SK74595A3 - Synthetic catalytic free radical scavengers usefull as antioxidants for preventions and therapy of disease - Google Patents
Synthetic catalytic free radical scavengers usefull as antioxidants for preventions and therapy of disease Download PDFInfo
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- SK74595A3 SK74595A3 SK745-95A SK74595A SK74595A3 SK 74595 A3 SK74595 A3 SK 74595A3 SK 74595 A SK74595 A SK 74595A SK 74595 A3 SK74595 A3 SK 74595A3
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- salen
- metal complex
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- antioxidant
- antioxidant salen
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/987,474 US5403834A (en) | 1992-12-07 | 1992-12-07 | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| PCT/US1993/011857 WO1994013300A1 (en) | 1992-12-07 | 1993-12-06 | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK74595A3 true SK74595A3 (en) | 1996-05-08 |
Family
ID=25533292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK745-95A SK74595A3 (en) | 1992-12-07 | 1993-12-06 | Synthetic catalytic free radical scavengers usefull as antioxidants for preventions and therapy of disease |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5403834A (de) |
| EP (2) | EP1642583A2 (de) |
| JP (1) | JP3502099B2 (de) |
| KR (1) | KR20040004386A (de) |
| AT (1) | ATE290867T1 (de) |
| AU (1) | AU697399B2 (de) |
| CA (1) | CA2150937C (de) |
| CZ (1) | CZ296288B6 (de) |
| DE (1) | DE69333775T2 (de) |
| GB (2) | GB2277873B (de) |
| HU (1) | HU225109B1 (de) |
| LV (1) | LV10924B (de) |
| NO (1) | NO319454B1 (de) |
| NZ (1) | NZ259200A (de) |
| OA (1) | OA10165A (de) |
| PL (1) | PL175446B1 (de) |
| RU (1) | RU2157213C2 (de) |
| SK (1) | SK74595A3 (de) |
| UA (1) | UA27949C2 (de) |
| WO (1) | WO1994013300A1 (de) |
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|---|---|---|---|---|
| US5653685A (en) * | 1990-10-10 | 1997-08-05 | Lrt, Inc. | Method of providing circulation via lung expansion and deflation |
| USRE36460E (en) * | 1990-10-10 | 1999-12-21 | Life Science Holdings, Inc. | Method of providing circulation via lung expansion and deflation |
| US5403834A (en) * | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5696109A (en) * | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US7582786B2 (en) * | 1992-12-07 | 2009-09-01 | Eukarion Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5834509A (en) * | 1992-12-07 | 1998-11-10 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5686436A (en) * | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| US6127356A (en) | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
| US6245758B1 (en) | 1994-05-13 | 2001-06-12 | Michael K. Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
| CA2189528A1 (en) * | 1994-05-13 | 1995-11-23 | Michael Keith Stern | Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor |
| US5681278A (en) * | 1994-06-23 | 1997-10-28 | Cormedics Corp. | Coronary vasculature treatment method |
| WO1996004311A1 (en) * | 1994-08-03 | 1996-02-15 | University Of Alabama At Birmingham Research Foundation | Monoclonal antibody to nitrotyrosine, methods for diagnosis and methods for treatment of disease |
| US5900433A (en) * | 1995-06-23 | 1999-05-04 | Cormedics Corp. | Vascular treatment method and apparatus |
| CA2247876A1 (en) * | 1996-03-08 | 1997-09-12 | Ronald M. Klatz | Liquid ventilation method and apparatus |
| AU4258097A (en) | 1996-09-06 | 1998-03-26 | Duke University | Methods for testing compounds for use as therapeutic antioxidants |
| US6369106B1 (en) * | 1996-12-26 | 2002-04-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Treatment of ischemic brain injuries with brain targeted anti oxidant compounds |
| US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| US5834178C1 (en) * | 1997-07-09 | 2002-04-23 | Univ Wayne State | Flush-storage solution for donor organs |
| US5829449A (en) * | 1997-09-19 | 1998-11-03 | Thione International, Inc. | Smoking products containing antioxidants |
| AT409306B (de) * | 1997-10-03 | 2002-07-25 | Hoffmann La Roche | Optisch chemischer sensor |
| ATE238307T1 (de) | 1997-11-03 | 2003-05-15 | Univ Duke | Substituierte porphyrinen |
