 410 N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -4-hydroxy-benzamide 761 429 3-chloro -N- (4- { 3- [1- (4-fluoro-phenyl) -ethyl] -thioureido.}. -phenyl) -benzamide 762 470 (4- { 3- [2- (3- [1,2,3] thiadiazole-4-carboxylic acid fluoro-5-trifluoromethyl-phenyl) -ethyl] -thioureido.] - phenyl) -amide (4-. {3- [2- (2 [1,2,3] thiadiazole -carboxylic acid 4-bis-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide (4-. {3- [2- (4 [1,2,3] thiadiaz acid-fluoro-3-trifluoromethyl-phenyl) -ethyl] -thioureido.} - phenyl) -amide ol-4-carboxylic acid 765 438 4-dimethylamino-N- (4-. { 3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido} phenyl) -benzamide 766 470 (4-. {3- [2- (2-fluoro-3-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide of the acid [1,2,3 ] thiadiazole-4-carboxylic acid 767 470 (4- {3- [2- (2-fluoro-5-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide of acid [1,2, 3] thiadiazole-4-carboxylic acid 768 510 (4- {3- [2- (3-iodo-phenyl) -ethyl] -thioureido} - phenyl) -amide of [1, 2, 3] thiadiazole 4-carboxylic acid 769 470 (4- {3- [2- (4-fluoro-2-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -amide [1,2,3] thiazol-4-carboxylic acid 770- 463 (4-. {3- [2- (3-bromo-phenyl) -ethyl] -thioureido} -phenyl) -amide of [1,2,3] thiadiazole-4 - carboxylic acid 771 427 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -propyl] thioureido}. phenyl) -benzamide 772 475 2-fluoro-N- ( 4- { 3- [(4-fluoro-phenyl) -phenylmethyl] -thioureido.}. Phenyl) -benzamide 773 455 2-fluoro-N- (4-. {3- 3 [l- (4- fluoro-phenyl) -pentyl] -thioureido.}.-phenyl) -benzamide 774 489 2-fluoro-N- (4-. {3- 3- [l- (4- fluoro-phenyl) -2-phenyl-ethyl] -thioureido} phenyl) -benzamide 775 409 2-fluoro-N-. { 4- [3- (1-o-tolyl-ethyl) -thioureido] phenyl} -benzamide 776 409 2-fluoro-N-. { 4- [3- (1-m-tolyl-ethyl) -thioureido] phenyl} -benzamide 777 425 2-fluoro-N- (4-. {3- [l- (4-methoxy-phenyl) -ethyl] -thioureido}. -phenyl) -benzamide 778 412 2-fluoro-N- ( 4- {3- [l- (2-fluoro-phenyl) -ethyl} -thioureido} -phenyl) -benzamide 779 429 N- (4-. {3- [l- (3-chloro- phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 780 473 N- (4-. {3- [l- (3-bromo-phenyl) -ethyl] -thioureido} - phenyl) -2-fluoro-benzamide 781 429 N- (4-. {3- [l- (4-chloro-phenyl) -ethyl] -thioureido} - phenyl) -2-fluoro-benzamide 782 409 2 -fluoro-N- { 4- [3- (1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide 783 473 N- (4-. {3- [l- (2-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 784 429 N- (4-. { 3- [l- (2-chloro-phenyl) -ethyl] -thioureido.] - phenyl) -2-fluoro-benzamide 785 462 2-fluoro-N- (4- [3- [l- (2- trifluoromethyl-phenyl) -ethyl] -thioureido.} - phenyl) -benzamide 786 462 2-fluoro-N- (4-. {3- [l- (3-trifluoromethyl-phenyl) -ethyl] -thioureido}. phenyl) -benzamide 787 462 2-fluoro-N- ( 4- {3- [l- (4-trifluoromethyl-phenyl) -ethyl] -thioureido} -phenyl) -benzamide 788 425 2-fluoro-N- (4-. {3- 3 [l- ( 2-methoxy-phenyl) -ethyl] -thioureido.}.-Phenyl) -benzamide 789 425 2-fluoro-N- (4-. {3- 3 [l- (3-methoxy-phenyl) -ethyl] -thioureido .}.-phenyl) -benzamide 790 441 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -2-methyl-propyl] -thioureido.} - phenyl) - benzamide 791 419 N- (4-. {3- (l- (3-cyano-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 792 419 N- (4-. 3- [1- (4-cyano-phenyl) -ethyl] -thioureido.] - phenyl) -2-fluoro-benzamide 793 438 N- (4-. {3- [1- (4-dimethylamino-phenyl) ) -ethyl] -thioureido.}.-phenyl) -2-fluoro-benzamide 794 438 N- (4-. {3- [l- (3-dimethylamino-phenyl) -ethyl] -thioureido} -phenyl ) -2-fluoro-benzamide 795 473 2-bromo-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. Phenyl) -benzamide 796 446 (4 - { 3- [l- (4-fluoro-f enyl) -ethyl] -thioureido} - quinoline-2-carboxylic acid phenyl) -amide 797 410 2-fluoro-N-. { 4- [3- (2-hydroxy-l-phenyl-ethyl) -thioureido] -phenyl} -benzamide 798 332 2-fluoro-N- [4- (3-isopropyl-thioureido) -phenyl] -benzamide 799 445 2-fluoro-N-. { 4- [3- (l-naphthalen-2-yl-ethyl) -thioureido] -phenyl} -benzamide 800 412 3-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. phenyl) -benzamide 801 412 4-fluoro-N- ( 4-. {3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido} -phenyl) -benzamide 802 384 2-fluoro-N-. { 4- [3- (l-furan-2-yl-ethyl) -thioureido] -phenyl} -benzamide 803 395 2-fluoro-N-. { 4- [3- (l-pyridin-4-yl-ethyl) -thioureido] -phenyl} -benzamide 804 397 2-fluoro-N- (4-. {3- [l- (l-methyl-lH-pyrrol-2-yl) ethyl] -thioureido}. phenyl) -benzamide 805 401 2- fluoro-N-. { 4- [3- (l-thiophen-3-yl-ethyl) -thioureido] -phenyl} -benzamide 806 445 N-. { 4- [3- (3-chloro-4-ethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 807 459 N-. { 4- [3- (3-chloro-4-propoxy-phenyl) -thioureido] • phenyl} -2-fluoro-benzamide 808 459 N-. { 4- [3- (3-chloro-4-isopropoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 809 473 N-. { 4- [3- (4-butoxy-3-chloro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 810 522 2-fluoro-N-. { 4- [3- (3-iodo-4-methoxy-phenyl) -thioureido] -phenyl} -benzamide 811 '475 N-. { 4- [3- (3-bromo-4-methoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 812 520 N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -2-iodo-benzamide 813 346 N- ( 4- { 3- [l- (4-fluoro-phenyl) -ethyl] -thioureido.}. - phenyl) -propionamide 814 286 N- [4- (3-phenyl-thioureido) -phenyl] -acetamide 1102 473 N- (4- { 3- [l- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 1103 473 N- (4- { 3 - [(ÍS) -1- (4-bromo-phenyl) -ethyl] -thioureido.}. -phenyl) -4-fluoro-benzamide 1104 485 N- (4- { 3- [(IS) -1 - (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-methoxy-benzamide 1105 485 N- (4-. {3- [(IR) -1- (4-bromo-phenyl) ) -ethyl] -thioureido.}.-phenyl) -2-methoxy-benzamide 1106 480 2-fluoro-N- (4. {[[( { 1-2-fluoro-4- (trifluoromethyl) phenyl] ethyl.}. amino) carbothioyl] -amino.} phenyl) benzamide 1107 506 (4-. {3- 3 [(SS) -1- (4-bromo-phenyl) -ethyl] -thioureido} - phenyl ) -isoquinoline-1-carboxylic acid amide 1108 506 (4-. {3- [(Sis) -1- (4-bromo-phenyl) -ethyl] -thioureido} - phenyl) -amide of isoquinoline -3- carboxylic acid 1109 461 (4- { 3- [(SS) -1- (4-chloro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid 1110 445 (4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -amide isoquinolin-1- carboxylic acid 452 N- 1111. { 4- [( { [(LS) -l- (4-cyanophenyl) ethyl] amino.} Carbothioyl) amino] phenyl} - 1-phenyl) ethyl] amino} carbothioyl) amino] phenyl} -1- isoquinolinecarboxamide EXAMPLE 815 (METHOD 32). { 4- [3- (2, 5-dichloro-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid amide To a solution of 0.16 g of 2,5-dichloroaniline in ml of tetrahydrofuran is added 0.20 g of freshly prepared 1,1'-thiocarbonyldiimidazole and the mixture is stirred for approximately 30 minutes at room temperature. 0.22 g of the acid (4-amino-phenyl) amide is added [1, 2, 3] thiadiazole-4-carboxylic acid to the reaction flask, and the mixture is stirred for about 6 hours. The solvent is then removed by evaporation under reduced pressure and 3 ml of hot acetonitrile are added. After 15 hours, the mixture is filtered and the collected precipitate is washed with acetonitrile and then with diethyl ether, and dried in air to provide the desired product as a white powder. Using the above procedure and the appropriate starting materials, the following compounds were prepared: Example M + H NAME OF THE COMPOUND No. 816 321 N-. { 4- [3- (3-chloro-phenyl) -thioureido] -phenyl} - acetamide 817 413 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-benzamide 818 443 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-2-methoxy-benzamide 819 443 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-3-methoxy-benzamide 820 443 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-4-methoxy-benzamide 821 431 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-4-methoxy-benzamide 822 431 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-3-fluoro-benzamide 823 431 N-. { 4- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl-4-fluoro-benzamide 824 437. { 4- [3- (3, 5-dichloro-4-methoxy-phenyl) -thioureido] phenyl} -furan-2-carboxylic acid amide 825 511 (4- [3- (5-Bromo-2, 4-dimethoxy-phenyl) -thioureido] -phenyl} -carbamic acid hexyl ester 826 481. { 4- [3- (5-Bromo-2,4-dimethoxy-phenyl) -thioureido] phenyl} -amide of hexanoic acid 827 505 N-. { 4- [3- (5-bromo-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 828 477. { 4- [3- (5-bromo-2,4-dimethoxy-phenyl) -thioureido] • phenyl} -furan-2-carboxylic acid amide 829 501 N-. { 4- [3- (5-bromo-2,4-dimethoxy-phenyl) -thioureido] phenyl} -2-methyl-benzamide 830 517 N-. { 4- [3- (5-bromo-2,4-dimethoxy-phenyl) -thioureido] phenyl} -4-methoxy-benzamide 831 395 N-. { 4- [3- (5-chloro-2-ethoxy-phenyl) -thioureido] phenyl} -acetamide 832 395 N-. { 4- [3- (5-Chloro-4-ethoxy-2-methoxy-phenyl) -thioureido] -fenyl} -acetamide 833 423 N-. { 4- [3- (2-Butoxy-5-chloro-4-methoxy-phenyl) -thioureido] -fenyl} -acetamide 834 423 N-. { 4- [3- (4-Butoxy-5-chloro-2-methoxy-phenyl) -thioureido] -fenyl} -acetamide 835 457 N-. { 4- [3- (2-benzyloxy-5-chloro-4-methoxy-f-enyl) -thioureido] phenyl} -acetamide 836 457 N-. { 4- [3- (4-benzyloxy-5-chloro-2-methoxy-f-enyl) -thioureido] phenyl} -acetamide 837 421. { 4- [3- (3-chloro-4-methoxy-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 838 424 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-5-methoxy-phenoxy} -acetamide 839 367 N-. { 4- [3- (5-chloro-2-hydroxy-4-methoxy-phenyl) -thioureido] -phenyl-acetamide 840 367 N-. { 4- [3- (3-chloro-2-methylsulfanyl-phenyl) -thioureido] phenyl} -acetamide 841 447 N- [4- (3. {3-chloro-4- [methyl- (1-methyl-piperidin-4-yl) -amino] -phenyl] -thioureido) phenyl] -acetamide 842 426 N- (4-. {3- [3-chloro-4- (methyl-phenyl-amino) -phenyl] -thioureido}. -phenyl) -acetamide 843 509 N- [4- (3-. {4- [(1-benzyl-pyrrolidin-3-yl) -methylamino] -3-chloro-phenyl] -thioureido) -phenyl] -acetamide 844 418 N- (4-. {3- 3 -chloro-4- (cyclopentyl-methyl-amino) -phenyl] -thioureido.} - phenyl) -acetamide 845 433 N- [4- (3. {3-chloro-4- [methyl- (1- methyl-pyrrolidin-3-yl) -amino] -phenyl.}. -thioureido) -phenyl] -acetamide 846 419. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 847 447 N-. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 848 465 N-. { 4- [3- (3-chloro-4-methylsulfanyl-phenyl) -thioureido] -phenyl} -2,6-difluoro-benzamide 849 445 N-. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 850 441 N-. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} -2-methyl-benzamide 851 434. { 4- [3- (3-chloro-4-dimethylamino-phenyl) -thioureido] -phenyl} - [1,2,3] thiadiazole-4-carboxylic acid 852 444 N- amide. { 4- [3- (3-chloro-4-dimethylamino-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 853 517 [4- (3. {3-chloro-4- [methyl- (1-methyl-piperidin-4-yl) -amino] -phenyl] -thioureido) -phenyl ] [1,2,3] thiadiazole-carboxylic acid 854 579 [4- (3-. {4- [(1-benzyl-pyrrolidin-3-yl) -methylamino] -3-chloro-phenyl] [1, 2, 3] thiadiazole-4-carboxylic acid amide 855 527 N- [4- (3. {3-chloro-4- [methyl- (l- methyl-piperidin-4-yl) -amino] -phenyl.}. -thioureido) -phenyl] -2-fluorobenzamide 856 435. { 4- [3- (5-chloro-2-methoxy-4-methyl-phenyl) -thioureido] phenyl} [1,2,3] thiadiazole-4-carboxylic acid amide 857 589 N- [4- (3-. {4- [(1-benzyl-pyrrolidin-3-yl) -methyl-amino] -3] -chloro-phenyl.}. -thioureido) -phenyl] -2- fluoro-benzamide 858 501. { 4- [3- (5-chloro-2,4-dimethoxy-phenyl) -thioureido] -3-trifluoromethyl-phenyl} -furan-2-carboxylic acid amide 859 366 2-fluoro-N- [4- (3-phenyl-thioureido) phenyl] -benzamide 860 338 [4- (3-phenyl-thioureido) -phenyl] -amide of the acid furan-2-carboxylic acid 861 356 [1,2,3] thiadiazole-carboxylic acid [4- (3-phenyl-thioureido) -phenyl] -amide] -amide 862 365 N- (4-. {3- 3- chloro-4- (1-hydroxy-ethyl) -phenyl] -thioureido} phenyl) -acetamide 863 435 (4-. {3- [3-chloro-4- (1-hydroxy-ethyl) -phenyl] - [1,2,3] thiadiazole -carboxylic acid thioureido.}. phenyl) -amide. Nitamide (4-. {3- [3-chloro-4- (2-hydroxy-ethyl) - phenyl] -thioureido.