SK4322003A3 - Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors - Google Patents

Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors Download PDF

Info

Publication number
SK4322003A3
SK4322003A3 SK432-2003A SK4322003A SK4322003A3 SK 4322003 A3 SK4322003 A3 SK 4322003A3 SK 4322003 A SK4322003 A SK 4322003A SK 4322003 A3 SK4322003 A3 SK 4322003A3
Authority
SK
Slovakia
Prior art keywords
alkyl
fluoroalkyl
substituted
hydroxy
halogen
Prior art date
Application number
SK432-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Neville J Anthony
Robert P Gomez
Steven D Young
Melissa Egbertson
John S Wai
Linghang Zhuang
Mark Embrey
Lekhanh Tran
Jeffrey Y Melamed
Marie H Langford
James P Guare
Thorsten E Fisher
Samson M Jolly
Michelle KUO
Debra S Perlow
Jennifer J Bennett
Timothy W Funk
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SK4322003A3 publication Critical patent/SK4322003A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK432-2003A 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors SK4322003A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23970700P 2000-10-12 2000-10-12
US28165601P 2001-04-05 2001-04-05
PCT/US2001/042564 WO2002030931A2 (fr) 2000-10-12 2001-10-09 Aza-naphtalenyle carboxamides et polyaza-naphtalenyle carboxamides utiles en tant qu'inhibiteurs de l'integrase du vih

Publications (1)

Publication Number Publication Date
SK4322003A3 true SK4322003A3 (en) 2003-09-11

Family

ID=26932782

Family Applications (1)

Application Number Title Priority Date Filing Date
SK432-2003A SK4322003A3 (en) 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors

Country Status (26)

Country Link
US (2) US6921759B2 (fr)
EP (1) EP1326865B1 (fr)
JP (1) JP4252797B2 (fr)
KR (1) KR20030036922A (fr)
CN (1) CN1469878A (fr)
AR (1) AR033845A1 (fr)
AT (1) ATE430745T1 (fr)
AU (3) AU2002211874A1 (fr)
BG (1) BG107677A (fr)
BR (1) BR0114610A (fr)
CA (1) CA2425440C (fr)
CZ (1) CZ20031028A3 (fr)
DE (1) DE60138635D1 (fr)
EA (1) EA200300449A1 (fr)
EE (1) EE200300145A (fr)
HU (1) HUP0302367A2 (fr)
IL (1) IL155089A0 (fr)
IS (1) IS6760A (fr)
MX (1) MXPA03003263A (fr)
NO (1) NO20031672L (fr)
NZ (1) NZ525088A (fr)
PE (1) PE20020509A1 (fr)
PL (1) PL360944A1 (fr)
SK (1) SK4322003A3 (fr)
WO (2) WO2002030931A2 (fr)
YU (1) YU27903A (fr)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20031028A3 (cs) * 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
CN1659143A (zh) 2001-03-01 2005-08-24 盐野义制药株式会社 具有hiv整合酶抑制活性的含氮杂芳基化合物
CN101513402B (zh) 2001-08-10 2012-03-21 盐野义制药株式会社 抗病毒药
WO2003016294A1 (fr) * 2001-08-17 2003-02-27 Merck & Co., Inc. Procede de preparation de sultames
EP1427726A1 (fr) * 2001-08-17 2004-06-16 Merck & Co., Inc. Procede de preparation de 5-sulfonamido-8-hydroxy-1, 6-naphtyridine-7-carboxamides
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
DE60218511T2 (de) * 2001-10-26 2007-10-25 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
BRPI0213522C1 (pt) * 2001-10-26 2021-05-25 St Di Ricerche Di Biologia Molecolare P Angeletti S P A compostos derivados de hidroxipirimidinona, composição farmacêutica, e, uso de um composto
DE10155075A1 (de) 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
JP4523281B2 (ja) 2002-01-17 2010-08-11 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
AU2003218130A1 (en) * 2002-03-15 2003-09-29 Merck And Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
WO2003086319A2 (fr) * 2002-04-10 2003-10-23 Merck & Co., Inc. Compositions pharmaceutiques contenant un inhibiteur de l'integrase du vih et un tensioactif non ionique
AU2003269878A1 (en) * 2002-05-22 2003-12-22 Smithkline Beecham Corporation Protease inhibitors
EP1388535A1 (fr) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Arylcycloalkylamines acylés et leurs utilisations comme produits pharmaceutiques
EP2045242A1 (fr) 2002-08-13 2009-04-08 Shionogi&Co., Ltd. Composants hétérocycliques disposant d'une activité inhibitoire contre l'intégrase du HIV
DE60322919D1 (de) 2002-09-11 2008-09-25 Merck & Co Inc 8-hydroxy-1-oxotetrahydropyrrolopyrazinverbindungen, die sich als inhibitoren von hiv-integrase eignen
AU2003267098B2 (en) 2002-09-11 2008-11-20 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
NZ539211A (en) 2002-10-04 2008-05-30 Prana Biotechnology Ltd Neurologically-active compounds
AU2003284001A1 (en) 2002-10-07 2004-05-04 Bristol-Myers Squibb Company Triazolone and triazolethione derivatives
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
EP1578748B1 (fr) 2002-12-27 2010-09-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Tetrahydro-4h-pyrido[1,2-a]pyrimidines et composes connexes convenant comme inhibiteurs de l'integrase du vih
US20040220273A1 (en) * 2003-03-12 2004-11-04 Jaemoon Lee Preparation of 2-aminomethyl-5-fluorobenzamides
US20060211687A1 (en) * 2003-03-12 2006-09-21 Michael Palucki Potassium salt of an hiv integrase inhibitor
WO2004101512A2 (fr) 2003-05-13 2004-11-25 Smithkline Beecham Corporation Inihbiteurs de l'integrase de la naphtyridine
EP1646611A1 (fr) * 2003-07-15 2006-04-19 Merck & Co., Inc. Antagonistes des recepteurs cgrp de l'hydroxypyridine
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
ATE433974T1 (de) 2003-09-19 2009-07-15 Gilead Sciences Inc Azachinolinolphosphonatverbindungen als integraseinhibitoren
CA2542047A1 (fr) 2003-10-20 2005-05-12 Merck & Co., Inc. Composes pyridopyrrolopyrazine dione hydroxy utiles comme inhibiteurs de l'integrase du vih
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
AU2005211349A1 (en) * 2004-01-30 2005-08-18 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. N-benzyl-3,4-dihyroxypyridine-2-carboxamide and N-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as HIV integrase inhibitors
WO2005075475A1 (fr) * 2004-02-04 2005-08-18 Shionogi & Co., Ltd. Derive de naphtylidine ayant une activite d'inhibition de la vih integrase elevee
BRPI0507628A (pt) 2004-02-11 2007-07-03 Smithkline Beecham Corp composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma infecção viral em um ser humano, uso de um composto composição farmacêutica, e, processo para a preparação de um composto
EP1725556A1 (fr) * 2004-03-09 2006-11-29 Merck & Co., Inc. Inhibiteurs de l'int grase du vih
WO2005087766A1 (fr) 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Inhibiteurs de l'intégrase du vih
AU2005227258A1 (en) * 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
CN101014574A (zh) * 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
WO2005110414A2 (fr) 2004-05-07 2005-11-24 Merck & Co., Inc. Inhibiteurs de l'integrase du vih
US7476666B2 (en) * 2004-06-09 2009-01-13 Merck & Co., Inc. HIV integrase inhibitors
RU2403066C2 (ru) * 2004-12-03 2010-11-10 Мерк Шарп Энд Домэ Корп Применение атазанавира для улучшения фармакокинетики лекарственных средств, метаболизируемых ugt1a1
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
