DK0678025T3 - Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform - Google Patents

Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform

Info

Publication number
DK0678025T3
DK0678025T3 DK94907804T DK94907804T DK0678025T3 DK 0678025 T3 DK0678025 T3 DK 0678025T3 DK 94907804 T DK94907804 T DK 94907804T DK 94907804 T DK94907804 T DK 94907804T DK 0678025 T3 DK0678025 T3 DK 0678025T3
Authority
DK
Denmark
Prior art keywords
camptothecin
insoluble
water
lactone ring
cancer
Prior art date
Application number
DK94907804T
Other languages
English (en)
Inventor
Beppino C Giovanella
Hellmuth R Hinz
Anthony J Kozielski
John S Stehlin
Original Assignee
Stehlin Foundation For Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer
Application granted granted Critical
Publication of DK0678025T3 publication Critical patent/DK0678025T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94907804T 1993-01-15 1994-01-14 Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform DK0678025T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US284493A 1993-01-15 1993-01-15
PCT/US1994/000403 WO1994015604A1 (en) 1993-01-15 1994-01-14 Transdermal treatment of cancer with water-insoluble s-camptothecin of the closed lactone ring form

Publications (1)

Publication Number Publication Date
DK0678025T3 true DK0678025T3 (da) 1998-10-07

Family

ID=21702794

Family Applications (3)

Application Number Title Priority Date Filing Date
DK02015200T DK1250926T3 (da) 1993-01-15 1994-01-14 Anvendelse af vanduoplöseligt S-camptothecin med en lukket lactonring i fremstilling af et medikament til behandling af coloncancer
DK97101631T DK0778024T3 (da) 1993-01-15 1994-01-14 Oral eller intramuskulær behandling af pancreascancer med vanduopløselig S-camptothecin i lukket lactonring-formen
DK94907804T DK0678025T3 (da) 1993-01-15 1994-01-14 Transdermal behandling af cancer med vand-ouopløslig S-camptothecin af den lukkede lactonringform

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK02015200T DK1250926T3 (da) 1993-01-15 1994-01-14 Anvendelse af vanduoplöseligt S-camptothecin med en lukket lactonring i fremstilling af et medikament til behandling af coloncancer
DK97101631T DK0778024T3 (da) 1993-01-15 1994-01-14 Oral eller intramuskulær behandling af pancreascancer med vanduopløselig S-camptothecin i lukket lactonring-formen

Country Status (9)

Country Link
EP (3) EP1250926B1 (da)
JP (1) JP3099128B2 (da)
AT (3) ATE165003T1 (da)
CA (1) CA2148822C (da)
DE (3) DE69435084T2 (da)
DK (3) DK1250926T3 (da)
ES (3) ES2301590T3 (da)
PT (1) PT1250926E (da)
WO (1) WO1994015604A1 (da)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
NZ235329A (en) * 1989-09-15 1992-01-29 Res Triangle Inst 20(s or rs)-camptothecin derivatives and pharmaceutical compositions
US5422344A (en) * 1990-05-08 1995-06-06 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method of treating retroviral infections in mammals
EP0540099B1 (en) * 1991-10-29 1996-04-17 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
EP1393729A3 (en) * 1991-11-15 2004-03-17 Smithkline Beecham Corporation Combination chemotherapy involving topotecan and a platinum coordination compound
CA2125293A1 (en) * 1991-12-10 1993-06-24 Randall Keith Johnson Treatment of colorectal cancer

Also Published As

Publication number Publication date
CA2148822C (en) 2001-03-27
PT1250926E (pt) 2008-06-11
EP1250926A2 (en) 2002-10-23
EP0778024B1 (en) 2002-11-13
DE69435084D1 (de) 2008-04-24
ES2186812T3 (es) 2003-05-16
DE69435084T2 (de) 2009-03-19
CA2148822A1 (en) 1994-07-21
ES2114681T3 (es) 1998-06-01
EP1250926A3 (en) 2002-11-20
ATE388706T1 (de) 2008-03-15
EP0778024A1 (en) 1997-06-11
DK0778024T3 (da) 2002-12-23
EP1250926B1 (en) 2008-03-12
DK1250926T3 (da) 2008-07-07
EP0678025A1 (en) 1995-10-25
ATE227573T1 (de) 2002-11-15
JPH08505626A (ja) 1996-06-18
DE69409633D1 (de) 1998-05-20
DE69431731T2 (de) 2003-03-13
JP3099128B2 (ja) 2000-10-16
WO1994015604A1 (en) 1994-07-21
DE69431731D1 (de) 2002-12-19
ATE165003T1 (de) 1998-05-15
EP0678025B1 (en) 1998-04-15
ES2301590T3 (es) 2008-07-01
DE69409633T2 (de) 1998-08-06

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