| CA2249778A1 (en) * | 1997-12-15 | 1999-06-15 | Bayer Corporation | Competitive apo-peroxidase assay |
| GB9817845D0 (en) | 1998-08-17 | 1998-10-14 | Glaxo Group Ltd | Chemical compounds |
| US7816403B2 (en) * | 1998-09-08 | 2010-10-19 | University Of Utah Research Foundation | Method of inhibiting ATF/CREB and cancer cell growth and pharmaceutical compositions for same |
| US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| CA2359116C (en) * | 1999-01-25 | 2009-03-17 | National Jewish Medical And Research Center | Substituted porphyrins |
| US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
| US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
| ATE291446T1 (de) | 1999-05-27 | 2005-04-15 | Monsanto Co | Biomaterialien, modifiziert mit superoxid- dismutase imitatoren |
| US20040110722A1 (en) * | 1999-05-27 | 2004-06-10 | Ornberg Richard L. | Modified hyaluronic acid polymers |
| US6179804B1 (en) * | 1999-08-18 | 2001-01-30 | Oxypatch, Llc | Treatment apparatus for wounds |
| AU3680501A (en) * | 2000-02-11 | 2001-08-20 | Res Dev Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| US20040047852A1 (en) * | 2001-03-02 | 2004-03-11 | Kennedy Thomas Preston | Method of treating cancer |
| US20030069281A1 (en) * | 2000-06-14 | 2003-04-10 | Irwin Fridovich | Tetrapyrroles |
| WO2002043514A1 (en) * | 2000-11-28 | 2002-06-06 | Lorillard Licensing Company, Llc | A smoking article including a selective carbon monoxide pump |
| US6481442B1 (en) | 2000-11-28 | 2002-11-19 | Lorillard Licensing Company, Llc | Smoking article including a filter for selectively removing carbonyls |
| US6589948B1 (en) | 2000-11-28 | 2003-07-08 | Eukarion, Inc. | Cyclic salen-metal compounds: reactive oxygen species scavengers useful as antioxidants in the treatment and prevention of diseases |
| US6692458B2 (en) * | 2000-12-19 | 2004-02-17 | Edwards Lifesciences Corporation | Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis |
| US20030050297A1 (en) * | 2001-01-19 | 2003-03-13 | Crapo James D. | Cancer therapy |
| ITPI20010014A1 (it) * | 2001-03-05 | 2002-09-05 | Ivo Pera | Composto per filtri per sigarette,o altri articoli da fumo,a base di sostanze antiossidanti ed il filtro cosi'ottenuto |
| KR100681326B1 (ko) * | 2001-04-20 | 2007-02-15 | 주식회사 중외제약 | 신규한 망간-키랄성 화합물 및 그의 이용방법 |
| CA2449024A1 (en) * | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
| WO2003010154A1 (en) | 2001-07-26 | 2003-02-06 | Samsung Electronics Co. Ltd. | Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses |
| WO2003010143A1 (en) | 2001-07-26 | 2003-02-06 | Samsung Electronics Co., Ltd. | Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses |
| WO2003010153A1 (en) * | 2001-07-26 | 2003-02-06 | Samsung Electronics Co. Ltd. | N-alkyl-n-phenylhydroxylamine compounds containing metal chelating groups, their preparation and their therapeutic uses |
| US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
| IL162614A0 (en) * | 2001-12-19 | 2005-11-20 | Res Dev Foundation | Liposomal delivery of vitamin e based compounds |
| CA2488500A1 (en) * | 2002-06-07 | 2003-12-18 | Duke University | Substituted porphyrins |
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| US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
| US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
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| RU2361615C2 (ru) * | 2002-12-09 | 2009-07-20 | Абраксис Байосайенс, Ллс. | Композиции и способы доставки фармакологических агентов |
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| WO2005030137A2 (en) * | 2003-09-24 | 2005-04-07 | The University Of Toledo, A University Instrumentality Of The State Of Ohio | Improving biomechanical performance of irradiated biological material |
| US20050100537A1 (en) * | 2003-11-10 | 2005-05-12 | Evans Gregory S. | Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals |
| US20090099150A1 (en) * | 2005-01-19 | 2009-04-16 | Daniela Salvemini | Methotrexate Combinations For Treating Inflammatory Diseases |
