SK70299A3 - Agent for producing a long-lasting saturation effect - Google Patents
Agent for producing a long-lasting saturation effect Download PDFInfo
- Publication number
- SK70299A3 SK70299A3 SK702-99A SK70299A SK70299A3 SK 70299 A3 SK70299 A3 SK 70299A3 SK 70299 A SK70299 A SK 70299A SK 70299 A3 SK70299 A3 SK 70299A3
- Authority
- SK
- Slovakia
- Prior art keywords
- sponge
- composition according
- stomach
- esophagus
- foodstuffs
- Prior art date
Links
- 230000000694 effects Effects 0.000 title claims abstract description 12
- 230000005923 long-lasting effect Effects 0.000 title description 3
- 210000002784 stomach Anatomy 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 28
- 239000012530 fluid Substances 0.000 claims abstract description 11
- 230000002496 gastric effect Effects 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000013013 elastic material Substances 0.000 claims abstract description 3
- 230000003111 delayed effect Effects 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims description 27
- 210000003238 esophagus Anatomy 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 102000008186 Collagen Human genes 0.000 claims description 10
- 108010035532 Collagen Proteins 0.000 claims description 10
- 229920001436 collagen Polymers 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 8
- 235000015872 dietary supplement Nutrition 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- 230000001055 chewing effect Effects 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 230000009747 swallowing Effects 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 229920001059 synthetic polymer Polymers 0.000 claims description 3
- 235000019219 chocolate Nutrition 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 102000034240 fibrous proteins Human genes 0.000 claims description 2
- 108091005899 fibrous proteins Proteins 0.000 claims description 2
- 230000037406 food intake Effects 0.000 claims description 2
- 238000009738 saturating Methods 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 229920006158 high molecular weight polymer Polymers 0.000 claims 1
- 239000004922 lacquer Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 3
- 230000002829 reductive effect Effects 0.000 abstract description 3
- 230000035622 drinking Effects 0.000 abstract description 2
- 239000000470 constituent Substances 0.000 abstract 1
- 230000009748 deglutition Effects 0.000 abstract 1
- 230000018984 mastication Effects 0.000 abstract 1
- 238000010077 mastication Methods 0.000 abstract 1
- 239000006260 foam Substances 0.000 description 13
- 238000004132 cross linking Methods 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 210000002421 cell wall Anatomy 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000002688 persistence Effects 0.000 description 3
- 235000020004 porter Nutrition 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000036186 satiety Effects 0.000 description 2
- 235000019627 satiety Nutrition 0.000 description 2
- 239000008259 solid foam Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 229920008347 Cellulose acetate propionate Polymers 0.000 description 1
- 229920001747 Cellulose diacetate Polymers 0.000 description 1
- 229920002284 Cellulose triacetate Polymers 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- -1 conchagens Chemical compound 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000019525 fullness Nutrition 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/25—Synthetic polymers, e.g. vinylic or acrylic polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP9605240 | 1996-11-27 | ||
PCT/EP1997/002676 WO1998023259A1 (de) | 1996-11-27 | 1997-05-26 | Mittel zur erzeugung eines langanhaltenden sättigungseffekts |
Publications (1)
Publication Number | Publication Date |
---|---|
SK70299A3 true SK70299A3 (en) | 2000-01-18 |
Family
ID=8166411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK702-99A SK70299A3 (en) | 1996-11-27 | 1997-05-26 | Agent for producing a long-lasting saturation effect |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0948316B1 (xx) |
CN (1) | CN1247467A (xx) |
AT (1) | ATE246488T1 (xx) |
AU (1) | AU727639B2 (xx) |
BR (1) | BR9713303A (xx) |
CA (1) | CA2273055A1 (xx) |
CZ (1) | CZ187999A3 (xx) |
