SK3602002A3 - Combination containing nateglinide and pharmaceutical composition comprising said combination for treating metabolic disorders - Google Patents
Combination containing nateglinide and pharmaceutical composition comprising said combination for treating metabolic disorders Download PDFInfo
- Publication number
- SK3602002A3 SK3602002A3 SK360-2002A SK3602002A SK3602002A3 SK 3602002 A3 SK3602002 A3 SK 3602002A3 SK 3602002 A SK3602002 A SK 3602002A SK 3602002 A3 SK3602002 A3 SK 3602002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- composition
- nateglinide
- pharmaceutically acceptable
- combination
- metformin
- Prior art date
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- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 title claims abstract description 176
- 229960000698 nateglinide Drugs 0.000 title claims abstract description 175
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 82
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- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract description 85
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- NKOHRVBBQISBSB-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)S1 NKOHRVBBQISBSB-UHFFFAOYSA-N 0.000 claims description 43
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- 239000008187 granular material Substances 0.000 claims description 38
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 38
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 19
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39836499A | 1999-09-17 | 1999-09-17 | |
| US54548000A | 2000-04-07 | 2000-04-07 | |
| GB0021055A GB0021055D0 (en) | 2000-08-26 | 2000-08-26 | Method of treating metabolic disorders,espicially diabetes,or a disease or condition associated with diabetes |
| PCT/EP2000/009074 WO2001021159A2 (en) | 1999-09-17 | 2000-09-15 | Pharmaceutical composition of nateglinide and another antidiabetcagent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK3602002A3 true SK3602002A3 (en) | 2002-07-02 |
Family
ID=27255861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK360-2002A SK3602002A3 (en) | 1999-09-17 | 2000-09-15 | Combination containing nateglinide and pharmaceutical composition comprising said combination for treating metabolic disorders |
Country Status (25)
| Country | Link |
|---|---|
| EP (2) | EP1212077A2 (sv) |
| JP (2) | JP2003509457A (sv) |
| KR (2) | KR100506428B1 (sv) |
| CN (1) | CN1309380C (sv) |
| AR (3) | AR028299A1 (sv) |
| AU (1) | AU7904400A (sv) |
| BE (1) | BE1013726A5 (sv) |
| BR (1) | BR0014525A (sv) |
| CA (1) | CA2381992C (sv) |
| CO (1) | CO5200844A1 (sv) |
| CZ (1) | CZ20011723A3 (sv) |
| FI (1) | FI20010683A (sv) |
| FR (1) | FR2798592B1 (sv) |
| HK (1) | HK1046101A1 (sv) |
| HU (1) | HUP0400932A3 (sv) |
| IL (1) | IL148168A0 (sv) |
| MY (2) | MY131810A (sv) |
| NO (1) | NO20021197L (sv) |
| NZ (2) | NZ517280A (sv) |
| PE (1) | PE20010739A1 (sv) |
| PL (1) | PL354168A1 (sv) |
| SG (1) | SG127714A1 (sv) |
| SK (1) | SK3602002A3 (sv) |
| TW (2) | TWI278312B (sv) |
| WO (1) | WO2001021159A2 (sv) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7358390B2 (en) | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| ATE399000T1 (de) | 1999-12-28 | 2008-07-15 | Ajinomoto Kk | Antidiabetes-zubereitung zur oralen verabreichung |
| RU2281764C2 (ru) * | 2000-03-17 | 2006-08-20 | Адзиномото Ко., Инк. | Лекарственные средства для лечения осложнений, связанных с диабетом, и невропатии и их применения |
| FR2809310B1 (fr) | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