}.-phenyl) -acetamide 865 445 N- (4-. {3- [3-chloro-4- (l-hydroxy-ethyl) -phenyl] -thioureido}. -phenyl) - 2-f-luoro-benzamide 866 417 (4-. {3- [3-chloro-4- (l-hydroxy-ethyl) -phenyl] -thioureido} -phenyl) -amide of furan-2-carboxylic acid 867 371. { 4- [3- (3-Amino-phenyl) -thioureido] -phenyl} -amide of acid [1, 2,3] thiadiazole-4-carboxylic acid 868 501. { 4- [3- (3-bromo-4-trifluoromethoxy-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 869 423 N-. { 4- [3- (3-tert-butyl-phenyl) -thioureido] -phenyl} - 2-fluoro-benzamide 870 440. { 4- [3- (4-chloro-3,5-dichloro-phenyl) -thioureido] phenyl} [1,2,3] thiadiazole-4-carboxylic acid amide 974 485 N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-trifluoromethyl-benzamide 975 412 N- (4-fluoro-phenyl) -4-. { 3- [l- (-fluoro-phenyl) -ethyl] -thioureido} -benzamide 976 446 (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid 977 468. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -isoquinoline-1-carboxylic acid amide 978 506 (4-. {3- [l - (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid 979 453 (4-. {3- [l- (4-cyano-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid 980 435 (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of benzofuran-2-carboxylic acid 981 457. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -benzofuran-2-carboxylic acid amide 982 495 (4-. {3- [l- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -amide of benzofuran-2-carboxylic acid 983 442 (4- { 3- [1- (4-cyano-phenyl) -ethyl] -thioureido.} - phenyl) -amide of benzofuran-2-carboxylic acid 984 446 (4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of isoquinoline-3-carboxylic acid 985 468. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -isoquinolin-3-carboxylic acid 986 453 (4-. {3- [1- (4-cyano-phenyl) -ethyl] -thioureido} -phenyl] -amide of isoquinoline-3-carboxylic acid 987 508 (4-. {3- [l- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-3-carboxylic acid 988 446 (4-. {3- 3- 1- (4-Fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of quinoline-3-carboxylic acid 989 446 (4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of quinoline-4-carboxylic acid 990 446 (4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of quinoline-6-carboxylic acid 991 446 (4-. {3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of quinoline-8-carboxylic acid 992 462 N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -2-trifluoromethyl-1-benzamide 993 419 2-cyano-N- (4- {3- 3- [- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -benzamide 994 473 N-. { 4- [3- (3-chloro-4-isobutoxy-phenyl) -thioureido] phenyl} -2-fluoro-benzamide 995 414 2-fluoro-N-. { 4- [3- (3-fluoro-4-methoxy-phenyl) -thioureido] -phenyl} -benzamide 996 475 N- (4-. {3- [3-chloro-4- (2-methoxy-ethoxy) -phenyl] -thioureido}. phenyl) -2-fluoro-benzamide 997 398 2-fluoro -N- { 4- [3- (3-fluoro-4-methyl-phenyl) -thioureido] -phenyl} -benzamide 998 464 2-fluoro-N-. { 4- [3- (4-methoxy-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide 999 449 N-. { 4- [3- (2-amino-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 1000 459 N- (4-. {3- [l- (3-chloro-4-methoxy-phenyl) -ethyl] -thioureido}. Phenyl) -2-fluoro-benzamide 1001 417 N-. { 4- [3- (5-chloro-2-hydroxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 1002 435 N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-fluoro-benzamide 1003 448 2-fluoro-N-. { 4- [3- (4-methyl-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide 1004 473 (S) -N- (4- { 3- [l- (4-bromo-phenyl) -ethyl] -thioureido}. phenyl) -2-fluoro-benzamide 1005 473 N- ( 4- {3- [(IR) -1- (4-bromo-phenyl) -ethyl] -thioureido} -phenyl) -2-fluoro-benzamide 1006 494 2-fluoro-N- (4- {3- [2-methoxy-4- (2, 2, 2-trifluoroethoxy) -phenyl] -thioureido.} - phenyl) -benzamide 1007 399 N-. { 4- [3- (2-amino-5-fluoro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 1008 502 N- (4-. {3- [l- (4-dimethylsulfamoyl-phenyl) -ethyl] -thioureido}. Phenyl) -2-fluoro-benzamide 1009 542 2-fluoro -N- [4- (3-. {L- [4-piperidin-l-sulfonyl) -phenyl] -ethyl} -thioureido) -phenyl] -benzamide 1010 562 N- (4-. {3- [2,4-bis- (2,2,2-trifluoro-ethoxy) -phenyl] -thioureido} -phenyl) - 2-f luoro-benzamide 1011 409 2-fluoro-N-. { 4- [3- ((SS) -1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide 1012 409 2-fluoro-N-. { 4- [3- ((IR) -1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide 1013 394 2-fluoro-N-. { 4- [3- ((SS) -1-phenyl-ethyl) -thioureido] -phenyl} -benzamide 1014 429 N- (4- { 3- [(IR) -1- (4-chloro-phenyl) -ethyl] -thioureido}. phenyl) -2-fluoro-benzamide 1015 429 N- ( 4- { 3- [(SS) -1- (4-chloro-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 1016 394 2-fluoro-N-. { 4- [3- ((IR) -1-phenyl-ethyl) -thioureido] -phenyl} -benzamide 1017 432 N- (4- { 3- [l- (4-cyano-phenyl) -ethyl] -thioureido.} - phenyl) -2-methoxy-benzamide 1018 447 N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-methoxy-benzamide 1019 485 N- (4-. {3- [l- (4-bromo-phenyl) -ethyl] -thioureido} - phenyl) -2-methoxy-benzamide 1020 419 3-cyano -N- (4- { 3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}.-Phenyl) -benzamide 1021 462 N- (4-. {3- 3 [l- ( 4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -4-trifluoromethyl-1-benzamide 1022 419 4-cyano-N- (4-. {3- [l- (4-fluoro-phenyl) - ethyl] -thioureido.}.-phenyl) -benzamide 1023 469 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2, 3 , 5, 6-tetramethyl-phenyl) -benzamide 1024 480 N- (4-. {3- [l- (4-cyano-phenyl) -ethyl] -thioureido} -2,5-dimethoxy-phenyl) -2-fluoro-benzamide 1025 473 2-fluoro -N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2,5-dimethoxy-phenyl) -benzamide 1026 530 N-. { 3,5-dichloro-4- [3- (5-chloro-2, -dimethoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 1027 447 N- (3-chloro-4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. Phenyl) -2-fluoro-benzamide 1028 480 2.3.4 , 5-tetrafluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -3-methyl-phenyl) -benzamide 109 462 2.4.5- trifluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -3-methyl-phenyl) -benzamide 1030 427 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -3-methyl-phenyl) -benzamide 1031 457 2-fluoro-N - (4- { 3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2-methoxy-5-methyl-1-phenyl) -benzamide 1032 443 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -3-methoxy-phenyl) -benzamide 1033 570 N- (2, 6-dibromo-4- { 3- [1- (4-fluoro-phenyl) -ethyl] thioureido}.-Phenyl) -2-fluoro-benzamide 1034 480 2-fluoro-N- (4-. { 3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido} -2-trifluoromethyl-phenyl) -benzamide 1035 541 N- (4-. {3- [l- (4-bromo-phenyl) -ethyl] -thioureido} -2- trifluoromethyl) -phenyl) -2-fluoro-benzamide 1036 487 N- (4-. {3- [l- (4-cyano-phenyl) -ethyl] -thioureido} -2- trifluoromethyl-phenyl) -2-fluoro-benzamide 1037 503 N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -2- trifluoromethyl-phenyl} -2-fluoro-benzamide 1038 447 N- (2-chloro-4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} - phenyl) -2-fluoro-benzamide 1039 454 N- (2- chloro-4- { 3- [l- (4-cyano-phenyl) -ethyl] -thioureido}. -phenyl) -2-fluoro-benzamide 1040 437 N- (2-cyano-4- { 3- [1- (4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide 1041 498 N- (4-. {3- [l- (4-bromo-phenyl ) -ethyl] -thioureido.} -2- cyano-phenyl) -2-fluoro-benzamide 1042 445 N- (2-cyano-4-. {3- [l- (4-cyano-phenyl) -ethyl) ] - thioureido.}. - phenyl) -2-fluoro-benzamide 1043 460 N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -2- cyano-phenyl} -2-fluoro-benzamide 1044 517 N- (2-benzoyl-4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. Phenyl) -2-fluoro-benzamide 1045 427 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2-methy1-phenyl) -benzamide 1046 487 N- (4-. {3- [l- (4-Bromo-phenyl) -ethyl] -thioureido} -2- methyl-phenyl) -2-fluoro-benzamide 1047 434 N- (4-y3- [l- (4- cyano-phenyl) -ethyl] -thioureido.} -2- methyl-phenyl) -2-fluoro-benzamide 1048 449 N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -2- methyl-phenyl} -2-fluoro-benzamide 1049 456 N- (2-dimethylamino-4-. {3- [l- (4-fluoro-phenyl) -eti1] -thioureido.} - phenyl) -2-fluoro-benzamide 1050 526 N- (2-benzyloxy-4-. {3- [l- (4-cyano-phenyl) -ethyl] -thioureido}. Phenyl) -2-fluoro-benzamide 1051 519 N- (2- benzyloxy-4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. phenyl) -2-fluoro-benzamide 1052 603 N- [4-. { 3- [1- (4-bromo-phenyl) -ethyl] -thioureido} -2- (2-morpholin-4-yl-ethoxy) -phenyl] -2-fluorobenzamide 1053 603 N- [4-. { 3- [1- (4-bromo-phenyl) -ethyl] -thioureido} -2- (2-morpholin-4-yl-ethoxy) -phenyl] -2-fluorobenzamide 1054 542 2-fluoro-N- [4-. { 3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido} -2- (2-morpholin-4-yl-ethoxy) -phenyl] -benzamide 1055 485 N- (2-butoxy-4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureid .}.-phenyl) -2-fluoro-benzamide 1056 492 N- (2-butoxy-4-. {3- [l- (4-cyano-phenyl) -ethyl] -thioureido}. -phenyl) - 2-fluoro-benzamide 1057 589 N- [4-. { 3- [1- (4-bromo-phenyl) -ethyl] -thioureido} -2- (2-diethylamino-ethoxy) -phenyl] -2-fluoro-benzamide 1058 528 N- (2- (2-diethylamino-ethoxy) -4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido}. Phenyl) -2-fluorobenzamide 1059 589 N- [4-. { 3- [1- (4-bromo-phenyl) -ethyl] -thioureido} -2- (2-diethylamino-ethoxy) -phenyl] -2-fluoro-benzamide 1060 557 N- (2-ethoxy-4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido}. -phenyl) -2-fluoro-benzamide 1061 464 N- (4- {.3- [l- (4-cyano-phenyl) -ethyl] -thioureido} -2- ethoxy-phenyl) -2-f-luoro-benzamide 1062 468 2-fluoro-N- [4 -. { 3- [L- (4-F-Loloro-phenyl) -ethyl] -thioureido} -2- (2-nitrile-ethoxy) -f-enyl] -benzamide 1063 475 N- [4 -. { 3- [1- (4-cyano-f-enyl) -ethyl] -thioureido} -2 - (2-nitrile-ethoxy) -phenyl] -2-f luoro-benzamide 1064 443 2-fluoro-N- (4-. {3- [l- (4-fluoro-phenyl)] -ethyl] - thioureido} -2-methoxy-phenyl) -benzamide 1065 489 2-fluoro-N- (5-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -bifeni1-2-yl) -benzamide 1066 514 (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2- trifluoromethyl-phenyl) -amide of isoquinoline-1-carboxylic acid 1067 503 (4 -. {3- (1- (4-Fluoro-phenyl) -ethyl] -thioureido} -2-trifluoromethyl-phenyl) -amide of benzofuran-2-carboxylic acid 1068 514 (4-. {3- Isoquinoline-3-carboxylic acid [l- (4-fluoro-phenyl) -ethyl] -thioureido.] -2- trifluoromethyl-phenyl) -amide 1069 471 (2-cyano-4-. {3- 3 Isoquinoline-1-carboxylic acid (4-fluoro-phenyl) -ethyl] -thioureido.}. -phenyl) -amide 1070 460 (2-cyano-4-. {3- [l- (4-fluoro- phenyl) -ethyl] -thioureido.} - phenyl) -amide of benzofuran-2-carboxylic acid 1071 471 (2-cyano-4-. {3- [l- (4-fluoro-phenyl) -ethyl] - isoquinolin-3-carboxylic acid thioureido.}. phenyl) -amide 1072 460 (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2- methyl-phenyl ) - isoq acid amide uinoline-1-carboxylic 1073 449 (4-. { 3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido} -2- methyl-phenyl) -amide of benzofuran-2-carboxylic acid 1074 460 (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -2- methyl-phenyl ) -aminoquinoline-3-carboxylic acid 1075 396 (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of pyrazine-2-carboxylic acid 1076 401 (4- {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of thiophene-2-carboxylic acid 1077 401 (4-. {3- [l- (4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of thiophene-3-carboxylic acid 1078 500. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-isopropylthiazole-4-carboxylic acid amide 1079 466. { 4- [3- (3, 5-dichloro-phenyl) -thioureido] -phenyl} - 2-isopropyl-thiazole-4-carboxylic acid amide 1080 466. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - 2-isopropyl-thiazole-4-carboxylic acid amide 1081-544-4- [3- (3,5-bis-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-isopropyl-thiazole-4-carboxylic acid amide 1082 480. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - 2-Butyl-thiazole-4-carboxylic acid amide 1083 514. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-butylthiazole-4-carboxylic acid amide 1084 480. { 4- [3- (3, 5-dichloro-phenyl) -thioureido] -phenyl} - 2-Butyl-thiazole-4-carboxylic acid amide 1085 548. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-butyl-thiazole-4-carboxylic acid amide 1086 438. { 4- [3- (3,5-dichloro-phenyl) -thioureido] -phenyl} - 2-methyl-thiazole-4-carboxylic acid amide 1087 438. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - 2-methyl-thiazole-4-carboxylic acid amide 1088 505. { 4- [3- (3, 5-bis-3-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-methylthiazole-4-carboxylic acid amide 1089 534. { 4- [3- (4-chloro-3-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-phenyl-thiazole-4-carboxylic acid amide 1090-500. { 4- [3- (3,5-dichloro-phenyl) -thioureido] -phenyl} - 2-isopropyl-thiazole-4-carboxylic acid amide 1091 500. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - 2-phenyl-thiazole-4-carboxylic acid amide 1092 * 568. { 4- [3- (3, 5-bis-trifluoromethyl-phenyl) -thioureido] -phenyl} 2-phenyl-thiazole-4-carboxylic acid amide 1093 401 2-fluoro-N-. { 4- [3- (l-thiazol-2-yl-ethyl) -thioureido] -phenyl} -benzamide 1094 588 2-fluoro-N- [4- (3. {1 l- [l- (toluene-4-sulfonyl) -1H-indol-2-yl] -ethyl.} -thioureido) -phenyl ] -benzamide 1095 446 2-fluoro-N-. { 4- [3- (l-quinolin-2-yl-ethyl) -thioureido] -phenyl} -benzamide 1096 446 2-fluoro-N-. { 4- [3- (l-quinolin-4-yl-ethyl) -thioureido] -phenyl} -benzamide 1097 446 2-fluoro-N-. { 4- [3- (l-isoquinolin-3-yl-ethyl) -thioureido] -phenyl} -benzamide 1098 446 2-fluoro-N-. { 4- [3- (1-isoquinolin-1-yl-ethyl) -thioureido] -phenyl} -benzamide 1099 446 2-fluoro-N-. { 4- [3- (l-quinolin-6-yl-ethyl) -thioureido] -phenyl} -benzamide 1100 446 2-fluoro-N-. { 4- [3- (l-quinolin-3-yl-ethyl) -thioureido] -phenyl} -benzamide 1101 413 2-methoxy-N-. { 4- [3- (l-thiophen-3-yl-ethyl) -thioureido] -phenyl} -benzamide EXAMPLE 871 (METHOD 33). { 4- [3- (3, 5-dichloro-phenyl) -thioureido] -phenyl} - [1,2, 3] thiadiazole-carboxylic acid amide To a solution of 0.16 g of 3,5-dichloroaniline in ml of tetrahydrofuran are added with 0.20 g of freshly prepared 1,1'-thiocarbonyl-di- (1, 2, 4) -triazole and the mixture is stirred for about 30 minutes at room temperature. 0.22 g of [1, 2, 3] -thiadiazole-4-carboxylic acid (4-aminophenyl) amide is added to the reaction flask and the mixture is stirred for about 6 hours. The solvent is then removed by evaporation under reduced pressure and 3 ml of hot acetonitrile are added. After 15 hours, the mixture is filtered and the collected precipitate is washed with acetonitrile and then with diethyl ether, and dried in air to provide the desired product as a white powder. [M + H] 424. Using the above procedure and the appropriate starting materials, the following compounds were prepared: EJ. M + H NAME OF COMPOUND NO. 872 465 N-. { 4- [3- (3,5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} -3-fluoro-benzamide 873 477 N-. { 4- [3- (3,5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} -2-methoxy-benzamide 874 465 N-. { 4- [3- (3, 5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 875 477 N-. { 4- [3- (3,5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} -3-methoxy-benzamide 876 399 N-. { 4- [3- (3, 5-dichloro-2-methoxy-4-methyl-phenyl) thioureido] -phenyl} -acetamide 877 365 N-. { 4- [3- (3-Chloro-4-methoxy-5-methyl-phenyl) -thioureido] -phenyl} -acetamide 878 331 N-. { 4- [3- (2-nitro-phenyl) -thioureido] -phenyl} - acetamide 879 331 N-. { 4- [3- (4-nitro-phenyl) -thioureido] -phenyl} - acetamide 880 477 N-. { 4- [3- (3,5-dichloro-4-methoxy-phenyl) -thioureido] -phenyl} -4-methoxy-benzamide 881 351 N-. { 4- [3- (2-chloro-5-methoxy-phenyl) -thioureido] -phenyl} -acetamide 882 428 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetamide 383 443 Methyl acid ester. { 4- [3- (4- acetylamino-phenyl) -thioureido] -2-6-dichloro-phenoxy} -acetic 384 457 Ethyl acid ester. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetic 385 447 N-. { 4- [3- (3,5-dichloro-4-phenoxy-phenyl) -thioureido] -phenyl} -acetamide 386 410 N- (4-. {3- [3, 5-dichloro-4- (2-nitrile-ethoxy) -phenyl] -thioureido}. -phenyl) -acetamide 387 485 Tert-butyl ester of the acid { 4- [3- (4- acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetic 388 469. { 4- [3- (3, 5-dichloro-2-methoxy-4-methyl-phenyl) -thioureido] -phenyl} - [1,2, 3] thiadiazole-4-carboxylic acid amide 389 335 N-. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -acetamide i 90 335 N-. { 4- [3- (5-chloro-2-methyl-phenyl) -thioureido] -phenyl} -acetamide 91 703 N-. { 4- [3- (4- { 4- [3- (4-acetylamino-phenyl) -thioureido] -2-chloro-phenyldisulfañyl} -3-chlorophenyl) -thioureido] -phenyl} -acetamide 192 369 N-. { 4- [3- (3,5-dichloro-4-methyl-phenyl) -thioureido] -phenyl} -acetamide 893 598 N-. { 4- (3,5-diiodo-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 894 504 N-. { 4- [3- (3,5-dibromo-2,4-dimethoxy-phenyl) -thioureido] -phenyl} -acetamide 895 317 N-. { 4- [3- (6-methoxy-pyridin-3-yl) -thioureido] -phenyl} -acetamide 896 347 N-. { 4- [3- (2,6-dimethoxy-pyridin-3-yl) -thioureido] -phenyl} -acetamide 897 457 Ester 2-. { 4- [3- (4-acetylamino-phenyl) -thioureido] -2,6-dichloro-phenoxy} -acetic acid acetic acid 898 365 4- [3- (4-acetylamino-phenyl) -thioureido] -2- chloro-benzoic acid 899 346 N-. { 4- [3- (3-chloro-4-cyano-phenyl) -thioureido] -phenyl} -acetamide 900 512 N- (4-. {3- [5-chloro-2- (4-chloro-phenoxy) -4-pyrrol-1-yl-phenyl] -t-oureido} -phenyl) - acetamide 901 355 N-. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - acetamide 902 339 N-. { 4- [3- (3-chloro-4-fluoro-phenyl) -thioureido] -phenyl} -acetamide 903 447 N-í4- [3- (3-chloro-4-iodo-phenyl) -thioureido] -phenyl} -acetamide 904 400 N-. { 4- [3- (4-bromo-3-chloro-phenyl) -thioureido] -phenyl} -acetamide 905 424 N- [4- (3-. {4- [bis- (2-hydroxy-ethyl) -amino] -3-chloro-phenyl] -thioureido) -phenyl] -acetamide 906 434 N- (4-. {3- [3-chloro-4- (hexyl-methyl-amino) -phenyl] -thioureido}. -phenyl) -acetamide 907 406 N- (4- { 3 - [3-Chloro-4- (isobutyl-methyl-amino) -phenyl] -thioureido.} - phenyl) -acetamide 908 389 N-. { 4- [3- (3-Chloro-4-trifluoromethyl-phenyl) -thioureido] -phenyl} -acetamide 909 441. { 4- [3- (3-Chloro-4-trifluoromethyl-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 910 459. { 4- [3- (3-chloro-4-trifluoromethyl-phenyl) -thioureido] phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 911 469 N-. { 4- [3- (3-Chloro-4-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 912 435 N-í4- [3- (3, -dichloro-phenyl) -thioureido] -phenyl} - 2-fluoro-benzamide 913 407. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 914 425. { 4- [3- (3,4-dichloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] -thiadiazole-4-carboxylic acid amide 915 '480 N-. { 4- [3- (4-bromo-3-chloro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 916 527 N-. { 4- [3- (3-chloro-4-iodo-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 917 452. { 4- [3- (4-bromo-3-chloro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 918 499. { 4- [3- (3-chloro-4-iodo-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 919 391. { 4- [3- (3-chloro-4-fluoro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 920 470. { 4- [3- (4-bromo-3-chloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 921 517. { 4- [3- (3-chloro-4-iodo-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 922 419 N-. { 4- [3- (3-chloro-4-fluoro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 923 409. { 4- [3- (3-chloro-4-fluoro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 924 388 N-. { 4- [3- (3-Chloro-4-isoxazol-5-yl-phenyl) -thioureido] -phenyl} -acetamide 925 387 N- (4-. {3- [3-chloro-4- (lH-pyrazol-3-yl) -phenyl] -thioureido} -phenyl) -acetamide 926 355 N-. { 4- [3- (2, 3-dichloro-phenyl) -thioureido] -phenyl} - acetamide 927 435 N-. { 4- [3- (2, 3-dichloro-phenyl) -thioureido] -phenyl} - 2-fluoro-benzamide 928 407. { 4- [3- (2,3-dichloro-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 929 425. { 4- [3- (2,3-dichloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 930 355 N-. { 4- [3- (2,5-dichloro-phenyl) -thioureido] -phenyl} - acetamide 931 435 N-. { 4- [3- (2, 5-dichloro-phenyl) -thioureido] -phenyl} - 2-fluoro-benzamide 932 407. { 4- [3- (2, 5-dichloro-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 933 355 N-. { 4- [3- (3,5-dichloro-phenyl) -thioureido] -phenyl} - acetamide 934 435 N-. { 4- [3- (3,5-dichloro-phenyl) -thioureido] -phenyl} - 2-fluoro-benzamide 935 407. { 4- [3- (3, -5-dichloro-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 936 390 N-. { 4- [3- (3,4,5-trichloro-phenyl) -thioureido] -phenyl} -acetamide 937 470 2-fluoro-N-. { 4- [3- (3,4,5-trichloro-phenyl) -thioureido] -phenyl} -benzamide 938 442. { 4- [3- (3,, 5-trichloro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 939 460. { 4- [3- (3,, 5-trichloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 940 458. { 4- [3- (3-Chloro-4-isoxazol-5-yl-phenyl) -thioureido] -f -enyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 941 457 (4-. {3- [3-chloro-4- (lH-pyrazol-3-yl) -phenyl] -thioureido]. [1,2, 3] thiadiazole-4-carboxylic acid phenyl) -amide 942 391. { 4- [3- (3-chloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 943 373. { 4- [3- (3-chloro-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 944 401 N-. { 4- [3- (3-chloro-phenyl) -thioureido] -phenyl} -2- fluoro-benzamide 945 373. { 4 - [3- (4-chloro-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 946 401 N-. { 4- [3- (4-chloro-phenyl) -thioureido] -phenyl} -2- fluoro-benzamide 947 391. { 4- [3- (4-chloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 948 401 N-. { 4- [3- (2-chloro-phenyl) -thioureido] -phenyl} -2- fluoro-benzamide 949 396 3- (3- [(furan-2-carbonyl) -amino] -phenyl] -thioureido) -benzoic acid methyl ester 950 424 3- Acid methyl ester. { 3- [4- (2-Fluoro-benzoylamino) -phenyl] -thioureido} -benzoic acid 951 414 3- (3 { 4- [([1,2,3] thiadiazole-4-carbonyl) -amino] -phenyl} -thioureido) -benzoic acid methyl ester 952 409 N- [4 - [[[[3- (aminocarbonyl) phenyl] amino] -thioxomethyl] amino] phenyl] -2-fluoro-benzamide 953 373 (4- [3- (2-chloro-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 954 381 { 4- [3- (3-carbamoyl-phenyl) - thoureido] -phenyl.} - furan-2-carboxylic acid amide 955 399. {4- [3- (3-carbamoyl-phenyl) -thioureido] -phenyl} -amide [1, 2, 3] thiadiazole-4-carboxylic acid 956 391. { 4- [3- (2-chloro-phenyl) -thioureido] -phenyl} - [1, 2, 3] thiadiazole-4-carboxylic acid amide 957 356. { - [3- (3-fluoro-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide 958 383 (4- [3- (3-nitro-phenyl) -thioureido] -phenyl} -amide of furan-2-carboxylic acid 959 411 2-fluoro-N- {4- [3- (3-nitro-phenyl) -thioureido] -phenyl} -benzamide 960 422 { 4- [3- (3-trifluoromethoxy-phenyl) -thioureido] -phenyl} - furan-2-carboxylic acid amide 961 450 2-fluoro-N-. { 4- [3- (3-trifluoromethoxy-phenyl) -thioureido] -phenyl} -benzamide 962 384 2-fluoro-N-. { 4- [3- (3-fluoro-phenyl) -thioureido] -phenyl} -benzamide 963 410 Acid 3-. { 3- [4- (2-Fluoro-benzoylamino) -phenyl] -thioureido} -benzoic acid 964 382 3- (3- {4- [(furan-2-carbonyl) -amino] -phenyl} -thioureido) -benzoic acid 965 408 N-. { 4- [3- (3-acetyl-phenyl) -thioureido] -phenyl} -2- fluoro-benzamide 966 502 N-. { 4- [3- (2-Butylsulfamoyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide 967 380. { 4- [3- (3-acetyl-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid 968 447 (4-. {3- [3- (2-hydroxy-ethanesulfonyl) -phenyl] -thioureido} -phenyl) -amide of furan-2-carboxylic acid 969 475 2-fluoro-N- (4-. {3- [3- (2-hydroxy-ethanesulfonyl) -phenyl] -thioureido}. Phenyl) -benzamide 970 474. { 4- [3- (3-Butylsulfamoyl-phenyl) -thioureido] -phenyl} -furan-2-carboxylic acid amide EXAMPLE 971 (METHOD 57) 1- (4-fluoro-phenyl) -2-methyl-propan-l-ol To a solution of 2 g of 4-fluorobenzaldehyde in 40 ml of diethyl ether at 0 ° C isopropylmagnesium bromide (2.0 M, 9.6 ml) is added dropwise with stirring.