EP1852434B1 (fr) * 2005-02-21 2011-07-13 Shionogi Co., Ltd. Dérivé de carbamoylpyridone bicyclique ayant une activité d'inhibition de la vih intégrase
US7981879B2 (en) * 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors
EP1881825B1 (fr) 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Inhibiteurs de l'intégrase du vih
EP1888581A2 (fr) * 2005-05-16 2008-02-20 Gilead Sciences, Inc. Hiv-composes inhibant l'integrase
US20080234231A1 (en) * 2005-08-04 2008-09-25 Johns Brian A Hiv Integrase Inhibitors
EP1910355A4 (fr) * 2005-08-04 2010-11-24 Glaxosmithkline Llc Inhibiteurs d'integrase du vih
EP1910356A4 (fr) * 2005-08-04 2009-10-21 Smithkline Beecham Corp Inhibiteurs de la vih integrase
JP2009503081A (ja) * 2005-08-04 2009-01-29 スミスクライン ビーチャム コーポレーション Ｈｉｖインテグラーゼ阻害薬
US7939537B2 (en) * 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors
EP1942736A2 (fr) * 2005-10-27 2008-07-16 Merck & Co., Inc. Inhibiteurs de l'integrase du vih
CA2626956A1 (fr) * 2005-10-27 2007-05-03 Shionogi & Co., Ltd. Derive de carbamoylpyridone polycyclique ayant une activite d'inhibition sur l'integrase du vih
EP1979349B1 (fr) * 2005-12-21 2010-07-28 Abbott Laboratories Composes antiviraux
WO2007136714A2 (fr) * 2006-05-16 2007-11-29 Gilead Sciences, Inc. Inhibiteurs d'intégrase
CA2657287A1 (fr) * 2006-07-17 2008-01-24 Merck & Co., Inc. Composes de 1-hydroxy naphtyridine en tant qu'agents anti-vih
WO2008014602A1 (fr) * 2006-07-25 2008-02-07 Envivo Pharmaceuticals, Inc. Dérivés de quinoline
CN101522609A (zh) * 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
US7960428B2 (en) 2006-09-29 2011-06-14 Idenix Pharmaceuticals, Inc. Enantiomerically pure phosphoindoles as HIV inhibitors
EP2084160A1 (fr) * 2006-10-18 2009-08-05 Merck & Co., Inc. Inhibiteurs du vih intégrase
WO2009067541A2 (fr) * 2007-11-20 2009-05-28 Gilead Sciences, Inc. Inhibiteurs d'intégrase
WO2009094190A2 (fr) 2008-01-25 2009-07-30 Chimerix, Inc. Méthodes de traitement d’infections virales
EP2318406B1 (fr) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Composés inhibiteurs et procédés de traitement du cancer
EP2379076B1 (fr) 2008-12-23 2014-11-12 The Trustees of Columbia University in the City of New York Inhibiteurs de la phosphodiestérase et utilisations de ces derniers
US8497383B2 (en) 2009-05-27 2013-07-30 Merck Sharp & Dohme Corp. HIV protease inhibitors
EP2488521B1 (fr) * 2009-10-13 2013-12-18 Elanco Animal Health Ireland Limited Inhibiteurs de l'intégrase macrocyclique
CA2777937C (fr) 2009-10-26 2017-08-29 Merck Sharp & Dohme Corp. Compositions pharmaceutiques solides contenant un inhibiteur d'integrase
EP2345642A1 (fr) 2009-12-29 2011-07-20 Polichem S.A. Dérivés de 8-hydroxyquinoline-7-carboxamide secondaire pour une utilisation en tant qu'agents antifongiques
EP2345641A1 (fr) 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide secondaire
EP2345643A1 (fr) 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations
DK2534150T3 (en) 2010-02-12 2017-06-12 Chimerix Inc METHODS OF TREATING VIRUS INFECTION
WO2011120153A1 (fr) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Composés et méthodes pour le traitement du vih
WO2011121105A1 (fr) 2010-04-02 2011-10-06 Tibotec Pharmaceuticals Inhibiteurs de l'intégrase macrocyclique
US9079834B2 (en) 2010-10-28 2015-07-14 Merck Canada Inc. HIV protease inhibitors
ES2635030T3 (es) 2010-12-23 2017-10-02 Merck Sharp & Dohme Corp. Quinoxalinas y aza-quinoxalinas como moduladores del receptor CRTH2
US9290453B2 (en) 2010-12-23 2016-03-22 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as CRTH2 receptor modulators
EP2487176A1 (fr) * 2011-02-14 2012-08-15 Elanco Animal Health Ireland Limited Inhibiteurs macrocycliques de l'intégrase pour une utilisation dans le traitement du virus de l'immunodéficience féline
UA112769C2 (uk) 2011-02-18 2016-10-25 Ендо Фармасьютікалз Інк. Аміноінданові сполуки і їх застосування при лікуванні болю
WO2013059928A1 (fr) 2011-10-26 2013-05-02 Merck Canada Inc. Inhibiteurs de la protéase du vih
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
JP2015527403A (ja) 2012-09-11 2015-09-17 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｉｖプロテアーゼ阻害剤
CN103709162B (zh) * 2012-09-29 2016-12-07 中国科学院上海药物研究所 三取代咪唑并二氮杂萘酮化合物及其制备方法和用途
CN104003986B (zh) * 2013-02-22 2016-06-08 中国科学院上海药物研究所 吡啶骈环类化合物及其制备方法、其药物组合物和用途
WO2015013835A1 (fr) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih
US9834526B2 (en) 2013-12-19 2017-12-05 Merck Sharp & Dohme Corp. HIV protease inhibitors
US9737545B2 (en) 2013-12-19 2017-08-22 Merck Sharp & Dohme Corp. HIV protease inhibitors
EP3113780B1 (fr) 2014-03-06 2019-08-14 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase du vih
EP3116862B1 (fr) 2014-03-10 2019-04-17 Merck Sharp & Dohme Corp. Dérivés de pipérazine utilisés en tant qu'inhibiteurs de la protéase du vih
WO2017151922A1 (fr) 2016-03-02 2017-09-08 The Board Of Regents Of The University Of Texas System Nanovaccin activant sting pour l'immunothérapie
CN106588922B (zh) * 2017-01-17 2018-04-27 北京工业大学 二取代八氢-1,6-萘啶类化合物及其制备方法和应用
EP3655401B1 (fr) 2017-07-18 2023-09-06 Merck Patent GmbH Antagonistes de tlr7/8 et leurs utilisations
CN109776415B (zh) * 2019-03-07 2020-11-17 福建南方制药股份有限公司 一种Roxadustat中间体的制备方法
CN115710249A (zh) * 2022-11-14 2023-02-24 广东工业大学 一种多取代异喹啉和1,6-萘啶化合物的制备方法及光电材料常见分子骨架

