LV12359B - FERMENTATIVE METHOD FOR DETERMINING 7ø- (4-CARBOXIBUTAMINE) CEFALOSPORATE ACID BY MODIFIED TRIGONOPSIS VARIABILIS FERMENTES D-AMINO ACQUISITION OXIDES PRODUCED IN ESCHERICHIA COLI - Google Patents

FERMENTATIVE METHOD FOR DETERMINING 7ø- (4-CARBOXIBUTAMINE) CEFALOSPORATE ACID BY MODIFIED TRIGONOPSIS VARIABILIS FERMENTES D-AMINO ACQUISITION OXIDES PRODUCED IN ESCHERICHIA COLI Download PDF

Info

Publication number
LV12359B
LV12359B LVP-99-87A LV990087A LV12359B LV 12359 B LV12359 B LV 12359B LV 990087 A LV990087 A LV 990087A LV 12359 B LV12359 B LV 12359B
Authority
LV
Latvia
Prior art keywords
enzyme
gene
amino acid
leu
acid oxidase
Prior art date
Application number
LVP-99-87A
Other languages
English (en)
Latvian (lv)
Other versions
LV12359A (lv
Inventor
Jose Luis Garcia Lopez
Estrella Cortes Rubio
Jorge Alonso Palacios
Encarnaci�n MELLADO DURAN
Bruno Diez Garcia
Jose Manuel Guisan Seijas
Francisco SALTO MALDONADO
Jose Luis Barredo Fuente
Original Assignee
Antibioticos, S.A.U.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos, S.A.U. filed Critical Antibioticos, S.A.U.
Publication of LV12359A publication Critical patent/LV12359A/xx
Publication of LV12359B publication Critical patent/LV12359B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LVP-99-87A 1997-09-25 1999-05-25 FERMENTATIVE METHOD FOR DETERMINING 7ø- (4-CARBOXIBUTAMINE) CEFALOSPORATE ACID BY MODIFIED TRIGONOPSIS VARIABILIS FERMENTES D-AMINO ACQUISITION OXIDES PRODUCED IN ESCHERICHIA COLI LV12359B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009702008A ES2131018B1 (es) 1997-09-25 1997-09-25 Un procedimiento enzimatico para preparar acido 7beta-(4-carboxibutanamido)cefalosporanico utilizando la enzima d-aminoacido oxidasa de trigonopsis variabilis modificada producida en escherichia coli.
PCT/ES1998/000262 WO1999015632A1 (es) 1997-09-25 1998-09-24 UN PROCEDIMIENTO ENZIMATICO PARA PREPARAR ACIDO 7β-(4-CARBOXIBUTANAMIDO) CEFALOSPORANICO UTILIZANDO LA ENZIMA D-AMINOACIDO OXIDASA DE TRIGONOPSIS VARIABILIS MODIFICADA PRODUCIDA EN ESCHERICHIA COLI.

Publications (2)

Publication Number Publication Date
LV12359A LV12359A (lv) 1999-10-20
LV12359B true LV12359B (en) 2000-03-20

Family

ID=8300695

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-87A LV12359B (en) 1997-09-25 1999-05-25 FERMENTATIVE METHOD FOR DETERMINING 7ø- (4-CARBOXIBUTAMINE) CEFALOSPORATE ACID BY MODIFIED TRIGONOPSIS VARIABILIS FERMENTES D-AMINO ACQUISITION OXIDES PRODUCED IN ESCHERICHIA COLI

Country Status (17)

Country Link
US (1) US6635458B2 (es)
EP (1) EP0969088A1 (es)
JP (1) JP2001506868A (es)
KR (1) KR20000069110A (es)
CN (1) CN1246147A (es)
AU (1) AU9162898A (es)
CA (1) CA2272354A1 (es)
CZ (1) CZ182399A3 (es)
EE (1) EE9900205A (es)
ES (1) ES2131018B1 (es)
HU (1) HUP0000797A2 (es)
IL (1) IL129533A0 (es)
LT (1) LT4628B (es)
LV (1) LV12359B (es)
SK (1) SK64899A3 (es)
WO (1) WO1999015632A1 (es)
ZA (1) ZA988754B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100342014C (zh) * 2004-04-08 2007-10-10 百瑞全球有限公司 重组d－氨基酸氧化酶
CN1912130B (zh) * 2005-08-08 2011-06-15 百瑞全球有限公司 一种用于制备7-氨基头孢霉烷酸的两步酶法
CN101016540B (zh) * 2006-02-10 2010-04-07 台湾尖端先进生技医药股份有限公司 C-端含有组氨酸标记的hoxb4重组蛋白质的制造方法及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2268022B1 (es) * 1974-04-22 1977-06-24 Rhone Poulenc Ind
JPS62262994A (ja) * 1986-05-12 1987-11-16 Asahi Chem Ind Co Ltd Ｄ−アミノ酸オキシダ−ゼ遺伝子
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
CA2100987C (en) 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
US5397653A (en) 1993-04-30 1995-03-14 Westinghouse Electric Corporation Filler wire composition and method of welding turbine component with filter wire composition and its product thereof
ES2109194B1 (es) 1996-04-22 1998-07-16 Antibioticos Sa Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.