After 1.5 hours, the reaction is quenched with aqueous ammonium chloride and extracted with diethyl ether. The diethyl ether extracts are washed with saturated sodium chloride, dried over anhydrous magnesium sulfate, filtered and evaporated to give an oil. The oil is purified by chromatography on silica gel eluting with 10% dichloromethane-hexanes to give the product, a yellow oil (1.76 g).

EXAMPLE 972 (METHOD 58) 1- (4-fluoro-phenyl) -2-methyl-propan-l-one To a solution of 1- (4-fluoro-phenyl) -2-methyl-propan-1-ol (1.6 g) in 10 ml of acetone at 0 ° C is added 20 ml of Jones reagent with stirring. After 10 minutes, excess Jones reagent is destroyed by the addition of isopropyl alcohol. Diethyl ether is added, followed by anhydrous magnesium and the mixture is filtered and evaporated to give the product, a yellow oil (1.2 g).

EXAMPLE 973 (METHOD 59) 3-dimethylamino-5-trifluoromethyl-benzonitrile To a solution of 3-dimethylamino-5-trifluoromethylbromobenzene (7.3 g) in N, N-dimethylformamide (20 ml) is added 2.7 g of cuprous cyanide and the 3e reaction is heated at reflux for 12 hours. The reaction is diluted with 40 ml of water and dichloromethane is added. The dichloromethane fraction is washed with concentrated ammonium hydroxide, then with water. The solution is dried over anhydrous magnesium sulfate, filtered and concentrated to give a yellow solid which is recrystallized from hexanes to give a yellow solid, (4.7 g). The previous compounds were tested for activity as inhibitors of the herpes virus.