| FR2816840B1 (fr) | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| CA2369967A1 (en) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methods of treating nuclear factor-kappa b mediated diseases and disorders |
| WO2002072146A2 (en) * | 2001-03-12 | 2002-09-19 | Novartis Ag | Combination of nateglinide or repaglinide with at least one further antidiabetic compound |
| FR2825023B1 (fr) * | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
| FR2826278B1 (fr) * | 2001-06-20 | 2005-03-25 | Lipha | Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant |
| ES2275889T3 (es) * | 2001-06-20 | 2007-06-16 | Merck Sante | Utilizacion de agentes antidiabeticos para fabricar un medicamento que tiene un efecto cicatrizante. |
| TW200304813A (en) * | 2002-03-11 | 2003-10-16 | Novartis Ag | Salts of organic acid |
| ATE419840T1 (de) | 2002-04-09 | 2009-01-15 | Flamel Tech Sa | Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen |
| DK1547614T3 (da) * | 2002-05-28 | 2011-04-04 | Ajinomoto Kk | Medicinsk sammensætning til inhibering af ekspressionen af ATP-citrat-lyase og anvendelse deraf |
| US6830759B2 (en) | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
| US6861553B2 (en) | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
| US7148376B2 (en) | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7420084B2 (en) | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| UA80991C2 (en) | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
| JP4505859B2 (ja) * | 2003-08-08 | 2010-07-21 | 味の素株式会社 | ナテグリニド含有製剤 |
| JP5168712B2 (ja) * | 2004-04-01 | 2013-03-27 | 味の素株式会社 | ナテグリニド含有製剤 |
| CN107501099B (zh) | 2004-06-24 | 2021-03-19 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| WO2006016602A1 (ja) * | 2004-08-10 | 2006-02-16 | Ajinomoto Co., Inc. | 苦味の低減したナテグリニド含有製剤 |
| PL1993360T3 (pl) | 2005-12-28 | 2017-08-31 | Vertex Pharmaceuticals Incorporated | Stałe postacie n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4- dihydro-4-oksochinolino-3-karboksyamidu |
| WO2007111933A2 (en) * | 2006-03-22 | 2007-10-04 | Intranasal Therapeutics , Inc. | Pharmaceutical compositions comprising a hypoglycemic agent and methods of using same |
| WO2010054286A2 (en) * | 2008-11-10 | 2010-05-14 | Auspex Pharmaceuticals, Inc. | Substituted hydroxyphenylamine compounds |
| WO2010060041A2 (en) * | 2008-11-21 | 2010-05-27 | Auspex Pharmaceuticals, Inc. | Phenylalanine amide inhibitors of atp-sensitive potassium channels |
| KR101955863B1 (ko) | 2009-03-20 | 2019-03-07 | 버텍스 파마슈티칼스 인코포레이티드 | 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법 |
| KR101035574B1 (ko) * | 2009-04-09 | 2011-05-23 | 대한민국 | 제 2형 당뇨병 치료효과를 판정하는 방법 |
| TWI631963B (zh) * | 2011-01-05 | 2018-08-11 | 雷西肯製藥股份有限公司 | 包含鈉－葡萄糖共同輸送體１與２之抑制劑的組合物與應用方法 |
| US9480663B2 (en) | 2011-01-07 | 2016-11-01 | Elcelyx Therapeutics, Inc. | Biguanide compositions and methods of treating metabolic disorders |
| US9572784B2 (en) | 2011-01-07 | 2017-02-21 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| US9211263B2 (en) | 2012-01-06 | 2015-12-15 | Elcelyx Therapeutics, Inc. | Compositions and methods of treating metabolic disorders |
| US8796338B2 (en) | 2011-01-07 | 2014-08-05 | Elcelyx Therapeutics, Inc | Biguanide compositions and methods of treating metabolic disorders |
| EA039943B1 (ru) | 2011-01-07 | 2022-03-30 | Анджи Фарма (Юс) Элэлси | Способ снижения уровней глюкозы в крови у субъекта |
| US11974971B2 (en) | 2011-01-07 | 2024-05-07 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| US11759441B2 (en) | 2011-01-07 | 2023-09-19 | Anji Pharmaceuticals Inc. | Biguanide compositions and methods of treating metabolic disorders |