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5751837B2 (fr) 1973-04-05 1982-11-04
US4416884A (en) 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
FR2632639B1 (fr) 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
IL101860A0 (en) 1991-05-31 1992-12-30 Ici Plc Heterocyclic derivatives
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5633362A (en) 1995-05-12 1997-05-27 E. I. Du Pont De Nemours And Company Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase
ES2211965T3 (es) 1995-08-02 2004-07-16 Darwin Discovery Limited Quinolonas y su utilizacion terapeutica.
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
EP0927164A1 (fr) 1996-09-10 1999-07-07 PHARMACIA & UPJOHN COMPANY 8-hydroxyquinoleines 7-substituees utilisees comme agents antiviraux
IL128994A (en) 1996-09-25 2004-12-15 Zeneca Ltd History of quinoline and naphthyridine and their salts, processes for their preparation, pharmaceutical preparations containing them and their use as medicines
US5766944A (en) 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
EP0997462B1 (fr) 1997-06-30 2004-12-22 Nippon Kayaku Kabushiki Kaisha Nouveaux derives de naphthyridine ou leurs sels
PL338783A1 (en) 1997-08-25 2000-11-20 Neurogen Corp Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors
GB9720052D0 (en) 1997-09-19 1997-11-19 Smithkline Beecham Plc Novel compounds
IL135180A0 (en) 1997-09-30 2001-05-20 Daiichi Seiyaku Co Sulfonyl derivatives
ATE303993T1 (de) 1997-12-22 2005-09-15 Pharmacia & Upjohn Co Llc 4-hydroxychinolin-3-carboxamide und hydrazide als antivirale wirkstoffe
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
SE9802550D0 (sv) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
JP2003503386A (ja) 1999-06-25 2003-01-28 メルク エンド カムパニー インコーポレーテッド １−（芳香族またはヘテロ芳香族置換）−３−（ヘテロ芳香族置換）−１，３−プロパンジオン類およびそれの使用
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CZ20031028A3 (cs) * 2000-10-12 2003-08-13 Merck & Co., Inc. Aza- a polyazanaftalenylkarboxamidy
CN1336363A (zh) 2001-07-25 2002-02-20 张元宾 乙酰磺胺酸钾的合成制备方法
AR036256A1 (es) * 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
EP1427726A1 (fr) 2001-08-17 2004-06-16 Merck & Co., Inc. Procede de preparation de 5-sulfonamido-8-hydroxy-1, 6-naphtyridine-7-carboxamides
BRPI0213522C1 (pt) 2001-10-26 2021-05-25 St Di Ricerche Di Biologia Molecolare P Angeletti S P A compostos derivados de hidroxipirimidinona, composição farmacêutica, e, uso de um composto
DE60218511T2 (de) 2001-10-26 2007-10-25 Istituto Di Richerche Di Biologia Molecolare P. Angeletti S.P.A. Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
WO2003086319A2 (fr) * 2002-04-10 2003-10-23 Merck & Co., Inc. Compositions pharmaceutiques contenant un inhibiteur de l'integrase du vih et un tensioactif non ionique