CITOMEGALOVIRUS HUMANO Production test. Monolayer cultures of human foreskin fibroblasts are infected with wild-type HCMV, typically at a multiplicity of infection equal to 0.2, in the presence of the inhibitor compound (varying concentrations). Three days after infection, the total virus produced in these cultures (for example the virus yield) is evaluated by harvesting and titrating the virus in 12-well plates of cultured human foreskin fibroblasts (performed in the absence of the inhibitor). ). Plaques are quantified at 2 weeks after infection. An inhibitor of HCMV is identified by reducing the titer of virus performance in the presence, compared to the titer in the absence, of the compound. In this assay, the relative anti-HCMV activity of an inhibitor is typically determined by calculating the IC 50 or IC 90 value, ie, the amount of the compound required to reduce the virus yield by 50% to 90%, respectively. Table I describes the IC50 data for the compounds tested against HCMV.

Microtiter plate assay. Plate cultures of ninety-six wells of human foreskin fibroblasts are infected in the presence of the inhibitor compound with a recombinant HCMV mutant virus whose genome contains the prokaryotic beta-glucuronidase gene (Jefferson, RA, SM Burgess, and D. Hirsh 1986. Beta-glucuronidase from Escherichia coli as a gene fusion marker, Proc. Nati, Acad. Sci. USA 83: 8447-8451) whose expression is controlled by a viral promoter. An example of such a virus is RV145 (Jones, T.R., V.P. Muzithras, and Y. Gluzman 1991. Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential, J. Virol. 65: 5860-5872). Since it is under the control of a viral promoter, the expression of beta-glucuronidase is an indirect indicator of the development and replication of HCMV in this assay. At 96 hours after infection, lysates from infected cells are prepared (using 50 mM sodium phosphate [pH 7.0] containing 0.1% Triton X-100 and 0.1% sarcosil) and evaluated for beta activity -glucuronidase using a substrate for the enzyme that when cleaved gives rise to a product that can be measured either colorimetrically in a spectrophotometer or fluorescently in a microfluorimeter. Examples of such substrates are p-nitrophenyl-beta-D-glucuronide and methylumbelliferylglucuronide, respectively. The presence of an antiviral compound is indicated by the reduced expression of the beta-glucuronidase gene residing in the HCMV genome, in comparison to the absence of the inhibitor. In this way, the generation of the chromophore or fluorophore product in this test is correspondingly reduced. The data from this assay generated using varying amounts of the inhibitor compound, are also used to estimate the IC 50 of an inhibitor compound.

HSV antiviral assay (ELISA) Vero cells (ATCC # CCL-81) are placed in 96-well tissue culture plates at 3.5xl04 cells per 100 μl of DMEM tissue culture (Dulbecco's modified Eagle's medium) supplemented with 2% fetal bovine serum (FBS) in each well. After incubation overnight at 37 ° C (in 5% C02) and 30 minutes before infection with HSV-1 (multiplicity of infection equal to 0.006), the cells are either untreated, or treated with the test compound (multiple concentrations) or the reference standard control drug. After approximately 24 hours after infection, incubation at 37 ° C (in 5% C02), the cells are fixed for the ELISA assay. The primary antibody is the murine anti-glycoprotein D HSV monoclonal primary antibody, and the secondary antibody is goat anti-mouse IgG linked to β-galactosidase. In this way, the degree of viral replication is determined by the evaluation of β-galactosidase activity by quantifying the generation of the fluorescent excision product 4-methyl-umbelliferone, after the addition of methyl-umbelliferyl-β-D -galactoside (Sigma # M1633) as substrate, in a microfluorimeter (365 nm for excitation and 450 nm for emission). The antiviral activity (IC50) of the test compound is determined by comparing the fluorescence obtained in the absence of the compound, to that obtained in the presence of the compound. The data is shown in Table I.

Antiviral assay of VZV (ELISA) For the generation of reserve VZV to be used in the assay, the Ellen strain of VZV (ATCC # VR-1367) is used to infect human foreskin fibroblast (HFF) cells at low multiplicity (less than 0.1) and is incubate all night at 37 ° C in 5% C02. After overnight incubation, the mixture of uninfected HFF cells infected with VZV are then harvested and added to each well of the 96-well plates (3.5xl04 cells in 100 μl of DMEM supplemented with 2% FBS) containing the test compound or reference control standard drug (in 100 μl of DMEM supplemented with 2% FBS per well). These cells are incubated for three days at 37 ° C in 5% C02, then fixed for the ELISA assay. The primary antibody is the murine anti-glycoprotein II monoclonal antibody from VZV (Applied Biosystems, Inc. # 13-145-100) and the secondary antibody is the goat anti-mouse IgG, linked to the β-galactosidase. Thus, the degree of viral replication is determined by evaluating the activity of β-galactosidase by quantifying the generation of the fluorescent excision product 4-methyl-umbelliferone after the addition of the substrate methyl-umbelliferyl-β-D- galactoside (Sigma # M1633) in a microfluorimeter (365 nm for excitation and 450 nm for emission). The antiviral activity (IC50) of the test compound is determined by comparing the fluorescence obtained in the absence of the compound to that obtained in the presence of the compound. The data is shown in Table I.