| CA2607237C (en) * | 2005-05-04 | 2010-03-23 | Coty Prestige Lancaster Group Gmbh | The use of free radical scavengers for protecting and treating skin and hair damages caused by chemotherapy |
| CN103705947A (zh) * | 2006-06-28 | 2014-04-09 | 株式会社Ihi | 药物、药物引导装置、磁性检测装置和药物设计方法 |
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| ES2600469T3 (es) | 2008-05-23 | 2017-02-09 | National Jewish Health | Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro |
| WO2010058280A1 (ja) | 2008-11-20 | 2010-05-27 | 株式会社Ihi | 自己磁性金属サレン錯体化合物 |
| KR101050273B1 (ko) * | 2008-11-21 | 2011-07-19 | 세종대학교산학협력단 | 살렌 전이금속 착화합물, 및 그 제조 방법 |
| JP5736367B2 (ja) * | 2010-04-06 | 2015-06-17 | 株式会社Ihi | 金属サレン錯体誘導体及びその製造方法 |
| US8933118B2 (en) | 2010-04-28 | 2015-01-13 | Ihi Corporation | Anti-brain-tumor drug |
| US9282923B2 (en) * | 2010-06-01 | 2016-03-15 | Ihi Corporation | Fluorochrome material and method for using the same |
| CN103517895A (zh) * | 2010-12-21 | 2014-01-15 | 株式会社Ihi | 金属沙仑配位化合物及其制造方法 |
| JP5873656B2 (ja) * | 2011-06-13 | 2016-03-01 | 株式会社Ihi | 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤 |
| JP6017766B2 (ja) * | 2011-07-26 | 2016-11-02 | 株式会社Ihi | 新規な金属サレン錯体化合物の抗がん剤 |
| JP6155190B2 (ja) * | 2011-10-04 | 2017-06-28 | 株式会社Ihi | 金属サレン錯体化合物応答性薬剤及び金属サレン錯体化合物の体内挙動制御システム |
| JP6046338B2 (ja) | 2011-10-27 | 2016-12-14 | 株式会社Ihi | ラジカル抑制剤 |
| JP6131271B2 (ja) * | 2012-01-05 | 2017-05-17 | プレッドファルマ・アーベー | カルマンガホジピル、新たな化学実体、および他の混合金属錯体、調製の方法、組成物、および処置の方法 |
| CN108030926B (zh) * | 2017-12-15 | 2021-07-13 | 武汉工程大学 | 一种具有高的SOD酶活性的Salen型锰配合物-壳聚糖复合材料及其制备方法 |
| RU2699040C1 (ru) * | 2018-07-23 | 2019-09-03 | Федеральное государственное бюджетное учреждение науки "Уральский научно-практический центр радиационной медицины Федерального медико-биологического агентства" (ФГБУН УНПЦ РМ ФМБА России) | Способ экстренной профилактики и лечения острой лучевой болезни (варианты) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| US5106841A (en) * | 1986-05-13 | 1992-04-21 | Chai-Tech Corporation | Antiviral compositions and method for their use |
| US5223538A (en) * | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
| CA2116335C (en) * | 1991-08-26 | 1999-08-24 | Eric N. Jacobsen | Chiral catalysts, catalytic oxidation and disproportionation reactions, and methods of producing epoxychromans and taxol |
| US5403834A (en) * | 1992-12-07 | 1995-04-04 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
-
1992
- 1992-12-07 US US07/987,474 patent/US5403834A/en not_active Expired - Lifetime
-
1993
- 1993-12-06 HU HU9501644A patent/HU225109B1/hu not_active IP Right Cessation
- 1993-12-06 AT AT94903498T patent/ATE290867T1/de not_active IP Right Cessation
- 1993-12-06 UA UA95062707A patent/UA27949C2/uk unknown
- 1993-12-06 EP EP05005538A patent/EP1642583A2/de not_active Withdrawn
- 1993-12-06 CZ CZ0144295A patent/CZ296288B6/cs not_active IP Right Cessation
- 1993-12-06 KR KR10-2003-7004595A patent/KR20040004386A/ko not_active Application Discontinuation
- 1993-12-06 GB GB9415050A patent/GB2277873B/en not_active Expired - Fee Related
- 1993-12-06 RU RU95116579/14A patent/RU2157213C2/ru not_active IP Right Cessation
- 1993-12-06 DE DE69333775T patent/DE69333775T2/de not_active Expired - Lifetime
- 1993-12-06 WO PCT/US1993/011857 patent/WO1994013300A1/en active IP Right Grant
- 1993-12-06 SK SK745-95A patent/SK74595A3/sk unknown
- 1993-12-06 JP JP51432894A patent/JP3502099B2/ja not_active Expired - Fee Related
- 1993-12-06 CA CA002150937A patent/CA2150937C/en not_active Expired - Fee Related
- 1993-12-06 AU AU57419/94A patent/AU697399B2/en not_active Ceased
- 1993-12-06 GB GB9621087A patent/GB2305107B/en not_active Expired - Fee Related
- 1993-12-06 EP EP94903498A patent/EP0746321B1/de not_active Expired - Lifetime
- 1993-12-06 NZ NZ259200A patent/NZ259200A/en not_active IP Right Cessation
- 1993-12-06 PL PL93309334A patent/PL175446B1/pl not_active IP Right Cessation
-
1995
- 1995-01-26 US US08/380,731 patent/US5827880A/en not_active Expired - Lifetime
- 1995-06-06 LV LVP-95-158A patent/LV10924B/en unknown
- 1995-06-06 NO NO19952237A patent/NO319454B1/no not_active Application Discontinuation
- 1995-06-06 OA OA60674A patent/OA10165A/en unknown
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