ATE211142T1 - Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog - Google Patents

Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog

Info

Publication number
ATE211142T1
ATE211142T1 AT90310085T AT90310085T ATE211142T1 AT E211142 T1 ATE211142 T1 AT E211142T1 AT 90310085 T AT90310085 T AT 90310085T AT 90310085 T AT90310085 T AT 90310085T AT E211142 T1 ATE211142 T1 AT E211142T1
Authority
AT
Austria
Prior art keywords
alkyl
methylenedioxy
ch2ch2ch2n
ch2ch2n
nhco
Prior art date
Application number
AT90310085T
Other languages
English (en)
Inventor
Monroe E Wall
Allan W Nicholas
Govindarajan Manikumar
Mansukh C Wani
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27019995&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE211142(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/407,749 external-priority patent/US5049668A/en
Priority claimed from US07/581,916 external-priority patent/US5180722A/en
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Application granted granted Critical
Publication of ATE211142T1 publication Critical patent/ATE211142T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT90310085T 1989-09-15 1990-09-14 Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog ATE211142T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/407,749 US5049668A (en) 1989-09-15 1989-09-15 10,11-methylenedioxy-20(RS)-camptothecin analogs
US07/581,916 US5180722A (en) 1987-04-14 1990-09-13 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs

Publications (1)

Publication Number Publication Date
ATE211142T1 true ATE211142T1 (de) 2002-01-15

Family

ID=27019995

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90310085T ATE211142T1 (de) 1989-09-15 1990-09-14 Verfahren zur herstellung von 10,11-methylendioxy-20(rs)-camptothecin und 10,11-methylendioxy-20(s)-camptothecin-analog

Country Status (8)

Country Link
EP (1) EP0418099B1 (de)
KR (1) KR0180245B1 (de)
AT (1) ATE211142T1 (de)
CA (1) CA2066780C (de)
DE (1) DE69033880T2 (de)
DK (1) DK0418099T3 (de)
ES (1) ES2165346T3 (de)
NZ (1) NZ235329A (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
AU671605B2 (en) 1991-11-15 1996-09-05 Smithkline Beecham Corporation Combination chemotherapy
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
EP0556585A3 (de) * 1992-01-24 1993-09-01 Takeda Chemical Industries, Ltd. Kondensierte Camptotherinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
WO1994015604A1 (en) * 1993-01-15 1994-07-21 The Stehlin Foundation For Cancer Research Transdermal treatment of cancer with water-insoluble s-camptothecin of the closed lactone ring form
IS4152A (is) * 1993-04-29 1994-10-30 Glaxo Inc. Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
CA2267328A1 (en) * 1996-09-30 1998-04-09 Bayer Aktiengesellschaft Glycoconjugates from modified camptothecin derivates (20-o-linkage)
DE19640207A1 (de) * 1996-09-30 1998-04-02 Bayer Ag Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung)
TW464652B (en) * 1996-10-30 2001-11-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
ID23424A (id) * 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
US6214821B1 (en) 1998-03-05 2001-04-10 Washington State University Research Foundation Methods and composition for the inhibition of cancer cells
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2005087808A2 (en) 2004-03-05 2005-09-22 Ludwig Institute For Cancer Research Growth factor binding constructs materials and methods
DK2547359T3 (en) 2010-03-15 2016-06-06 The Board Of Trustees Of The Univ Of Illionis Inhibitors of beta integrin G-protein alpha subunit-BINDING INTERACTIONS
US9029502B2 (en) 2010-12-20 2015-05-12 The Regents Of The University Of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
JP6912386B2 (ja) 2015-01-26 2021-08-04 ザ ユニバーシティー オブ シカゴ 癌特異的なＩＬ１３Ｒα２を認識するＣＡＲ Ｔ細胞
CN107683289B (zh) 2015-01-26 2021-08-06 芝加哥大学 IL13Rα2结合剂和其在癌症治疗中的用途
CA3071599A1 (en) 2017-08-07 2019-02-14 Amgen Inc. Treatment of triple negative breast cancer or colorectal cancer with liver metastases with an anti pd-l1 antibody and an oncolytic virus
ES3017207T3 (en) 2019-03-20 2025-05-12 Univ California Claudin-6 antibodies and drug conjugates
JP7682797B2 (ja) 2019-03-20 2025-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン６二重特異性抗体
CA3136496A1 (en) 2019-04-09 2020-10-15 The Board Of Trustees Of The University Of Illinois Drug adsorbed highly porous activated carbon for enhanced drug delivery
US20220195059A1 (en) 2019-04-30 2022-06-23 Instituto de Medicina Molecular João Lobo Antunes Rank Pathway Inhibitors in Combination with CDK Inhibitors
WO2020263793A1 (en) 2019-06-24 2020-12-30 Amgen Inc. Inhibition of sirp-gamma for cancer treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体

Also Published As

Publication number Publication date
DE69033880D1 (de) 2002-01-31
KR0180245B1 (ko) 1999-03-20
EP0418099A3 (en) 1992-01-15
DE69033880T2 (de) 2002-06-06
ES2165346T3 (es) 2002-03-16
DK0418099T3 (da) 2002-04-02
CA2066780A1 (en) 1991-03-16
NZ235329A (en) 1992-01-29
CA2066780C (en) 2002-04-02
EP0418099A2 (de) 1991-03-20
EP0418099B1 (de) 2001-12-19
KR920702362A (ko) 1992-09-03

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UEP Publication of translation of european patent specification
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