SK323792A3 - Camptothecin derivatives, method of producing the same, pharmaceutical compositions containing same, their use and intermediate products - Google Patents
Camptothecin derivatives, method of producing the same, pharmaceutical compositions containing same, their use and intermediate products Download PDFInfo
- Publication number
- SK323792A3 SK323792A3 SK3237-92A SK323792A SK323792A3 SK 323792 A3 SK323792 A3 SK 323792A3 SK 323792 A SK323792 A SK 323792A SK 323792 A3 SK323792 A3 SK 323792A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- camptothecin
- ethylenedioxy
- formula
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78427591A | 1991-10-29 | 1991-10-29 | |
| US82672992A | 1992-01-28 | 1992-01-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK279298B6 SK279298B6 (sk) | 1998-09-09 |
| SK323792A3 true SK323792A3 (en) | 1998-09-09 |
Family
ID=27120258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK3237-92A SK323792A3 (en) | 1991-10-29 | 1992-10-27 | Camptothecin derivatives, method of producing the same, pharmaceutical compositions containing same, their use and intermediate products |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0540099B1 (ko) |
| JP (2) | JP3020760B2 (ko) |
| KR (1) | KR100246154B1 (ko) |
| CN (1) | CN1072683A (ko) |
| AP (1) | AP306A (ko) |
| AT (1) | ATE136898T1 (ko) |
| AU (1) | AU657007B2 (ko) |
| CA (1) | CA2081580A1 (ko) |
| CZ (1) | CZ284023B6 (ko) |
| DE (1) | DE69209969T2 (ko) |
| DK (1) | DK0540099T3 (ko) |
| ES (1) | ES2086643T3 (ko) |
| FI (3) | FI104373B (ko) |
| GR (1) | GR3020120T3 (ko) |
| HU (2) | HU217970B (ko) |
| IL (1) | IL103571A (ko) |
| IS (1) | IS1708B (ko) |
| MX (1) | MX9206211A (ko) |
| MY (1) | MY108261A (ko) |
| NO (1) | NO302073B1 (ko) |
| NZ (1) | NZ244914A (ko) |
| OA (1) | OA09767A (ko) |
| RU (1) | RU2119921C1 (ko) |
| SK (1) | SK323792A3 (ko) |
| TW (1) | TW221994B (ko) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
| ES2186812T3 (es) * | 1993-01-15 | 2003-05-16 | Stehlin Foundation For Cancer | Tratamiento oral o intramuscular del cancer pancreatico con s-camptotecina insoluble en agua de la forma de anillo de lactona cerrado. |
| US5369127A (en) * | 1993-04-21 | 1994-11-29 | Allergan, Inc. | 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents |
| IS4152A (is) * | 1993-04-29 | 1994-10-30 | Glaxo Inc. | Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra |
| MX9403275A (es) * | 1993-05-03 | 1995-01-31 | Smithkline Beecham Corp | Metilendioxi[3,'4':6,7]indolizino-[1,2-b]quinolinonas substituidas. |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| US5491237A (en) | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
| IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
| US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| KR960029336A (ko) | 1995-01-09 | 1996-08-17 | 김충환 | 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제 |
| US5496952A (en) * | 1995-02-07 | 1996-03-05 | North Carolina State University | Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs |
| US5670500A (en) * | 1995-05-31 | 1997-09-23 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| ATE275132T1 (de) * | 1995-06-27 | 2004-09-15 | Takeda Chemical Industries Ltd | 4-acylamino(halogen)alkyl-chinolin derivate, deren herstellung und deren verwendung als melatonin-agonisten |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| WO1997019085A1 (en) * | 1995-11-22 | 1997-05-29 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| TW464652B (en) | 1996-10-30 | 2001-11-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| US6559309B2 (en) * | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
| US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
| US6046209A (en) * | 1997-05-27 | 2000-04-04 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| CZ298259B6 (cs) | 2000-02-28 | 2007-08-08 | Aventis Pharma S. A. | Farmaceutická kombinace k lécení rakoviny obsahující CPT-11 a capecitabin |
| US6548488B2 (en) | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US6545010B2 (en) | 2000-03-17 | 2003-04-08 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| JP2004517821A (ja) | 2000-10-27 | 2004-06-17 | アベンティス・ファーマ・ソシエテ・アノニム | 癌治療のためのカンプトセシン及びスチルベン誘導体からなる組合せ |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| WO2012050591A1 (en) | 2010-10-15 | 2012-04-19 | Rutgers, The State University Of New Jersey | Hydrogel formulation for dermal and ocular delivery |