Also Published As

Publication number Publication date
SK64899A3 (en) 2000-05-16
ES2131018B1 (es) 2000-04-01
CZ182399A3 (cs) 1999-09-15
ZA988754B (en) 1999-06-28
EE9900205A (et) 1999-12-15
LT4628B (lt) 2000-02-25
KR20000069110A (ko) 2000-11-25
WO1999015632A1 (es) 1999-04-01
CN1246147A (zh) 2000-03-01
CA2272354A1 (en) 1999-04-01
JP2001506868A (ja) 2001-05-29
LV12359A (lv) 1999-10-20
HUP0000797A2 (en) 2000-07-28
EP0969088A1 (en) 2000-01-05
IL129533A0 (en) 2000-02-29
AU9162898A (en) 1999-04-12
US20030119087A1 (en) 2003-06-26
ES2131018A1 (es) 1999-07-01
LT99051A (en) 1999-10-25
US6635458B2 (en) 2003-10-21

Similar Documents

Publication Publication Date Title
JP4012257B2 (ja) 新規カルボニル還元酵素、およびこれをコードする遺伝子、ならびにこれらの利用方法
US5726032A (en) Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA
US5807730A (en) Nitrile hydratase
US5424196A (en) Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives
JP4173571B2 (ja) 新規アルコールアルデヒド脱水素酵素
US5795733A (en) Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA
US5602016A (en) D-amino acid oxidase from F. solani and DNA therefor
Alonso et al. Engineering the D-amino acid oxidase from Trigonopsis variabilis to facilitate its overproduction in Escherichia coli and its downstream processing by tailor-made metal chelate supports
JP2954601B2 (ja) 二次代謝産物生産増加のための生合成遺伝子又は制御遺伝子の単離法及び使用法
US6825018B1 (en) Sorbitol dehydrogenase, gene encoding the same and use thereof
US6635458B2 (en) Enzymatic process for the preparation of cephalosporanic 7$B(G)-(4-Carboxybutanamide) acid by means of the modified enzyme D-aminoacid oxidase of trigonopsis variabilis produced in escherichia coli
US6187574B1 (en) Process for producing the enzyme D-amino acid oxidase of Rhodotorula gracilis in host cells
US5314819A (en) Protein having nitrile hydratase activity obtained from rhizobium, gene encoding the same, and a method for producing amides from nitriles via a transformant containing the gene
MXPA99004513A (es) Un procedimiento enzimatico para preparar acido 7beta-(4-carboxibutanamido) cefalosporanico utilizando la enzima
US5019509A (en) Method and compositions for the production of l-alanine and derivatives thereof
IE912083A1 (en) An oxido reductase enzyme system obtainable from p.¹chrysogenum, the set of genes encoding the same and the use¹of oxido reductase enzyme systems or genes encoding the same¹for increasing antibiotic production
US5928925A (en) Rice ornithine carbamyltransferase gene, and a vector containing said gene and a transformant
JP3508871B2 (ja) クレアチニンデイミナーゼ活性を有する蛋白質の遺伝情報を有するｄｎａ並びにクレアチニンデイミナーゼの製造法
JP4039037B2 (ja) 還元酵素遺伝子及びその利用
JPH09262089A (ja) ニワトリ乳酸デヒドロゲナーゼのｂ型サブユニットをコードするｄｎａ
JPH08242863A (ja) 新規なグルタミン酸デヒドロゲナーゼをコードする遺伝子及び該遺伝子を用いたグルタミン酸デヒドロゲナーゼの製造法
EP0716698A1 (en) Process for the efficient production of 7-ADCA via 2-(carboxyethylthio)acetyl-7-ADCA and 3-(carboxymethylthio)propionyl-7-ADCA