SK381192A3 - Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives - Google Patents

Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives Download PDF

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Publication number
SK381192A3
SK381192A3 SK3811-92A SK381192A SK381192A3 SK 381192 A3 SK381192 A3 SK 381192A3 SK 381192 A SK381192 A SK 381192A SK 381192 A3 SK381192 A3 SK 381192A3
Authority
SK
Slovakia
Prior art keywords
carbon atoms
group
formula
compound
alkyl
Prior art date
Application number
SK3811-92A
Other languages
English (en)
Slovak (sk)
Other versions
SK279109B6 (sk
Inventor
Holger Heitsch
Rainer Henning
Adalbert Wagner
Hermann Gerhards
Reinhard Becker
Bernward Scholkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of SK279109B6 publication Critical patent/SK279109B6/sk
Publication of SK381192A3 publication Critical patent/SK381192A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK3811-92A 1992-03-07 1992-12-21 Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives SK381192A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207241 1992-03-07

Publications (2)

Publication Number Publication Date
SK279109B6 SK279109B6 (sk) 1998-06-03
SK381192A3 true SK381192A3 (en) 1998-06-03

Family

ID=6453463

Family Applications (1)

Application Number Title Priority Date Filing Date
SK3811-92A SK381192A3 (en) 1992-03-07 1992-12-21 Imidazole derivatives with a lateral biphenylsulfonyl urea or biphenylsulfonyl urethane chain, method of preparation the same and a pharmaceutical composition containing said derivatives

Country Status (25)

Country Link
US (1) US5604251A (ru)
EP (1) EP0560177B1 (ru)
JP (1) JP3542813B2 (ru)
KR (1) KR930019637A (ru)
CN (1) CN1036341C (ru)
AT (1) ATE230732T1 (ru)
AU (1) AU663565B2 (ru)
BR (1) BR9300761A (ru)
CA (1) CA2091135A1 (ru)
CZ (1) CZ281983B6 (ru)
DE (1) DE59310323D1 (ru)
DK (1) DK0560177T3 (ru)
ES (1) ES2187501T3 (ru)
FI (1) FI930970A (ru)
HU (1) HUT64041A (ru)
IL (1) IL104971A0 (ru)
MA (1) MA22814A1 (ru)
NO (1) NO303632B1 (ru)
NZ (1) NZ247059A (ru)
PH (1) PH31466A (ru)
PL (1) PL173023B1 (ru)
RU (1) RU2116300C1 (ru)
SK (1) SK381192A3 (ru)
TW (1) TW215434B (ru)
ZA (1) ZA931585B (ru)