TABLE 1 IC50 IC 50% I 5o Ug / ml (μg / ml) Inhibition (μg / ml) HCMV HSV 10 μg / ml VZV VZV 114 5 0.3 17 > 10 115 8 4 98 4 116 3 2 0 > 10 117 3 0.3 15 > 10 118 3 0.15 > 10 119 > 10 0.5 1 > 10 120 5 0.8 25 > 10 121 6 0.3 0 > 10 Example IC50 IC50% IC 50 μg / ml Jg / ml) Inhibition (μg / ml) HCMV HSV 10 μg / ml VZV VZV 122 4 0.3 13 > 10 133 0.6 7 36 > 10 134 4 > 10 50 > 10 135 5 1.5 0 > 10 136 10 1 40 > 10 137 10 10 72 > 15 138 8 1 57 > 10 139 6 6 95 4 140 4 0.15 65 10 141 6 0.25 40 > 10 142 10 0.4 51 > 15 143 > 10 1 68 > 15 156 10 2 17 > 10 157 8 0.9 32 > 10 180 1.5 1.3 36 > 10 181 > 10 1.5 60 > 10 182 10 10 32 > 10 184 > 50 > 50 > 10 185 10 3 32 > 10 186 > 10 0.2 52 > 10 187 > 10 0.2 53 > 10 Example IC5o IC5o% IC50 μg / ml [g / ml) Inhibition (μg / ml HCMV HSV 10 μg / ml VZV VZV 188> 10 1.2 22 >; 10 189 > 10 2.5 59 > 10 191 > 10 8 22 > 10 192 > 10 0.5 14 > 10 193 > 10 1.5 106 3.8 194 > 10 1.5 45 > 10 208 > 10 10 25 > 10 209 > 50 > 50 22 > 10 210 > 10 5 14 > 10 219 > 10 2.5 30 > 10 220 > 10 > 10 35 > 10 221 > 10 > 10 17 > 10 222 > 50 > 50 17 > 10 231 > 10 0.5 11 > 10 232 > 10 1 21 > 10 234 1 0.2 68 > 10 235 > 10 0.2 50 > 10 238 > 10 > 10 38 > 10 244 > 10 > 10 18 > 10 247 > 10 > 10 74 5 emplo IC50 IC50% IC50 μg / ml μg / ml) Inhibition (μg / ml) HCMV HSV 10 μg / ml VZV VZV 248 2 > 10 96 2 250 > 10 > 10 42 > 10 253 8 1.2 100 6 254 4 0.9 110 4 255 > 10 1.2 0 > 10 256 9 2 15 > 10 257 7 2.5 105 2.5 258 5 1.5 92 1.5 278 > 10 > 10 15 > 10 293 > 10 > 50 2 > 10 332 0.9 1 90 8 333 2.5 0.04 92 4.5 340 0.25 3 99 4 342 1.4 0.2 62 > 10 346 2 6 62 > 10 348 0.8 4 95 8 349 1.2 5 110 4 355 > 10 0.035 40 > 10 357 9 > 10 44 40 362 > 10 > 10 8 > 10 364 > 10 > 10 73 > 15 emplo IC5o IC50% of IC5o μg / ml (μg / ml) Inhibition (μg / ml) HCMV HSV 10 μg / ml VZV VZV 367 > 10 > 10 20 > 10 370 > 10 > 10 16 > 10 373 6 9 4 > 10 374 3 3 70 4 375 1.5 5 95 7 380 > 10 > 10 50 > 10 386 2 > 10 29 > 10 387 > 10 > 10 26 > 10 392 0.5 > 10 92 2 393 0.5 > 10 62 > 10 395 3 0.2 64 > 10 397 10 5 35 > 10 399 1.5 > 10 59 > 10 404 8 0.4 15 > 10 407 > 10 4 87 0.7 414 > 10 6 70 > fifteen 417 > 10 6 15 > 10 423 1 4 87 0.9 425 0.5 3 103 > 7.5 432 10 1.6 0 > 10 433 > 10 > 10 0 > 10 Example IC5o IC50% of IC5o μg / ml (μg / ml) Inhibition (μg / ml HCMV HSV 10 μg / ml VZV VZV 434 5 10 0> 10 437> 10 0.05 0 8 442 2 1 81 8 448 9 >10 0> 10 452 2 4 75 1 454 4 1.5 55> 10 458> 10 0.06 25> 10 459> 10 0.12 25> 10 460 2 0.09 50> 10 461> 10> 10 33> 10 463> 10> 10 19> 10 465> 10> 10 31> 10 475> 10 5 28> 10 476> 10 10 21> 10 477> 10 > 10 15> 10 484> 10 0.4 28> 10 487> 10 4 48> 10 490 2.5 1 68> 10 492 2> 10 32> 10 496 10> 10 25> 10 497 10> 10 10> 10 IC50 IC5o% of IC5o μg / ml (μg / ml) Inhibition (μg / ml) HCMV HSV 10 μg / ml VZV VZV 502 1.8 > 10 13 > 10 504 2 6 99 4.5 511 > 10 > 10 10 > 10 517 1.1 > 10 5 > 10 518 4 0.25 32 > 10 519 1.7 0.4 18 > 10 523 3.2 0.6 75 4 527 > 10 > 10 20 > 10 531 5 > 10 6 536 > 10 > 10 > 10 538 > 10 > 10 10 540 > 0.5 > 10 > 10 543 0.3 > 10 > 10 549 > 10 > 10 > 10 552 > 0.5 > 10 > 10 553 > 0.5 > 10 7 563 > 0.5 > 10 9 566 > 0.5 2 567 > 0.5 2 568 > 0.5 2.3 569 > 0.5 3 Example IC50 IC50% IC 50 μg / ml Ug / ml) Inhibition μg / ml) HCMV HSV 10 μg / ml VZV VZV 570 > 0.5 > 10 576 0.5 8 577 > 7.5 578 > 10 580 > 10 583 > 10 586 10 589 7 > 10 0.36 591 7 > 10 1.5 596 2 > 10 > 10 598 > 10 > 10 > 10 610 > 0.5 > 10 616 > 10 623 > 10 625 4 628 > 10 > 10 10 636 > 10 > 10 5 653 > 0.5 > 10,656 > 0.5 5 661 > 0.5 > 10 664 > 0.5 10 use IC5o IC50% IC50 μg / ml (μg / ml) Inhibition (μg / ml) HCMV HSV 10 μg / ml VZV VZV 666 > 0.5 10 669 > 0.5 > 10 672 > 0.5 > 10 673 > 0.5 7 677 > 0.5 > 10 680 > 0.5 > 10 687 > 0.5 1.2 695 > 3 > 10 696 > 3 10 719 > 0.5 > 10 721 > 10 724 > 10 725 > 10 727 > 10 752 > 0.5 > 10 753 > 0.5 > 10 > 7.5 754 > 10 > 10 0.2 755 > 10 > 10 7 756 > 10 > 10 0.3 757 > 10 > 10 1.5 Example IC50 IC5o% IC5o Ug / ml (Ug / ml) Inhibition (Ug / ml) HCMV HSV 10 ug / ml VZV VZV 758 > 10 > 10 > 10 760 > 10 > 10 > 10 761 1.5 10 > 10 765 2.3 10 Example IC50 IC50% IC50 Ug / ml (Ug / ml) Inhibition (Ug / ml) HCMV HSV 10 ug / ml VZV VZV 771 0.4 > 10 772 0.35 > 10 773 1.2 > 10 > 7.5 774 0.5 > 10 775 1 > 10 > 7.5 776 0.9 > 10 > 7.5 777 1.7 > 10 > 7.5 778 0.8 > 10 3 779 1.2 > 10 > 7.5 780 1 > 10 1.2 781 1.8 > 10 0.6 782 0.9 > 10 3 783 1.1 > 10 0.3 IC50 IC5o% of IC50 Ug / ml (Ug / ml) Inhibition (Ug / ml HCMV HSV 10 ug / ml VZV VZV 784 1.1 > 10 0.7 785 > 2.2 > 10 > 7.5 786 1.5 > 10 > 7.5 787 1.2 > 10 > 7.5 788 1.8 > 10 > 7.5 789 > 2.2 > 10 1.5 790 1.5 > 10 2.5 791 7.3 > 10 7 792 5 > 10 > 7.5 793 3.2 9 3.1 794 6.2 7 0.4 795 4.1 8.6 > 7.5 797 > 10 > 10 1.7 799 1.7 > 10 > 7.5 800 > 10 > 10 > 7.5 801 > 10 > 10 > 7.5 806 > 10 > 10 > 7.5 807 10 > 10 0.9 808 > 10 > 10 > 7.5 809 > 10 > 10 > 7.5 mplo IC5o IC50% of IC50 Ug / ml (Ug / ml) Inhibition (Ug / ml) HCMV HSV 10 ug / ml VZV VZV 10 2.7 1.1 > 7.5 11 3.1 0.8 - > 7.5 12 3.4 17 2 1 66 12 18 4 1.2 32 > 10 19 4 6 93 2.5 8 4 20 > 10 21 1 0.15 55 > 10 22 3 3 0 > 10 23 6 6 7 > 10 27 10 0.2 70 3.5 29 10 0.25 50 > fifteen > 10 1.5 16 > 10 47 0.3 0.4 65 > 10 48 0.3 0.085 101 1.3 49 > 10 > 10 38 > 10 50 2 0.09 28 5 52 0.6 4 80 6.5 55 0.7 2.5 52 > 10 57 6 2 80 7 59 > 10 > 10 20 > 10 IC5o IC50% of IC5o Ug / ml (Ug / ml) Inhibition (Ug / ml HCMV HSV 10 ug / ml VZV VZV 865 0.3 4 52 > 10 869 2.5 5.5 77 3 872 0.6 4 28 > 10 873 0.3 > 10 23 > 10 874 0.2 5 75 3.5 875 0.4 6 20 > 10 880 10 > 10 30 > 10 911 8 > 10 38 > 10 912 > 10 8 21 > 10 915 > 10 > 10 29 > 10 916 3 > 10 30 > 10 922 > 10 1 40 > 10 927 2 5 1 2 931 > 10 4 51 > 10 934 > 10 > 10 18 > 10 937 2 0.7 25 > 10 944 3 > 10 > 10 946 > 10 > 10 > 10 948 4 6 4 > 10 950 > 10 8 > Example IC5o IC50% IC5o Ug / ml (Ug / ml) Inhibition (Ug / ml HCMV HSV 10 ug / ml VZV VZV 952> 10> 10 22> 10 959 > 10 0.7 33 > 10 961 > 10 > 10 53 > 10 962 > 10 > 10 10 > 10 963 > 10 > 10 30 > 10 964 > 10 > 10 0 > 10 965 > 10 6 12 > 10 966 2.5 7 95 8 969 > 10 > 10 19 > 10 974 > 10 > 10 > 7.5 975 > 10 > 10 0.87 976 > 10 > 10 0.04 977 > 10 > 10 0.05 978 7.8 > 10 0.04 979 3.7 > 10 0.13 980 > 10 > 10 0.15 981 > 10 > 10 0.2 982 1.3 > 10 0.10 983 1.1 > 10 0.60 984 1.5 7.2 0.08 985 > 10 > 10 0.035 j emplo IC5o IC50% of IC50 Ug / ml (Ug / ml) Inhibition (Ug / ml HCMV HSV 10 ug / ml VZV VZV 986 5.2> 10 0.05 987 1.5 3 0.046 988 > 10 > 10 3.4 989 2.9 4.1 3 990 4.4 8.9 3.5 991 7.4 > 10 0.1 992 4 1.2 993 2.7 994 > 10 > 10 > 10 995 > 10 > 10 > 10 996 > 10 > 10 10 997 4 1.9 > 10 998 > 10 3 5 999 4 2.2 9.4 1000 2 > 10 6 1001 2.6 4.3 3.6 1002 2.1 > 10 0.08 1003 > 10 > 10 > 10 1004 4.2 > 10 0.06 1005 2.1 2.9 4.3 Example IC50 IC5o% IC50 Ug / ml (Ug / ml) Inhibition (Ug / ml) HCMV HSV 10 ug / ml VZV VZV 1006 8.9 8.3 11 1007 > 10 1.2 > 10 1008 8.5 > 10 > 10 1009 > 10 > 10 > 10 1010 > 10 > 10 > 10 1011 6.8 > 10 0.55 1012 7.1 > 10 > 7.5 1013 8.2 > 10 0.27 1014 2.9 > 10 > 7.5 1015 2.5 > 10 0.03 1016 6.4 > 10 > 7.5 1017 > 10 > 10 0.3 1018 > 10 > 10 0.09 1019 2.6 > 10 0.05 1020 6.5 > 10 6.3 1021 > 10 > 10 0.4 1022 4.4 > 10 1.5 1102 1.7 0.2 1103 3.4 0.47 1104 4.9 0.09 1105 2.5 > 7.5 Example IC50 IC50% IC50 Ug / ml (Ug / ml) Inhibition (Ug / ml) HCMV HSV 10 ug / ml VZV VZV 1106 1.1 > 7.5 1107 8.1 0.05 1108 2.3 0.05 1109 4.4 0.03 1110 3.3 0.05 1111 > 10 0.1 Thus, the compounds of the present invention are potent inhibitors of the growth and replication of herpes viruses, including HCMV, VZV and HSV, effectively inhibiting viral production. In accordance with the present invention, the compounds of the present invention can be administered to a patient suffering from a herpes virus, including HCMV, VZV and HSV in an amount effective to inhibit the virus. The compounds of the present invention are thus useful for improving or eliminating the symptoms of herpes virus infections including, but not limited to humans.

