SK64899A3 - Enzymatic process for the preparation of cephalosporanic 7beta-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of i(trigonopsis variabilis) produced in i(escherichia coli) - Google Patents

Enzymatic process for the preparation of cephalosporanic 7beta-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of i(trigonopsis variabilis) produced in i(escherichia coli) Download PDF

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Publication number
SK64899A3
SK64899A3 SK648-99A SK64899A SK64899A3 SK 64899 A3 SK64899 A3 SK 64899A3 SK 64899 A SK64899 A SK 64899A SK 64899 A3 SK64899 A3 SK 64899A3
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SK
Slovakia
Prior art keywords
enzyme
gene
leu
ser
gly
Prior art date
Application number
SK648-99A
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English (en)
Slovak (sk)
Inventor
Lopez Jose Luis Garcia
Rubio Estrella Cortes
Palacios Jorge Alonso
Duran Encarnacion Mellado
Garcia Bruno Diez
Seijas Jose Manuel Guisan
Maldonado Francisci Salto
Fuente Jose Luis Barredo
Original Assignee
Antibioticos Sau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Antibioticos Sau filed Critical Antibioticos Sau
Publication of SK64899A3 publication Critical patent/SK64899A3/sk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK648-99A 1997-09-25 1998-09-24 Enzymatic process for the preparation of cephalosporanic 7beta-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of i(trigonopsis variabilis) produced in i(escherichia coli) SK64899A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009702008A ES2131018B1 (es) 1997-09-25 1997-09-25 Un procedimiento enzimatico para preparar acido 7beta-(4-carboxibutanamido)cefalosporanico utilizando la enzima d-aminoacido oxidasa de trigonopsis variabilis modificada producida en escherichia coli.
PCT/ES1998/000262 WO1999015632A1 (es) 1997-09-25 1998-09-24 UN PROCEDIMIENTO ENZIMATICO PARA PREPARAR ACIDO 7β-(4-CARBOXIBUTANAMIDO) CEFALOSPORANICO UTILIZANDO LA ENZIMA D-AMINOACIDO OXIDASA DE TRIGONOPSIS VARIABILIS MODIFICADA PRODUCIDA EN ESCHERICHIA COLI.

Publications (1)

Publication Number Publication Date
SK64899A3 true SK64899A3 (en) 2000-05-16

Family

ID=8300695

Family Applications (1)

Application Number Title Priority Date Filing Date
SK648-99A SK64899A3 (en) 1997-09-25 1998-09-24 Enzymatic process for the preparation of cephalosporanic 7beta-(4-carboxybutanamide) acid by means of the modified enzyme d-aminoacid oxidase of i(trigonopsis variabilis) produced in i(escherichia coli)

Country Status (17)

Country Link
US (1) US6635458B2 (es)
EP (1) EP0969088A1 (es)
JP (1) JP2001506868A (es)
KR (1) KR20000069110A (es)
CN (1) CN1246147A (es)
AU (1) AU9162898A (es)
CA (1) CA2272354A1 (es)
CZ (1) CZ182399A3 (es)
EE (1) EE9900205A (es)
ES (1) ES2131018B1 (es)
HU (1) HUP0000797A2 (es)
IL (1) IL129533A0 (es)
LT (1) LT4628B (es)
LV (1) LV12359B (es)
SK (1) SK64899A3 (es)
WO (1) WO1999015632A1 (es)
ZA (1) ZA988754B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100342014C (zh) * 2004-04-08 2007-10-10 百瑞全球有限公司 重组d－氨基酸氧化酶
CN1912130B (zh) * 2005-08-08 2011-06-15 百瑞全球有限公司 一种用于制备7-氨基头孢霉烷酸的两步酶法
CN101016540B (zh) * 2006-02-10 2010-04-07 台湾尖端先进生技医药股份有限公司 C-端含有组氨酸标记的hoxb4重组蛋白质的制造方法及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2268022B1 (es) * 1974-04-22 1977-06-24 Rhone Poulenc Ind
JPS62262994A (ja) * 1986-05-12 1987-11-16 Asahi Chem Ind Co Ltd Ｄ−アミノ酸オキシダ−ゼ遺伝子
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
CA2100987C (en) 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
US5397653A (en) 1993-04-30 1995-03-14 Westinghouse Electric Corporation Filler wire composition and method of welding turbine component with filter wire composition and its product thereof
ES2109194B1 (es) 1996-04-22 1998-07-16 Antibioticos Sa Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.

Also Published As

Publication number Publication date
LT4628B (lt) 2000-02-25
LV12359B (en) 2000-03-20
US20030119087A1 (en) 2003-06-26
ES2131018A1 (es) 1999-07-01
CZ182399A3 (cs) 1999-09-15
ES2131018B1 (es) 2000-04-01
EE9900205A (et) 1999-12-15
WO1999015632A1 (es) 1999-04-01
AU9162898A (en) 1999-04-12
IL129533A0 (en) 2000-02-29
LV12359A (lv) 1999-10-20
US6635458B2 (en) 2003-10-21
LT99051A (en) 1999-10-25
EP0969088A1 (en) 2000-01-05
JP2001506868A (ja) 2001-05-29
KR20000069110A (ko) 2000-11-25
HUP0000797A2 (en) 2000-07-28
ZA988754B (en) 1999-06-28
CA2272354A1 (en) 1999-04-01
CN1246147A (zh) 2000-03-01

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