| US20090104254A1 (en) | 2004-12-22 | 2009-04-23 | Rutgers, The State University Of New Jersey | Controlled Release Hydrogels |
| AU2007232206B2 (en) | 2006-03-30 | 2013-04-04 | Drais Pharmaceuticals, Inc. | Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same |
| CN101407524B (zh) * | 2007-10-09 | 2012-07-18 | 江苏先声药物研究有限公司 | 噁嗪骈喜树碱衍生物及其制备方法和用途 |
| CN100592871C (zh) * | 2008-03-14 | 2010-03-03 | 浙江林学院 | 一种杀虫剂组合物及其加工方法 |
| ES2373172B1 (es) * | 2010-07-16 | 2012-12-10 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales. |
| US8980909B2 (en) | 2011-01-12 | 2015-03-17 | Crystal Biopharmaceutical Llc | HDAC inhibiting derivatives of camptothecin |
| US20190343828A1 (en) * | 2018-04-06 | 2019-11-14 | Seattle Genetics, Inc. | Camptothecin peptide conjugates |
| CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
| AU2022330892A1 (en) * | 2021-08-19 | 2024-03-21 | Hainan Simcere Zaiming Pharmaceutical Co., Ltd. | Camptothecin derivative, and pharmaceutical composition and use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
-
1992
- 1992-10-23 EP EP92203263A patent/EP0540099B1/en not_active Expired - Lifetime
- 1992-10-23 DK DK92203263.6T patent/DK0540099T3/da active
- 1992-10-23 DE DE69209969T patent/DE69209969T2/de not_active Expired - Fee Related
- 1992-10-23 ES ES92203263T patent/ES2086643T3/es not_active Expired - Lifetime
- 1992-10-23 AT AT92203263T patent/ATE136898T1/de not_active IP Right Cessation
- 1992-10-27 SK SK3237-92A patent/SK323792A3/sk unknown
- 1992-10-27 TW TW081108539A patent/TW221994B/zh active
- 1992-10-27 CZ CS923237A patent/CZ284023B6/cs not_active IP Right Cessation
- 1992-10-28 NZ NZ244914A patent/NZ244914A/xx not_active IP Right Cessation
- 1992-10-28 CN CN92113782A patent/CN1072683A/zh not_active Withdrawn
- 1992-10-28 AU AU27385/92A patent/AU657007B2/en not_active Ceased
- 1992-10-28 IL IL103571A patent/IL103571A/en not_active IP Right Cessation
- 1992-10-28 CA CA002081580A patent/CA2081580A1/en not_active Abandoned
- 1992-10-28 NO NO924158A patent/NO302073B1/no unknown
- 1992-10-28 OA OA60295A patent/OA09767A/en unknown
- 1992-10-28 HU HU9203384A patent/HU217970B/hu not_active IP Right Cessation
- 1992-10-28 MY MYPI92001954A patent/MY108261A/en unknown
- 1992-10-28 AP APAP/P/1992/000439A patent/AP306A/en active
- 1992-10-28 JP JP4312862A patent/JP3020760B2/ja not_active Expired - Fee Related
- 1992-10-28 RU RU92004336A patent/RU2119921C1/ru not_active IP Right Cessation
- 1992-10-28 FI FI924878A patent/FI104373B/fi active
- 1992-10-28 KR KR1019920019884A patent/KR100246154B1/ko not_active IP Right Cessation
- 1992-10-28 MX MX9206211A patent/MX9206211A/es unknown
- 1992-10-28 IS IS3936A patent/IS1708B/is unknown
-
1995
- 1995-06-14 HU HU95P/P00203P patent/HU211349A9/hu unknown
-
1996
- 1996-05-31 GR GR960401497T patent/GR3020120T3/el unknown
-
1998
- 1998-10-08 FI FI982185A patent/FI982185A/fi unknown
-
1999
- 1999-11-02 JP JP31294099A patent/JP3229298B2/ja not_active Expired - Fee Related
-
2002
- 2002-06-07 FI FI20021090A patent/FI20021090A/fi not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SK323792A3 (en) | Camptothecin derivatives, method of producing the same, pharmaceutical compositions containing same, their use and intermediate products | |
| US5559235A (en) | Water soluble camptothecin derivatives | |
| US5342947A (en) | Preparation of water soluble camptothecin derivatives | |
| US6100273A (en) | Water soluble camptothecin derivatives | |
| KR0178808B1 (ko) | 인체 결장직장암의 효능있는 억제제로서의 캠프토테신 동족체 | |
| US7781587B2 (en) | Solubilized topoisomerase poisons | |
| US5401747A (en) | Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer | |
| US7858627B2 (en) | Topoisomerase-targeting agents | |
| CZ299794B6 (cs) | Analogy kamptothecinu, zpusob jejich prípravy a farmaceutické prostredky obsahující tyto analogy | |
| JPH10503525A (ja) | カンプトテシン誘導体及びその製造方法 | |
| EP0696285A1 (en) | Water soluble derivatives of camptothecin and their use as antitumor agents | |
| SI9300183A (sl) | Vodotopni kamptotecinski derivati | |
| PL173684B1 (pl) | Pochodne kamptotecyny i sposób wytwarzania pochodnych kamptofecyny |