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FR2716883B1 (fr) * 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
CZ263098A3 (cs) 1996-02-20 1999-05-12 Bristol-Myers Squibb Company Způsoby přípravy bifenylisoxazolsulfonamidů
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
WO1998025460A1 (en) * 1996-12-13 1998-06-18 Zymogenetics, Inc. Compositions and methods for stimulating bone growth
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
EP1023441A1 (en) 1997-10-16 2000-08-02 The Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with nf-at3 function
DE19802969A1 (de) 1998-01-27 1999-07-29 Hoechst Marion Roussel De Gmbh Verfahren zur Herstellung von S-Alkyl(Aryl)-substituierten Imidazol-Derivaten
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP1165472A4 (en) 1999-03-19 2002-11-20 Bristol Myers Squibb Co METHOD FOR PRODUCING BIPHENYL ISOXAZOLE
WO2004002226A1 (en) * 2002-06-28 2004-01-08 Baylor College Of Medicine Modulators of cdk9 as a therapeutic target in cardiac hypertrophy
US20040106647A1 (en) * 2002-06-28 2004-06-03 Schneider Michael D. Modulators of Cdk9 as a therapeutic target in cardiac hypertrophy
EP1631268A2 (en) * 2003-05-21 2006-03-08 Board Of Regents The University Of Texas System Inhibition of protein kinase c-mu (pkd) as a treatment for cardiac hypertrophy and heart failure
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
EP1660092A2 (en) * 2003-07-03 2006-05-31 Myriad Genetics, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US7485653B2 (en) * 2003-11-03 2009-02-03 Gilead Sciences, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
EP1685108B1 (en) * 2003-11-03 2008-07-23 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
EP1699436A2 (en) * 2003-12-12 2006-09-13 Myogen, Inc. Enoximone formulations and their use in the treatment of cardiac hypertrophy and heart failure
CA2560528A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
WO2005092333A1 (en) * 2004-03-22 2005-10-06 Myogen, Inc. (r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
CA2572179A1 (en) * 2004-06-23 2006-01-19 Myogen, Inc. Enoximone formulations and their use in the treatment of pde-iii mediated diseases
US8258145B2 (en) * 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
EP1833482A4 (en) 2005-01-03 2011-02-16 Myriad Genetics Inc COMPOUNDS AND ITS THERAPEUTIC USE
WO2007014033A2 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of Colorado, A Body Corporate Inhibition of extracellular signal-regulated kinase 1/2 as a treatment for cardiac hypertrophy and heart failure
US20090306373A1 (en) * 2005-12-20 2009-12-10 Gamber Gabriel G 4,7-dihydrothieno[2,3-b]pyridine compounds and pharmaceutical compositions
PT2056882E (pt) 2006-08-01 2012-11-19 Univ Texas Identificação de um micro-rna que ativa a expressão da cadeia pesada de beta-miosina
KR101706259B1 (ko) 2007-07-31 2017-02-14 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 섬유증을 조절하는 마이크로-ｒｎａ 집단 및 이의 용도
CN102036689B (zh) 2008-03-17 2014-08-06 得克萨斯系统大学董事会 神经肌肉突触维持和再生中涉及的微小rna的鉴定
WO2012064743A2 (en) 2010-11-08 2012-05-18 The Johns Hopkins University Methods for improving heart function
GB2605148A (en) * 2021-03-23 2022-09-28 Vicore Pharma Ab New compounds

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JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4355044A (en) * 1980-12-19 1982-10-19 Bernardo Heller D-Phenylalanine treatment
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Also Published As

Publication number Publication date
JP3542813B2 (ja) 2004-07-14
EP0560177A1 (de) 1993-09-15
FI930970A (fi) 1993-09-08
SK279109B6 (sk) 1998-06-03
NO303632B1 (no) 1998-08-10
BR9300761A (pt) 1993-09-14
HU9300618D0 (en) 1993-05-28
PL173023B1 (pl) 1998-01-30
ES2187501T3 (es) 2003-06-16
HUT64041A (en) 1993-11-29
NO930817D0 (no) 1993-03-05
CN1036341C (zh) 1997-11-05
ZA931585B (en) 1993-09-27
DE59310323D1 (de) 2003-02-13
TW215434B (ru) 1993-11-01
MA22814A1 (fr) 1993-10-01
CZ381192A3 (en) 1993-12-15
CN1076192A (zh) 1993-09-15
US5604251A (en) 1997-02-18
EP0560177B1 (de) 2003-01-08
PH31466A (en) 1998-11-03
AU663565B2 (en) 1995-10-12
IL104971A0 (en) 1993-07-08
NO930817L (no) 1993-09-08
CZ281983B6 (cs) 1997-04-16
ATE230732T1 (de) 2003-01-15
CA2091135A1 (en) 1993-09-08
FI930970A0 (fi) 1993-03-04
KR930019637A (ko) 1993-10-18
PL297955A1 (en) 1993-09-20
AU3401193A (en) 1993-09-09
RU2116300C1 (ru) 1998-07-27
DK0560177T3 (da) 2003-04-14
NZ247059A (en) 1995-03-28
JPH069572A (ja) 1994-01-18

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