HUP0400932A2 - Nateglinidet és más antidiabetikus vegyületet tartalmazó gyógyszerkészítmény, eljárás az előállítására és az alkalmazására - Google Patents
Nateglinidet és más antidiabetikus vegyületet tartalmazó gyógyszerkészítmény, eljárás az előállítására és az alkalmazásáraInfo
- Publication number
- HUP0400932A2 HUP0400932A2 HU0400932A HUP0400932A HUP0400932A2 HU P0400932 A2 HUP0400932 A2 HU P0400932A2 HU 0400932 A HU0400932 A HU 0400932A HU P0400932 A HUP0400932 A HU P0400932A HU P0400932 A2 HUP0400932 A2 HU P0400932A2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- composition containing
- pharmaceutical composition
- same
- nateglinide
- Prior art date
Links
- 229960000698 nateglinide Drugs 0.000 title abstract 3
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 title abstract 3
- 230000003178 anti-diabetic effect Effects 0.000 title abstract 2
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical compound C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960002354 repaglinide Drugs 0.000 abstract 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001467 thiazolidinediones Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Abstract
A találmány egy kombinációs gyógyszerészeti készítményre vonatkozik,amely (I) képletű nateglinidet vagy repaglinidet és legalább egymásik, a tiazolidin-dion származékok (glitazonok), szulfonil-karbamidszármazékok vagy a metformin csoportba tartozó antidiabetikumottartalmaz egyidejű, külön vagy egymást követő használatra abetegségek, különösen a metabolikus rendellenességek, és leginkább aII. típusú diabetes és a betegséggel összefüggő rendellenességek ésállapotok megelőzésében, kifejlődésének késleltetésében vagykezelésében; a találmány vonatkozik egy nateglinidet és egygyógyszerészetileg elfogadható vivőanyagot tartalmazó készítményre ésegy ilyen készítmény előállítására is. Ó
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39836499A | 1999-09-17 | 1999-09-17 | |
US54548000A | 2000-04-07 | 2000-04-07 | |
GB0021055A GB0021055D0 (en) | 2000-08-26 | 2000-08-26 | Method of treating metabolic disorders,espicially diabetes,or a disease or condition associated with diabetes |
PCT/EP2000/009074 WO2001021159A2 (en) | 1999-09-17 | 2000-09-15 | Pharmaceutical composition of nateglinide and another antidiabetcagent |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0400932A2 true HUP0400932A2 (hu) | 2004-07-28 |
HUP0400932A3 HUP0400932A3 (en) | 2007-11-28 |
Family
ID=27255861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400932A HUP0400932A3 (en) | 1999-09-17 | 2000-09-15 | Pharmaceutical composition containing nateglinide and another antidiabetic compound, process for its preparation and for use the same |
Country Status (25)
Country | Link |
---|---|
EP (2) | EP1212077A2 (hu) |
JP (2) | JP2003509457A (hu) |
KR (2) | KR100506428B1 (hu) |
CN (1) | CN1309380C (hu) |
AR (3) | AR028299A1 (hu) |
AU (1) | AU7904400A (hu) |
BE (1) | BE1013726A5 (hu) |
BR (1) | BR0014525A (hu) |
CA (1) | CA2381992C (hu) |
CO (1) | CO5200844A1 (hu) |
CZ (1) | CZ20011723A3 (hu) |
FI (1) | FI20010683A (hu) |
FR (1) | FR2798592B1 (hu) |
HK (1) | HK1046101A1 (hu) |
HU (1) | HUP0400932A3 (hu) |
IL (1) | IL148168A0 (hu) |
MY (2) | MY131810A (hu) |
NO (1) | NO20021197L (hu) |
NZ (2) | NZ517280A (hu) |
PE (1) | PE20010739A1 (hu) |
PL (1) | PL354168A1 (hu) |
SG (1) | SG127714A1 (hu) |
SK (1) | SK3602002A3 (hu) |
TW (2) | TWI278311B (hu) |
WO (1) | WO2001021159A2 (hu) |
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US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
JP4822039B2 (ja) * | 1999-12-28 | 2011-11-24 | 味の素株式会社 | 経口投与用糖尿病薬製剤 |
WO2001068136A1 (fr) * | 2000-03-17 | 2001-09-20 | Ajinomoto Co., Inc. | Medicaments permettant de traiter les complications du diabete et des neuropathies et utilisation de ces medicaments |
FR2809310B1 (fr) * | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
FR2816840B1 (fr) | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
CA2369967A1 (en) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methods of treating nuclear factor-kappa b mediated diseases and disorders |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
AU2002254940A1 (en) * | 2001-03-12 | 2002-09-24 | Novartis Pharma Gmbh | Combination of nateglinide or repaglinide with at least one further antidiabetic compound |
FR2825023B1 (fr) * | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