DE (1) | DE59710550D1 (xx) |
HU (1) | HUP0003422A3 (xx) |
NZ (1) | NZ335956A (xx) |
RO (1) | RO120688B1 (xx) |
SI (1) | SI20007A (xx) |
SK (1) | SK70299A3 (xx) |
TR (1) | TR199901192T2 (xx) |
WO (1) | WO1998023259A1 (xx) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003508468A (ja) * | 1999-09-06 | 2003-03-04 | バイゼル ギュンター | 長時間持続性の満腹効果を得るための架橋された薬剤及びその製法 |
WO2001017510A1 (de) * | 1999-09-06 | 2001-03-15 | Beisel Guenther | Mittel zur stimulanz der darmtätigkeit sowie verfahren zu dessen herstellung |
AU7284300A (en) * | 1999-09-06 | 2001-04-10 | Gunther Beisel | Method for improving and maintaining bowel function as well as a method for the production thereof |
US6677318B1 (en) | 2000-09-05 | 2004-01-13 | Beisel Guenther | Cross-linked agent for generation of a long-lasting satiety effect and method for the production of the said |
DE10044846A1 (de) * | 2000-09-11 | 2002-04-04 | Guenther Beisel | Mittel mit verlängerter Magenverweilzeit zur Erzeugung eines langanhaltenden Sättigungseffektes sowie dessen Verwendung |
NO312804B1 (no) * | 2001-03-08 | 2002-07-08 | Alf Reidar Sandstad | Framgangsmåte for utvinning av fluider fra mage- og tarmsystemet hos dyr, samt fôr for gjennomföring av denneframgangsmåten |
DE10216551A1 (de) * | 2002-04-15 | 2003-10-30 | Guenther Beisel | Mittel zur Erzeugung eines Sättigungseffektes und zur Gewichtsreduktion |
AU2003296628A1 (en) * | 2002-12-19 | 2004-07-14 | Gunther Beisel | Agent with a retarded release of substances |
DE10259507A1 (de) * | 2002-12-19 | 2004-07-08 | Beisel, Günther | Mittel zur Erzeugung eines Sättigungseffekts und zur Gewichtsreduzierung bei Tieren |
CN104799290A (zh) * | 2015-05-04 | 2015-07-29 | 程晋生 | 一种压缩纤维颗粒及其吸脂排毒清肠的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298002A (en) * | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
JPS5668608A (en) * | 1979-11-06 | 1981-06-09 | Lion Corp | Sponge base for medicine |
ES2067150T3 (es) * | 1990-03-27 | 1995-03-16 | Bioelastics Res Ltd | Sistema de suministro de drogas bioelastomericas. |
DE4119140C2 (de) * | 1991-06-11 | 1994-05-11 | Merz & Co Gmbh & Co | Poröser, in Körperflüssigkeiten und Sekreten löslicher, spongoider Formkörper, dessen Herstellung und Verwendung |
IL105529A0 (en) * | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
US6126970A (en) * | 1995-12-01 | 2000-10-03 | Janssen Pharmaceutica N.V. | Cisapride sustained release |
AU1090697A (en) * | 1995-12-19 | 1997-07-14 | Thermicedge Corporation | Spheres useful in a detachable connective medium for ball grid array assemblies |
-
1997
- 1997-05-26 AU AU30919/97A patent/AU727639B2/en not_active Ceased
- 1997-05-26 DE DE59710550T patent/DE59710550D1/de not_active Expired - Fee Related
- 1997-05-26 NZ NZ335956A patent/NZ335956A/xx unknown
- 1997-05-26 AT AT97925943T patent/ATE246488T1/de not_active IP Right Cessation
- 1997-05-26 BR BR9713303A patent/BR9713303A/pt not_active IP Right Cessation
- 1997-05-26 SI SI9720084A patent/SI20007A/sl not_active IP Right Cessation
- 1997-05-26 EP EP97925943A patent/EP0948316B1/de not_active Expired - Lifetime
- 1997-05-26 CZ CZ991879A patent/CZ187999A3/cs unknown
- 1997-05-26 WO PCT/EP1997/002676 patent/WO1998023259A1/de not_active Application Discontinuation
- 1997-05-26 CN CN97180994A patent/CN1247467A/zh active Pending
- 1997-05-26 HU HU0003422A patent/HUP0003422A3/hu unknown
- 1997-05-26 TR TR1999/01192T patent/TR199901192T2/xx unknown
- 1997-05-26 SK SK702-99A patent/SK70299A3/sk unknown
- 1997-05-26 CA CA002273055A patent/CA2273055A1/en not_active Abandoned
- 1997-05-26 RO RO99-00610A patent/RO120688B1/ro unknown
Also Published As
Publication number | Publication date |
---|---|
TR199901192T2 (xx) | 1999-07-21 |
DE59710550D1 (de) | 2003-09-11 |
WO1998023259A1 (de) | 1998-06-04 |
CN1247467A (zh) | 2000-03-15 |
HUP0003422A2 (hu) | 2001-02-28 |
BR9713303A (pt) | 2000-03-21 |
EP0948316B1 (de) | 2003-08-06 |
CZ187999A3 (cs) | 1999-10-13 |
EP0948316A1 (de) | 1999-10-13 |
NZ335956A (en) | 2000-09-29 |
CA2273055A1 (en) | 1998-06-04 |
HUP0003422A3 (en) | 2001-03-28 |
SI20007A (sl) | 2000-02-29 |
RO120688B1 (ro) | 2006-06-30 |
AU727639B2 (en) | 2000-12-21 |
AU3091997A (en) | 1998-06-22 |
ATE246488T1 (de) | 2003-08-15 |
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