ES2186812T3 - Tratamiento oral o intramuscular del cancer pancreatico con s-camptotecina insoluble en agua de la forma de anillo de lactona cerrado. - Google Patents

Tratamiento oral o intramuscular del cancer pancreatico con s-camptotecina insoluble en agua de la forma de anillo de lactona cerrado.

Info

Publication number
ES2186812T3
ES2186812T3 ES97101631T ES97101631T ES2186812T3 ES 2186812 T3 ES2186812 T3 ES 2186812T3 ES 97101631 T ES97101631 T ES 97101631T ES 97101631 T ES97101631 T ES 97101631T ES 2186812 T3 ES2186812 T3 ES 2186812T3
Authority
ES
Spain
Prior art keywords
camptothecin
oral
insoluble
water
closed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97101631T
Other languages
English (en)
Inventor
Beppino C Giovanella
Hellmuth R Hinz
Anthony J Kozielski
John S Stehlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stehlin Foundation for Cancer Research
Original Assignee
Stehlin Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stehlin Foundation for Cancer Research filed Critical Stehlin Foundation for Cancer Research
Application granted granted Critical
Publication of ES2186812T3 publication Critical patent/ES2186812T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

USO DE UN AGENTE QUE ES UN COMPUESTO DE CAMPOTECINA 20 (S) INSOLUBLE EN AGUA CON UN NUCLEO DE LACTONA CERRADA, UN DERIVADO O UNA MEZCLA DEL MISMO EN LA FABRICACION DE UN MEDICAMENTO PARA UTILIZAR EN UN METODO PARA TRATAR EL CANCER PANCREATICO EN UN SER HUMANO QUE SUPONE LA ADMINISTRACION ORAL O INTRAMUSCULAR DE UNA CANTIDAD EFECTIVA DE DICHO AGENTE.
ES97101631T 1993-01-15 1994-01-14 Tratamiento oral o intramuscular del cancer pancreatico con s-camptotecina insoluble en agua de la forma de anillo de lactona cerrado. Expired - Lifetime ES2186812T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US284493A 1993-01-15 1993-01-15

Publications (1)

Publication Number Publication Date
ES2186812T3 true ES2186812T3 (es) 2003-05-16

Family

ID=21702794

Family Applications (3)

Application Number Title Priority Date Filing Date
ES02015200T Expired - Lifetime ES2301590T3 (es) 1993-01-15 1994-01-14 Utilizacion de camptotecina insoluble en agua en la forma de anillo de lactona cerrado para la obtencion de un medicamento para el tratamiento del cancer de colon.
ES94907804T Expired - Lifetime ES2114681T3 (es) 1993-01-15 1994-01-14 Tratamiento transdermico de cancer con camptotecina insoluble en agua en la forma de anillo de lactona cerrado.
ES97101631T Expired - Lifetime ES2186812T3 (es) 1993-01-15 1994-01-14 Tratamiento oral o intramuscular del cancer pancreatico con s-camptotecina insoluble en agua de la forma de anillo de lactona cerrado.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES02015200T Expired - Lifetime ES2301590T3 (es) 1993-01-15 1994-01-14 Utilizacion de camptotecina insoluble en agua en la forma de anillo de lactona cerrado para la obtencion de un medicamento para el tratamiento del cancer de colon.
ES94907804T Expired - Lifetime ES2114681T3 (es) 1993-01-15 1994-01-14 Tratamiento transdermico de cancer con camptotecina insoluble en agua en la forma de anillo de lactona cerrado.

Country Status (9)

Country Link
EP (3) EP1250926B1 (es)
JP (1) JP3099128B2 (es)
AT (3) ATE227573T1 (es)
CA (1) CA2148822C (es)
DE (3) DE69435084T2 (es)
DK (3) DK0778024T3 (es)
ES (3) ES2301590T3 (es)
PT (1) PT1250926E (es)
WO (1) WO1994015604A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
ATE211142T1 (de) * 1989-09-15 2002-01-15 Res Triangle Inst Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog
US5422344A (en) * 1990-05-08 1995-06-06 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method of treating retroviral infections in mammals
ATE136898T1 (de) * 1991-10-29 1996-05-15 Glaxo Wellcome Inc Wasserlösliche camptothecinderivate
EP1393730A3 (en) * 1991-11-15 2004-03-17 Smithkline Beecham Corporation Combination chemotherapy involving topotecan and a platinum coordination compound
CA2125293A1 (en) * 1991-12-10 1993-06-24 Randall Keith Johnson Treatment of colorectal cancer

Also Published As

Publication number Publication date
EP0678025A1 (en) 1995-10-25
DE69431731T2 (de) 2003-03-13
ATE165003T1 (de) 1998-05-15
EP0778024B1 (en) 2002-11-13
DE69431731D1 (de) 2002-12-19
WO1994015604A1 (en) 1994-07-21
JPH08505626A (ja) 1996-06-18
EP1250926B1 (en) 2008-03-12
DK0678025T3 (da) 1998-10-07
JP3099128B2 (ja) 2000-10-16
EP0778024A1 (en) 1997-06-11
DE69435084D1 (de) 2008-04-24
DK1250926T3 (da) 2008-07-07
PT1250926E (pt) 2008-06-11
DK0778024T3 (da) 2002-12-23
ES2301590T3 (es) 2008-07-01
CA2148822A1 (en) 1994-07-21
ATE227573T1 (de) 2002-11-15
EP0678025B1 (en) 1998-04-15
EP1250926A2 (en) 2002-10-23
DE69409633D1 (de) 1998-05-20
DE69435084T2 (de) 2009-03-19
ES2114681T3 (es) 1998-06-01
CA2148822C (en) 2001-03-27
DE69409633T2 (de) 1998-08-06
ATE388706T1 (de) 2008-03-15
EP1250926A3 (en) 2002-11-20

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