FR2826278B1 (fr) * | 2001-06-20 | 2005-03-25 | Lipha | Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant |
WO2003003971A2 (fr) * | 2001-06-20 | 2003-01-16 | Merck Sante | Utilisation d'agents antidiabetiques pour fabriquer un medicament ayant un effet cicatrisant |
TW200304813A (en) * | 2002-03-11 | 2003-10-16 | Novartis Ag | Salts of organic acid |
ATE419840T1 (de) | 2002-04-09 | 2009-01-15 | Flamel Tech Sa | Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen |
DK1547614T3 (da) * | 2002-05-28 | 2011-04-04 | Ajinomoto Kk | Medicinsk sammensætning til inhibering af ekspressionen af ATP-citrat-lyase og anvendelse deraf |
US6830759B2 (en) | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
US6861553B2 (en) | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
US7420084B2 (en) | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7148376B2 (en) | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7358390B2 (en) | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
UA80991C2 (en) | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
JP4505859B2 (ja) * | 2003-08-08 | 2010-07-21 | 味の素株式会社 | ナテグリニド含有製剤 |
KR20120064735A (ko) * | 2004-04-01 | 2012-06-19 | 아지노모토 가부시키가이샤 | 나테글리니드 함유 제제 |
LT2489659T (lt) | 2004-06-24 | 2018-03-26 | Vertex Pharmaceuticals Incorporated | Atp rišančios kasetės transporterių moduliatoriai |
WO2006016602A1 (ja) * | 2004-08-10 | 2006-02-16 | Ajinomoto Co., Inc. | 苦味の低減したナテグリニド含有製剤 |
RS60205B1 (sr) | 2005-12-28 | 2020-06-30 | Vertex Pharma | Farmaceutske kompozicije amorfnog oblika n-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksohinolin-3-karboksamida |
US20090318502A1 (en) * | 2006-03-22 | 2009-12-24 | Intranasal Therapeutics, Inc. | Pharmaceutical Compositions Comprising a Hypoglycemic Agent and Methods of Using Same |
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-
2000
- 2000-09-14 AR ARP000104821A patent/AR028299A1/es not_active Application Discontinuation
- 2000-09-14 CO CO00069666A patent/CO5200844A1/es not_active Application Discontinuation
- 2000-09-15 MY MYPI20004314A patent/MY131810A/en unknown
- 2000-09-15 CN CNB008019762A patent/CN1309380C/zh not_active Expired - Lifetime
- 2000-09-15 SK SK360-2002A patent/SK3602002A3/sk unknown
- 2000-09-15 NZ NZ517280A patent/NZ517280A/en not_active IP Right Cessation
- 2000-09-15 SG SG200401291A patent/SG127714A1/en unknown
- 2000-09-15 CZ CZ20011723A patent/CZ20011723A3/cs unknown
- 2000-09-15 EP EP00969260A patent/EP1212077A2/en not_active Ceased
- 2000-09-15 EP EP08167253A patent/EP2011507A2/en not_active Withdrawn
- 2000-09-15 TW TW089118960A patent/TWI278311B/zh not_active IP Right Cessation
- 2000-09-15 AU AU79044/00A patent/AU7904400A/en not_active Abandoned
- 2000-09-15 PL PL00354168A patent/PL354168A1/xx not_active Application Discontinuation
- 2000-09-15 BR BR0014525-4A patent/BR0014525A/pt not_active IP Right Cessation
- 2000-09-15 PE PE2000000955A patent/PE20010739A1/es not_active Application Discontinuation
- 2000-09-15 JP JP2001524585A patent/JP2003509457A/ja not_active Withdrawn
- 2000-09-15 HU HU0400932A patent/HUP0400932A3/hu unknown
- 2000-09-15 IL IL14816800A patent/IL148168A0/xx unknown
- 2000-09-15 NZ NZ528738A patent/NZ528738A/en not_active IP Right Cessation
- 2000-09-15 KR KR10-2002-7003551A patent/KR100506428B1/ko not_active IP Right Cessation
- 2000-09-15 TW TW092125226A patent/TWI278312B/zh not_active IP Right Cessation
- 2000-09-15 WO PCT/EP2000/009074 patent/WO2001021159A2/en active IP Right Grant
- 2000-09-15 MY MYPI20050152A patent/MY143051A/en unknown
- 2000-09-15 CA CA2381992A patent/CA2381992C/en not_active Expired - Fee Related
- 2000-09-15 KR KR1020047010952A patent/KR100544244B1/ko not_active IP Right Cessation
- 2000-09-15 BE BE2000/0585A patent/BE1013726A5/fr not_active IP Right Cessation
- 2000-09-15 FR FR0011782A patent/FR2798592B1/fr not_active Expired - Fee Related
-
2001
- 2001-02-05 AR ARP010100516A patent/AR028504A2/es unknown
- 2001-04-02 FI FI20010683A patent/FI20010683A/fi not_active Application Discontinuation
-
2002
- 2002-03-11 NO NO20021197A patent/NO20021197L/no unknown
- 2002-10-25 HK HK02107767.4A patent/HK1046101A1/zh unknown
-
2006
- 2006-09-06 JP JP2006241423A patent/JP2006335767A/ja active Pending
-
2009
- 2009-07-28 AR ARP090102868A patent/AR072329A2/es unknown
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