The compounds of the invention can be administered to a patient, either pure or with a conventional pharmaceutical carrier. Applicable solid carriers can include one or more substances that can also act as flavoring agents, lubricants, solubilizers, suspending agents, fillers, glidants, compression aids, binders or tablet disintegrating agents or an encapsulating material. In powders, the carrier is a finely divided solid which is in admixture with the finely divided active ingredient. In tablets, the active ingredient is mixed with a carrier having the necessary compression properties in suitable proportions, and compacted in the desired shape and size. The powders and tablets preferably contain up to 99% of the active ingredient. Suitable solid carriers include, for example, calcium phosphate, magnesium stearate, talc, sugars, lactose, dextrin, starch, gelatin, cellulose, methylcellulose, sodium carboxymethylcellulose, polyvinylpyrrolidine, low melting point waxes, and ion exchange resins. . Liquid carriers can be used in the preparation of solutions, suspensions, emulsions, syrups and elixirs. The active ingredient of this invention can be dissolved or suspended in a pharmaceutically acceptable liquid carrier such as water, an organic solvent, a mixture of both or pharmaceutically acceptable oils or fats. The liquid carrier may contain other suitable pharmaceutical additives such as solubilizers, emulsifiers, buffers, preservatives, sweeteners, flavoring agents, suspending agents, thickening agents, colorants, viscosity regulators, stabilizers or osmo-regulators. Suitable examples of liquid carriers for oral and parenteral administration include water (particularly containing additives as described above, for example, cellulose derivatives, preferably sodium carboxymethylcellulose solution), alcohols (including monohydric alcohols and polyhydric alcohols for example, glycols) and their derivatives, and oils (e.g. coconut and peanut oil). For parenteral administration, the carrier can also be an oily ester such as ethyl oleate and isopropyl myristate. Sterile liquid carriers are used in sterile liquid form compositions for parenteral administration. Liquid pharmaceutical compositions which are sterile solutions or suspensions may be used for example by intramuscular, intraperitoneal or subcutaneous injection. Sterile solutions can also be administered intravenously. The oral administration can be either in the form of a liquid or solid composition. Preferably, the pharmaceutical composition is in unit dosage form, for example, as tablets or capsules. In such form, the composition is subdivided into unit doses containing appropriate quantities of the active ingredient; the unit dosage forms may be packaged compositions, for example packaged powders, flasks, ampoules, pre-filled syringes or sacks containing liquids. The unit dosage form can be, for example, a capsule or a tablet itself, or it can be the appropriate number of any such compositions in package or package form. The therapeutically effective dose that will be used in the treatment of herpes virus infection should be subjectively determined by the attending physician. The variables involved include the patient's condition, age and weight. The novel method of the invention for the treatment of herpes virus infection comprises the administration to a subject, including humans, of an effective amount of at least one compound of the formula I or a pharmaceutically acceptable, non-toxic salt of the same. The compounds can be administered orally, rectally, parenterally or topically to the skin and mucous membranes. The usual daily dose is dependent on the specific compound, the method of treatment and the condition of the patient. The usual daily dose is 0.01-1000 mg / kg for oral application, preferably 0.5-500 mg / kg, and 0.1-100 mg / kg for parenteral administration, preferably 0.5-50 mg / kg.

It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is that which is clear from the present description of the invention.

Claims (27)

CLAIMS Having described the invention as above, the content of the following claims is claimed as property:

1. A compound that has the formula: characterized in that R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 at 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -COR6, -OR6, -SR6, -SOR6, -S02R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3-7 membered heterocycloalkyl or a 3-7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together can forming a 3-7 membered heterocycloalkyl; W is oxygen, NRβ, or absent; And it is - (CO) - or (C02) -, or it is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -C02R6, COR6, -CONR7R8, -0C0R6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -S02R6, SR6N (R7R8), -N (R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J;

J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6, or a pharmaceutically acceptable salt thereof. 2. A compound according to claim 1, characterized in that Ri to R5 are independently alkyl of 1 to 6 carbon atoms, halogen, perhaloalkyl of 1 to 6 carbon atoms, ORß or N (R7R8).

3. A compound according to claim 1, characterized in that R is halogen, trifluoromethyl or cyano.

4. A compound according to claim 1, characterized in that G is substituted with one or more groups selected from alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6 , -COR6, -OR6, -SR6, -SOR6, -S02R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ.

5. A compound according to claim 1, characterized in that G is phenyl.

6. A compound according to claim 5, characterized in that G is substituted phenyl.

7. A compound according to claim 1, characterized in that G is substituted by one or more groups selected from alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, halogen, -SR6, -SOR6, N (R7R8) or -WY- (CH2) n ~ Z.