| WO2013066277A1 (en) * | 2011-11-03 | 2013-05-10 | Mahmut Bilgic | Synergic compositions |
| WO2013077820A1 (en) * | 2011-11-23 | 2013-05-30 | Mahmut Bilgic | Treatment package composed of dosage forms comprising nateglinide -metformin hydrochloride |
| EA201491335A1 (ru) | 2012-01-06 | 2015-04-30 | Элселикс Терапьютикс, Инк. | Бигуанидные композиции и способы лечения метаболических расстройств |
| AU2013207329B2 (en) | 2012-01-06 | 2017-10-26 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| IL265430B2 (en) | 2012-02-27 | 2024-08-01 | Vertex Pharma | Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof |
| AU2015330923B2 (en) | 2014-10-07 | 2020-03-12 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| CN105646332B (zh) * | 2014-11-09 | 2018-05-25 | 复旦大学 | 氨基甲基哌啶类衍生物及其制备方法和药物用途 |
| CN114099520A (zh) * | 2021-12-31 | 2022-03-01 | 中国药科大学 | 格列喹酮用于制备治疗溃疡性结肠炎的药物的用途 |
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2000
- 2000-09-14 CO CO00069666A patent/CO5200844A1/es not_active Application Discontinuation
- 2000-09-14 AR ARP000104821A patent/AR028299A1/es not_active Application Discontinuation
- 2000-09-15 WO PCT/EP2000/009074 patent/WO2001021159A2/en active IP Right Grant
- 2000-09-15 SK SK360-2002A patent/SK3602002A3/sk unknown
- 2000-09-15 CZ CZ20011723A patent/CZ20011723A3/cs unknown
- 2000-09-15 TW TW092125226A patent/TWI278312B/zh not_active IP Right Cessation
- 2000-09-15 CN CNB008019762A patent/CN1309380C/zh not_active Expired - Lifetime
- 2000-09-15 BR BR0014525-4A patent/BR0014525A/pt not_active IP Right Cessation
- 2000-09-15 IL IL14816800A patent/IL148168A0/xx unknown
- 2000-09-15 KR KR10-2002-7003551A patent/KR100506428B1/ko not_active IP Right Cessation
- 2000-09-15 MY MYPI20004314A patent/MY131810A/en unknown
- 2000-09-15 NZ NZ517280A patent/NZ517280A/en not_active IP Right Cessation
- 2000-09-15 EP EP00969260A patent/EP1212077A2/en not_active Ceased
- 2000-09-15 MY MYPI20050152A patent/MY143051A/en unknown
- 2000-09-15 NZ NZ528738A patent/NZ528738A/en not_active IP Right Cessation
- 2000-09-15 JP JP2001524585A patent/JP2003509457A/ja not_active Withdrawn
- 2000-09-15 FR FR0011782A patent/FR2798592B1/fr not_active Expired - Fee Related
- 2000-09-15 EP EP08167253A patent/EP2011507A2/en not_active Withdrawn
- 2000-09-15 HU HU0400932A patent/HUP0400932A3/hu unknown
- 2000-09-15 CA CA2381992A patent/CA2381992C/en not_active Expired - Fee Related
- 2000-09-15 AU AU79044/00A patent/AU7904400A/en not_active Abandoned
- 2000-09-15 PL PL00354168A patent/PL354168A1/xx not_active Application Discontinuation
- 2000-09-15 TW TW089118960A patent/TWI278311B/zh not_active IP Right Cessation
- 2000-09-15 PE PE2000000955A patent/PE20010739A1/es not_active Application Discontinuation
- 2000-09-15 KR KR1020047010952A patent/KR100544244B1/ko not_active IP Right Cessation
- 2000-09-15 BE BE2000/0585A patent/BE1013726A5/fr not_active IP Right Cessation
- 2000-09-15 SG SG200401291A patent/SG127714A1/en unknown
-
2001
- 2001-02-05 AR ARP010100516A patent/AR028504A2/es unknown
- 2001-04-02 FI FI20010683A patent/FI20010683A/sv not_active Application Discontinuation
-
2002
- 2002-03-11 NO NO20021197A patent/NO20021197L/no unknown
- 2002-10-25 HK HK02107767.4A patent/HK1046101A1/zh unknown
-
2006
- 2006-09-06 JP JP2006241423A patent/JP2006335767A/ja active Pending
-
2009
- 2009-07-28 AR ARP090102868A patent/AR072329A2/es unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7358390B2 (en) | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
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