Also Published As

Publication number Publication date
AR033845A1 (es) 2004-01-07
MXPA03003263A (es) 2003-06-06
US6921759B2 (en) 2005-07-26
CZ20031028A3 (cs) 2003-08-13
EP1326865A2 (fr) 2003-07-16
PL360944A1 (en) 2004-09-20
WO2002030930A2 (fr) 2002-04-18
EE200300145A (et) 2003-06-16
JP2004511483A (ja) 2004-04-15
DE60138635D1 (de) 2009-06-18
NO20031672L (no) 2003-06-05
IL155089A0 (en) 2003-10-31
JP4252797B2 (ja) 2009-04-08
ATE430745T1 (de) 2009-05-15
WO2002030931A2 (fr) 2002-04-18
AU2002211527B2 (en) 2006-08-24
IS6760A (is) 2003-03-27
WO2002030931A3 (fr) 2002-10-24
BR0114610A (pt) 2005-12-13
AU2002211874A1 (en) 2002-04-22
PE20020509A1 (es) 2002-06-20
HUP0302367A2 (hu) 2003-11-28
EA200300449A1 (ru) 2003-10-30
WO2002030930A3 (fr) 2002-08-29
EP1326865B1 (fr) 2009-05-06
CA2425440A1 (fr) 2002-04-18
NZ525088A (en) 2004-11-26
CA2425440C (fr) 2010-04-13
KR20030036922A (ko) 2003-05-09
CN1469878A (zh) 2004-01-21
YU27903A (sh) 2006-05-25
BG107677A (bg) 2003-11-28
AU1152702A (en) 2002-04-22
US20050176718A1 (en) 2005-08-11
NO20031672D0 (no) 2003-04-11
US20030055071A1 (en) 2003-03-20

Similar Documents

Publication Publication Date Title
SK4322003A3 (en) Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
JP4287649B2 (ja) Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
TWI399380B (zh) 抗病毒化合物
ES2274913T3 (es) Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de vih integrada.
KR101689421B1 (ko) 치환된 이미다조피리디닐-아미노피리딘 화합물
JP4523281B2 (ja) Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
TWI516263B (zh) 經取代之５－氟－１ｈ－吡唑并吡啶類及其用途
JP4733986B2 (ja) ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物
JP4719317B2 (ja) 縮合複素環誘導体およびその用途
WO2018157857A1 (fr) Inhibiteur de kinase de régulation du signal apoptotique, son procédé de préparation et son application
RU2711500C2 (ru) Композиции и способы, которые можно использовать для лечения пролиферативных заболеваний
JP7269917B2 (ja) Ａｈｒ阻害剤およびその使用
AU2002211527A1 (en) Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
KR20090106604A (ko) 축합 피리딘 화합물
TW201138770A (en) Viral polymerase inhibitors
EA019027B1 (ru) Производные флуорена, содержащие их композиции и применение
TWI783205B (zh) 鹵代烯丙基胺類化合物及其用途
SK57893A3 (en) Imidazopyridine derivatives, process for their preparation and pharmaceutical compositions
WO2005019188A1 (fr) Derive de pyrimidine fusionne et utilisation associee
AU2010212560A1 (en) Derivatives of azaindoles as inhibitors of protein kinases Abl and Src
AU2015311730A1 (en) Camkii inhibitors and uses thereof
JP2004115450A (ja) 医薬組成物
WO2023230612A1 (fr) Inhibiteurs de pad4 hétérocycliques
WO2014132220A1 (fr) Formes solides de dérivés hétérocycliques bicycliques utilisées en tant que médiateurs du récepteur pdgf

Legal Events

Date Code Title Description
FB9A Suspension of patent application procedure