8. A compound according to claim 1, characterized in that G is 2-fluorophenyl.

9. A compound according to claim 1, characterized in that G is fused bicyclic heteroaryl.

10. A compound according to claim 9, characterized in that G is quinoline, isoquinoline or benzofuran.

11. A compound according to claim 1, characterized in that X is a bond.

12. A compound according to claim 1, characterized in that X is straight chain alkyl.

13. A compound according to claim 1, characterized in that X is straight chain alkyl of 1 to 4 carbon atoms.

14. A compound according to claim 1, characterized in that X is CH (J). 15. A compound according to claim 1, characterized in that J is methyl. 16. A compound according to claim 1, characterized in that it is selected from N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-trifluoromethylbenzamide N- (4-fluoro-phenyl) -4-. { 3- [1- (4-fluoro-phenyl) -ethyl] -thiureido} -benzamide. (4- ({3- (1- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of isoquinoline-1-carboxylic acid,. { - [3- (l-benzofuran-2-yl-ethyl-) thioureido] -phenyl} -isoquinoline-1-carboxylic acid amide, isoquinoline-1-carboxylic acid (4-. {3- [1- (4-bromo-phenyl) -ethyl] -thioureido,} -phenyl) -amide, ( 4- (1- (3- (1- (-cyano-phenyl) -ethyl] -thioureido.} - phenyl) -amide of isoquinoline-1-carboxylic acid, (-. {3- [1- (4- fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -amide of benzofuran-2-carboxylic acid,. { 4- [3- (1-benzofuran-2-i1-ethyl) -thioureido] -phenyl} benzofuran-2-carboxylic acid amide, benzofuran-2-carboxylic acid (4- {3- [l- (4-bromo-phenyl) -ethyl] -thioureido} -phenyl) -amide, ( 4- ({3- (1- (4-cyano-phenyl) -ethyl] -thioureido} -phenyl) -amide of benzofuran-2-carboalicylic acid, (4- { 3- [1 - Isoquinoline-3-carboxylic acid (4-fluoro-phenyl) -ethyl] -thioureido.}. Phenyl) -amide ,. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -isoquinoline-3-carboxylic acid amide, isoquinoline-3-carboxylic acid 4- ({3- (1- (4-cyano-phenyl) -ethyl] -thioureido} -phenyl) -amide, ( 4- {3- (1- (4-bromo-phenyl) -yl] -thioureido} -phenyl) -amide of isoquinoline-3-carboxylic acid, (4-. {3- [1- ( 4-fluoro-phenyl) -ethyl] -thioureido.} -phenyl) -amide quinoline-3-carboxylic acid, (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido quinoline-4-carboxylic acid amide-4-phenyl) -amide, quinoline, 4- ({3- [l- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide -3-carboxylic acid, 4- (3. {[3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide of quinoline-8-carboxylic acid, N- (4- {. 3- [1- (4-Fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -2-trifluoromethyl-benzamide, 2-cyano-N- (4-. {3- 3- [1- (4-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -benzamide, N-. { 4- [3- (3-chloro-4-isobutoxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- (3-fluoro-methoxy-phenyl) -thioureido] -phenyl} -benzamide, N- (4-. {3- [3-chloro-4- (2-methoxy-ethoxy) -phenyl] -thiureido}. phenyl) -2-fluoro-benzamide, 2-fluoro-N -. { 4- [3- (3-chloro-4-methyl-phenyl) -thioureido] -phenyl} -benzamide, 2-fluoro-N-. { 4- [3- (4-methoxy-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide, N-. { 4- [3- (2-amino-5-trifluoromethyl-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, N- (4-. {3- [1- (3-chloro-4-methoxy-phenyl) -ethyl] -thiureido}. Phenyl) -2-fluoro-benzamide, N -. { 4- [3- (5-chloro-2-hydroxy-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- (4-methyl-3-trifluoromethyl-phenyl) -thioureido] -phenyl} -benzamide, (S) -N- (4- { 3- [1- (4-bromo-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide, N- (4- {. 3- [(IR) -1- (-bromo-phenyl) -ethyl] -thioureido.}.-Phenyl) -2-fluoro-benzamide, 2-fluoro-N- (4-. {3- [2-methoxy-4- (2,2,2-trifluoroethoxy) -phenyl] -thioureido}. Phenyl) -benzamide, N-. { 4- [3- (2-amino-5-fluoro-phenyl) -thioureido] -phenyl} -2-fluoro-benzamide, N- (4-. {3- [1- (4-dimethylsulfamoyl-phenyl) -ethyl] -thiureido}. Phenyl) -2-fluoro-benzamide, 2-fluoro-N - [4- (3- { L- [4- (piperidin-1-sulfonyl) -phenyl] -ethyl.}. -thioureido) -phenyl] -benza.mida, N- (4- { 3 - [2, 4-bis- (2, 2, 2-trifluoro-ethoxy) -phenyl] -thiureido.} - phenyl) -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- ((SS) -1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide, 2-fluoro-N-4 - [3- ((IR) -1-p-tolyl-ethyl) -thioureido] -phenyl} -benzamide, 2-fluoro-N-. { 4- [3- ((SS) -1-phenyl-ethyl) -thioureido] -phenyl} -benzamide, N- (4- { 3- [(IR) -1- (4-chloro-phenyl) -ethyl] -thioureido.}. -phenyl) -2-benzamide, N- (4-. { 3- [(1S) -1- (4-chloro-phenyl) -ethyl] -thioureido.} - phenyl) -2-fluoro-benzamide, 2-fluoro-N-. { 4- [3- ((IR) -1-phenyl-ethyl) -thioureido] -phenyl} -benzamide, N- (4- { 3- [1- (4-cyano-phenyl) -ethyl] -thiureido.} - phenyl) -2-methoxy-benzamide, N-. { 4- [3- (1-benzofuran-2-yl-ethyl) -thioureido] -phenyl} -2-methoxy-benzamide, N- (4-. {3- [1- (4-bromo-phenyl) -ethyl] -thioureido}. Phenyl) -2-methoxy-benzamide, 3-cyano-N - (4- { 3- [l- (-fluoro-phenyl) -ethyl] -thioureido.} - phenyl) -benzamide, N- (4-. {3- [1- (4-fluoro- phenyl) -ethyl] -thioureido.} - phenyl) -4-trifluoromethyl-benzamide, 4-cyano-N- (4-. {3- [1- (4-fluoro-phenyl) -ethyl] -thioureido}-phenyl) -benzamide, N- (4-. {3- [1- (4-bromo-phenyl) -ethyl] -thioureido}. phenyl) -2-fluoro-benzamide, N- (4 - { 3- [(SS) -1- (4-bromo-phenyl) -ethyl] -thioureido.} Phenyl) -4-fluoro-benzamide, N- (4-. {3- 3 [(lS ) -l- (-bromo-phenyl) -ethyl] -thioureido. '' phenyl) -2-methoxy-benzamide, N- (4-. {3- [(IR) -1- (-bromo-phenyl) ) -ethyl] -turned.} .phenyl) -2-methoxy-benzamide, 2-fluoro-N- (4. {[[( { 1- [2-fluoro-4- (trifluoromethyl) phenyl-keptyl} amino) carbothioyl] amino.}. phenyl) -benzamide, (4-. {3- 3 [(lS) -l- (4-bromo-phenyl) -ethyl] -thioureido} -phenyl) -amide of isoquinoline-1-carboxylic acid, (4- { 3- [( S) -1- (4-bromophenyl) -ethyl] -thioureido} -quinyl) -aminoquin-3-carboxylic acid amide, isoquinolinic acid (4- {3- [(S)) -l- (-chloro-phenyl) -ethyl] -thioureido} -phenyl) -amide -1-carboxylic acid, isoquinoline-1-carboxylic acid (4- ({3- [1- (4-fluoro-phenyl) -ethyl] -thioureido} -phenyl) -amide, and N-. { 4- [( { [(LS) -l- (4-cyanophenyl) -ethyl] -amino.} - carbothioyl) amino] phenyl} -1-phenyl) ethyl] amino} carbothioyl) -amino] phenyl} -1-isoquinolinecarboxamide, and the pharmaceutical salts thereof. 17. A pharmaceutical composition, characterized in that it comprises a compound of the formula:

R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -COR6, -OR6, -SR6, -SOR6, -S02R6, -CONR7R8, -NR6N (R7R8 ), -N (R7R8) or WY- (CH2) nZ with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3-7 membered heterocycloalkyl or a 3-7 membered heteroaryl; Re and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together can forming a 3-7 membered heterocycloalkyl; W is oxygen, NRe, or is absent; And it is - (CO) - or (C02) -, or it is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -C02R6, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -S02R6, SR6N (R7R8), -N (R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; and X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J;

J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutically salt thereof, and a pharmaceutically acceptable carrier or diluent. 18. A method for inhibiting the replication of a herpes virus, characterized in that the method comprises contacting a compound of the formula: wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 at 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -COR6, -OR6, -SR6, -SOR6, -S02R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R, taken together form a 3-7 membered heterocycloalkyl or a 3-7 membered heteroaryl; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and Rg, taken together can forming a 3-7 membered heterocycloalkyl; W is oxygen, NR6, or is absent; And it is - (CO) - or (C02) -, or it is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -C02R6, C0R6, -CONR7R8, -OCOR6, -NR6COR, -OCONR6, -OR6, -SR6, -SOR6, -S02R6, SR6N (R7R8), -N (R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; Y

X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J;

J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, with a herpes virus.

19. The method according to claim 18, characterized in that the herpes virus is human cytomegalovirus.

20. The method according to claim 18, characterized in that the herpes virus is the varicella zoster virus.

21. The method according to claim 20, characterized in that the compound is the optical isomer (S) substantially pure.

22. The method according to claim 18, characterized in that the herpes virus is the herpes simplex virus.

23. A method for the treatment of a patient suffering from a herpes virus infection, characterized in that the method comprises administering to the patient a therapeutically effective amount of a compound having the formula: wherein R1-R5 is independently selected from hydrogen , alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -C0R6, -OR6, -SR6, -SOR6, -S02R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3 or R3 and R4, taken together form a 3-7 membered heterocycloalkyl or a 3-7 membered heteroaryl; R6 and R are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together can forming a 3-7 membered heterocycloalkyl; W is oxygen, NR6, or is absent; And it is - (CO) - or (C02) -, or it is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -C02R6, COR6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -OR6, -SR6, -SOR6, -S02R6, SR6N (R7R8), -N (R7R8) or phenyl; G is aryl or fused bicyclic heteroaryl; Y X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof.

24. The method according to claim 23, characterized in that the herpes virus is human cytomegalovirus.

25. The method according to claim 23, characterized in that the herpes virus is the varicella zoster virus.

26. The method according to claim 25, characterized in that the compound is the substantially pure (S) isomer.

27. The method according to claim 23, characterized in that the herpes virus is the herpes simplex virus. SUMMARY OF THE INVENTION Compounds having the formula (I), wherein R1-R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 carbon atoms, aryl, heteroaryl, halogen, -CN, -N02, -C02R6, -COR6, -OR6, -SR6, - S0R6, -S02R6, -CONR7R8, -NR6N (R7R8), -N (R7R8) or WY- (CH2) nZ with the proviso that at least one of R1-R5 is not hydrogen; or R2 and R3, or R3 and R4, taken together form a heteroalkyl of 3 to 7 members or a heteroaryl of 3 to 7 members; R6 and R7 are independently hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, or aryl; R8 is hydrogen, alkyl of 1 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, heterocycloalkyl of 3 to 10 members, aryl or heteroaryl, or R7 and R8, taken together can forming a 3-7 membered heterocycloalkyl; W is oxygen, NRβ, or absent; And it is - (CO) - or (C02) - or it is absent; Z is alkyl of 1 to 4 carbon atoms, -CN, -C02R6, C0R6, -CONR7R8, -OCOR6, -NR6COR7, -OCONR6, -0R6, -SR6, -SOR6, -S02R6, SR6N (R7R8), ~ N (R7Rg) or phenyl; G is aryl or fused bicyclic heteroaryl; X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 atoms carbon, or (CH) J; J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; useful in the treatment of diseases associated with herpes virus, including human cytomegalovirus, herpes simplex virus, Epstein-Barr virus, varicella zoster virus, human herpes virus 6 and 7, and Kaposi herpes virus.