DE69431731D1 - Orale oder intramuskuläre Behandlung von Pankreaskrebs durch wasserunlösliches S-Camptothecin mit geschlossenem Lactonring - Google Patents

Orale oder intramuskuläre Behandlung von Pankreaskrebs durch wasserunlösliches S-Camptothecin mit geschlossenem Lactonring

Info

Publication number
DE69431731D1
DE69431731D1 DE69431731T DE69431731T DE69431731D1 DE 69431731 D1 DE69431731 D1 DE 69431731D1 DE 69431731 T DE69431731 T DE 69431731T DE 69431731 T DE69431731 T DE 69431731T DE 69431731 D1 DE69431731 D1 DE 69431731D1
Authority
DE
Germany
Prior art keywords
camptothecin
oral
insoluble
water
lactone ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431731T
Other languages
English (en)
Other versions
DE69431731T2 (de
Inventor
Beppino C Giovanella
Hellmuth R Hinz
Anthony J Kozielski
John S Stehlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stehlin Foundation for Cancer Research
Original Assignee
Stehlin Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stehlin Foundation for Cancer Research filed Critical Stehlin Foundation for Cancer Research
Publication of DE69431731D1 publication Critical patent/DE69431731D1/de
Application granted granted Critical
Publication of DE69431731T2 publication Critical patent/DE69431731T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69431731T 1993-01-15 1994-01-14 Orale oder intramuskuläre Behandlung von Pankreaskrebs durch wasserunlösliches S-Camptothecin mit geschlossenem Lactonring Expired - Fee Related DE69431731T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US284493A 1993-01-15 1993-01-15

Publications (2)

Publication Number Publication Date
DE69431731D1 true DE69431731D1 (de) 2002-12-19
DE69431731T2 DE69431731T2 (de) 2003-03-13

Family

ID=21702794

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69409633T Expired - Fee Related DE69409633T2 (de) 1993-01-15 1994-01-14 Transdermal behandlung von krebs mit wasserunlöslichem s-camtothecin mit geschlossenem lactoring
DE69435084T Expired - Fee Related DE69435084T2 (de) 1993-01-15 1994-01-14 Die Verwendung von wasserunlöslichem S-Camptothecin mit geschlossenem Lactonring für die Herstellung eines Medikamentes zur Behandlung von Darmkrebs
DE69431731T Expired - Fee Related DE69431731T2 (de) 1993-01-15 1994-01-14 Orale oder intramuskuläre Behandlung von Pankreaskrebs durch wasserunlösliches S-Camptothecin mit geschlossenem Lactonring

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69409633T Expired - Fee Related DE69409633T2 (de) 1993-01-15 1994-01-14 Transdermal behandlung von krebs mit wasserunlöslichem s-camtothecin mit geschlossenem lactoring
DE69435084T Expired - Fee Related DE69435084T2 (de) 1993-01-15 1994-01-14 Die Verwendung von wasserunlöslichem S-Camptothecin mit geschlossenem Lactonring für die Herstellung eines Medikamentes zur Behandlung von Darmkrebs

Country Status (9)

Country Link
EP (3) EP0678025B1 (de)
JP (1) JP3099128B2 (de)
AT (3) ATE388706T1 (de)
CA (1) CA2148822C (de)
DE (3) DE69409633T2 (de)
DK (3) DK0778024T3 (de)
ES (3) ES2301590T3 (de)
PT (1) PT1250926E (de)
WO (1) WO1994015604A1 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
DE69033880T2 (de) * 1989-09-15 2002-06-06 Res Triangle Inst Res Triangle Verfahren zur herstellung von 10,11-Methylendioxy-20(RS)-Camptothecin und 10,11-Methylendioxy-20(S)-Camptothecin-Analog
US5422344A (en) * 1990-05-08 1995-06-06 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method of treating retroviral infections in mammals
DE69209969T2 (de) * 1991-10-29 1996-09-12 Glaxo Wellcome Inc Wasserlösliche Camptothecinderivate
MX9206577A (es) * 1991-11-15 1993-05-01 Smithkline Beecham Corp COMPOSICIóN FARMACEUTICA PARA INHIBIR EL CRECIMIENTO DE CELULAS TUMORALES
CA2125293A1 (en) * 1991-12-10 1993-06-24 Randall Keith Johnson Treatment of colorectal cancer

Also Published As

Publication number Publication date
EP1250926A3 (de) 2002-11-20
ES2301590T3 (es) 2008-07-01
ATE227573T1 (de) 2002-11-15
EP1250926A2 (de) 2002-10-23
EP0678025A1 (de) 1995-10-25
ES2114681T3 (es) 1998-06-01
ATE165003T1 (de) 1998-05-15
EP0778024A1 (de) 1997-06-11
DE69435084T2 (de) 2009-03-19
DE69409633T2 (de) 1998-08-06
DE69435084D1 (de) 2008-04-24
DE69409633D1 (de) 1998-05-20
JPH08505626A (ja) 1996-06-18
JP3099128B2 (ja) 2000-10-16
PT1250926E (pt) 2008-06-11
DK1250926T3 (da) 2008-07-07
EP0678025B1 (de) 1998-04-15
DE69431731T2 (de) 2003-03-13
EP1250926B1 (de) 2008-03-12
EP0778024B1 (de) 2002-11-13
DK0678025T3 (da) 1998-10-07
ATE388706T1 (de) 2008-03-15
WO1994015604A1 (en) 1994-07-21
DK0778024T3 (da) 2002-12-23
ES2186812T3 (es) 2003-05-16
CA2148822A1 (en) 1994-07-21
CA2148822C (en) 2001-03-27

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DE69431731D1 (de) Orale oder intramuskuläre Behandlung von Pankreaskrebs durch wasserunlösliches S-Camptothecin mit geschlossenem Lactonring
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee